SK

Summary

Gene Symbol: SK
Description: small conductance calcium-activated potassium channel
Alias: BcDNA:GM01744, CG10706, CG12733, CG4179, Dmel\CG10706, dSK, small conductance calcium-activated potassium channel, CG10706-PH, CG10706-PI, CG10706-PJ, CG10706-PK, CG10706-PL, CG10706-PM, CG10706-PN, CG10706-PO, CG10706-PP, CG10706-PQ, CG10706-PR, CG10706-PS, CG10706-PT, CG10706-PU, SK-PH, SK-PI, SK-PJ, SK-PK, SK-PL, SK-PM, SK-PN, SK-PO, SK-PP, SK-PQ, SK-PR, SK-PS, SK-PT, SK-PU
Species: fruit fly

Top Publications

  1. Abou Tayoun A, Li X, Chu B, Hardie R, Juusola M, Dolph P. The Drosophila SK channel (dSK) contributes to photoreceptor performance by mediating sensitivity control at the first visual network. J Neurosci. 2011;31:13897-910 pubmed publisher
    ..Here, we generated a Drosophila line that lacks the single highly conserved SK gene in its genome (dSK). In R1-R6 photoreceptors, dSK encodes a slow Ca²?-activated K(+) current similar to its mammalian counterparts...
  2. McCormack T. Comparison of K+-channel genes within the genomes of Anopheles gambiae and Drosophila melanogaster. Genome Biol. 2003;4:R58 pubmed
  3. Glazov E, Pheasant M, McGraw E, Bejerano G, Mattick J. Ultraconserved elements in insect genomes: a highly conserved intronic sequence implicated in the control of homothorax mRNA splicing. Genome Res. 2005;15:800-8 pubmed
  4. Blow N, Salomon R, GARRITY K, Reveillaud I, Kopin A, Jackson F, et al. Vibrio cholerae infection of Drosophila melanogaster mimics the human disease cholera. PLoS Pathog. 2005;1:e8 pubmed
    ..loss; (ii) flies harboring mutant alleles of either adenylyl cyclase, Gsalpha, or the Gardos K channel homolog SK are resistant to V. cholerae infection; and (iii) ingestion of a K channel blocker along with V...
  5. Sénatore S, Rami Reddy V, Semeriva M, Perrin L, Lalevee N. Response to mechanical stress is mediated by the TRPA channel painless in the Drosophila heart. PLoS Genet. 2010;6:e1001088 pubmed publisher
  6. Dimitriadi M, Sleigh J, Walker A, Chang H, Sen A, Kalloo G, et al. Conserved genes act as modifiers of invertebrate SMN loss of function defects. PLoS Genet. 2010;6:e1001172 pubmed publisher
  7. Qurashi A, Liu H, Ray L, Nelson D, Duan R, Jin P. Chemical screen reveals small molecules suppressing fragile X premutation rCGG repeat-mediated neurodegeneration in Drosophila. Hum Mol Genet. 2012;21:2068-75 pubmed publisher
    ..Our results demonstrate the utility of Drosophila models for unbiased small molecule screens and point to PLA(2) as a possible therapeutic target to treat FXTAS. ..
  8. Abou Tayoun A, PIKIELNY C, Dolph P. Roles of the Drosophila SK channel (dSK) in courtship memory. PLoS ONE. 2012;7:e34665 pubmed publisher
    ..Here, we take advantage of Drosophila melanogaster with its single SK gene (dSK) and well-established courtship memory assay to investigate the contribution of this channel to memory...
  9. Ma L, Ma J, Xu K. Effect of spaceflight on the circadian rhythm, lifespan and gene expression of Drosophila melanogaster. PLoS ONE. 2015;10:e0121600 pubmed publisher

More Information

Publications12

  1. Pan L, Xie W, Li K, Yang Z, Xu J, Zhang W, et al. Heterochromatin remodeling by CDK12 contributes to learning in Drosophila. Proc Natl Acad Sci U S A. 2015;112:13988-93 pubmed publisher
    ..Taken together, these results define a previously unidentified role of CDK12 in controlling the epigenetic transition between euchromatin and heterochromatin and suggest a chromatin regulatory mechanism in neuronal behaviors. ..
  2. Gertner D, Desai S, Lnenicka G. Synaptic excitation is regulated by the postsynaptic dSK channel at the Drosophila larval NMJ. J Neurophysiol. 2014;111:2533-43 pubmed publisher
    ..This reduction in synaptic excitation was due to the postsynaptic Drosophila SK (dSK) channel; synaptic depression, increased membrane conductance and RMP hyperpolarization were reduced in dSK mutants ..
  3. Murali T, Pacifico S, Finley R. Integrating the interactome and the transcriptome of Drosophila. BMC Bioinformatics. 2014;15:177 pubmed publisher
    ..This organization implies that tissue or stage specific networks can be best identified from interactome data by using filters designed to include both ubiquitously expressed and specifically expressed genes and proteins. ..