SIFa

Summary

Gene Symbol: SIFa
Description: SIFamide
Alias: CG33527, Dmel\CG33527, Drm-IFa, Drm-SIFa, IFAMIDE, IFa, Neb-LFamide, SIFR, SIFamide, AYRKPPFNGSLFamide, CG33527-PB, IFamide, Neb-LFamide, SIFa-PB, neuropeptide AYRKPPFNGSIFamide, neuropeptide IFamide
Species: fruit fly

Top Publications

  1. Shang Y, Donelson N, Vecsey C, Guo F, Rosbash M, Griffith L. Short neuropeptide F is a sleep-promoting inhibitory modulator. Neuron. 2013;80:171-83 pubmed publisher
    ..sNPF acutely increases sleep without altering feeding behavior, which it affects only on a much longer time scale. The profound effect of sNPF on sleep indicates that it is an important sleep-promoting molecule. ..
  2. Verleyen P, Huybrechts J, Baggerman G, Van Lommel A, De Loof A, Schoofs L. SIFamide is a highly conserved neuropeptide: a comparative study in different insect species. Biochem Biophys Res Commun. 2004;320:334-41 pubmed
    Neb-LFamide or AYRKPPFNGSLFamide was originally purified from the grey flesh fly Neobellieria bullata as a myotropic neuropeptide...
  3. Yew J, Wang Y, Barteneva N, Dikler S, Kutz Naber K, Li L, et al. Analysis of neuropeptide expression and localization in adult drosophila melanogaster central nervous system by affinity cell-capture mass spectrometry. J Proteome Res. 2009;8:1271-84 pubmed publisher
    ..Neuropeptide profiling also was performed on targeted populations of cells which were enriched with immunoaffinity purification using a genetically expressed marker. ..
  4. Baggerman G, Boonen K, Verleyen P, De Loof A, Schoofs L. Peptidomic analysis of the larval Drosophila melanogaster central nervous system by two-dimensional capillary liquid chromatography quadrupole time-of-flight mass spectrometry. J Mass Spectrom. 2005;40:250-60 pubmed
    ..Among the 38 sequenced peptides, some originate from precursors, such as the tachykinin and the IFamide precursor that were entirely missed in the first study...
  5. Terhzaz S, Rosay P, Goodwin S, Veenstra J. The neuropeptide SIFamide modulates sexual behavior in Drosophila. Biochem Biophys Res Commun. 2007;352:305-10 pubmed
    The expression of Drosophila neuropeptide AYRKPPFNGSIFamide (SIFamide) was shown by both immunohistology and in situ hybridization to be restricted to only four neurons of the pars intercerebralis...
  6. Kahsai L, Winther A. Chemical neuroanatomy of the Drosophila central complex: distribution of multiple neuropeptides in relation to neurotransmitters. J Comp Neurol. 2011;519:290-315 pubmed publisher
    ..neuropeptides; Drosophila tachykinin, short neuropeptide F, myoinhibitory peptide, allatostatin A, proctolin, SIFamide, neuropeptide F, and FMRFamide...
  7. Carlsson M, Diesner M, Schachtner J, Nassel D. Multiple neuropeptides in the Drosophila antennal lobe suggest complex modulatory circuits. J Comp Neurol. 2010;518:3359-80 pubmed publisher
    ..These were short neuropeptide F, tachykinin related peptide, allatostatin A, myoinhibitory peptide, SIFamide, IPNamide, and myosuppressin...
  8. J rgensen L, Hauser F, Cazzamali G, Williamson M, Grimmelikhuijzen C. Molecular identification of the first SIFamide receptor. Biochem Biophys Res Commun. 2006;340:696-701 pubmed publisher
    SIFamide is the short name and also the C terminus of the Drosophila neuropeptide AYRKPPFNGSIFamide. SIFamide has been isolated or predicted from various insects and crustaceans, and appears to be extremely well conserved among these ..
  9. Sellami A, Veenstra J. SIFamide acts on fruitless neurons to modulate sexual behavior in Drosophila melanogaster. Peptides. 2015;74:50-6 pubmed publisher
    ..Bisexual behavior in males also occurs in the absence of the neuropeptide SIFamide. We show here that the SIFamide neurons do not express fruitless...

More Information

Publications18

  1. Sellami A, Wegener C, Veenstra J. Functional significance of the copper transporter ATP7 in peptidergic neurons and endocrine cells in Drosophila melanogaster. FEBS Lett. 2012;586:3633-8 pubmed publisher
    ..effect differed from one cell type to another; it was very pronounced for AKH and corazonin, but much less so for SIFamide and myosuppressin...
  2. Santos J, Vömel M, Struck R, Homberg U, Nässel D, Wegener C. Neuroarchitecture of peptidergic systems in the larval ventral ganglion of Drosophila melanogaster. PLoS ONE. 2007;2:e695 pubmed
    ..The data can further be useful to identify colocalized transmitters and receptors, and develop peptidergic neurons as new landmarks. ..
  3. Johnson E, Tift F, McCauley A, Liu L, Roman G. Functional characterization of kurtz, a Drosophila non-visual arrestin, reveals conservation of GPCR desensitization mechanisms. Insect Biochem Mol Biol. 2008;38:1016-22 pubmed publisher
    ..Furthermore, we report that kurtz mutants exhibit hypersensitivity to osmotic stress, implicating GPCR desensitization as an important feature of the endocrine events that shape this stress response. ..
  4. Wegener C, Gorbashov A. Molecular evolution of neuropeptides in the genus Drosophila. Genome Biol. 2008;9:R131 pubmed publisher
    ..The last common ancestor of Drosophila obviously had a set of neuropeptides and peptide hormones identical to that of modern fruit flies. This is remarkable, since drosophilid flies have adapted to very different environments. ..
  5. Johnson E, Bohn L, Taghert P. Drosophila CG8422 encodes a functional diuretic hormone receptor. J Exp Biol. 2004;207:743-8 pubmed
    ..The identification of a Drosophila receptor for the DH neuropeptide provides a basis for genetic analysis of this critical factor's roles in maintaining physiological homeostasis. ..
  6. Cavanaugh D, Geratowski J, Wooltorton J, Spaethling J, Hector C, Zheng X, et al. Identification of a circadian output circuit for rest:activity rhythms in Drosophila. Cell. 2014;157:689-701 pubmed publisher
    ..Notably, selective activation or ablation of just six DH44+ PI cells causes arrhythmicity. These findings delineate a circuit through which clock cells can modulate locomotor rhythms. ..
  7. Salisbury J, Boggio K, Hsu Y, Quijada J, Sivachenko A, Gloeckner G, et al. A rapid MALDI-TOF mass spectrometry workflow for Drosophila melanogaster differential neuropeptidomics. Mol Brain. 2013;6:60 pubmed publisher
    ..While the data analysis methods should be compatible with other sample preparations, the presented sample preparation method was sufficient to identify previously unconfirmed D. melanogaster neuropeptides. ..
  8. Park S, Sonn J, Oh Y, Lim C, Choe J. SIFamide and SIFamide receptor defines a novel neuropeptide signaling to promote sleep in Drosophila. Mol Cells. 2014;37:295-301 pubmed publisher
    b>SIFamide receptor (SIFR) is a Drosophila G protein-coupled receptor for the neuropeptide SIFamide (SIFa)...
  9. Mertens I, Meeusen T, Huybrechts R, De Loof A, Schoofs L. Characterization of the short neuropeptide F receptor from Drosophila melanogaster. Biochem Biophys Res Commun. 2002;297:1140-8 pubmed