Gene Symbol: sev
Description: sevenless
Alias: 7LES, 7less, CG18085, CT3980, DROSEV, DROSEV1, DmHD-265, Dmel\CG18085, HD-265, SEV, Sev, sev(AC)[[14]], sevenless, CG18085-PA, sev-PA
Species: fruit fly

Top Publications

  1. Fortini M, Rubin G. Analysis of cis-acting requirements of the Rh3 and Rh4 genes reveals a bipartite organization to rhodopsin promoters in Drosophila melanogaster. Genes Dev. 1990;4:444-63 pubmed
  2. Papatsenko D, Sheng G, Desplan C. A new rhodopsin in R8 photoreceptors of Drosophila: evidence for coordinate expression with Rh3 in R7 cells. Development. 1997;124:1665-73 pubmed
    ..Consistent with this, rh5 expression in R8 disappears when R7 cells are absent (in sevenless mutant)...
  3. Kumar J, Tio M, Hsiung F, Akopyan S, Gabay L, Seger R, et al. Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation. Development. 1998;125:3875-85 pubmed
    ..Similarly, SEVENLESS-dependent activation results in cytoplasmic appearance of dp-ERK for 6 hours...
  4. Hafen E, Basler K, Edstroem J, Rubin G. Sevenless, a cell-specific homeotic gene of Drosophila, encodes a putative transmembrane receptor with a tyrosine kinase domain. Science. 1987;236:55-63 pubmed
    ..In this process, the sevenless gene is essential for the development of a single type of photoreceptor cell...
  5. Kramer S, Okabe M, Hacohen N, Krasnow M, Hiromi Y. Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila. Development. 1999;126:2515-25 pubmed
    ..These receptor tyrosine kinase-mediated pathways may share not only intracellular signaling components but also extracellular factors that modulate the strength of the signal. ..
  6. Fortini M, Simon M, Rubin G. Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation. Nature. 1992;355:559-61 pubmed
    ..Mutations in three genes, sevenless (sev), bride-of-sevenless (boss) and seven-in-absentia (sina) cause the R7 precursor to become a non-neural cone ..
  7. Smith R, Carroll P, Allard J, Simon M. MASK, a large ankyrin repeat and KH domain-containing protein involved in Drosophila receptor tyrosine kinase signaling. Development. 2002;129:71-82 pubmed
    The receptor tyrosine kinases Sevenless (SEV) and the Epidermal growth factor receptor (EGFR) are required for the proper development of the Drosophila eye...
  8. Xu C, Kauffmann R, Zhang J, Kladny S, Carthew R. Overlapping activators and repressors delimit transcriptional response to receptor tyrosine kinase signals in the Drosophila eye. Cell. 2000;103:87-97 pubmed
    ..We show that prospero is controlled by signals from the EGF receptor DER and the Sevenless receptor...
  9. Freeman M. Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell. 1996;87:651-60 pubmed
    ..DER is even required in R7, where it can replace Sevenless, another RTK...

More Information


  1. Kramer H, Cagan R, Zipursky S. Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor. Nature. 1991;352:207-12 pubmed
    ..Genetic data suggest that the induction is mediated by two transmembrane proteins encoded by bride of sevenless and sevenless...
  2. Bhattacharya A, Baker N. The HLH protein Extramacrochaetae is required for R7 cell and cone cell fates in the Drosophila eye. Dev Biol. 2009;327:288-300 pubmed publisher
    ..A model is proposed in which Extramacrochaetae acts in parallel to or as a feed-forward regulator of the E(spl)-Complex to promote Notch signaling in particular cellular contexts. ..
  3. Gerresheim F. Isolation of Drosophila melanogaster mutants with a wavelength-specific alteration in their phototactic response. Behav Genet. 1988;18:227-46 pubmed
  4. Basler K, Hafen E. Ubiquitous expression of sevenless: position-dependent specification of cell fate. Science. 1989;243:931-4 pubmed
    ..The sevenless gene is required for the correct determination of one of the eight photoreceptor cells (R7) in each ommatidium...
  5. Yasuyama K, Meinertzhagen I. Extraretinal photoreceptors at the compound eye's posterior margin in Drosophila melanogaster. J Comp Neurol. 1999;412:193-202 pubmed
    ..The pathway of eyelet's axon bundle coincides with the precocious pathway of Bolwig's nerve that arises from the larval organ of sight. The origin and possible function of eyelet are discussed. ..
  6. Rubin G. Signal transduction and the fate of the R7 photoreceptor in Drosophila. Trends Genet. 1991;7:372-7 pubmed
    The sevenless protein tyrosine kinase receptor plays a central role in the pathway of cell fate induction that determines the development of the R7 photoreceptor in the Drosophila eye...
  7. Chou W, Hall K, Wilson D, Wideman C, Townson S, Chadwell L, et al. Identification of a novel Drosophila opsin reveals specific patterning of the R7 and R8 photoreceptor cells. Neuron. 1996;17:1101-15 pubmed
    ..In sevenless mutant files, which lack R7 photoreceptor cells, the expression of the Rh5 protein in R8 cells is disrupted, ..
  8. Casci T, Vinós J, Freeman M. Sprouty, an intracellular inhibitor of Ras signaling. Cell. 1999;96:655-65 pubmed
    ..We show that it also interacts genetically with the receptor tyrosine kinases Torso and Sevenless, and it was first discovered through its effect on FGF receptor signaling...
  9. Van Vactor D, Cagan R, Kramer H, Zipursky S. Induction in the developing compound eye of Drosophila: multiple mechanisms restrict R7 induction to a single retinal precursor cell. Cell. 1991;67:1145-55 pubmed
    ..This process is mediated by bride of sevenless (boss), a cell-surface bound ligand, and the sevenless (sev) tyrosine kinase receptor...
  10. Simon M. Receptor tyrosine kinases: specific outcomes from general signals. Cell. 2000;103:13-5 pubmed
  11. Basler K, Siegrist P, Hafen E. The spatial and temporal expression pattern of sevenless is exclusively controlled by gene-internal elements. EMBO J. 1989;8:2381-6 pubmed
    The sevenless gene controls the fate of a single photoreceptor cell type in the developing eye of Drosophila. Its RNA and protein accumulate transiently in a subpopulation of cells in the developing eye imaginal disc...
  12. Lai Z, Rubin G. Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein. Cell. 1992;70:609-20 pubmed
    ..Our data suggest that yan functions as a cell-autonomous negative regulator of photoreceptor development; in the presumptive R7 and cone cells, yan appears to act antagonistically to the proneural signal mediated by sevenless and Ras1.
  13. Kozlova T, Semeshin V, Tretyakova I, Kokoza E, Pirrotta V, Grafodatskaya V, et al. Molecular and cytogenetical characterization of the 10A1-2 band and adjoining region in the Drosophila melanogaster polytene X chromosome. Genetics. 1994;136:1063-73 pubmed
    ..In contrast, the 10A1-2 band contains three genes and at least six transcribed DNA fragments. (3) Comparison of genetic and physical maps shows that in this region 0.01 centiMorgan corresponds to 3.3 kb of DNA. ..
  14. Shi Y, Noll M. Determination of cell fates in the R7 equivalence group of the Drosophila eye by the concerted regulation of D-Pax2 and TTK88. Dev Biol. 2009;331:68-77 pubmed publisher
    ..Thus, the fates of R1/R6/R7 and cone cells are determined by a dual mechanism that coordinately activates one fate while inhibiting the other. ..
  15. Robertson H, Hime G, Lada H, Bowtell D. A Drosophila analogue of v-Cbl is a dominant-negative oncoprotein in vivo. Oncogene. 2000;19:3299-308 pubmed
    ..mutation able to enhance signalling from the Drosophila Egfr and cooperate with activating mutations in the sevenless pathway to produce melanotic tumours...
  16. Moses K, Rubin G. Glass encodes a site-specific DNA-binding protein that is regulated in response to positional signals in the developing Drosophila eye. Genes Dev. 1991;5:583-93 pubmed
    ..This specificity may represent a regulation of glass protein activity after cells are recruited to the photoreceptor cell fate. ..
  17. Rogge R, Karlovich C, Banerjee U. Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases. Cell. 1991;64:39-48 pubmed
    We have isolated a dominant mutation in a gene called Son of sevenless (Sos) that is an allele-specific suppressor of the sevenless phenotype...
  18. Chou W, Huber A, Bentrop J, Schulz S, Schwab K, Chadwell L, et al. Patterning of the R7 and R8 photoreceptor cells of Drosophila: evidence for induced and default cell-fate specification. Development. 1999;126:607-16 pubmed
    ..Removal of the R7 cells in sevenless, boss or sina mutants, disrupts Rh5 expression and dramatically increases the number of Rh6-expressing R8 cells...
  19. Dickson B, Sprenger F, Hafen E. Prepattern in the developing Drosophila eye revealed by an activated torso--sevenless chimeric receptor. Genes Dev. 1992;6:2327-39 pubmed
    Induction of the R7 photoreceptor cell fate in the developing eye of Drosophila depends on the activation of the sevenless receptor tyrosine kinase in the R7 precursor cell...
  20. Morey M, Yee S, Herman T, Nern A, Blanco E, Zipursky S. Coordinate control of synaptic-layer specificity and rhodopsins in photoreceptor neurons. Nature. 2008;456:795-9 pubmed publisher
  21. Simon M, Bowtell D, Dodson G, Laverty T, Rubin G. Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase. Cell. 1991;67:701-16 pubmed
    ..decrease the effectiveness of signaling by a protein tyrosine kinase, the product of the Drosophila melanogaster sevenless gene. These mutations define seven genes whose wild-type products may be required for signaling by sevenless...
  22. Bowtell D, Simon M, Rubin G. Ommatidia in the developing Drosophila eye require and can respond to sevenless for only a restricted period. Cell. 1989;56:931-6 pubmed
    The sevenless gene encodes a putative cell surface receptor that is expressed in a highly specific and complex pattern in the developing Drosophila eye...
  23. Tomlinson A, Bowtell D, Hafen E, Rubin G. Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of Drosophila. Cell. 1987;51:143-50 pubmed
    The Drosophila gene sevenless encodes a putative trans-membrane receptor required for the formation of one particular cell, the R7 photoreceptor, in each ommatidium of the compound eye...
  24. Yamaguchi S, Desplan C, Heisenberg M. Contribution of photoreceptor subtypes to spectral wavelength preference in Drosophila. Proc Natl Acad Sci U S A. 2010;107:5634-9 pubmed publisher
    ..Involvement of all photoreceptors [R1-R6, R7, R8 (blue), R8 (green)] distinguishes phototaxis from motion detection that is mediated exclusively by R1-R6. ..
  25. Gaul U, Mardon G, Rubin G. A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase. Cell. 1992;68:1007-19 pubmed
    ..Inactivation of the locus, Gap1, mimics constitutive activation of the Sevenless receptor tyrosine kinase and eliminates the need for a functional Sevenless protein in the R7 cell...
  26. Wernet M, Mazzoni E, Celik A, Duncan D, Duncan I, Desplan C. Stochastic spineless expression creates the retinal mosaic for colour vision. Nature. 2006;440:174-80 pubmed publisher
    ..Therefore, this study suggests that the entire retinal mosaic required for colour vision is defined by the stochastic expression of a single transcription factor, Spineless. ..
  27. Banerjee U, Renfranz P, Pollock J, Benzer S. Molecular characterization and expression of sevenless, a gene involved in neuronal pattern formation in the Drosophila eye. Cell. 1987;49:281-91 pubmed
    The Drosophila sevenless mutation results in lack of a single neuron (photoreceptor cell R7) in every ommatidium of the compound eye; the developmental defect occurs in the larval eye disc...
  28. Dickson B, Dominguez M, van der Straten A, Hafen E. Control of Drosophila photoreceptor cell fates by phyllopod, a novel nuclear protein acting downstream of the Raf kinase. Cell. 1995;80:453-62 pubmed
    ..phyl thus represents a possible target gene of the Raf pathway during eye development, controlling the fates of a novel subset of photoreceptors. ..
  29. Kauffmann R, Li S, Gallagher P, Zhang J, Carthew R. Ras1 signaling and transcriptional competence in the R7 cell of Drosophila. Genes Dev. 1996;10:2167-78 pubmed
    The receptor tyrosine kinase Sevenless determines R7 cell fate by activation of the Ras1 pathway in a subset of equivalent cells competent to respond in the Drosophila eye...
  30. Bowtell D, Kimmel B, Simon M, Rubin G. Regulation of the complex pattern of sevenless expression in the developing Drosophila eye. Proc Natl Acad Sci U S A. 1989;86:6245-9 pubmed
    The sevenless gene encodes a cell surface receptor that has protein-tyrosine kinase activity and is expressed in a highly specific and complex pattern in the developing Drosophila eye...
  31. Zheng L, Carthew R. Lola regulates cell fate by antagonizing Notch induction in the Drosophila eye. Mech Dev. 2008;125:18-29 pubmed
    ..The predicted consequence of this mechanism is to sharpen a cell's responsiveness to Notch signaling by creating a threshold. ..
  32. Chang H, Solomon N, Wassarman D, Karim F, Therrien M, Rubin G, et al. phyllopod functions in the fate determination of a subset of photoreceptors in Drosophila. Cell. 1995;80:463-72 pubmed
    ..phyl is also required for embryonic nervous system and sensory bristle development. ..
  33. Cook T. Cell diversity in the retina: more than meets the eye. Bioessays. 2003;25:921-5 pubmed
    ..As Prospero, the Drosophila homolog of Prox1, also participates in retinal cell specification, these data provide a forum for asking new questions concerning pathways that may regulate retinogenesis across evolution. ..
  34. Mikeladze Dvali T, Wernet M, Pistillo D, Mazzoni E, Teleman A, Chen Y, et al. The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors. Cell. 2005;122:775-87 pubmed
    ..This represents an unexpected postmitotic role for genes controlling cell proliferation (warts and its partner hippo and salvador) and cell growth (melted). ..
  35. Almudi I, Stocker H, Hafen E, Corominas M, Serras F. SOCS36E specifically interferes with Sevenless signaling during Drosophila eye development. Dev Biol. 2009;326:212-23 pubmed publisher
    ..We have used the specification of the R7 photoreceptor cells controlled by the Sevenless receptor tyrosine kinase (Sev) pathway to screen for modulators of pathway activity and to uncover the ..
  36. Hayashi T, Kojima T, Saigo K. Specification of primary pigment cell and outer photoreceptor fates by BarH1 homeobox gene in the developing Drosophila eye. Dev Biol. 1998;200:131-45 pubmed
    ..Here, we show evidence that BarH1 ectopically expressed under the control of the sevenless enhancer (sev-BarH1) causes two types of cone cell transformation: transformation of anterior/posterior cone ..
  37. Yamaguchi S, Wolf R, Desplan C, Heisenberg M. Motion vision is independent of color in Drosophila. Proc Natl Acad Sci U S A. 2008;105:4910-5 pubmed publisher
    ..We conclude that the color channel (R7/R8) does not contribute to motion detection as monitored by the optomotor response. ..
  38. Meisner H, Daga A, Buxton J, Fernandez B, Chawla A, Banerjee U, et al. Interactions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development. Mol Cell Biol. 1997;17:2217-25 pubmed
    ..Expression of D-Cbl directed by the sevenless enhancer in intact Drosophila compromises severely the development of the R7 photoreceptor neuron...
  39. Zhimulev I, Pokholkova G, Bgatov A, Semeshin V, Belyaeva E. Fine cytogenetical analysis of the band 10A1-2 and the adjoining regions in the Drosophila melanogaster X chromosome. II. Genetical analysis. Chromosoma. 1981;82:25-40 pubmed
    ..distal edge of the band; (ii) and (iii) two genes: v and 1(1)BP4; (iv) silent DNA in middle of the band, (v) locus sev on the proximal edge of the band. About 70% of the band's DNA was found to be silent...
  40. Basler K, Christen B, Hafen E. Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye. Cell. 1991;64:1069-81 pubmed
    Cell fate in the developing eye is determined by a cascade of inductive interactions. In this process, the sevenless protein--a receptor tyrosine kinase--is required for the specification of the R7 photoreceptor cell fate...
  41. Brown N, Sattler C, Markey D, Carroll S. hairy gene function in the Drosophila eye: normal expression is dispensable but ectopic expression alters cell fates. Development. 1991;113:1245-56 pubmed
    ..The effects of ectopic hairy expression may result from interactions with proneural genes involved in the development of the eye and other sensory organs. ..
  42. Rogers E, Hsiung F, Rodrigues A, Moses K. Slingshot cofilin phosphatase localization is regulated by receptor tyrosine kinases and regulates cytoskeletal structure in the developing Drosophila eye. Mech Dev. 2005;122:1194-205 pubmed
    ..Ssh protein becomes apically concentrated in cells that express elevated levels of the Sevenless (Sev) receptor-tyrosine kinase (RTK), even those which receive no ligand...
  43. Vasiliauskas D, Mazzoni E, Sprecher S, Brodetskiy K, Johnston R, Lidder P, et al. Feedback from rhodopsin controls rhodopsin exclusion in Drosophila photoreceptors. Nature. 2011;479:108-12 pubmed publisher
    ..Our observations reveal a thus far unappreciated spectral plasticity of R8 photoreceptors, and identify rhodopsin feedback as an exclusion mechanism. ..
  44. Vatolina T, Boldyreva L, Demakova O, Demakov S, Kokoza E, Semeshin V, et al. Identical functional organization of nonpolytene and polytene chromosomes in Drosophila melanogaster. PLoS ONE. 2011;6:e25960 pubmed publisher
    ..As appeared, origin recognition complexes are located almost totally in the interbands of chromosomes. ..
  45. Schlichting M, Grebler R, Menegazzi P, Helfrich Förster C. Twilight dominates over moonlight in adjusting Drosophila's activity pattern. J Biol Rhythms. 2015;30:117-28 pubmed publisher
    ..To adjust nocturnal activity levels to a wild-type manner, all photoreceptor cells work together in a complex way, with rhodopsin 6 having a prominent role. ..
  46. Shishido E, Emori Y, Saigo K. Identification of seven novel protein-tyrosine kinase genes of Drosophila by the polymerase chain reaction. FEBS Lett. 1991;289:235-8 pubmed
  47. Sawamoto K, Okabe M, Tanimura T, Mikoshiba K, Nishida Y, Okano H. The Drosophila secreted protein Argos regulates signal transduction in the Ras/MAPK pathway. Dev Biol. 1996;178:13-22 pubmed
    ..argos mutation enhanced the overproduction of R7 neurons caused by gain-of-function alleles of Son of sevenless and Dsor1...
  48. Perrimon N, Perkins L. There must be 50 ways to rule the signal: the case of the Drosophila EGF receptor. Cell. 1997;89:13-6 pubmed
  49. Banerjee U, Renfranz P, Hinton D, Rabin B, Benzer S. The sevenless+ protein is expressed apically in cell membranes of developing Drosophila retina; it is not restricted to cell R7. Cell. 1987;51:151-8 pubmed
    In the sevenless (sev) mutants of Drosophila, a single cell type, photoreceptor R7, does not develop...
  50. Schlichting M, Grebler R, Peschel N, Yoshii T, Helfrich Forster C. Moonlight detection by Drosophila's endogenous clock depends on multiple photopigments in the compound eyes. J Biol Rhythms. 2014;29:75-86 pubmed publisher
  51. Periz G, Fortini M. Ca(2+)-ATPase function is required for intracellular trafficking of the Notch receptor in Drosophila. EMBO J. 1999;18:5983-93 pubmed
    ..Notch and several other transmembrane proteins are mislocalized in tissue clones homozygous for Ca-P60A mutations, demonstrating a general effect on membrane protein trafficking caused by a deficiency in Ca(2+)-ATPase. ..
  52. Sunio A, Metcalf A, Kramer H. Genetic dissection of endocytic trafficking in Drosophila using a horseradish peroxidase-bride of sevenless chimera: hook is required for normal maturation of multivesicular endosomes. Mol Biol Cell. 1999;10:847-59 pubmed
    ..dissect this defect in more detail, we developed a new approach to visualize the pathway taken by the Bride of Sevenless (Boss) ligand after its internalization into R7 cells...
  53. Simon M. Signal transduction during the development of the Drosophila R7 photoreceptor. Dev Biol. 1994;166:431-42 pubmed
  54. Biggs W, Zavitz K, Dickson B, van der Straten A, Brunner D, Hafen E, et al. The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway. EMBO J. 1994;13:1628-35 pubmed
    ..During retinal development in Drosophila, the sevenless (Sev) RTK is required for development of the R7 photoreceptor cell...
  55. Asha H, De Ruiter N, Wang M, Hariharan I. The Rap1 GTPase functions as a regulator of morphogenesis in vivo. EMBO J. 1999;18:605-15 pubmed
    ..Rap1 mutations also disrupt cell migrations and cause abnormalities in cell shape. These findings indicate a role for Rap proteins as regulators of morphogenesis in vivo. ..
  56. Shamloula H, Mbogho M, Pimentel A, Chrzanowska Lightowlers Z, Hyatt V, Okano H, et al. rugose (rg), a Drosophila A kinase anchor protein, is required for retinal pattern formation and interacts genetically with multiple signaling pathways. Genetics. 2002;161:693-710 pubmed
    ..Our results suggest that rg is required for correct retinal pattern formation and may function in cell fate determination through its interactions with the EGFR and Notch signaling pathways. ..
  57. Morey M, Serras F, Baguna J, Hafen E, Corominas M. Modulation of the Ras/MAPK signalling pathway by the redox function of selenoproteins in Drosophila melanogaster. Dev Biol. 2001;238:145-56 pubmed hyperactivation of the Ras/MAPK cassette and the activated forms of the Drosophila EGF receptor (DER) and Sevenless (Sev) receptor tyrosine kinases (RTKs), which signal in the eye and wing, respectively...
  58. Feldmann P, Eicher E, Leevers S, Hafen E, Hughes D. Control of growth and differentiation by Drosophila RasGAP, a homolog of p120 Ras-GTPase-activating protein. Mol Cell Biol. 1999;19:1928-37 pubmed
    ..Genetic interactions, however, suggested a Ras-independent role for RasGAP in the regulation of growth. The system described here should enable genetic screens to be performed to identify regulators and effectors of p120 Ras-GAP. ..
  59. Basler K, Hafen E. Control of photoreceptor cell fate by the sevenless protein requires a functional tyrosine kinase domain. Cell. 1988;54:299-311 pubmed
    The sevenless (sev) gene determines the fate of a single photoreceptor cell type in the eye of Drosophila. It encodes a putative cell-surface protein with homology to tyrosine kinases...
  60. BIRKHOLZ D, Chou W, Phistry M, Britt S. rhomboid mediates specification of blue- and green-sensitive R8 photoreceptor cells in Drosophila. J Neurosci. 2009;29:2666-75 pubmed publisher
    ..This suggests that rhomboid may function in R8 cells to activate Epidermal growth factor receptor signaling in R7 cells and promote their differentiation to a signaling competent state. ..
  61. Perrimon N. Signalling pathways initiated by receptor protein tyrosine kinases in Drosophila. Curr Opin Cell Biol. 1994;6:260-6 pubmed
    ..e. Grb2, Sos, Ras-Gap, p21ras, Raf, MEK and MAPK, genetic studies have suggested that two novel proteins, the protein tyrosine phosphatase (PTPase) Csw and the transmembrane protein Rho, are involved in RPTK signalling. ..
  62. Bonfini L, Karlovich C, Dasgupta C, Banerjee U. The Son of sevenless gene product: a putative activator of Ras. Science. 1992;255:603-6 pubmed
    The Son of sevenless (Sos) gene functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases. The Sos gene has now been isolated and sequenced...
  63. Zhang S, Odenwald W. Misexpression of the white (w) gene triggers male-male courtship in Drosophila. Proc Natl Acad Sci U S A. 1995;92:5525-9 pubmed
    ..These findings demonstrate that, in Drosophila, both genetic and environmental factors play a role in male sexual behavior...
  64. Ting C, Yonekura S, Chung P, Hsu S, Robertson H, Chiba A, et al. Drosophila N-cadherin functions in the first stage of the two-stage layer-selection process of R7 photoreceptor afferents. Development. 2005;132:953-63 pubmed
    ..We propose that Ncad isoforms do not form an adhesion code; rather, they provide permissive adhesion between R7 growth cones and their temporary targets. ..
  65. Norton P, Hynes R, Rees D. sevenless: Seven found?. Cell. 1990;61:15-6 pubmed