shtd

Summary

Gene Symbol: shtd
Description: shattered
Alias: APC1, Apc1, CG9198, Dmel\CG9198, SHTD, Shtd, shattered, CG9198-PA, shtd-PA
Species: fruit fly

Top Publications

  1. Harper J, Burton J, Solomon M. The anaphase-promoting complex: it's not just for mitosis any more. Genes Dev. 2002;16:2179-206 pubmed
  2. Buttitta L, Katzaroff A, Edgar B. A robust cell cycle control mechanism limits E2F-induced proliferation of terminally differentiated cells in vivo. J Cell Biol. 2010;189:981-96 pubmed publisher
    ..These mechanisms are essential for proper development, as evading them leads to tissue outgrowths composed of dividing but terminally differentiated cells. ..
  3. Whitfield Z, Chisholm J, Hawley R, Orr Weaver T. A meiosis-specific form of the APC/C promotes the oocyte-to-embryo transition by decreasing levels of the Polo kinase inhibitor matrimony. PLoS Biol. 2013;11:e1001648 pubmed publisher
    ..These data indicate APC(Cort) ubiquitylates Mtrm at the oocyte-to-embryo transition, thus preventing excessive inhibition of Polo kinase activity due to Mtrm's presence. ..
  4. Acquaviva C, Pines J. The anaphase-promoting complex/cyclosome: APC/C. J Cell Sci. 2006;119:2401-4 pubmed
  5. Silies M, Klämbt C. APC/C(Fzr/Cdh1)-dependent regulation of cell adhesion controls glial migration in the Drosophila PNS. Nat Neurosci. 2010;13:1357-64 pubmed publisher
    ..This represents a simple mechanism by which a subcellular gradient of adhesiveness can coordinate glial migration with axonal growth...
  6. Mohd Sarip A, Lagarou A, Doyen C, van der Knaap J, Aslan U, Bezstarosti K, et al. Transcription-independent function of Polycomb group protein PSC in cell cycle control. Science. 2012;336:744-7 pubmed publisher
    ..Thus, PSC appears to mediate both developmental gene silencing and posttranslational control of mitosis. Direct regulation of cell cycle progression might be a crucial part of the PcG system's function in development and cancer. ..
  7. Défachelles L, Hainline S, Menant A, Lee L, Karess R. A maternal effect rough deal mutation suggests that multiple pathways regulate Drosophila RZZ kinetochore recruitment. J Cell Sci. 2015;128:1204-16 pubmed publisher
  8. Meghini F, Martins T, Tait X, Fujimitsu K, Yamano H, Glover D, et al. Targeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit. Nat Commun. 2016;7:12607 pubmed publisher
    ..Finally, we show that Spd2 is also a novel APC/C(Fzr) substrate. Our study is the first to demonstrate the critical importance of distinct subcellular pools of APC/C activators in the spatiotemporal control of APC/C activity. ..