Gene Symbol: Shab
Description: Shaker cognate b
Alias: CG1066, CG43128, CG9965, Dmel\CG43128, Dmel_CG1066, Dmel_CG9965, Kv2, dShab, shab, shb, shaker cognate b, CG43128-PA, CG43128-PB, CG43128-PC, CG43128-PH, CG43128-PI, CG43128-PJ, CG43128-PK, CG43128-PL, CG43128-PM, CG43128-PN, Shab-PA, Shab-PB, Shab-PC, Shab-PH, Shab-PI, Shab-PJ, Shab-PK, Shab-PL, Shab-PM, Shab-PN, shaker
Species: fruit fly
Products:     Shab

Top Publications

  1. Wei A, Covarrubias M, Butler A, Baker K, Pak M, Salkoff L. K+ current diversity is produced by an extended gene family conserved in Drosophila and mouse. Science. 1990;248:599-603 pubmed
    The Drosophila Shaker gene on the X chromosome has three sister genes, Shal, Shab, and Shaw, which map to the second and third chromosomes...
  2. Butler A, Wei A, Baker K, Salkoff L. A family of putative potassium channel genes in Drosophila. Science. 1989;243:943-7 pubmed
    Mutant flies in which the gene coding for the Shaker potassium channel is deleted still have potassium currents similar to those coded by the Shaker gene. This suggests the presence of a family of Shaker-like genes in Drosophila...
  3. Jepson J, Savva Y, Yokose C, Sugden A, Sahin A, Reenan R. Engineered alterations in RNA editing modulate complex behavior in Drosophila: regulatory diversity of adenosine deaminase acting on RNA (ADAR) targets. J Biol Chem. 2011;286:8325-37 pubmed publisher
    ..Our data demonstrate that network-wide temporal and spatial regulation of ADAR activity can tune the complex system of RNA-editing sites and modulate multiple ethologically relevant behavioral modalities. ..
  4. Ryan M, Maloney R, Reenan R, Horn R. Characterization of five RNA editing sites in Shab potassium channels. Channels (Austin). 2008;2:202-9 pubmed
    ..One of the editing sites, position 660, aligns with the Shaker 449 residue, which is known to be important in tetraethylammonium (TEA) block...
  5. McCormack K, Tanouye M, Iverson L, Lin J, Ramaswami M, McCormack T, et al. A role for hydrophobic residues in the voltage-dependent gating of Shaker K+ channels. Proc Natl Acad Sci U S A. 1991;88:2931-5 pubmed
    ..Herein we examine the role of the repeat region in Shaker K+ channels through substitution of the leucines in the repeat and through coexpression of normal and truncated ..
  6. Diao F, Waro G, Tsunoda S. Fast inactivation of Shal (K(v)4) K+ channels is regulated by the novel interactor SKIP3 in Drosophila neurons. Mol Cell Neurosci. 2009;42:33-44 pubmed publisher
    ..As a scaffold-like protein, SKIP3 is likely to lead to the identification of a novel regulatory complex that modulates Shal channel inactivation. ..
  7. Hoopengardner B, Bhalla T, Staber C, Reenan R. Nervous system targets of RNA editing identified by comparative genomics. Science. 2003;301:832-6 pubmed
    ..These results point to a pivotal role for RNA editing in nervous system function. ..
  8. Singh A, Singh S. Unmasking of a novel potassium current in Drosophila by a mutation and drugs. J Neurosci. 1999;19:6838-43 pubmed
    ..However, a likely null mutation in the Shab K(+) channel gene (Shab(3)) reduces I(K) but does not eliminate it...
  9. Tsunoda S, Salkoff L. Genetic analysis of Drosophila neurons: Shal, Shaw, and Shab encode most embryonic potassium currents. J Neurosci. 1995;15:1741-54 pubmed
    ..Unlike muscles, where the presence of Shaker is obvious, Shaker currents are not detectable in these neurons...

More Information


  1. Frolov R, Berim I, Singh S. Inhibition of delayed rectifier potassium channels and induction of arrhythmia: a novel effect of celecoxib and the mechanism underlying it. J Biol Chem. 2008;283:1518-24 pubmed
    ..1 channels. A genetically null mutant of Drosophila Shab (Kv2) channels reproduced the cardiac effect of celecoxib, and the drug was unable to further enhance the effect of ..
  2. Diao F, Chaufty J, Waro G, Tsunoda S. SIDL interacts with the dendritic targeting motif of Shal (K(v)4) K+ channels in Drosophila. Mol Cell Neurosci. 2010;45:75-83 pubmed publisher
    ..The identification of SIDL may provide the first step for future investigation into the molecular machinery regulating the LL-motif-dependent targeting of K(+) channels. ..
  3. Ping Y, Tsunoda S. Inactivity-induced increase in nAChRs upregulates Shal K(+) channels to stabilize synaptic potentials. Nat Neurosci. 2011;15:90-7 pubmed publisher
    ..This response then induced an increase in the transient A-type K(+) current carried by Shaker cognate L (Shal; also known as voltage-gated K(+) channel 4, Kv4) channels...
  4. Tsunoda S, Salkoff L. The major delayed rectifier in both Drosophila neurons and muscle is encoded by Shab. J Neurosci. 1995;15:5209-21 pubmed
    ..all the whole cell delayed rectifier current (IK), while leaving unaltered the transient A-current encoded by the Shaker gene...
  5. Hegde P, Gu G, Chen D, Free S, Singh S. Mutational analysis of the Shab-encoded delayed rectifier K(+) channels in Drosophila. J Biol Chem. 1999;274:22109-13 pubmed
    ..Mutations that affect I(A) (Shaker) and I(CF) (slowpoke) have helped greatly in the analysis of these currents and their role in membrane ..
  6. Bhogal B, Jepson J, Savva Y, Pepper A, Reenan R, Jongens T. Modulation of dADAR-dependent RNA editing by the Drosophila fragile X mental retardation protein. Nat Neurosci. 2011;14:1517-24 pubmed publisher
    ..These results link dFMR1 with the RNA-editing pathway and suggest that proper NMJ synaptic architecture requires modulation of dADAR activity by dFMR1. ..
  7. Covarrubias M, Wei A, Salkoff L. Shaker, Shal, Shab, and Shaw express independent K+ current systems. Neuron. 1991;7:763-73 pubmed
    ..diversity of K+ currents observed in living cells? Previous work has shown that different subunits encoded by the Shaker gene subfamily are able to form heteromultimers, which add to the diversity of currents...
  8. Lee J, Wu C. Genetic modifications of seizure susceptibility and expression by altered excitability in Drosophila Na(+) and K(+) channel mutants. J Neurophysiol. 2006;96:2465-78 pubmed
    ..Surprisingly, modifications in sustained K(+) currents in eag and Shab mutants increased thresholds for DD induction and GF pathway failure...
  9. Berger S, Crook S. Modeling the Influence of Ion Channels on Neuron Dynamics in Drosophila. Front Comput Neurosci. 2015;9:139 pubmed publisher
  10. Joiner M, Asztalos Z, Jones C, Tully T, Wu C. Effects of mutant Drosophila K+ channel subunits on habituation of the olfactory jump response. J Neurogenet. 2007;21:45-58 pubmed
    ..Habituation in the olfactory jump assay in Hyperkinetic and Shaker mutants was drastically different from the degree of defect in the giant fiber-mediated escape reflex, indicating ..
  11. Herrera Valdez M, McKiernan E, Berger S, Ryglewski S, Duch C, Crook S. Relating ion channel expression, bifurcation structure, and diverse firing patterns in a model of an identified motor neuron. J Comput Neurosci. 2013;34:211-29 pubmed publisher
    ..We propose Shab and DmNa v to be two candidate genes that could encode these core currents, and find that changes in Shab channel ..
  12. Vähäsöyrinki M, Niven J, Hardie R, Weckström M, Juusola M. Robustness of neural coding in Drosophila photoreceptors in the absence of slow delayed rectifier K+ channels. J Neurosci. 2006;26:2652-60 pubmed
    ..We show that the Shab gene encodes the slow delayed rectifier K+ channel and identify a novel voltage-gated K+ conductance...
  13. Gasque G, Labarca P, Reynaud E, Darszon A. Shal and shaker differential contribution to the K+ currents in the Drosophila mushroom body neurons. J Neurosci. 2005;25:2348-58 pubmed
    b>Shaker, a voltage-dependent K+ channel, is enriched in the mushroom bodies (MBs), the locus of olfactory learning in Drosophila...
  14. McCormack T. Comparison of K+-channel genes within the genomes of Anopheles gambiae and Drosophila melanogaster. Genome Biol. 2003;4:R58 pubmed
  15. Jan L, Jan Y. How might the diversity of potassium channels be generated?. Trends Neurosci. 1990;13:415-9 pubmed
    ..How might this tremendous diversity of potassium channels be generated? Partial answers have begun to emerge as molecular studies of potassium channel genes have become possible over the past few years. ..
  16. Yool A, Schwarz T. Alteration of ionic selectivity of a K+ channel by mutation of the H5 region. Nature. 1991;349:700-4 pubmed
    ..The mutations that substantially altered selectivity had little effect on the gating properties of the channel. We conclude that the H5 region is likely to line the pore of the K+ channel...
  17. Wallner M, Meera P, Toro L. Determinant for beta-subunit regulation in high-conductance voltage-activated and Ca(2+)-sensitive K+ channels: an additional transmembrane region at the N terminus. Proc Natl Acad Sci U S A. 1996;93:14922-7 pubmed
    ..Both the unique S0 region and the exoplasmic N terminus are necessary for this gain of function. ..
  18. Bhalla T, Rosenthal J, Holmgren M, Reenan R. Control of human potassium channel inactivation by editing of a small mRNA hairpin. Nat Struct Mol Biol. 2004;11:950-6 pubmed
    ..Drosophila melanogaster Shaker channels, mimicking this editing event through mutation, exhibit a similar effect...
  19. Frolov R, Singh S. Inhibition of ion channels and heart beat in Drosophila by selective COX-2 inhibitor SC-791. PLoS ONE. 2012;7:e38759 pubmed publisher
  20. Stephan M, Agnew W. Voltage-sensitive Na+ channels: motifs, modes and modulation. Curr Opin Cell Biol. 1991;3:676-84 pubmed
    ..At the same time, however, electrophysiological studies have revealed new, more complex functional properties in the form of at least two gating modes and the existence of as yet unidentified modulatory factors. ..
  21. Rieder L, Savva Y, Reyna M, Chang Y, Dorsky J, Rezaei A, et al. Dynamic response of RNA editing to temperature in Drosophila. BMC Biol. 2015;13:1 pubmed publisher
    ..Environmental cues, in this case temperature, rapidly reprogram the Drosophila transcriptome through RNA editing, presumably resulting in altered proteomic ratios of edited and unedited proteins. ..
  22. Chouinard S, Wilson G, Schlimgen A, Ganetzky B. A potassium channel beta subunit related to the aldo-keto reductase superfamily is encoded by the Drosophila hyperkinetic locus. Proc Natl Acad Sci U S A. 1995;92:6763-7 pubmed
    ..Drosophila Hyperkinetic (Hk) mutant revealed defects in the function or regulation of K+ channels encoded by the Shaker (Sh) locus...
  23. Huang Q, Wu Y, Wei X, He W, Liu X, Ye J. Evolutionary analysis of voltage-gated potassium channels by Bayes method. J Mol Neurosci. 2014;53:41-9 pubmed publisher
  24. Butler A, Wei A, Salkoff L. Shal, Shab, and Shaw: three genes encoding potassium channels in Drosophila. Nucleic Acids Res. 1990;18:2173-4 pubmed
  25. Krause Y, Krause S, Huang J, Liu C, Hardie R, Weckström M. Light-dependent modulation of Shab channels via phosphoinositide depletion in Drosophila photoreceptors. Neuron. 2008;59:596-607 pubmed publisher
    ..whole-cell recordings of isolated photoreceptors, we show that light selectively modulated the delayed rectifier (Shab) current...
  26. Xu J, Yu W, Jan Y, Jan L, Li M. Assembly of voltage-gated potassium channels. Conserved hydrophilic motifs determine subfamily-specific interactions between the alpha-subunits. J Biol Chem. 1995;270:24761-8 pubmed
    ..Most of the cloned genes for the alpha-subunits are classified into four subfamilies: Kv1 (Shaker), Kv2 (Shab), Kv3 (Shaw), and Kv4 (Shal)...
  27. Parrish J, Kim C, Tang L, Bergquist S, Wang T, Derisi J, et al. Krüppel mediates the selective rebalancing of ion channel expression. Neuron. 2014;82:537-44 pubmed publisher
    ..rebalancing of ion channel expression including, but not limited to, the enhanced expression and function of Shaker and slowpoke...
  28. Strong M, Chandy K, Gutman G. Molecular evolution of voltage-sensitive ion channel genes: on the origins of electrical excitability. Mol Biol Evol. 1993;10:221-42 pubmed
    ..A series of gene duplications produced at least seven mammalian homologues of the Drosophila Shaker K+ channel; clones of only three of these genes are available from all three mammalian species examined (mouse, ..
  29. Carrillo E, Arias Olguin I, Islas L, Gomez Lagunas F. Shab K (+) channel slow inactivation: a test for U-type inactivation and a hypothesis regarding K (+) -facilitated inactivation mechanisms. Channels (Austin). 2013;7:97-108 pubmed publisher
    Herein, we report the first characterization of Shab slow inactivation. Open Shab channels inactivate within seconds, with two voltage-independent time constants. Additionally, Shab presents significant closed-state inactivation...
  30. Adnot S, Chabrier P, Brun Buisson C, Viossat I, Braquet P. Atrial natriuretic factor attenuates the pulmonary pressor response to hypoxia. J Appl Physiol (1985). 1988;65:1975-83 pubmed
    ..No change in PVR or SVR occurred in normoxic animals at any ANF infusion rate. These results suggest that ANF may act as an endogenous pulmonary vasodilator that could modulate the pulmonary pressor response to hypoxia...
  31. Fogle K, Baik L, Houl J, Tran T, Roberts L, Dahm N, et al. CRYPTOCHROME-mediated phototransduction by modulation of the potassium ion channel β-subunit redox sensor. Proc Natl Acad Sci U S A. 2015;112:2245-50 pubmed publisher
    ..Multiple K(+) channel α-subunits that coassemble with Hk, including Shaker, Ether-a-go-go, and Ether-a-go-go-related gene, are ion conducting channels for CRY/Hk-coupled light response...
  32. Ping Y, Hahm E, Waro G, Song Q, Vo Ba D, Licursi A, et al. Linking aβ42-induced hyperexcitability to neurodegeneration, learning and motor deficits, and a shorter lifespan in an Alzheimer's model. PLoS Genet. 2015;11:e1005025 pubmed publisher
    ..We conclude that Aβ42-induced hyperactivity plays a critical role in the age-dependent cognitive and motor decline of this Aβ42-Drosophila model, and possibly in AD. ..
  33. Carrillo E, Pacheco L, Balleza D, Gomez Lagunas F. K⁺-dependent selectivity and external Ca²⁺ block of Shab K⁺ channels. PLoS ONE. 2015;10:e0120431 pubmed publisher
    ..Here we show that Shab is a typical K⁺ channel that excludes Na⁺ under bi-ionic, Na(o)/K(i) or Na(o)/Rb(i), conditions...
  34. Perney T, Kaczmarek L. The molecular biology of K+ channels. Curr Opin Cell Biol. 1991;3:663-70 pubmed
    ..Expression of different members of these subfamilies, coupled with mutational analysis, has advanced our knowledge of the structure and function of voltage-dependent K+ channels. ..
  35. Jepson J, Reenan R. Adenosine-to-inosine genetic recoding is required in the adult stage nervous system for coordinated behavior in Drosophila. J Biol Chem. 2009;284:31391-400 pubmed publisher
  36. Pimentel D, Donlea J, Talbot C, Song S, Thurston A, Miesenbock G. Operation of a homeostatic sleep switch. Nature. 2016;536:333-337 pubmed publisher
    ..The switch to electrical silence involved the downregulation of voltage-gated A-type currents carried by Shaker and Shab, and the upregulation of voltage-independent leak currents through a two-pore-domain potassium channel ..
  37. Peng I, Wu C. Differential contributions of Shaker and Shab K+ currents to neuronal firing patterns in Drosophila. J Neurophysiol. 2007;97:780-94 pubmed
    ..Mutations of Sh and Shab K(+) channels removed part of inactivating I(A) and sustained I(K), respectively, and the remaining I(A) and I(K) ..
  38. Ueda A, Wu C. Distinct frequency-dependent regulation of nerve terminal excitability and synaptic transmission by IA and IK potassium channels revealed by Drosophila Shaker and Shab mutations. J Neurosci. 2006;26:6238-48 pubmed
    ..the roles of the Shab IK channel and its mammalian Kv2 counterparts is relatively poor, as compared with that for Shaker IA channels and their Kv1 homologues...
  39. Chopra M, Gu G, Singh S. Mutations affecting the delayed rectifier potassium current in Drosophila. J Neurogenet. 2000;14:107-23 pubmed
    ..The z66 and the z4 mutations, which lie in the Shab K(+) channel gene, provide an opportunity to undertake analysis of the functioning of these channels and to study ..
  40. Pak M, Covarrubias M, Ratcliffe A, Salkoff L. A mouse brain homolog of the Drosophila Shab K+ channel with conserved delayed-rectifier properties. J Neurosci. 1991;11:869-80 pubmed
    We have cloned and expressed a mouse brain K+ channel that is the homolog of the Drosophila Shab K+ channel...
  41. Yang Y, Lv J, Gui B, Yin H, Wu X, Zhang Y, et al. A-to-I RNA editing alters less-conserved residues of highly conserved coding regions: implications for dual functions in evolution. RNA. 2008;14:1516-25 pubmed publisher
    ..We analyzed the RNA editing of the Kv2 K(+) channel from different insects spanning more than 300 million years of evolution: Drosophila melanogaster, ..
  42. Peng I, Wu C. Drosophila cacophony channels: a major mediator of neuronal Ca2+ currents and a trigger for K+ channel homeostatic regulation. J Neurosci. 2007;27:1072-81 pubmed
    ..Among K+ channel transcripts, Shaker mRNA levels were preferentially increased in cac flies...
  43. Berke B, Lee J, Peng I, Wu C. Sub-cellular Ca2+ dynamics affected by voltage- and Ca2+-gated K+ channels: Regulation of the soma-growth cone disparity and the quiescent state in Drosophila neurons. Neuroscience. 2006;142:629-44 pubmed
    ..Fura-2-based imaging revealed in cultured embryonic neurons that the loss of either voltage-gated, inactivating Shaker channels or Ca(2+)-gated Slowpoke BK channels led to robust spontaneous Ca(2+) transients that preferentially ..
  44. Salkoff L, Baker K, Butler A, Covarrubias M, Pak M, Wei A. An essential 'set' of K+ channels conserved in flies, mice and humans. Trends Neurosci. 1992;15:161-6 pubmed
    ..This conservation of the K+ channel subfamilies Shaker, Shal, Shab, and Shaw suggests that not only the broad outlines of membrane electrical properties but also many ..
  45. Yao W, Wu C. Distinct roles of CaMKII and PKA in regulation of firing patterns and K(+) currents in Drosophila neurons. J Neurophysiol. 2001;85:1384-94 pubmed
    ..The results suggest that PKA modulates Shaker A-type currents, whereas CaMKII modulates Shal-A type currents plus delayed rectifier Shab currents...
  46. Logothetis D, Kammen B, Lindpaintner K, Bisbas D, Nadal Ginard B. Gating charge differences between two voltage-gated K+ channels are due to the specific charge content of their respective S4 regions. Neuron. 1993;10:1121-9 pubmed
    ..However, differences in residues inside the S4 region are not sufficient to account for each channel's characteristic voltage range of activation. ..
  47. Yu W, Xu J, Li M. NAB domain is essential for the subunit assembly of both alpha-alpha and alpha-beta complexes of shaker-like potassium channels. Neuron. 1996;16:441-53 pubmed
    There are at least five subfamilies of Shaker-like K+ channels. The diverse function of K+ channels are thought to be further modulated by hydrophilic beta subunits...
  48. Frolov R, Bagati A, Casino B, Singh S. Potassium channels in Drosophila: historical breakthroughs, significance, and perspectives. J Neurogenet. 2012;26:275-90 pubmed K(+) channel research, including identification and fi rst cloning of a voltage-activated K(+) channel, Shaker, a founding member of the K(V)1 family...