Gene Symbol: Shaw
Description: Shaker cognate w
Alias: CG15419, CG2822, Dmel\CG2822, Kv3, Kv3.1, Shaw2, dShaw, dShaw2, shaw, shaker cognate w, CG2822-PA, CG2822-PB, CG2822-PC, CG2822-PD, CG2822-PE, Shaw-PA, Shaw-PB, Shaw-PC, Shaw-PD, Shaw-PE
Species: fruit fly

Top Publications

  1. Butler A, Wei A, Baker K, Salkoff L. A family of putative potassium channel genes in Drosophila. Science. 1989;243:943-7 pubmed
    ..DNA probe and low-stringency hybridization, three additional family members have now been isolated, Shab, Shaw, and Shal. The Shaker family genes are not clustered in the genome...
  2. Diao F, Chaufty J, Waro G, Tsunoda S. SIDL interacts with the dendritic targeting motif of Shal (K(v)4) K+ channels in Drosophila. Mol Cell Neurosci. 2010;45:75-83 pubmed publisher
    ..The identification of SIDL may provide the first step for future investigation into the molecular machinery regulating the LL-motif-dependent targeting of K(+) channels. ..
  3. Tsunoda S, Salkoff L. Genetic analysis of Drosophila neurons: Shal, Shaw, and Shab encode most embryonic potassium currents. J Neurosci. 1995;15:1741-54 pubmed
    ..b>Shaw encodes a 42 pS noninactivating channel distinctive for its extremely low voltage sensitivity; Shaw channels have a ..
  4. Tsunoda S, Salkoff L. The major delayed rectifier in both Drosophila neurons and muscle is encoded by Shab. J Neurosci. 1995;15:5209-21 pubmed
    ..Although most of the delayed rectifier current is the product of the Shab gene, the Shaw gene contributes a small "leak" current to most neurons and muscle cells...
  5. McCormack K, Tanouye M, Iverson L, Lin J, Ramaswami M, McCormack T, et al. A role for hydrophobic residues in the voltage-dependent gating of Shaker K+ channels. Proc Natl Acad Sci U S A. 1991;88:2931-5 pubmed
    ..Our results suggest that the leucines mediate interactions that play an important role in the transduction of charge movement into channel opening and closing. ..
  6. Wei A, Covarrubias M, Butler A, Baker K, Pak M, Salkoff L. K+ current diversity is produced by an extended gene family conserved in Drosophila and mouse. Science. 1990;248:599-603 pubmed
    The Drosophila Shaker gene on the X chromosome has three sister genes, Shal, Shab, and Shaw, which map to the second and third chromosomes...
  7. Diao F, Waro G, Tsunoda S. Fast inactivation of Shal (K(v)4) K+ channels is regulated by the novel interactor SKIP3 in Drosophila neurons. Mol Cell Neurosci. 2009;42:33-44 pubmed publisher
    ..As a scaffold-like protein, SKIP3 is likely to lead to the identification of a novel regulatory complex that modulates Shal channel inactivation. ..
  8. Hodge J, Choi J, O Kane C, Griffith L. Shaw potassium channel genes in Drosophila. J Neurobiol. 2005;63:235-54 pubmed
    Drosophila Shaw encodes a voltage-insensitive, slowly activating, noninactivating K(+) current. The functional and developmental roles of this channel are unknown...
  9. Covarrubias M, Rubin E. Ethanol selectively blocks a noninactivating K+ current expressed in Xenopus oocytes. Proc Natl Acad Sci U S A. 1993;90:6957-60 pubmed
    ..We report that only the Drosophila Shaw2 channel, which does not inactivate upon prolonged depolarization, is rapidly and reversibly blocked by ethanol in ..

More Information


  1. Ping Y, Hahm E, Waro G, Song Q, Vo Ba D, Licursi A, et al. Linking aβ42-induced hyperexcitability to neurodegeneration, learning and motor deficits, and a shorter lifespan in an Alzheimer's model. PLoS Genet. 2015;11:e1005025 pubmed publisher
    ..We conclude that Aβ42-induced hyperactivity plays a critical role in the age-dependent cognitive and motor decline of this Aβ42-Drosophila model, and possibly in AD. ..
  2. Frolov R, Bagati A, Casino B, Singh S. Potassium channels in Drosophila: historical breakthroughs, significance, and perspectives. J Neurogenet. 2012;26:275-90 pubmed
    ..Drosophila has also helped in discovering other K(+) channels, such as Shab, Shaw, Shal, Eag, Sei, Elk, and also Slo, a Ca(2+) - and voltage-dependent K(+) channel...
  3. Salkoff L, Baker K, Butler A, Covarrubias M, Pak M, Wei A. An essential 'set' of K+ channels conserved in flies, mice and humans. Trends Neurosci. 1992;15:161-6 pubmed
    ..This conservation of the K+ channel subfamilies Shaker, Shal, Shab, and Shaw suggests that not only the broad outlines of membrane electrical properties but also many molecular details as well ..
  4. McCormack T. Comparison of K+-channel genes within the genomes of Anopheles gambiae and Drosophila melanogaster. Genome Biol. 2003;4:R58 pubmed
    ..and Anopheles are present in a 1:1 ratio, Anopheles has more genes in three K+-channel types, namely KQT, Kv3, and inward rectifier channels...
  5. Logothetis D, Kammen B, Lindpaintner K, Bisbas D, Nadal Ginard B. Gating charge differences between two voltage-gated K+ channels are due to the specific charge content of their respective S4 regions. Neuron. 1993;10:1121-9 pubmed
    ..However, differences in residues inside the S4 region are not sufficient to account for each channel's characteristic voltage range of activation. ..
  6. Strong M, Chandy K, Gutman G. Molecular evolution of voltage-sensitive ion channel genes: on the origins of electrical excitability. Mol Biol Evol. 1993;10:221-42 pubmed
    ..The Shaw-related K+ channels and the Na+ channel family have also undergone considerable expansion in mammals, relative to ..
  7. Xu J, Yu W, Jan Y, Jan L, Li M. Assembly of voltage-gated potassium channels. Conserved hydrophilic motifs determine subfamily-specific interactions between the alpha-subunits. J Biol Chem. 1995;270:24761-8 pubmed
    ..of the cloned genes for the alpha-subunits are classified into four subfamilies: Kv1 (Shaker), Kv2 (Shab), Kv3 (Shaw), and Kv4 (Shal)...
  8. Covarrubias M, Wei A, Salkoff L. Shaker, Shal, Shab, and Shaw express independent K+ current systems. Neuron. 1991;7:763-73 pubmed
    ..We show that Drosophila Shaker, Shal, Shab, and Shaw subunits form functional homomultimers, but that a molecular barrier to heteropolymerization is present...
  9. Stephan M, Agnew W. Voltage-sensitive Na+ channels: motifs, modes and modulation. Curr Opin Cell Biol. 1991;3:676-84 pubmed
    ..At the same time, however, electrophysiological studies have revealed new, more complex functional properties in the form of at least two gating modes and the existence of as yet unidentified modulatory factors. ..
  10. Gasque G, Labarca P, Reynaud E, Darszon A. Shal and shaker differential contribution to the K+ currents in the Drosophila mushroom body neurons. J Neurosci. 2005;25:2348-58 pubmed
    ..We found that transcripts for shab, shaw, shaker, and shal, among which only Shaker and Shal have been reported to code for A-type currents, are present in ..
  11. Berger S, Crook S. Modeling the Influence of Ion Channels on Neuron Dynamics in Drosophila. Front Comput Neurosci. 2015;9:139 pubmed publisher
  12. Hoopengardner B, Bhalla T, Staber C, Reenan R. Nervous system targets of RNA editing identified by comparative genomics. Science. 2003;301:832-6 pubmed
    ..These results point to a pivotal role for RNA editing in nervous system function. ..
  13. Yu W, Xu J, Li M. NAB domain is essential for the subunit assembly of both alpha-alpha and alpha-beta complexes of shaker-like potassium channels. Neuron. 1996;16:441-53 pubmed
  14. Butler A, Wei A, Salkoff L. Shal, Shab, and Shaw: three genes encoding potassium channels in Drosophila. Nucleic Acids Res. 1990;18:2173-4 pubmed
  15. Jan L, Jan Y. How might the diversity of potassium channels be generated?. Trends Neurosci. 1990;13:415-9 pubmed
    ..How might this tremendous diversity of potassium channels be generated? Partial answers have begun to emerge as molecular studies of potassium channel genes have become possible over the past few years. ..
  16. Harris T, Shahidullah M, Ellingson J, Covarrubias M. General anesthetic action at an internal protein site involving the S4-S5 cytoplasmic loop of a neuronal K(+) channel. J Biol Chem. 2000;275:4928-36 pubmed
    ..Domain swapping between dShaw2 (alkanol-sensitive) and hKv3...
  17. Adnot S, Chabrier P, Brun Buisson C, Viossat I, Braquet P. Atrial natriuretic factor attenuates the pulmonary pressor response to hypoxia. J Appl Physiol (1985). 1988;65:1975-83 pubmed
    ..No change in PVR or SVR occurred in normoxic animals at any ANF infusion rate. These results suggest that ANF may act as an endogenous pulmonary vasodilator that could modulate the pulmonary pressor response to hypoxia...
  18. Agosto J, Choi J, Parisky K, Stilwell G, Rosbash M, Griffith L. Modulation of GABAA receptor desensitization uncouples sleep onset and maintenance in Drosophila. Nat Neurosci. 2008;11:354-9 pubmed publisher
    ..These experiments uncouple the regulation of sleep latency from that of sleep duration and suggest that the kinetics of GABA(A) receptor signaling dictate sleep latency. ..
  19. Hodge J, Stanewsky R. Function of the Shaw potassium channel within the Drosophila circadian clock. PLoS ONE. 2008;3:e2274 pubmed publisher
    ..that regulate resting membrane potential (RMP) in the native clock of Drosophila we modulated the function of Shaw, a widely expressed neuronal potassium (K(+)) channel known to regulate RMP in Drosophila central neurons...
  20. Parisky K, Agosto J, Pulver S, Shang Y, Kuklin E, Hodge J, et al. PDF cells are a GABA-responsive wake-promoting component of the Drosophila sleep circuit. Neuron. 2008;60:672-82 pubmed publisher
  21. Pak M, Covarrubias M, Ratcliffe A, Salkoff L. A mouse brain homolog of the Drosophila Shab K+ channel with conserved delayed-rectifier properties. J Neurosci. 1991;11:869-80 pubmed
    ..The mShab current closely resembles a native delayed-rectifier-type potassium current, IK, in hippocampal neurons. ..
  22. Zhang J, Qu X, Covarrubias M, Germann M. Insight into the modulation of Shaw2 Kv channels by general anesthetics: structural and functional studies of S4-S5 linker and S6 C-terminal peptides in micelles by NMR. Biochim Biophys Acta. 2013;1828:595-601 pubmed publisher
    The modulation of the Drosophila Shaw2 Kv channel by 1-alkanols and inhaled anesthetics is correlated with the involvement of the S4-S5 linker and C-terminus of S6, and consistent with stabilization of the channel's closed state...
  23. Yool A, Schwarz T. Alteration of ionic selectivity of a K+ channel by mutation of the H5 region. Nature. 1991;349:700-4 pubmed
    ..The mutations that substantially altered selectivity had little effect on the gating properties of the channel. We conclude that the H5 region is likely to line the pore of the K+ channel...
  24. Diao F, Ironfield H, Luan H, Diao F, Shropshire W, Ewer J, et al. Plug-and-play genetic access to drosophila cell types using exchangeable exon cassettes. Cell Rep. 2015;10:1410-21 pubmed publisher
    ..We also introduce an exchangeable, MiMIC-like Trojan exon construct that can be targeted to coding introns using the Crispr/Cas system. ..
  25. Wallner M, Meera P, Toro L. Determinant for beta-subunit regulation in high-conductance voltage-activated and Ca(2+)-sensitive K+ channels: an additional transmembrane region at the N terminus. Proc Natl Acad Sci U S A. 1996;93:14922-7 pubmed
    ..Both the unique S0 region and the exoplasmic N terminus are necessary for this gain of function. ..
  26. Shahidullah M, Harris T, Germann M, Covarrubias M. Molecular features of an alcohol binding site in a neuronal potassium channel. Biochemistry. 2003;42:11243-52 pubmed
    Aliphatic alcohols (1-alkanols) selectively inhibit the neuronal Shaw2 K(+) channel at an internal binding site. This inhibition is conferred by a sequence of 13 residues that constitutes the S4-S5 loop in the pore-forming subunit...
  27. Covarrubias M, Vyas T, Escobar L, Wei A. Alcohols inhibit a cloned potassium channel at a discrete saturable site. Insights into the molecular basis of general anesthesia. J Biol Chem. 1995;270:19408-16 pubmed
    ..of ethanol (17-170mM) selectively inhibited a noninactivating cloned K+ channel encoded by Drosophila Shaw2. Here, we have conducted equilibrium dos-inhibition experiments, single channel recording, and mutagenesis in ..
  28. Perney T, Kaczmarek L. The molecular biology of K+ channels. Curr Opin Cell Biol. 1991;3:663-70 pubmed
    ..Expression of different members of these subfamilies, coupled with mutational analysis, has advanced our knowledge of the structure and function of voltage-dependent K+ channels. ..