Gene Symbol: sll
Description: slalom
Alias: 1422/14, CG7623, Dmel\CG7623, Sll, anon-WO0118547.555, anon-WO0172774.85, l(3)S142214, slalom, CG7623-PA, CG7623-PB, sll-PA, sll-PB
Species: fruit fly

Top Publications

  1. Kamiyama S, Suda T, Ueda R, Suzuki M, Okubo R, Kikuchi N, et al. Molecular cloning and identification of 3'-phosphoadenosine 5'-phosphosulfate transporter. J Biol Chem. 2003;278:25958-63 pubmed
    ..human gene encoding a PAPS transporter, which we have named PAPST1, and the Drosophila melanogaster ortholog, slalom (sll). The amino acid sequence of PAPST1 (432 amino acids) exhibited 48...
  2. Perrimon N, Hacker U. Wingless, hedgehog and heparan sulfate proteoglycans. Development. 2004;131:2509-11; author reply 2511-3 pubmed
  3. Zhu X, Stevens L, Stein D. Synthesis of the sulfate donor PAPS in either the Drosophila germline or somatic follicle cells can support embryonic dorsal-ventral axis formation. Development. 2007;134:1465-9 pubmed
    ..This finding indicates the existence of a conduit for the movement of PAPS between the germline and the follicle cells, which highlights a previously unappreciated mechanism of soma/germline cooperation affecting pattern formation. ..
  4. Zhang Z, Zhu X, Stevens L, Stein D. Distinct functional specificities are associated with protein isoforms encoded by the Drosophila dorsal-ventral patterning gene pipe. Development. 2009;136:2779-89 pubmed publisher
    ..This suggests the existence of a second mechanism that polarizes the Drosophila embryo, in addition to the ventrally restricted transcription of the pipe gene. ..
  5. Lüders F, Segawa H, Stein D, Selva E, Perrimon N, Turco S, et al. Slalom encodes an adenosine 3'-phosphate 5'-phosphosulfate transporter essential for development in Drosophila. EMBO J. 2003;22:3635-44 pubmed
    ..Mutations in this gene, which we call slalom, display defects in Wg and Hh signaling, which are likely due to the lack of sulfation of glycosaminoglycans by ..
  6. Chandrasekaran V, Beckendorf S. senseless is necessary for the survival of embryonic salivary glands in Drosophila. Development. 2003;130:4719-28 pubmed
    ..Furthermore, we show that in the salivary glands, sens acts as an anti-apoptotic protein by repressing reaper and possibly hid. ..
  7. Zhu X, Sen J, Stevens L, Goltz J, Stein D. Drosophila pipe protein activity in the ovary and the embryonic salivary gland does not require heparan sulfate glycosaminoglycans. Development. 2005;132:3813-22 pubmed
    ..Taken together, our data provide evidence that Pipe acts as a sulfotransferase, but argue against the hypothesis that the target of Pipe is a heparan sulfate glycosaminoglycan. ..
  8. Goda E, Kamiyama S, Uno T, Yoshida H, Ueyama M, Kinoshita Toyoda A, et al. Identification and characterization of a novel Drosophila 3'-phosphoadenosine 5'-phosphosulfate transporter. J Biol Chem. 2006;281:28508-17 pubmed
    ..The amino acid sequence of dPAPST2 showed 50.5 and 21.5% homology to the human PAPST2 and SLALOM, respectively...
  9. Nishihara S. Glycosyltransferases and transporters that contribute to proteoglycan synthesis in Drosophila: Identification and functional analyses using the heritable and inducible RNAi system. Methods Enzymol. 2010;480:323-51 pubmed publisher

More Information


  1. Chang W, Chang C, Chang Y, Sung H, Lin M, Chang S, et al. The Drosophila GOLPH3 homolog regulates the biosynthesis of heparan sulfate proteoglycans by modulating the retrograde trafficking of exostosins. Development. 2013;140:2798-807 pubmed publisher
    ..Our data demonstrate that GOLPH3 modulates the activities of EXTs, thus implicating a putative role for GOLPH3 in the formation of MO. ..