Gene Symbol: sesB
Description: stress-sensitive B
Alias: A/A-T/sesB, ADP/ATP translocase, ADT2, ANT, ANT1, CG16944, Dmel\CG16944, EM12, Hmr, S12, SesB, anon-WO02059370.55, dANT, jive, l(1)9Ed, l(1)9Fa, l(1)DC701, l(1)EM31, l(1)G0126, l(1)G0247, l(1)G0386, l(1)S12, orangi, ses B, stress-sensitive B, ADP,ATP carrier protein, CG16944-PA, CG16944-PB, CG16944-PC, CG16944-PD, CG16944-PE, Stress-sensitive B, adenine nuclear translocase, adenine nucleotide translocase, drosophila ANT, lethal(1)9Ed, sesB-PA, sesB-PB, sesB-PC, sesB-PD, sesB-PE, stress sensitive B
Species: fruit fly

Top Publications

  1. Perrimon N, Engstrom L, Mahowald A. The effects of zygotic lethal mutations on female germ-line functions in Drosophila. Dev Biol. 1984;105:404-14 pubmed
    ..Three loci were found which, in germ-line clones, produced embryonic phenotypes that resemble maternal effect mutations. The implications of this study for the genetic analysis of early development are discussed. ..
  2. Terhzaz S, Cabrero P, Chintapalli V, Davies S, Dow J. Mislocalization of mitochondria and compromised renal function and oxidative stress resistance in Drosophila SesB mutants. Physiol Genomics. 2010;41:33-41 pubmed publisher
    ..In Drosophila, sesB encodes the ubiquitous isoform of adenine nucleotide translocase (ANT, the mitochondrial inner membrane ATP/ADP exchanger); null alleles are lethal, whereas ..
  3. Chen S, Oliveira M, Sanz A, Kemppainen E, Fukuoh A, Schlicht B, et al. A cytoplasmic suppressor of a nuclear mutation affecting mitochondrial functions in Drosophila. Genetics. 2012;192:483-93 pubmed publisher
    ..Our findings provide a paradigm for understanding the role of mtDNA genotype in human disease. ..
  4. Fergestad T, Bostwick B, Ganetzky B. Metabolic disruption in Drosophila bang-sensitive seizure mutants. Genetics. 2006;173:1357-64 pubmed
    ..Our data implicate cellular metabolism in regulating seizure susceptibility and suggest that differential sensitivity of neuronal subtypes to metabolic changes underlies distinct types of seizure activity. ..
  5. Munro T, Kwon S, Schnapp B, St Johnston D. A repeated IMP-binding motif controls oskar mRNA translation and anchoring independently of Drosophila melanogaster IMP. J Cell Biol. 2006;172:577-88 pubmed
    ..Our findings establish a parallel requirement for IBEs in the regulation of localized maternal mRNAs in D. melanogaster and X. laevis. ..
  6. Brand M, Pakay J, Ocloo A, Kokoszka J, Wallace D, Brookes P, et al. The basal proton conductance of mitochondria depends on adenine nucleotide translocase content. Biochem J. 2005;392:353-62 pubmed
    ..We show that the proton conductance of muscle mitochondria from mice in which isoform 1 of the adenine nucleotide translocase has been ablated is half that of wild-type controls...
  7. Rikhy R, Ramaswami M, Krishnan K. A temperature-sensitive allele of Drosophila sesB reveals acute functions for the mitochondrial adenine nucleotide translocase in synaptic transmission and dynamin regulation. Genetics. 2003;165:1243-53 pubmed is an allele of the stress sensitive B (sesB) locus that encodes a mitochondrial adenine nucleotide translocase (ANT) and results in a unique ts paralytic behavior that is accompanied by a complete loss of synaptic ..
  8. Zhang Y, Roote J, Brogna S, Davis A, Barbash D, Nash D, et al. stress sensitive B encodes an adenine nucleotide translocase in Drosophila melanogaster. Genetics. 1999;153:891-903 pubmed
    ..We show that mutations in this gene correspond to the previously described loci, sesB and l(1)9Ed...
  9. Celotto A, Frank A, McGrath S, Fergestad T, Van Voorhies W, Buttle K, et al. Mitochondrial encephalomyopathy in Drosophila. J Neurosci. 2006;26:810-20 pubmed
    ..This Drosophila mutant recapitulates key features of the human neuromuscular disorders enabling detailed in vivo studies of these enigmatic diseases. ..

More Information


  1. Hutter P, Karch F. Molecular analysis of a candidate gene for the reproductive isolation between sibling species of Drosophila. Experientia. 1994;50:749-62 pubmed
    The X-linked gene Hmr in Drosophila melanogaster, when mutated, rescues otherwise inviable interspecific hybrids from crosses between D. melanogaster and any of its three most closely related species D. simulans, D. mauritiana and D...
  2. Homyk T, Szidonya J, Suzuki D. Behavioral mutants of Drosophila melanogaster. III. Isolation and mapping of mutations by direct visual observations of behavioral phenotypes. Mol Gen Genet. 1980;177:553-65 pubmed
  3. Lefevre G. Salivary chromosome bands and the frequency of crossing over in Drosophila melanogaster. Genetics. 1971;67:497-513 pubmed
  4. Chen C, Buhl E, Xu M, Croset V, Rees J, Lilley K, et al. Drosophila Ionotropic Receptor 25a mediates circadian clock resetting by temperature. Nature. 2015;527:516-20 pubmed publisher
    ..This pathway operates in the absence of known 'hot' and 'cold' sensors in the Drosophila antenna, revealing the existence of novel periphery-to-brain temperature signalling channels. ..
  5. Barbash D, Roote J, Ashburner M. The Drosophila melanogaster hybrid male rescue gene causes inviability in male and female species hybrids. Genetics. 2000;154:1747-71 pubmed
    The Drosophila melanogaster mutation Hmr rescues inviable hybrid sons from the cross of D. melanogaster females to males of its sibling species D. mauritiana, D. simulans, and D. sechellia...
  6. Chang K, MIN K. Drosophila melanogaster homolog of Down syndrome critical region 1 is critical for mitochondrial function. Nat Neurosci. 2005;8:1577-85 pubmed
    ..These results identify nebula/DSCR1 as a regulator of mitochondrial function and integrity and further suggest that an increased level of DSCR1 may contribute to the mitochondrial dysfunction seen in Down syndrome. ..
  7. Hutter P. X-linked small GTPase and OXPHOS genes are candidates for the genetic basis of hybrid inviability in Drosophila. Dev Genes Evol. 2002;212:504-12 pubmed
    ..Alterations in some of these genes are postulated to override hybrid inviability, thus revealing a pathway which implicates mitotic genes as critical players in this barrier to reproduction. ..
  8. Zhimulev I, Pokholkova G, Bgatov A, Semeshin V, Belyaeva E. Fine cytogenetical analysis of the band 10A1-2 and the adjoining regions in the Drosophila melanogaster X chromosome. II. Genetical analysis. Chromosoma. 1981;82:25-40 pubmed
    ..About 70% of the band's DNA was found to be silent. - Using the set of chromosome rearrangements removing different parts of the band it was shown that these five sequences may function independently from each other. ..
  9. Brooks A, Yang L, Duff M, Hansen K, Park J, Dudoit S, et al. Conservation of an RNA regulatory map between Drosophila and mammals. Genome Res. 2011;21:193-202 pubmed publisher
    ..This observation suggests that the regulatory codes of individual RNA binding proteins may be nearly immutable, yet the regulatory modules controlled by these proteins are highly evolvable. ..
  10. Trotta N, Rodesch C, Fergestad T, Broadie K. Cellular bases of activity-dependent paralysis in Drosophila stress-sensitive mutants. J Neurobiol. 2004;60:328-47 pubmed
    ..this study investigates synaptic function more specifically in two stress-sensitive mutants: stress-sensitive B (sesB), which encodes a mitochondrial ADP/ATP translocase (ANT); and Atpalpha(2206), a conditional mutant of the Na+/K+ ..
  11. Fergestad T, Olson L, Patel K, Miller R, Palladino M, Ganetzky B. Neuropathology in Drosophila mutants with increased seizure susceptibility. Genetics. 2008;178:947-56 pubmed publisher
    ..These results emphasize the importance of proper cellular metabolism in maintaining both the activity and viability of neurons. ..
  12. Choo A, O Keefe L, Lee C, Gregory S, Shaukat Z, Colella A, et al. Tumor suppressor WWOX moderates the mitochondrial respiratory complex. Genes Chromosomes Cancer. 2015;54:745-61 pubmed publisher
    ..Thus, the ability of WWOX to facilitate escape from mitochondrial damage-induced glycolysis (Warburg effect) is, therefore, a plausible mechanism for its tumor suppressor activity. ..
  13. Herrig D, Modrick A, Brud E, Llopart A. Introgression in the Drosophila subobscura--D. Madeirensis sister species: evidence of gene flow in nuclear genes despite mitochondrial differentiation. Evolution. 2014;68:705-19 pubmed publisher
    ..Contrary to other observations in Drosophila, the mitochondrial genome appears resilient to gene flow in the presence of nuclear exchange...
  14. Ribeiro A, Silva R, Foyn H, Tiago M, Rathore O, Arnesen T, et al. Naa50/San-dependent N-terminal acetylation of Scc1 is potentially important for sister chromatid cohesion. Sci Rep. 2016;6:39118 pubmed publisher
  15. Bartolomé C, Maside X, Yi S, Grant A, Charlesworth B. Patterns of selection on synonymous and nonsynonymous variants in Drosophila miranda. Genetics. 2005;169:1495-507 pubmed
    ..The joint intensity of selection and biased gene conversion, in terms of the product of effective population size and the sum of the selection and conversion coefficients, was estimated to be approximately 0.65. ..
  16. Nash D, Janca F. Hypomorphic lethal mutations and their implications for the interpretation of lethal complementation studies in Drosophila. Genetics. 1983;105:957-68 pubmed
    ..Accidental inclusion of disguised haplo-specific lethals in autosomal complementation tests will generate spurious examples of interallelic complementation. ..
  17. Echtay K, Esteves T, Pakay J, Jekabsons M, Lambert A, Portero Otin M, et al. A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling. EMBO J. 2003;22:4103-10 pubmed
    ..induce uncoupling of mitochondria through the uncoupling proteins UCP1, UCP2 and UCP3 and the adenine nucleotide translocase (ANT)...
  18. Guan Z, Saraswati S, Adolfsen B, Littleton J. Genome-wide transcriptional changes associated with enhanced activity in the Drosophila nervous system. Neuron. 2005;48:91-107 pubmed
    ..These data identify a collection of activity-regulated transcripts that may link changes in neuronal firing patterns to transcription-dependent modulation of brain function, including activity-dependent synaptic rewiring. ..
  19. Hutter P. Rapidly evolving Rab GTPase paralogs and reproductive isolation in Drosophila. Adv Genet. 2007;58:1-23 pubmed
    Alterations at the X-linked Hmr gene of Drosophila melanogaster can fully restore viability and partially restore fertility in hybrid flies from crosses between D. melanogaster and any of its three most closely related species...
  20. Kim Y, Shin M, Yang D, Yamaguchi M, Park S, Yoo M. Transcriptional regulation of the Drosophila ANT gene by the DRE/DREF system. Genes Cells. 2007;12:569-79 pubmed
    b>Adenine nucleotide translocase (ANT) is a crucial component in the maintenance of cellular energy homeostasis, as well as in the formation of the mitochondrial permeability transition pores...
  21. Santamaria M, Lanave C, Saccone C. The evolution of the adenine nucleotide translocase family. Gene. 2004;333:51-9 pubmed publisher
    ..In order to track the evolutionary history of the ANT gene family, we have collected and analyzed 46 sequences from fungi to mammals...
  22. Sen A, Damm V, Cox R. Drosophila clueless is highly expressed in larval neuroblasts, affects mitochondrial localization and suppresses mitochondrial oxidative damage. PLoS ONE. 2013;8:e54283 pubmed publisher
    ..Mutations in two other genes encoding mitochondrial proteins, technical knockout and stress sensitive B, do not cause neuroblast mitochondrial mislocalization, even though technical knockout mutant larvae suffer ..
  23. Shaw P, Tononi G, Greenspan R, Robinson D. Stress response genes protect against lethal effects of sleep deprivation in Drosophila. Nature. 2002;417:287-91 pubmed
    ..These data represent the first step in identifying the molecular mechanisms that constitute the sleep homeostat. ..
  24. Toivonen J, Walker G, Martinez Diaz P, Bjedov I, Driege Y, Jacobs H, et al. No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects. PLoS Genet. 2007;3:e95 pubmed
    ..In addition, we saw no effects on lifespan of expression knockdown of the Indy orthologues nac-2 and nac-3 in the nematode Caenorhabditis elegans. ..
  25. Lucey B, Leahy A, Rosas R, Shaw P. A new model to study sleep deprivation-induced seizure. Sleep. 2015;38:777-85 pubmed publisher
    ..Seizure activity was evaluated in an adult bang-sensitive seizure mutant, stress sensitive B (sesB(9ed4)), and in an adult temperature sensitive seizure mutant seizure (sei(ts1)) under baseline and ..
  26. Devorkin L, Go N, Hou Y, Moradian A, Morin G, Gorski S. The Drosophila effector caspase Dcp-1 regulates mitochondrial dynamics and autophagic flux via SesB. J Cell Biol. 2014;205:477-92 pubmed publisher
    ..Loss of Dcp-1 led to mitochondrial elongation, increased levels of the mitochondrial adenine nucleotide translocase stress-sensitive B (SesB), increased adenosine triphosphate (ATP), and a reduction in autophagic flux...
  27. Louvi A, Tsitilou S. A cDNA clone encoding the ADP/ATP translocase of Drosophila melanogaster shows a high degree of similarity with the mammalian ADP/ATP translocases. J Mol Evol. 1992;35:44-50 pubmed
    ..DNA transfer hybridization experiments suggest that more than one gene coding for the ADP/ATP translocase is present in the D. melanogaster genome. ..
  28. Boylan K, Mische S, Li M, Marques G, Morin X, Chia W, et al. Motility screen identifies Drosophila IGF-II mRNA-binding protein--zipcode-binding protein acting in oogenesis and synaptogenesis. PLoS Genet. 2008;4:e36 pubmed publisher
    ..In oocytes, where Imp function is not essential, we implicate a specific Imp domain in the establishment of dorsoventral polarity. ..
  29. Vartiainen S, Chen S, George J, Tuomela T, Luoto K, O Dell K, et al. Phenotypic rescue of a Drosophila model of mitochondrial ANT1 disease. Dis Model Mech. 2014;7:635-48 pubmed publisher
    A point mutation in the Drosophila gene that codes for the major adult isoform of adenine nuclear translocase (ANT) represents a model for human diseases that are associated with ANT insufficiency [stress-sensitive B(1) (sesB(1))]...
  30. Janca F, Woloshyn E, Nash D. Heterogeneity of lethals in a "simple" lethal complementation group. Genetics. 1986;112:43-64 pubmed
    ..We suggest that the reason why recessive lethal mutations rarely present complex complementation patterns is that complex loci tend to produce mutations that affect several subfunctions. ..
  31. Rikhy R, Kamat S, Ramagiri S, Sriram V, Krishnan K. Mutations in dynamin-related protein result in gross changes in mitochondrial morphology and affect synaptic vesicle recycling at the Drosophila neuromuscular junction. Genes Brain Behav. 2007;6:42-53 pubmed
    ..Like stress-sensitive B (sesB), a mitochondrial adenosine triphosphate (ATP) translocase mutant we studied earlier for its effects on synaptic ..
  32. Li Y, Rao X, MATTOX W, Amos C, Liu B. RNA-Seq Analysis of Differential Splice Junction Usage and Intron Retentions by DEXSeq. PLoS ONE. 2015;10:e0136653 pubmed publisher
    ..The analysis confirmed previous findings on the alternative splicing of the trol and Ant2 (sesB) genes in the CG8144 (ps)-depletion experiment and identified some new alternative splicing events in other RNAi ..