Gene Symbol: Skeletor
Description: skeletor
Alias: 2Ab3, CG14681, CG14682, CG31261, CG32922, CG33676, CG43161, Dmel\CG43161, Dmel_CG14681, Dmel_CG33676, skeletor, skeletor, CG43161-PB, CG43161-PC, CG43161-PD, CG43161-PE, Skeletor-PB, Skeletor-PC, Skeletor-PD, Skeletor-PE
Species: fruit fly
Products:     Skeletor

Top Publications

  1. Johansen K. Dynamic remodeling of nuclear architecture during the cell cycle. J Cell Biochem. 1996;60:289-96 pubmed
  2. Johansen K, Johansen J, Baek K, Jin Y. Remodeling of nuclear architecture during the cell cycle in Drosophila embryos. J Cell Biochem. 1996;63:268-79 pubmed
  3. Johansen K, Johansen J, Jin Y, Walker D, Wang D, Wang Y. Chromatin structure and nuclear remodeling. Crit Rev Eukaryot Gene Expr. 1999;9:267-77 pubmed
    ..processes: JIL-1 is a tandem serine-threonine kinase implicated in the regulation of chromatin structure, whereas Skeletor is a novel protein participating in structural nuclear remodeling during the cell cycle...
  4. Walker D, Wang D, Jin Y, Rath U, Wang Y, Johansen J, et al. Skeletor, a novel chromosomal protein that redistributes during mitosis provides evidence for the formation of a spindle matrix. J Cell Biol. 2000;151:1401-12 pubmed
    ..In Drosophila, we have cloned and characterized a novel nuclear protein, skeletor, that we propose is part of a macromolecular complex forming such a spindle matrix...
  5. Silverman Gavrila R, Wilde A. Ran is required before metaphase for spindle assembly and chromosome alignment and after metaphase for chromosome segregation and spindle midbody organization. Mol Biol Cell. 2006;17:2069-80 pubmed
    ..The Ran pathway mediates these mitotic events, in part, by facilitating the correct targeting of the kinase Aurora A and the kinesins KLP61F and KLP3A to spindles. ..
  6. Sengupta S, Rath U, Yao C, Zavortink M, Wang C, Girton J, et al. Digitor/dASCIZ Has Multiple Roles in Drosophila Development. PLoS ONE. 2016;11:e0166829 pubmed publisher
    In this study we provide evidence that the spindle matrix protein Skeletor in Drosophila interacts with the human ASCIZ (also known as ATMIN and ZNF822) ortholog, Digitor/dASCIZ...
  7. Bownes M, Charlesworth B, Davis I, Finnegan D, Heck M, Jarman A, et al. Report on the 17(th) European Drosophila research conference. Bioessays. 2002;24:99-101 pubmed
  8. Ostrowski S, Dierick H, Bejsovec A. Genetic control of cuticle formation during embryonic development of Drosophila melanogaster. Genetics. 2002;161:171-82 pubmed
  9. Wilson P, Simmons R, Saighal S, Shigali S. Novel nuclear defects in KLP61F-deficient mutants in Drosophila are partially suppressed by loss of Ncd function. J Cell Sci. 2004;117:4921-33 pubmed
    ..Our results are consistent with a model in which KLP61F prevents Ncd-mediated collapse of a nonmicrotubule matrix derived from the interphase nucleus. ..

More Information


  1. Aravind L. DOMON: an ancient extracellular domain in dopamine beta-monooxygenase and other proteins. Trends Biochem Sci. 2001;26:524-6 pubmed
    ..This domain was predicted to adopt an all-beta fold with seven or eight strands and might function as a module mediating a range of extracellular adhesive interactions. ..
  2. Qi H, Rath U, Wang D, Xu Y, Ding Y, Zhang W, et al. Megator, an essential coiled-coil protein that localizes to the putative spindle matrix during mitosis in Drosophila. Mol Biol Cell. 2004;15:4854-65 pubmed
    ..ortholog in Drosophila with an extended coiled-coil domain, colocalizes with the putative spindle matrix proteins Skeletor and Chromator during mitosis...
  3. Qi H, Rath U, Ding Y, Ji Y, Blacketer M, Girton J, et al. EAST interacts with Megator and localizes to the putative spindle matrix during mitosis in Drosophila. J Cell Biochem. 2005;95:1284-91 pubmed interphase, redistributes during mitosis to colocalize with the spindle matrix proteins, Megator and Skeletor. EAST and Megator also colocalize to the intranuclear space surrounding the chromosomes at interphase...
  4. Johansen J, Johansen K. The spindle matrix through the cell cycle in Drosophila. Fly (Austin). 2009;3:213-20 pubmed
  5. Scholey J, Rogers G, Sharp D. Mitosis, microtubules, and the matrix. J Cell Biol. 2001;154:261-6 pubmed
    ..The mechanical events of mitosis depend on the action of microtubules and mitotic motors, but whether these spindle components act alone or in concert with a spindle matrix is an important question. ..