Gene Symbol: Sgs4
Description: Salivary gland secretion 4
Alias: CG12181, Dmel\CG12181, EG:96G10.6, SGS-4, SGS4, Sgs, Sgs-4, sgs-4, sgs4, salivary gland secretion 4, CG12181-PC, Sgs4-PC, salivary gland secretion protein 4
Species: fruit fly

Top Publications

  1. Korge G. Larval saliva in Drosophila melanogaster: production, composition, and relationship to chromosome puffs. Dev Biol. 1977;58:339-55 pubmed
  2. Cao C, Liu Y, Lehmann M. Fork head controls the timing and tissue selectivity of steroid-induced developmental cell death. J Cell Biol. 2007;176:843-52 pubmed
    ..More generally, they suggest that cell identity factors like Fkh play a pivotal role in the normal control of developmental cell death. ..
  3. Lehmann M. Drosophila Sgs genes: stage and tissue specificity of hormone responsiveness. Bioessays. 1996;18:47-54 pubmed
    The up- and down-regulation of the salivary gland secretion protein (Sgs) genes during the third larval instar of Drosophila melanogaster are controlled by fluctuations of the titre of the steroid hormone 20-hydroxyecdysone (20E)...
  4. Barnett S, Flynn K, Webster M, Beckendorf S. Noncoordinate expression of Drosophila glue genes: Sgs-4 is expressed at many stages and in two different tissues. Dev Biol. 1990;140:362-73 pubmed
    ..We present evidence that, in contrast to the other glue genes, Sgs-4 is turned on throughout Drosophila development and is not expressed exclusively in the larval salivary glands...
  5. Renault N, King Jones K, Lehmann M. Downregulation of the tissue-specific transcription factor Fork head by Broad-Complex mediates a stage-specific hormone response. Development. 2001;128:3729-37 pubmed
    ..Most of the known BR-C target genes, including the salivary gland secretion protein (Sgs) genes, are terminal differentiation genes that are thought to be directly regulated by BR-C-encoded transcription ..
  6. Bayer C, von Kalm L, Fristrom J. Relationships between protein isoforms and genetic functions demonstrate functional redundancy at the Broad-Complex during Drosophila metamorphosis. Dev Biol. 1997;187:267-82 pubmed
    ..The establishment of these relationships between BR-C genetic functions and protein isoforms is an important step toward understanding the roles of BR-C proteins in directing metamorphic responses to ecdysone. ..
  7. Hall B, Thummel C. The RXR homolog ultraspiracle is an essential component of the Drosophila ecdysone receptor. Development. 1998;125:4709-17 pubmed
  8. Guay P, Guild G. The ecdysone-induced puffing cascade in Drosophila salivary glands: a Broad-Complex early gene regulates intermolt and late gene transcription. Genetics. 1991;129:169-75 pubmed
    ..In addition, the rbp function is required for the transcription of four intermolt genes (Sgs-3, Sgs-4, Sgs-5 and 71E gene VII)...
  9. Mougneau E, Von Seggern D, Fowler T, Rosenblatt J, Jongens T, Rogers B, et al. A transcriptional switch between the Pig-1 and Sgs-4 genes of Drosophila melanogaster. Mol Cell Biol. 1993;13:184-95 pubmed
    Pig-1 and Sgs-4 are a pair of closely linked and divergently transcribed Drosophila melanogaster genes, which are both expressed in larval salivary glands but at different times during development...

More Information


  1. Beckendorf S, Kafatos F. Differentiation in the salivary glands of Drosophila melanogaster: characterization of the glue proteins and their developmental appearance. Cell. 1976;9:365-73 pubmed
    ..Synthesis of five of the glue proteins stops abruptly within a few minutes after the glue is released. The sixth protein continues to be synthesized for at least 30 min after glue release. ..
  2. Roth G, Wattler S, Bornschein H, Lehmann M, Korge G. Structure and regulation of the salivary gland secretion protein gene Sgs-1 of Drosophila melanogaster. Genetics. 1999;153:753-62 pubmed
    The Drosophila melanogaster gene Sgs-1 belongs to the secretion protein genes, which are coordinately expressed in salivary glands of third instar larvae. Earlier analysis had implied that Sgs-1 is located at the 25B2-3 puff...
  3. Lehmann M, Korge G. The fork head product directly specifies the tissue-specific hormone responsiveness of the Drosophila Sgs-4 gene. EMBO J. 1996;15:4825-34 pubmed
    ..binding protein 2 (SEBP2) in the regulatory region of the Drosophila salivary gland secretion protein gene 4 (Sgs-4) and show that despite these sites' correspondence with previously described Broad-Complex protein binding sites, ..
  4. von Kalm L, Crossgrove K, Von Seggern D, Guild G, Beckendorf S. The Broad-Complex directly controls a tissue-specific response to the steroid hormone ecdysone at the onset of Drosophila metamorphosis. EMBO J. 1994;13:3505-16 pubmed
    ..and primary ecdysone response gene, the Broad-Complex, transmits the hormonal signal to one of its targets, the Sgs-4 glue gene...
  5. Hansson L, Lambertsson A. Steroid regulation of glue protein genes in Drosophila melanogaster. Hereditas. 1989;110:61-7 pubmed
    Transcript accumulation of the 3C glue protein gene Sgs-4 was induced in cultured salivary glands of Drosophila third instar larvae by supplementing the culture medium with 20-OH-ecdysone...
  6. Crowley T, Meyerowitz E. Steroid regulation of RNAs transcribed from the Drosophila 68c polytene chromosome puff. Dev Biol. 1984;102:110-21 pubmed
    ..salivary gland polytene chromosomes harbors the structural genes for the three salivary gland glue proteins sgs-3, sgs-7, and sgs-8...
  7. Georgel P, Ramain P, Giangrande A, Dretzen G, Richards G, Bellard M. Sgs-3 chromatin structure and trans-activators: developmental and ecdysone induction of a glue enhancer-binding factor, GEBF-I, in Drosophila larvae. Mol Cell Biol. 1991;11:523-32 pubmed
    The transcription of the Drosophila melanogaster 68C salivary gland glue gene Sgs-3 involves the interaction of a distal and a proximal regulatory region...
  8. Lam G, Thummel C. Inducible expression of double-stranded RNA directs specific genetic interference in Drosophila. Curr Biol. 2000;10:957-63 pubmed
    ..They also demonstrate that dsRNA expression can inactivate Drosophila gene function at later stages of development, providing a new tool for functional genomic studies in Drosophila. ..
  9. Furia M, D Avino P, Crispi S, Artiaco D, Polito L. Dense cluster of genes is located at the ecdysone-regulated 3C puff of Drosophila melanogaster. J Mol Biol. 1993;231:531-8 pubmed
    ..of three genes, named ng-2, ng-3 and ng-4, which we found to be closely linked to each other and to Sgs-4, Pig-1 and ng-1, three other genes previously mapped at this polytene region...
  10. Lehmann M, Korge G. Ecdysone regulation of the Drosophila Sgs-4 gene is mediated by the synergistic action of ecdysone receptor and SEBP 3. EMBO J. 1995;14:716-26 pubmed
    The steroid hormone 20-hydroxyecdysone controls both induction and repression of the Drosophila 'intermolt gene' Sgs-4...
  11. Bernardo T, Dubrovskaya V, Jannat H, Maughan B, Dubrovsky E. Hormonal regulation of the E75 gene in Drosophila: identifying functional regulatory elements through computational and biological analysis. J Mol Biol. 2009;387:794-808 pubmed
    ..We propose that the presence of multiple EcREs with distinct features provides flexibility to the rapid and powerful response of E75A to ecdysone during Drosophila development. ..
  12. McBrayer Z, Ono H, Shimell M, Parvy J, Beckstead R, Warren J, et al. Prothoracicotropic hormone regulates developmental timing and body size in Drosophila. Dev Cell. 2007;13:857-71 pubmed
    ..These results indicate that final body size in insects is determined by a balance between growth-rate regulators such as insulin and developmental timing cues such as PTTH that set the duration of the feeding interval. ..
  13. Hofmann A, Lehmann M. The transcriptional switch between the Drosophila genes Pig-1 and Sgs-4 depends on a SEBP1 binding site within a shared enhancer region. Mol Gen Genet. 1998;259:656-63 pubmed
    The Drosophila genes Pig-1 and Sgs-4 are adjacent and oppositely transcribed genes which share a common enhancer region located in the intergenic region between the two transcription start sites...
  14. Vandersmissen H, Van Hiel M, Van Loy T, Vleugels R, Vanden Broeck J. Silencing D. melanogaster lgr1 impairs transition from larval to pupal stage. Gen Comp Endocrinol. 2014;209:135-47 pubmed publisher
  15. Tartof K, Henikoff S. Trans-sensing effects from Drosophila to humans. Cell. 1991;65:201-3 pubmed
  16. Bhadra U, Pal Bhadra M, Birchler J. Role of the male specific lethal (msl) genes in modifying the effects of sex chromosomal dosage in Drosophila. Genetics. 1999;152:249-68 pubmed
  17. Tang T, Kumar S, Shen Y, Lu J, Wu M, Shi S, et al. Adverse interactions between micro-RNAs and target genes from different species. Proc Natl Acad Sci U S A. 2010;107:12935-40 pubmed publisher
    ..After the buffering function has evolved, heterospecific combinations may cause adverse effects. ..
  18. Artavanis Tsakonas S, Muskavitch M, Yedvobnick B. Molecular cloning of Notch, a locus affecting neurogenesis in Drosophila melanogaster. Proc Natl Acad Sci U S A. 1983;80:1977-81 pubmed
    ..5-kb poly(A)+ RNA is essential for wild-type Notch function. We discuss these structural and transcriptional data in light of the existing genetic and developmental characterization of the Notch locus. ..
  19. Korge G. Direct correlation between a chromosome puff and the synthesis of a larval saliva protein in Drosophila melanogaster. Chromosoma. 1977;62:155-74 pubmed
    The structural gene Sgs-4 responsible for larval saliva protein 4 of Drosophila melanogaster was localized, with the help of Notch deficiencies, within the section between bands 3C10 and 3D1 of the X chromosome...
  20. Santel A, Blumer N, Kämpfer M, Renkawitz Pohl R. Flagellar mitochondrial association of the male-specific Don Juan protein in Drosophila spermatozoa. J Cell Sci. 1998;111 ( Pt 22):3299-309 pubmed
    ..Therefore we suppose that Don Juan is a nuclear-encoded, germ-cell specifically expressed mitochondrial protein, which might be involved in the final steps of mitochondrial differentiation within the flagellum. ..
  21. Furia M, D Avino P, Digilio F, Crispi S, Giordano E, Polito L. Effect of ecd1 mutation on the expression of genes mapped at the Drosophila melanogaster 3C11-12 intermoult puff. Genet Res. 1992;59:19-26 pubmed
    ..temperature at various times of the development; after 24 or 48 h, the levels of the transcripts derived from Sgs-4, Pig-1 and ng-1, the three genes located at the 3C11-12 polytene bands, were determined...
  22. Nighorn A, Qiu Y, Davis R. Progress in understanding the Drosophila dnc locus. Comp Biochem Physiol Biochem Mol Biol. 1994;108:1-9 pubmed
    ..This paper reviews the recent developments in the understanding of the structure and function of the gene identified by the first and best-characterized of these mutants, the Drosophila dunce mutant. ..
  23. Costantino B, Bricker D, Alexandre K, Shen K, Merriam J, Antoniewski C, et al. A novel ecdysone receptor mediates steroid-regulated developmental events during the mid-third instar of Drosophila. PLoS Genet. 2008;4:e1000102 pubmed publisher
    ..This result is novel because it demonstrates for the first time that at least some 20E-mediated, mid-larval, developmental responses are controlled by an uncharacterized receptor that does not contain an RXR-like component. ..
  24. Jongens T, Fowler T, Shermoen A, Beckendorf S. Functional redundancy in the tissue-specific enhancer of the Drosophila Sgs-4 gene. EMBO J. 1988;7:2559-67 pubmed
    During the last day of larval development, the Sgs-4 glue gene of Drosophila melanogaster is expressed at high levels in a single tissue, the larval salivary glands...
  25. Furia M, Digilio F, Artiaco D, Giordano E, Polito L. A new gene nested within the dunce genetic unit of Drosophila melanogaster. Nucleic Acids Res. 1990;18:5837-41 pubmed
    ..gene of Drosophila melanogaster has proved to be particularly complex, with two divergently transcribed genes, Sgs-4 and Pig-1, nested within its 79 kb intron (1)...
  26. Lehmann M, Siegmund T, Lintermann K, Korge G. The pipsqueak protein of Drosophila melanogaster binds to GAGA sequences through a novel DNA-binding domain. J Biol Chem. 1998;273:28504-9 pubmed
    ..Psq may thus represent the prototype of a new family of DNA-binding proteins...
  27. Jensen J, Bauer DuMont V, Ashmore A, Gutierrez A, Aquadro C. Patterns of sequence variability and divergence at the diminutive gene region of Drosophila melanogaster: complex patterns suggest an ancestral selective sweep. Genetics. 2007;177:1071-85 pubmed
  28. McGinnis W, Beckendorf S. Association of a Drosophila transposable element of the roo family with chromosomal deletion breakpoints. Nucleic Acids Res. 1983;11:737-51 pubmed
    A 9.3 kb transposable element of the roo family has been found inserted 3' to the Sgs-4 glue protein gene of Drosophila...
  29. Bhadra U, Pal Bhadra M, Birchler J. Histone acetylation and gene expression analysis of sex lethal mutants in Drosophila. Genetics. 2000;155:753-63 pubmed
    ..In both cases we find relatively little effect upon X chromosomal gene expression. ..
  30. Fisk G, Thummel C. The DHR78 nuclear receptor is required for ecdysteroid signaling during the onset of Drosophila metamorphosis. Cell. 1998;93:543-55 pubmed
    ..We propose that DHR78 is a ligand-activated receptor that plays a central role in directing the onset of Drosophila metamorphosis. ..
  31. Kaplan C, Morris J, Wu C, Winston F. Spt5 and spt6 are associated with active transcription and have characteristics of general elongation factors in D. melanogaster. Genes Dev. 2000;14:2623-34 pubmed
    ..Furthermore, Spt5 and Spt6 do not colocalize widely with the unphosphorylated, nonelongating form of Pol II. These results strongly suggest that Spt5 and Spt6 play closely related roles associated with active transcription in vivo. ..
  32. Hofmann A, Brünner M, Schwendemann A, Strödicke M, Karberg S, Klebes A, et al. The winged-helix transcription factor JUMU regulates development, nucleolus morphology and function, and chromatin organization of Drosophila melanogaster. Chromosome Res. 2010;18:307-24 pubmed publisher
    ..The human winged-helix nude gene shows similarities to jumu and its overexpression in Drosophila causes bristle mutations. ..
  33. Reim I, Stanewsky R, Saumweber H. The puff-specific RRM protein NonA is a single-stranded nucleic acid binding protein. Chromosoma. 1999;108:162-72 pubmed
    ..Here we compare NonA binding to RNA from the Sgs-4 gene, an in situ target for NonA, with binding to Sgs-3 RNA, which is not a target of NonA...
  34. Korge G. Chromosome puff activity and protein synthesis in larval salivary glands of Drosophila melanogaster. Proc Natl Acad Sci U S A. 1975;72:4550-4 pubmed
    ..3 was found to lie within a segment of the third chromosome which includes section 68C; the gene for fraction 4, Sgs-4, was found to lie within section 3C8-3D1 of the X chromosome (1 - 3-5)...
  35. McNabb S, Beckendorf S. Cis-acting sequences which regulate expression of the Sgs-4 glue protein gene of Drosophila. EMBO J. 1986;5:2331-40 pubmed
    The Sgs-4 glue protein gene of Drosophila is expressed only in third-instar larval salivary glands...
  36. Muskavitch M, Hogness D. Molecular analysis of a gene in a developmentally regulated puff of Drosophila melanogaster. Proc Natl Acad Sci U S A. 1980;77:7362-6 pubmed
    ..puffs that regress as the ecdysone concentration increases is located at the 3C11-12 bands, the site of the Sgs-4 gene, which codes for the sgs-4 protein, one of the proteins in the salivary glue secretion...
  37. Furia M, Digilio F, Artiaco D, Favia G, Polito L. Molecular characterization of a Drosophila melanogaster variant strain defective in the Sgs-4 gene dosage compensation. Biochim Biophys Acta. 1992;1130:314-6 pubmed
    The X-linked Sgs-4 gene of Drosophila melanogaster encodes a salivary glue protein...
  38. Davis R, Dauwalder B. The Drosophila dunce locus: learning and memory genes in the fly. Trends Genet. 1991;7:224-9 pubmed
    ..In addition, the recent cloning and characterization of dunce counterparts from mammals has revealed that these too may participate in animal behavior and, in particular, in the regulation of mood. ..
  39. Kornher J, Brutlag D. Proximity-dependent enhancement of Sgs-4 gene expression in D. melanogaster. Cell. 1986;44:879-83 pubmed
    A weakly expressed allele of Sgs-4 obtained from the Kochi strain of D...
  40. Fletcher J, Thummel C. The ecdysone-inducible Broad-complex and E74 early genes interact to regulate target gene transcription and Drosophila metamorphosis. Genetics. 1995;141:1025-35 pubmed
    ..This data is consistent with current models which propose that combinations of ecdysone primary-response genes regulate common morphogenetic pathways during insect metamorphosis. ..
  41. Galceran J, Llanos J, Sampedro J, Pongs O, Izquierdo M. Transcription at the ecdysone-inducible locus 2B5 in Drosophila. Nucleic Acids Res. 1990;18:539-45 pubmed
    ..Null mutations at the 2B5 locus prevents ecdysone inducible transcription. This evidence supports the fact that 2B5 codes for an ecdysone-dependent transcriptional regulator. ..
  42. Krumm A, Roth G, Korge G. Transformation of salivary gland secretion protein gene Sgs-4 in Drosophila: stage- and tissue-specific regulation, dosage compensation, and position effect. Proc Natl Acad Sci U S A. 1985;82:5055-9 pubmed
    The Sgs-4 gene of Drosophila melanogaster encodes one of the larval secretion proteins and is active only in salivary glands at the end of larval development. This gene lies in the X chromosome and is controlled by dosage compensation--i...
  43. Furia M, Digilio F, Artiaco D, D Avino P, Cavaliere D, Polito L. Molecular organization of the Drosophila melanogaster Pig-1 gene. Chromosoma. 1991;101:49-54 pubmed
    ..We also report that the level of Pig-1 transcript is nearly fourfold reduced in a variant strain carrying a deletion within the Pig-1 upstream sequence, thus identifying a regulatory element required for high level gene expression. ..
  44. Yin V, Thummel C, Bashirullah A. Down-regulation of inhibitor of apoptosis levels provides competence for steroid-triggered cell death. J Cell Biol. 2007;178:85-92 pubmed
    ..It also provides a molecular mechanism for the acquisition of competence in steroid signaling pathways. ..
  45. Hofmann A, Korge G. Upstream sequences of dosage-compensated and non-compensated alleles of the larval secretion protein gene Sgs-4 in Drosophila. Chromosoma. 1987;96:1-7 pubmed
    The X chromosomal gene Sgs-4 coding for a larval secretion protein of Drosophila melanogaster is expressed stage and tissue specifically and is hyperexpressed in male larvae of most Drosophila stocks which show dosage compensation...
  46. Ritter A, Beckstead R. Sox14 is required for transcriptional and developmental responses to 20-hydroxyecdysone at the onset of drosophila metamorphosis. Dev Dyn. 2010;239:2685-94 pubmed publisher
    ..We also show that the Sox14-regulated gene set correlates well with Sox14 expression in a variety of larval and adult tissues. Thus, Sox14 is a critical transcription factor required for 20E signaling at the onset of metamorphosis. ..
  47. Henikoff S. Position-effect variegation after 60 years. Trends Genet. 1990;6:422-6 pubmed
    ..However, new insights are being gained from recent studies of genetic modifiers, new model systems, and variegating genes showing exceptional behavior. ..
  48. McGinnis W, Shermoen A, Beckendorf S. A transposable element inserted just 5' to a Drosophila glue protein gene alters gene expression and chromatin structure. Cell. 1983;34:75-84 pubmed
    The Drosophila Sgs-4 gene directs the developmentally regulated production of a glue protein in the salivary glands of mature larvae...
  49. Hiebert J, Birchler J. Effects of the maleless mutation on X and autosomal gene expression in Drosophila melanogaster. Genetics. 1994;136:913-26 pubmed
    ..These observations suggest that if mle plays a role in the discrimination of the X and the autosomes, it may do so by modification of the effects of dosage sensitive regulatory genes. ..
  50. McGinnis W, Farrell J, Beckendorf S. Molecular limits on the size of a genetic locus in Drosophila melanogaster. Proc Natl Acad Sci U S A. 1980;77:7367-71 pubmed
    ..The locus we have chosen, Sgs-4, codes for one of the glue proteins secreted by larval Drosophila salivary glands...
  51. Prado A, Canal I, Ferrus A. The haplolethal region at the 16F gene cluster of Drosophila melanogaster: structure and function. Genetics. 1999;151:163-75 pubmed
    ..We propose that the HL at 16F represents a long-range cis regulatory region that acts upon a number of functionally related genes whose combined haploidy would yield the dominant-lethal effect. ..
  52. Shermoen A, Beckendorf S. A complex of interacting DNAase I-hypersensitive sites near the Drosophila glue protein gene, Sgs4. Cell. 1982;29:601-7 pubmed
    The chromatin structure adjacent to the Drosophila glue protein gene Sgs4 changes drastically when the gene is active...
  53. Chiang P, Kurnit D. Study of dosage compensation in Drosophila. Genetics. 2003;165:1167-81 pubmed
    ..As exemplified by the BR-C locus and its dependent Sgs genes, multiple genes in a given pathway could exhibit coordinate regulatory modulation...
  54. Granadino B, Torres M, Bachiller D, Torroja E, Barbero J, Sanchez L. Genetic and molecular analysis of new female-specific lethal mutations at the gene Sxl of Drosophila melanogaster. Genetics. 1991;129:371-83 pubmed
  55. Kuan Y, Brewer Jensen P, Bai W, Hunter C, Wilson C, Bass S, et al. Drosophila suppressor of sable protein [Su(s)] promotes degradation of aberrant and transposon-derived RNAs. Mol Cell Biol. 2009;29:5590-603 pubmed publisher
    ..These Su(s) targets include cryptic wild-type transcripts from the developmentally regulated Sgs4 and ng1 genes, noncoding RNAs derived from tandemly repeated alphabeta/alphagamma elements within an Hsp70 locus, ..
  56. Maschat F, Dubertret M, Therond P, Claverie J, Lepesant J. Structure of the ecdysone-inducible P1 gene of Drosophila melanogaster. J Mol Biol. 1990;214:359-72 pubmed
    ..Short stretches of nucleotide sequences similar to sequences located in the 5' regions of other genes expressed in the D. melanogaster fat body were found in the proximal promoter and transcribed region of the P1 gene. ..
  57. Hamann S, Strätling W. Specific binding of Drosophila nuclear protein PEP (protein on ecdysone puffs) to hsp70 DNA and RNA. Nucleic Acids Res. 1998;26:4108-15 pubmed
    ..In summary, our results suggest the recognition of specific transcripts as a molecular basis for the association of the protein with specific hnRNP complexes. ..
  58. Andres A, Thummel C. Hormones, puffs and flies: the molecular control of metamorphosis by ecdysone. Trends Genet. 1992;8:132-8 pubmed
    ..Molecular characterization of some of these genes has provided valuable clues to regulatory mechanisms by which the ecdysone signal is transduced and amplified. ..
  59. Sun X, Song Q. PKC-mediated USP phosphorylation is required for 20E-induced gene expression in the salivary glands of Drosophila melanogaster. Arch Insect Biochem Physiol. 2006;62:116-27 pubmed
    ..The composite data suggest that PKC-mediated USP phosphorylation is required for 20E-induced gene expression in the salivary glands of Drosophila melanogaster. ..
  60. Baker B, Gorman M, Mar n I. Dosage compensation in Drosophila. Annu Rev Genet. 1994;28:491-521 pubmed publisher
  61. Ruaud A, Lam G, Thummel C. The Drosophila nuclear receptors DHR3 and betaFTZ-F1 control overlapping developmental responses in late embryos. Development. 2010;137:123-31 pubmed publisher
    ..Taken together, these studies define the lethal phenotypes of DHR3 and betaFTZ-F1 mutants, and provide evidence for functional bifurcation in the 20E-responsive transcriptional cascade. ..
  62. Granadino B, Campuzano S, Sanchez L. The Drosophila melanogaster fl(2)d gene is needed for the female-specific splicing of Sex-lethal RNA. EMBO J. 1990;9:2597-602 pubmed
    ..homozygous females hypertranscribe their two X chromosomes, as measured by comparing the level of the X-linked sgs-4 transcript, which is dosage compensated, with that of the autosomal sgs-3 transcript...
  63. Furuhashi H, Nakajima M, Hirose S. DNA supercoiling factor contributes to dosage compensation in Drosophila. Development. 2006;133:4475-83 pubmed
    ..These findings demonstrate that SCF plays a role in transcriptional activation via alteration of chromatin structure and provide evidence that SCF contributes to dosage compensation. ..
  64. Pile L, Wassarman D. Chromosomal localization links the SIN3-RPD3 complex to the regulation of chromatin condensation, histone acetylation and gene expression. EMBO J. 2000;19:6131-40 pubmed
  65. Kozlova T, Lam G, Thummel C. Drosophila DHR38 nuclear receptor is required for adult cuticle integrity at eclosion. Dev Dyn. 2009;238:701-7 pubmed publisher
    ..In contrast, cuticle gene expression is significantly reduced in DHR38(Y214) mutant pupae. These studies define the essential functions of DHR38 and provide a genetic context for further characterization of its roles during development. ..
  66. Ryuda M, Shimada K, Koyanagi R, Azumi K, Tanimura T, Hayakawa Y. Analysis of hunger-driven gene expression in the Drosophila melanogaster larval central nervous system. Zoolog Sci. 2008;25:746-52 pubmed publisher
    ..Given that these genes contribute to mediating hunger-driven changes in food preference and intake in D. melanogaster larvae, the dysfunction of these key genes could cause the defect in food preference observed in GS1189-strain larvae. ..
  67. Kaiser K, Furia M, Glover D. Dosage compensation at the sgs4 locus of Drosophila melanogaster. J Mol Biol. 1986;187:529-36 pubmed
    The X-linked sgs4 gene of Drosophila melanogaster encodes a salivary glue protein. Non-dosage-compensated alleles of this gene have been described by G...
  68. Bialecki M, Shilton A, Fichtenberg C, Segraves W, Thummel C. Loss of the ecdysteroid-inducible E75A orphan nuclear receptor uncouples molting from metamorphosis in Drosophila. Dev Cell. 2002;3:209-20 pubmed
    ..We propose that ecdysteroid-induced E75A expression defines a feed-forward pathway that amplifies or maintains the ecdysteroid titer during larval development, ensuring proper temporal progression through the life cycle. ..
  69. Chen C, Malone T, Beckendorf S, Davis R. At least two genes reside within a large intron of the dunce gene of Drosophila. Nature. 1987;329:721-4 pubmed least two other genes are shown to reside within the large intron, including the well-defined glue protein gene, Sgs-4...