slimfast

Summary

Gene Symbol: slimfast
Description: slimfast
Alias: CG11128, Dmel\CG11128, Slif, slifA, slimfast, CG11128-PA, CG11128-PB, CG11128-PC, slif-PA, slif-PB, slif-PC
Species: fruit fly

Top Publications

  1. Bradley G, Leevers S. Amino acids and the humoral regulation of growth: fat bodies use slimfast. Cell. 2003;114:656-8 pubmed
    ..In this issue of Cell, Colombani et al. demonstrate that amino acid-responsive TOR signaling in the Drosophila fat body modulates insulin signaling and growth in peripheral tissues. ..
  2. Colombani J, Raisin S, Pantalacci S, Radimerski T, Montagne J, Leopold P. A nutrient sensor mechanism controls Drosophila growth. Cell. 2003;114:739-49 pubmed
    ..In a genetic screen for growth modifiers, we identified slimfast, a gene that encodes an amino acid transporter...
  3. Hennig K, Colombani J, Neufeld T. TOR coordinates bulk and targeted endocytosis in the Drosophila melanogaster fat body to regulate cell growth. J Cell Biol. 2006;173:963-74 pubmed
    ..stimulates bulk endocytic uptake and inhibits the targeted endocytic degradation of the amino acid importer Slimfast. Thus, TOR simultaneously down-regulates aspects of endocytosis that inhibit growth and up-regulates potential ..
  4. Cheng L, Bailey A, Leevers S, Ragan T, Driscoll P, Gould A. Anaplastic lymphoma kinase spares organ growth during nutrient restriction in Drosophila. Cell. 2011;146:435-47 pubmed publisher
    ..First, Alk suppresses the growth requirement for amino acid sensing via Slimfast/Rheb/TOR complex 1. And second, Alk, rather than insulin-like receptor, primarily activates PI3-kinase...
  5. Geminard C, Rulifson E, Leopold P. Remote control of insulin secretion by fat cells in Drosophila. Cell Metab. 2009;10:199-207 pubmed publisher
    ..Thus, the availability of nutrients is remotely sensed in fat body cells and conveyed to the brain IPCs by a humoral signal controlling ILP release. ..
  6. Goberdhan D, Meredith D, Boyd C, Wilson C. PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids. Development. 2005;132:2365-75 pubmed
    ..As PATH is likely to be saturated in vivo, we propose that one specialised function of high-affinity PAT-related molecules is to maintain growth as local nutrient levels fluctuate during development. ..
  7. Sousa Nunes R, Yee L, Gould A. Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila. Nature. 2011;471:508-12 pubmed publisher
    ..Here we provide in vivo evidence that Slimfast amino-acid sensing and Target of rapamycin (TOR) signalling activate a fat-body-derived signal (FDS) required for ..
  8. Hall D, Grewal S, de la Cruz A, Edgar B. Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila. BMC Biol. 2007;5:10 pubmed
    ..The effect of insulin signaling upon TOR activity varies according to cellular type and context. ..
  9. Turner T, Stewart A, Fields A, Rice W, Tarone A. Population-based resequencing of experimentally evolved populations reveals the genetic basis of body size variation in Drosophila melanogaster. PLoS Genet. 2011;7:e1001336 pubmed publisher
    ..By using significantly associated polymorphisms as a priori candidates in follow-up studies, these data are expected to provide considerable power to determine the genetic basis of natural variation in body size. ..

More Information

Publications24

  1. Okamoto N, Nishimura T. Signaling from Glia and Cholinergic Neurons Controls Nutrient-Dependent Production of an Insulin-like Peptide for Drosophila Body Growth. Dev Cell. 2015;35:295-310 pubmed publisher
    ..These results provide a molecular framework that explains how the production of an endocrine hormone in a specific tissue is coordinated with environmental conditions. ..
  2. Resnik Docampo M, de Celis J. MAP4K3 is a component of the TORC1 signalling complex that modulates cell growth and viability in Drosophila melanogaster. PLoS ONE. 2011;6:e14528 pubmed publisher
  3. Arquier N, Geminard C, Bourouis M, Jarretou G, Honegger B, Paix A, et al. Drosophila ALS regulates growth and metabolism through functional interaction with insulin-like peptides. Cell Metab. 2008;7:333-8 pubmed publisher
    ..These results lead us to propose an evolutionary perspective in which ALS function appeared prior to the separation between metabolic and growth effects that are associated with vertebrate insulin and IGFs. ..
  4. Storelli G, Defaye A, Erkosar B, Hols P, Royet J, Leulier F. Lactobacillus plantarum promotes Drosophila systemic growth by modulating hormonal signals through TOR-dependent nutrient sensing. Cell Metab. 2011;14:403-14 pubmed publisher
    ..Our results indicate that the intestinal microbiota should also be envisaged as a factor that influences the systemic growth of its host...
  5. Ghosh A, Rideout E, Grewal S. TIF-IA-dependent regulation of ribosome synthesis in drosophila muscle is required to maintain systemic insulin signaling and larval growth. PLoS Genet. 2014;10:e1004750 pubmed publisher
  6. Nuzhdin S, Brisson J, Pickering A, Wayne M, Harshman L, McIntyre L. Natural genetic variation in transcriptome reflects network structure inferred with major effect mutations: insulin/TOR and associated phenotypes in Drosophila melanogaster. BMC Genomics. 2009;10:124 pubmed publisher
    ..In summary, our results question the assertion of the 'sparse' nature of genetic networks, while validating and extending candidate gene approaches in the analyses of complex traits. ..
  7. Raisin S, Pantalacci S, Breittmayer J, Leopold P. A new genetic locus controlling growth and proliferation in Drosophila melanogaster. Genetics. 2003;164:1015-25 pubmed
    ..This suggested either that a particular combination of these transcripts was necessary or that other sequences are involved. ..
  8. Shim J, Mukherjee T, Banerjee U. Direct sensing of systemic and nutritional signals by haematopoietic progenitors in Drosophila. Nat Cell Biol. 2012;14:394-400 pubmed publisher
    ..We expect that this study will promote investigation of such possible direct signal sensing mechanisms by mammalian myeloid progenitors...
  9. Benmimoun B, Polesello C, Waltzer L, Haenlin M. Dual role for Insulin/TOR signaling in the control of hematopoietic progenitor maintenance in Drosophila. Development. 2012;139:1713-7 pubmed publisher
    ..Hence, our study highlights the role of the IIS/TOR pathways in orchestrating hematopoietic progenitor fate and links blood cell fate to nutritional status. ..
  10. Bjordal M, Arquier N, Kniazeff J, Pin J, Leopold P. Sensing of amino acids in a dopaminergic circuitry promotes rejection of an incomplete diet in Drosophila. Cell. 2014;156:510-21 pubmed publisher
    ..Taken together, these data identify a central amino-acid-sensing mechanism operating in specific DA neurons and controlling food intake. ..
  11. Gutierrez E, Wiggins D, Fielding B, Gould A. Specialized hepatocyte-like cells regulate Drosophila lipid metabolism. Nature. 2007;445:275-80 pubmed
    ..Tissue-specific manipulations of the Slimfast amino-acid channel, the Lsd2 fat-storage regulator and the Brummer lipase indicate that oenocytes act downstream ..
  12. Rajan A, Perrimon N. Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion. Cell. 2012;151:123-37 pubmed publisher
    ..Strikingly, we find that human Leptin can rescue the upd2 mutant phenotypes, suggesting that Upd2 is the functional homolog of Leptin. ..
  13. Armstrong A, Laws K, Drummond Barbosa D. Adipocyte amino acid sensing controls adult germline stem cell number via the amino acid response pathway and independently of Target of Rapamycin signaling in Drosophila. Development. 2014;141:4479-88 pubmed publisher
    ..These studies reveal a new step in adipocyte-stem cell crosstalk. ..
  14. Ivanov D, Escott Price V, Ziehm M, Magwire M, Mackay T, Partridge L, et al. Longevity GWAS Using the Drosophila Genetic Reference Panel. J Gerontol A Biol Sci Med Sci. 2015;70:1470-8 pubmed publisher
    ..Genes in the target of rapamycin pathway (TOR; Chrb, slif, mipp2, dredd, RpS9, dm) contributed to the significant enrichment of this pathway among the top-ranked 100 genes (..
  15. Nowak K, Seisenbacher G, Hafen E, Stocker H. Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues. elife. 2013;2:e00380 pubmed publisher
    ..Akt/PKB and TORC1, and a reduction in amino acid uptake by reducing the levels of the amino acid transporter Slimfast caused clones of PTEN mutant cells to collapse...