Gene Symbol: Sin1
Description: SAPK-interacting protein 1
Alias: CG10105, Dmel\CG10105, dSin1, sin1, SAPK-interacting protein 1, CG10105-PA, Sin1-PA, Stress-activated protein kinase [SAPK]-interacting protein, stress-activated map kinase-interacting protein 1
Species: fruit fly

Top Publications

  1. Hietakangas V, Cohen S. Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth. Genes Dev. 2007;21:632-7 pubmed
    ..Mutants removing critical TORC2 components, rictor and sin1, strongly reduced AKT hydrophobic motif (HM) phosphorylation and AKT activity, but showed only minor growth ..
  2. Koike Kumagai M, Yasunaga K, Morikawa R, Kanamori T, Emoto K. The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signalling pathway. EMBO J. 2009;28:3879-92 pubmed publisher
    ..We here report that Sin1, Rictor, and target of rapamycin (TOR), components of the TOR complex 2 (TORC2), are required for dendritic tiling ..
  3. Frias M, Thoreen C, Jaffe J, Schroder W, Sculley T, Carr S, et al. mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s. Curr Biol. 2006;16:1865-70 pubmed
    ..Even though all mTORC2s can phosphorylate Akt/PKB in vitro, insulin regulates the activity of only two of them. Thus, we propose that cells contain several mTORC2 flavors that may phosphorylate Akt/PKB in response to different signals. ..
  4. Glatter T, Schittenhelm R, Rinner O, Roguska K, Wepf A, J√ľnger M, et al. Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome. Mol Syst Biol. 2011;7:547 pubmed publisher
    ..Subsequent genetic studies in flies suggest a role for dTTT in controlling cell growth via a dTORC1- and dTORC2-dependent mechanism. ..
  5. Han C, Wang D, Soba P, Zhu S, Lin X, Jan L, et al. Integrins regulate repulsion-mediated dendritic patterning of drosophila sensory neurons by restricting dendrites in a 2D space. Neuron. 2012;73:64-78 pubmed publisher
    ..Moreover, overexpression of integrins in these mutant neurons effectively reduces dendritic crossing and restores tiling, revealing an additional mechanism for tiling. ..
  6. Papatheodorou I, Ziehm M, Wieser D, Alic N, Partridge L, Thornton J. Using answer set programming to integrate RNA expression with signalling pathway information to infer how mutations affect ageing. PLoS ONE. 2012;7:e50881 pubmed publisher
    ..Our methods are available in the web-service NetEffects: ..
  7. Vachias C, Fritsch C, Pouchin P, Bardot O, Mirouse V. Tight coordination of growth and differentiation between germline and soma provides robustness for drosophila egg development. Cell Rep. 2014;9:531-41 pubmed publisher
    ..Altogether, our results reveal an integrated and particularly robust mechanism ensuring the spatial and temporal coordination of tissue size, cell size, and cell differentiation for the proper development of two adjacent tissues. ..
  8. Yang Q, Inoki K, Ikenoue T, Guan K. Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev. 2006;20:2820-32 pubmed
    ..Here, we report that Sin1 is an essential component of TORC2 but not of TORC1, and functions similarly to Rictor, the defining member of ..
  9. Wu Z, Sawada T, Shiba K, Liu S, Kanao T, Takahashi R, et al. Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance. Genes Dev. 2013;27:157-62 pubmed publisher
    ..Genetically, mTORC2 and Trc act upstream of Parkin. Thus, multiplex kinase signaling is acting between PINK1 and Parkin to regulate MQC, a process highly conserved in mammals. ..

More Information


  1. Jevtov I, Zacharogianni M, van Oorschot M, van Zadelhoff G, Aguilera Gomez A, Vuillez I, et al. TORC2 mediates the heat stress response in Drosophila by promoting the formation of stress granules. J Cell Sci. 2015;128:2497-508 pubmed publisher
    ..We propose that TORC2 mediates heat resistance in Drosophila by promoting the cell autonomous formation of stress granules. ..
  2. Allen V, O Connor R, Ulgherait M, Zhou C, Stone E, Hill V, et al. period-Regulated Feeding Behavior and TOR Signaling Modulate Survival of Infection. Curr Biol. 2016;26:184-194 pubmed publisher
    ..We further demonstrate that TOR signaling mediates both resistance and tolerance of infection and identify TORC2 as a novel potential therapeutic target for increasing survival of infection. ..
  3. Meltzer S, Yadav S, Lee J, Soba P, Younger S, Jin P, et al. Epidermis-Derived Semaphorin Promotes Dendrite Self-Avoidance by Regulating Dendrite-Substrate Adhesion in Drosophila Sensory Neurons. Neuron. 2016;89:741-55 pubmed publisher
    ..These results reveal a novel role for semaphorins in dendrite patterning and illustrate how epidermal-derived cues regulate neural circuit assembly. ..
  4. Zheng X, Sehgal A. AKT and TOR signaling set the pace of the circadian pacemaker. Curr Biol. 2010;20:1203-8 pubmed publisher
  5. Dimitroff B, Howe K, Watson A, Campion B, Lee H, Zhao N, et al. Diet and energy-sensing inputs affect TorC1-mediated axon misrouting but not TorC2-directed synapse growth in a Drosophila model of tuberous sclerosis. PLoS ONE. 2012;7:e30722 pubmed publisher
    ..S6k), synapse overgrowth was only suppressed by reducing the function of Tor complex 2 (TorC2) components (Rictor, Sin1)...
  6. Nagai T, Mizuno K. Multifaceted roles of Furry proteins in invertebrates and vertebrates. J Biochem. 2014;155:137-46 pubmed publisher
    ..Here, we review current knowledge about the diverse cellular functions and regulation of Fry proteins in invertebrates and vertebrates. ..
  7. Lee J, Peng Y, Lin W, Parrish J. Coordinate control of terminal dendrite patterning and dynamics by the membrane protein Raw. Development. 2015;142:162-73 pubmed publisher
    ..Thus, Raw defines a potential point of convergence in distinct pathways shaping terminal dendrite patterning. ..