Ser

Summary

Gene Symbol: Ser
Description: Serrate
Alias: CG6127, CT18858, Dmel\CG6127, Rpw, SER, mel(3)8, ser, std, CG6127 gene product from transcript CG6127-RB, CG6127-PA, CG6127-PB, Ser-PA, Ser-PB, beaded, dmSerrate, ripped wing, serrate, serratoid
Species: fruit fly

Top Publications

  1. ncbi Notch signaling: cell fate control and signal integration in development
    S Artavanis-Tsakonas
    Massachusetts General Hospital Cancer Center, Department of Cell Biology, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Science 284:770-6. 1999
  2. ncbi Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation
    D Doherty
    Howard Hughes Medical Institute, University of California, San Francisco, 94143 0724, USA
    Genes Dev 10:421-34. 1996
  3. ncbi Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc
    J F de Celis
    Department of Genetics, University of Cambridge, UK
    Development 122:359-69. 1996
  4. ncbi Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing
    F J Diaz-Benjumea
    Differentiation Program, European Molecular Biology Laboratory, Heidelberg, Germany
    Development 121:4215-25. 1995
  5. doi Mechanisms of ligand-mediated inhibition in Notch signaling activity in Drosophila
    Ulla Maj Fiuza
    Department of Genetics, University of Cambridge, Cambridge, United Kingdom
    Dev Dyn 239:798-805. 2010
  6. pmc Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand
    Il Man Kim
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Circ Res 106:1233-43. 2010
  7. doi AP-1 controls the trafficking of Notch and Sanpodo toward E-cadherin junctions in sensory organ precursors
    Najate Benhra
    CNRS UMR 6061 Institut de Génétique et Développement de Rennes, Universite de Rennes 1, 2 avenue du Professeur Bernard, 35000 Rennes, France
    Curr Biol 21:87-95. 2011
  8. ncbi The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate
    C A Micchelli
    Department of Zoology, University of Wisconsin, Madison 53706, USA
    Development 124:1485-95. 1997
  9. pmc A Serrate-expressing signaling center controls Drosophila hematopoiesis
    Tim Lebestky
    Molecular Biology Institute, University of California Los Angeles, Los Angeles, California 90095, USA
    Genes Dev 17:348-53. 2003
  10. ncbi Structural conservation of Notch receptors and ligands
    R J Fleming
    Department of Biology, The University of Rochester, Hutchison Hall, Rochester, NY, 14627, USA
    Semin Cell Dev Biol 9:599-607. 1998

Research Grants

  1. A novel Dlg isoform and identification of its interacting proteins
    Kyung Ok Cho; Fiscal Year: 2007
  2. The enhancer of rudimentary gene
    STUART TSUBOTA; Fiscal Year: 2002
  3. SPECTRAL CONFOCAL MICROSCOPE
    Peter Bryant; Fiscal Year: 2002
  4. NOTCH SIGNALING IN HEMATOPOIETIC CELLS
    THOMAS KADESCH; Fiscal Year: 2002
  5. TRANSCRIPTIONAL DETERMINANTS OF B LYMPHOCYTES
    THOMAS KADESCH; Fiscal Year: 2002
  6. Signaling Mechanisms of the Drosophila JAK/STAT Pathway
    Hong Luo; Fiscal Year: 2003
  7. Analysis of fringe-dependent cell-signaling
    Kenneth Irvine; Fiscal Year: 2004
  8. Molecular Mechanisms of Segmentation
    Cordelia Rauskolb; Fiscal Year: 2005
  9. Molecular Genetics of Drosophila MAGUK's
    Peter Bryant; Fiscal Year: 2005
  10. Left/right asymmetric neuronal cell fate specification
    Oliver Hobert; Fiscal Year: 2006

Detail Information

Publications139 found, 100 shown here

  1. ncbi Notch signaling: cell fate control and signal integration in development
    S Artavanis-Tsakonas
    Massachusetts General Hospital Cancer Center, Department of Cell Biology, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Science 284:770-6. 1999
    ..Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis...
  2. ncbi Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation
    D Doherty
    Howard Hughes Medical Institute, University of California, San Francisco, 94143 0724, USA
    Genes Dev 10:421-34. 1996
    ..Wing margin formation in Drosophila requires the Notch receptor and, in the dorsal compartment, one of its ligands, Serrate. We provide evidence that Delta, the other known ligand for Notch, is also essential for this process...
  3. ncbi Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc
    J F de Celis
    Department of Genetics, University of Cambridge, UK
    Development 122:359-69. 1996
    ..In addition, Serrate, a similar transmembrane protein to Delta, behaves as a ligand required in dorsal cells to activate Notch at the ..
  4. ncbi Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing
    F J Diaz-Benjumea
    Differentiation Program, European Molecular Biology Laboratory, Heidelberg, Germany
    Development 121:4215-25. 1995
    ..Interaction between cells in adjacent compartments establish the organizer. We report here that Serrate and Notch mediate the interaction between dorsal and ventral cells to direct localized expression of Wingless at ..
  5. doi Mechanisms of ligand-mediated inhibition in Notch signaling activity in Drosophila
    Ulla Maj Fiuza
    Department of Genetics, University of Cambridge, Cambridge, United Kingdom
    Dev Dyn 239:798-805. 2010
    The transmembrane proteins Delta and Serrate act as ligands for the signaling receptor Notch. In addition to this activating role, Delta and Serrate can also inhibit Notch signaling activity...
  6. pmc Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand
    Il Man Kim
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Circ Res 106:1233-43. 2010
    ..Drosophila has been recognized as a model to study human cardiac diseases...
  7. doi AP-1 controls the trafficking of Notch and Sanpodo toward E-cadherin junctions in sensory organ precursors
    Najate Benhra
    CNRS UMR 6061 Institut de Génétique et Développement de Rennes, Universite de Rennes 1, 2 avenue du Professeur Bernard, 35000 Rennes, France
    Curr Biol 21:87-95. 2011
    ..Because AP-1 does not prevent endocytosis and recycling of the Notch ligand Delta, our data indicate that the DE-cadherin junctional domain may act as a launching pad through which endocytosed Notch ligand is trafficked for signaling...
  8. ncbi The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate
    C A Micchelli
    Department of Zoology, University of Wisconsin, Madison 53706, USA
    Development 124:1485-95. 1997
    ..on the dorsal and ventral side by domains of cells expressing elevated levels of the Notch ligands Delta and Serrate. We show first that cut acts to maintain margin wingless expression, providing a potential explanation of the cut ..
  9. pmc A Serrate-expressing signaling center controls Drosophila hematopoiesis
    Tim Lebestky
    Molecular Biology Institute, University of California Los Angeles, Los Angeles, California 90095, USA
    Genes Dev 17:348-53. 2003
    ..Two major branches of Drosophila hematopoiesis give rise to plasmatocytes/macrophages and crystal cells. Serrate signaling through the Notch pathway is critical in the regulation of Lz expression and the specification of ..
  10. ncbi Structural conservation of Notch receptors and ligands
    R J Fleming
    Department of Biology, The University of Rochester, Hutchison Hall, Rochester, NY, 14627, USA
    Semin Cell Dev Biol 9:599-607. 1998
    ..Within this review, the known functional properties of these domains are analyzed with respect to their contributions to ligand/receptor interactions and Notch signalling...
  11. ncbi Asymmetric Notch activation specifies photoreceptors R3 and R4 and planar polarity in the Drosophila eye
    M Fanto
    Developmental Biology Programme, EMBL, Heidelberg, Germany
    Nature 397:523-6. 1999
    ..This two-tiered mechanism explains how small differences in the level and/or timing of Fz activation reliably generate a binary cell-fate decision, leading to specification of R3 and R4 and ommatidial chirality...
  12. ncbi Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe
    Vladislav M Panin
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University, Piscataway, New Jersey 08854, USA
    J Biol Chem 277:29945-52. 2002
    ..O-fucose on mammalian Delta 1 and Jagged1 can be elongated with Manic Fringe in vivo, and Drosophila Delta and Serrate are substrates for Drosophila Fringe in vitro...
  13. ncbi Notch signaling controls lineage specification during Drosophila larval hematopoiesis
    Bernard Duvic
    Unité Propre de Recherche 9022, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, 67084, Strasbourg, France
    Curr Biol 12:1923-7. 2002
    ..We demonstrate that, in this process, Serrate, not Delta, is the Notch ligand...
  14. ncbi Regulation of notch signaling by o-linked fucose
    Tetsuya Okajima
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Cell 111:893-904. 2002
    ....
  15. ncbi Serrate-Notch signaling defines the scope of the initial denticle field by modulating EGFR activation
    James W Walters
    Weill Graduate School of Medical Sciences, New York, NY 10021, USA
    Dev Biol 286:415-26. 2005
    ..segmental patterning, distinct signaling territories are established that employ either the Hedgehog, Spitz, Serrate or Wingless ligands. How these pathways control segmental pattern is not completely clear...
  16. ncbi Lobe and Serrate are required for cell survival during early eye development in Drosophila
    Amit Singh
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Development 133:4771-81. 2006
    ..Here, we show that Lobe (L) and the Notch (N) ligand Serrate (Ser), which are both involved in ventral eye growth, are required for cell survival in the early eye disc...
  17. doi Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling
    Anne Marie Martinez
    Institut de Genetique Humaine, Centre Nationale de la Recherche Scientifique, Montpellier, France
    Nat Genet 41:1076-82. 2009
    ..These data show that ph is a tumor suppressor locus that controls cellular proliferation by silencing multiple Notch signaling components...
  18. ncbi The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster
    R J Fleming
    Howard Hughes Medical Institute, Department of Cell Biology, Yale University, New Haven, Connecticut 06511
    Genes Dev 4:2188-201. 1990
    Mutations in the third chromosome gene Serrate are shown to display genetic interactions with specific alleles of the neurogenic locus Notch, which encodes a transmembrane protein with epidermal growth factor (EGF) homology...
  19. ncbi Fringe modulates Notch-ligand interactions
    V M Panin
    Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University, Piscataway, New Jersey 08855, USA
    Nature 387:908-12. 1997
    ..Three genes, fringe (fng), Serrate (Ser) and Delta (Dl), are involved in the cellular interactions leading to Notch activation...
  20. pmc Delta and Serrate are redundant Notch ligands required for asymmetric cell divisions within the Drosophila sensory organ lineage
    C Zeng
    Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, California 94143, USA
    Genes Dev 12:1086-91. 1998
    ..cell-cell communication via Notch (N) receptor, mitotic recombination that removes the N ligand Delta (Dl) or Serrate (Ser) in the SOL had mild or no effect...
  21. ncbi A subset of notch functions during Drosophila eye development require Su(H) and the E(spl) gene complex
    P Ligoxygakis
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, and Department of Biology, University of Crete, Box 1527, GR 71110 Heraklion, Greece
    Development 125:2893-900. 1998
    ..Using misexpression experiments we also show that particular Enhancer-of-split bHLH genes can differ greatly in their contribution to lateral specification...
  22. pmc Beadex encodes an LMO protein that regulates Apterous LIM-homeodomain activity in Drosophila wing development: a model for LMO oncogene function
    M Milan
    European Molecular Biology Laboratory EMBL, 69117 Heidelberg, Germany
    Genes Dev 12:2912-20. 1998
    ..The dominant interference mechanism of dLMO action may serve as a model for the mechanism by which LMO oncogenes cause cancer when misexpressed in T cells...
  23. ncbi Dorsal-ventral signaling in the Drosophila eye
    V Papayannopoulos
    Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University, Piscataway, NJ 08854, USA
    Science 281:2031-4. 1998
    ..These observations imply that the developmental homology between Drosophila wings and vertebrate limbs extends to Drosophila eyes...
  24. ncbi Notch signalling mediates segmentation of the Drosophila leg
    J F de Celis
    Department of Genetics and Department of Anatomy, University of Cambridge, Downing Street, Cambridge, UK
    Development 125:4617-26. 1998
    ..The genes fringe, Delta, Serrate and Suppressor of Hairless, also participate in Notch function during leg development, and their expression is ..
  25. ncbi Fringe, Notch, and making developmental boundaries
    K D Irvine
    Waksman Institute, Department of Molecular Biology and Biochemistry, 190 Frelinghuysen Rd, Rutgers University, Piscataway, New Jersey 08854, USA
    Curr Opin Genet Dev 9:434-41. 1999
    ..Lunatic Fringe has been shown to be required for vertebrate somitogenesis, where it appears to act as a crucial link between a molecular clock and the regulation of Notch signaling...
  26. ncbi The abruptex mutations of notch disrupt the establishment of proneural clusters in Drosophila
    K Brennan
    Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, United Kingdom
    Dev Biol 216:230-42. 1999
    ..In addition we show that the overexpression of certain dominant negative Notch molecules can disrupt the initiation of proneural cluster development in a manner similar to the Abruptex mutants...
  27. ncbi Structural requirements for notch signalling with delta and serrate during the development and patterning of the wing disc of Drosophila
    N Lawrence
    Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK
    Development 127:3185-95. 2000
    The delta and Serrate proteins interact with the extracellular domain of the Notch receptor and initiate signalling through the receptor...
  28. ncbi Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins
    G Struhl
    Department of Genetics and Development, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Mol Cell 6:625-36. 2000
    ..Hence, Notch, beta-APP, and perhaps other proteins may be targeted for Presenilin-mediated transmembrane cleavage by upstream processing events that sever the extracellular domain from the rest of the protein...
  29. ncbi Modulation of notch-ligand binding by protein O-fucosyltransferase 1 and fringe
    Tetsuya Okajima
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Biol Chem 278:42340-5. 2003
    ..assayed the ability of tagged, soluble forms of the Notch extracellular domain to bind to its ligands, Delta and Serrate. Down-regulation of OFUT1 by RNA interference in Notch-secreting cells inhibits both Delta-Notch and Serrate-..
  30. ncbi Notch signaling: control of cell communication and cell fate
    Eric C Lai
    Howard Hughes Medical Institute, 545 Life Sciences Addition, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Development 131:965-73. 2004
    ..This primer describes the mechanism of Notch signal transduction and how it is used to control the formation of biological patterns...
  31. ncbi Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch
    Weidong Wang
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, NY 10032, USA
    Development 131:5367-80. 2004
    Recent findings suggest that Delta/Serrate/Lag2 (DSL) signals activate Notch by an unprecedented mechanism that requires the ligands to be endocytosed in signal-sending cells to activate the receptor in signal-receiving cells...
  32. ncbi Chaperone activity of protein O-fucosyltransferase 1 promotes notch receptor folding
    Tetsuya Okajima
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Science 307:1599-603. 2005
    ..This ability of OFUT1 to facilitate folding of Notch did not require its fucosyltransferase activity. Thus, a glycosyltransferase can bind its substrate in the endoplasmic reticulum to facilitate normal folding...
  33. ncbi Bunched sets a boundary for Notch signaling to pattern anterior eggshell structures during Drosophila oogenesis
    Leonard Dobens
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Bldg 149 13th Street, Charlestown, MA 02129, USA
    Dev Biol 287:425-37. 2005
    ..bun is necessary, but not sufficient, to down-regulate Serrate protein levels throughout the follicular epithelium...
  34. pmc Self-refinement of Notch activity through the transmembrane protein Crumbs: modulation of gamma-secretase activity
    Héctor Herranz
    ICREA and Institut de Recerca Biomedica, Parc Cientific de Barcelona, Josep Samitier, 1 5, 08028 Barcelona, Spain
    EMBO Rep 7:297-302. 2006
    ..These results indicate a novel molecular mechanism of the regulation of Notch signal, and also that defects in Crumbs might be involved in similar abnormal gamma-Secretase complex activity observed in Alzheimer's disease...
  35. pmc Differentiation of the Drosophila serotonergic lineage depends on the regulation of Zfh-1 by Notch and Eagle
    Hyung Kook Lee
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Mol Cell Neurosci 36:47-58. 2007
    ..Our observations on the regulation of Zfh-1 provide a new approach for examining the function of Zfh-1 in motor neurons and larval locomotion...
  36. pmc Endosomal entry regulates Notch receptor activation in Drosophila melanogaster
    Thomas Vaccari
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    J Cell Biol 180:755-62. 2008
    ....
  37. ncbi Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor
    I Rebay
    Howard Hughes Medical Institute, Department of Cell Biology, Yale University, New Haven, Connecticut 06511
    Cell 67:687-99. 1991
    ..We report a novel molecular interaction between Notch and Serrate, another EGF-homologous transmembrane protein containing a region of striking similarity to Delta, and show that ..
  38. ncbi Cell recognition, signal induction, and symmetrical gene activation at the dorsal-ventral boundary of the developing Drosophila wing
    J Kim
    Howard Hughes Medical Institute, University of Wisconsin, Madison 53706, USA
    Cell 82:795-802. 1995
    ..dorsal cell behavior, and the expression of two dorsally expressed putative signaling molecules, fringe (fng) and Serrate (Ser), are regulated by the apterous selector gene...
  39. ncbi Serrate expression can functionally replace Delta activity during neuroblast segregation in the Drosophila embryo
    Y Gu
    Department of Biology, University of Rochester, NY 14627
    Development 121:855-65. 1995
    b>Serrate and Delta encode structurally related proteins in D. melanogaster that bind within a common extracellular region on the NOTCH receptor molecule...
  40. ncbi Structure/function studies of lin-12/Notch proteins
    I Greenwald
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, College of Physicians and Surgeons, New York, New York 10032
    Curr Opin Genet Dev 4:556-62. 1994
    ..These studies have also suggested that the different lin-12/Notch proteins in a given organism are interchangeable biochemically and have addressed the role of lin-12/Notch genes in development...
  41. pmc Modifications of the notch function by Abruptex mutations in Drosophila melanogaster
    J F de Celis
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Spain
    Genetics 136:183-94. 1994
    ..This protein functions as a receptor that interacts with other transmembrane proteins, such as Serrate and Delta, which also have EGF repeats in their extracellular domain...
  42. ncbi The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: control of cell proliferation
    S A Speicher
    Institut fur Entwicklungsbiologie, Universitat zu Koln, FRG
    Development 120:535-44. 1994
    The Drosophila gene Serrate encodes a transmembrane protein with 14 EGF-like repeats in its extracellular domain. Here we show that loss-of-function mutations in this gene lead to larval lethality...
  43. pmc Genetic and molecular characterization of a Notch mutation in its Delta- and Serrate-binding domain in Drosophila
    J F de Celis
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Spain
    Proc Natl Acad Sci U S A 90:4037-41. 1993
    ..Two other transmembrane proteins, encoded by the genes Delta and Serrate, genetically and molecularly behave as Notch ligands...
  44. ncbi Serrate and wingless cooperate to induce vestigial gene expression and wing formation in Drosophila
    J P Couso
    Department of Zoology, University of Cambridge, UK
    Curr Biol 5:1437-48. 1995
    ....
  45. ncbi The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands
    X Sun
    Howard Hughes Medical Institute, Yale University, New Haven, Connecticut 06536 0812, USA
    Development 122:2465-74. 1996
    We examined the function of the intracellular domains of the two known Drosophila Notch ligands, Delta and Serrate, by expressing wild-type and mutant forms in the developing Drosophila eye under the sevenless promoter...
  46. ncbi Functional relationships between Notch, Su(H) and the bHLH genes of the E(spl) complex: the E(spl) genes mediate only a subset of Notch activities during imaginal development
    J F de Celis
    Department of Genetics, University of Cambridge, UK
    Development 122:2719-28. 1996
    ..Transcriptional activation mediated by Suppressor of Hairless and transcriptional repression mediated by Enhancer of split could provide greater diversity in the response of individual genes to Notch activity...
  47. ncbi Evolution of proneural atonal expression during distinct regulatory phases in the developing Drosophila eye
    N E Baker
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Curr Biol 6:1290-301. 1996
    ..signalling using a temperature-sensitive Notch allele, by the expression of activated Notch or of the ligand Serrate, and by monitoring expression of the atonal-dependant gene scabrous and of the Notch-dependent Enhancer of split ..
  48. ncbi Proneural function of neurogenic genes in the developing Drosophila eye
    N E Baker
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Curr Biol 7:122-32. 1997
    ..On this basis, complete elimination of Notch gene function would be expected to cause neural hyperplasia in the eye...
  49. ncbi Transcriptional regulation of Notch and Delta: requirement for neuroblast segregation in Drosophila
    L Seugnet
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, Illkirch, CU de Strasbourg, France
    Development 124:2015-25. 1997
    ..Notch signalling would enable all cells to mutually repress each other and only a cell with an elevated neural potential could overcome this repression...
  50. ncbi Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc
    R J Fleming
    Department of Biology, The University of Rochester, NY 14627, USA
    Development 124:2973-81. 1997
    ..The Notch ligands Serrate and Delta are required on opposite sides of the presumptive wing margin and, even though activated forms of Notch ..
  51. ncbi An intrinsic dominant negative activity of serrate that is modulated during wing development in Drosophila
    T Klein
    Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, United Kingdom
    Dev Biol 189:123-34. 1997
    The Serrate and Delta genes of Drosophila encode two transmembrane proteins that act as ligands for the Notch receptor...
  52. ncbi Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing
    J F de Celis
    Department of Genetics, University of Cambridge, UK
    Development 124:3241-51. 1997
    ..We find that clones of cells expressing either Notch or its ligands Delta and Serrate in the wing mimic Notch activation at the dorsoventral boundary producing non-autonomous effects on proliferation,..
  53. ncbi Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila
    X Sun
    Department of Cell Biology, Boyer Center for Molecular Medicine, Yale University, New Haven, Connecticut 06536 0812, USA
    Development 124:3439-48. 1997
    We examined the function of secreted forms of the two known Drosophila Notch ligands, DELTA and SERRATE, by expressing them under various promoters in the Drosophila developing eye and wing...
  54. ncbi Dorsal-ventral signaling in limb development
    K D Irvine
    Waksman Institute, Rutgers, State University of New Jersey, Piscataway 08854 8020, USA
    Curr Opin Cell Biol 9:867-76. 1997
    ..Drosophila have indicated that Fringe functions by inhibiting the ability of Notch to be activated by one ligand, Serrate, while potentiating the ability of Notch to be activated by another ligand, Delta...
  55. ncbi Different spatial and temporal interactions between Notch, wingless, and vestigial specify proximal and distal pattern elements of the wing in Drosophila
    T Klein
    Department of Zoology, University of Cambridge, United Kingdom
    Dev Biol 194:196-212. 1998
    ..Our results also indicate that the growth of the cells in the wing blade results from a synergistic effect of the three genes N, wg, and vg on the cells that have been specified as wing blade...
  56. ncbi LIN-12/Notch signaling: lessons from worms and flies
    I Greenwald
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032 USA
    Genes Dev 12:1751-62. 1998
  57. ncbi Interactions among Delta, Serrate and Fringe modulate Notch activity during Drosophila wing development
    T Klein
    Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK
    Development 125:2951-62. 1998
    ..the activity of the dorsal specific nuclear protein Apterous, which regulates the expression of the Notch ligand, Serrate, and the Fringe signalling molecule...
  58. ncbi Dissection of cis-regulatory elements of the Drosophila gene Serrate
    A Bachmann
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstrasse 1, D 40225 Dusseldorf, Germany
    Dev Genes Evol 208:346-51. 1998
    The Drosophila gene Serrate encodes a membrane spanning protein, which is expressed in a complex pattern during embryogenesis and larval stages...
  59. ncbi Positive and negative control of Serrate expression during early development of the Drosophila wing
    A Bachmann
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstr 1, 40225, Dusseldorf, Germany
    Mech Dev 76:67-78. 1998
    The product of the Drosophila gene Serrate acts as a short-range signal during wing development to induce the organising centre at the dorsal/ventral compartment boundary, from which growth and patterning of the wing is controlled...
  60. ncbi Cis-interactions between Delta and Notch modulate neurogenic signalling in Drosophila
    T L Jacobsen
    Program in Genetics, Cell and Developmental Biology, Department of Biology, Indiana University, Bloomington, Indiana, USA
    Development 125:4531-40. 1998
    We find that ectopic expression of Delta or Serrate in neurons within developing bristle organs is capable of non-autonomously inducing the transformation of the pre-trichogen cell into a tormogen cell in a wide variety of developmental ..
  61. ncbi The vestigial gene product provides a molecular context for the interpretation of signals during the development of the wing in Drosophila
    T Klein
    Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK
    Development 126:913-25. 1999
    ..These results lead us to propose a general role for Wingless during development in which it stabilizes cell fate decisions that have been implemented by other molecules...
  62. ncbi Hox genes differentially regulate Serrate to generate segment-specific structures
    E L Wiellette
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA
    Development 126:1985-95. 1999
    ..We have identified the Drosophila signaling protein Serrate as the product of a Hox downstream gene that acts in many segments as a component of such pathways...
  63. ncbi Notch-mediated segmentation and growth control of the Drosophila leg
    C Rauskolb
    Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University, Piscataway, New Jersey, 08854, USA
    Dev Biol 210:339-50. 1999
    ..This segmentation process requires the participation of the Notch ligands, Serrate and Delta, as well as Fringe...
  64. ncbi Composite signalling from Serrate and Delta establishes leg segments in Drosophila through Notch
    S A Bishop
    School of Biological Sciences, Royal Holloway College, University of London, Egham, Surrey TW20 0EX, UK
    Development 126:2993-3003. 1999
    The receptor protein NOTCH and its ligands SERRATE and DELTA are involved in many developmental processes in invertebrates and vertebrates alike...
  65. ncbi Fringe-dependent separation of dorsal and ventral cells in the Drosophila wing
    C Rauskolb
    Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University, Piscataway, New Jersey 08854, USA
    Nature 401:476-80. 1999
    ..Our results indicate that the primary mechanism by which fng establishes a compartment border is by positioning a stripe of Notch activation, but also that fng may exert additional influences on compartmentalization...
  66. ncbi Decoding vectorial information from a gradient: sequential roles of the receptors Frizzled and Notch in establishing planar polarity in the Drosophila eye
    A Tomlinson
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Development 126:5725-38. 1999
    ..As a consequence of this reciprocal cell fate decision, the R4 cell moves asymmetrically relative to the R3 cell, initiating the appropriate chiral pattern of the remaining cells of the ommatidium...
  67. ncbi Notch signaling in the nervous system. Pieces still missing from the puzzle
    N E Baker
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Bioessays 22:264-73. 2000
    ..This review will outline the experimental evidence supporting this view of Notch signaling, and briefly evaluate some of the possible mechanisms that have been suggested...
  68. ncbi Relationships between extramacrochaetae and Notch signalling in Drosophila wing development
    A Baonza
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, Cantoblanco, Madrid 28049, Spain
    Development 127:2383-93. 2000
    ..We propose that at least during vein differentiation and wing margin formation, extramacrochaetae is regulated by Notch and collaborates with other Notch-downstream genes such as Enhancer of split-m(beta)...
  69. ncbi Temporal regulation of apterous activity during development of the Drosophila wing
    M Milan
    European Molecular Biology Laboratory, Meyerhofstrasse 1, Germany
    Development 127:3069-78. 2000
    ..Apterous-dependent expression of Serrate and fringe in dorsal cells leads to the restricted activation of Notch along the dorsoventral compartment ..
  70. ncbi Glycosyltransferase activity of Fringe modulates Notch-Delta interactions
    K Brückner
    European Molecular Biology Laboratory, Heidelberg, Germany
    Nature 406:411-5. 2000
    ..We suggest that cell-type-specific modification of glycosylation may provide a general mechanism to regulate ligand-receptor interactions in vivo...
  71. pmc Delta signaling from the germ line controls the proliferation and differentiation of the somatic follicle cells during Drosophila oogenesis
    H Lopez-Schier
    Wellcome CRC Institute and Department of Genetics, University of Cambridge, Cambridge CB2 1QR, UK
    Genes Dev 15:1393-405. 2001
    ..The germ line therefore regulates the development of the follicle cells through two complementary signaling pathways: Gurken signals twice to control spatial patterning, whereas Delta signals twice to exert temporal control...
  72. ncbi Wing disc development in the fly: the early stages
    T Klein
    Institut fur Genetik, Universitat zu Koln, Weyertal 121, 50931, Koln, Germany
    Curr Opin Genet Dev 11:470-5. 2001
    ..Recent data have now started to provide some insight in the molecular processes required for the definition of the major boundaries and subdivision of the wing anlage into the hinge and blade region...
  73. ncbi Notch signalling and the initiation of neural development in the Drosophila eye
    A Baonza
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Development 128:3889-98. 2001
    ..We also report that Notch drives the transition from pre-proneural to proneural by downregulating two repressors of Atonal: Hairy and Extramacrochaetae...
  74. ncbi Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate
    P Ramain
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch Cedex, France
    Curr Biol 11:1729-38. 2001
    ..The activated NICD, interacting with Suppressor of Hairless [Su(H)], stimulates genes of the E(spl) complex, which in turn repress the proneural genes achaete/scute...
  75. ncbi Unequal segregation of Neuralized biases Notch activation during asymmetric cell division
    Roland Le Borgne
    Departement de Biologie, Ecole Normale Superieure, CNRS UMR 8542, 46, rue d Ulm 75230, Cedex, Paris, France
    Dev Cell 5:139-48. 2003
    ..We propose that coordinated upregulation of ligand activity by Neuralized and inhibition of receptor activity by Numb results in a robust bias in Notch signaling...
  76. ncbi Multiple signaling pathways and a selector protein sequentially regulate Drosophila wing development
    Shian Jang Yan
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Development 131:285-98. 2004
    ..can be achieved during wing development, we studied the regulatory network that controls the expression of Serrate (Ser), a ligand for the Notch (N) signaling pathway, which is essential for the development of the Drosophila ..
  77. ncbi Growth and specification of the eye are controlled independently by Eyegone and Eyeless in Drosophila melanogaster
    Maria Dominguez
    Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, Campus de San Juan, Apartado 18, Sant Joan d Alacant E 03550, Spain
    Nat Genet 36:31-9. 2004
    ..These results show that growth and eye specification are subject to independent control and explain hyperplasia in a new way...
  78. ncbi Blood cells of Drosophila: cell lineages and role in host defence
    Marie Meister
    Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, 67084 Strasbourg, France
    Curr Opin Immunol 16:10-5. 2004
    ..Crystal cells and lamellocytes have no clear mammalian homologues. Research into the molecular mechanisms that underlie the various immune functions of Drosophila blood cells, such as non-self recognition, is now taking wing...
  79. ncbi Regulation of notch signaling activity
    Francois Schweisguth
    CNRS UMR 8542, Ecole Normale Superieure, Paris, France
    Curr Biol 14:R129-38. 2004
    ..Recent analyses of the cell biology of the Notch receptor have identified several fundamental mechanisms that contribute to regulate Notch signaling activity in space and time...
  80. pmc Cellular immune response to parasitization in Drosophila requires the EBF orthologue collier
    Michele Crozatier
    Centre de Biologie du Developpement, Centre National de la Recherche Scientifique and Université Paul Sabatier, Toulouse, France
    PLoS Biol 2:E196. 2004
    ..Further investigations on Col/EBF expression and function in other phyla should provide fresh insight into the evolutionary origin of lymphoid cells...
  81. ncbi Drosophila deltex mediates suppressor of Hairless-independent and late-endosomal activation of Notch signaling
    Kazuya Hori
    Department of Biological Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278 8510, Japan
    Development 131:5527-37. 2004
    ..compartment boundary enhancer of vestigial (vgBE), in a manner that was independent of the Delta (Dl)/Serrate (Ser) ligands- or Su(H)...
  82. pmc Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila
    Roland Le Borgne
    Ecole Normale Superieure, CNRS UMR 8542, Paris, France
    PLoS Biol 3:e96. 2005
    Signaling by the Notch ligands Delta (Dl) and Serrate (Ser) regulates a wide variety of essential cell-fate decisions during animal development...
  83. ncbi The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta
    Eric C Lai
    Department of Molecular and Cell Biology, Howard Hughes Medical Institute, 545 Life Sciences Addition, University of California at Berkeley, Berkeley, CA 94720 3200, USA
    Development 132:2319-32. 2005
    The receptor Notch and its ligands of the Delta/Serrate/LAG2 (DSL) family are the central components in the Notch pathway, a fundamental cell signaling system that regulates pattern formation during animal development...
  84. ncbi The Drosophila lymph gland as a developmental model of hematopoiesis
    Seung Hye Jung
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Development 132:2521-33. 2005
    ..The cellular events identified in this analysis further establish Drosophila as a model system for hematopoiesis...
  85. ncbi Distinct roles for Mind bomb, Neuralized and Epsin in mediating DSL endocytosis and signaling in Drosophila
    Weidong Wang
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, NY 10032, USA
    Development 132:2883-94. 2005
    Ligands of the Delta/Serrate/Lag2 (DSL) family must normally be endocytosed in signal-sending cells to activate Notch in signal-receiving cells...
  86. ncbi Notch signaling in hematopoiesis and lymphopoiesis: lessons from Drosophila
    Freddy Radtke
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland
    Bioessays 27:1117-28. 2005
    ..Recent studies indicating that aberrant NOTCH signaling is frequently linked to the induction of T leukemia in humans will also be discussed...
  87. ncbi Notch receptor encodes two structurally separable functions in Drosophila: a genetic analysis
    Tim Langdon
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, U K
    Dev Dyn 235:998-1013. 2006
    ..Our results support the existence of at least two different activities of Notch each of which can be associated with specific structural domains...
  88. ncbi Border of Notch activity establishes a boundary between the two dorsal appendage tube cell types
    Ellen J Ward
    Department of Biochemistry, University of Washington, Box 357350, Seattle, WA 98195 7350, USA
    Dev Biol 297:461-70. 2006
    ..Generating a boundary by the Notch pathway might constitute an evolutionarily conserved first step during organ formation in many tissues...
  89. pmc Dynamical analysis of the regulatory network defining the dorsal-ventral boundary of the Drosophila wing imaginal disc
    Aitor Gonzalez
    Developmental Biology Institute of Marseille Luminy, 13288 Marseille, France
    Genetics 174:1625-34. 2006
    ..Finally, another mutant simulation shows that cut expression might be shifted to late larval stages because of a potential interference with the early signaling process...
  90. pmc Lethal giant discs, a novel C2-domain protein, restricts notch activation during endocytosis
    Jennifer L Childress
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Curr Biol 16:2228-33. 2006
    ..Taken together, our data identify Lgd as a novel tumor-suppressor protein that regulates Notch signaling by targeting Notch for degradation or recycling...
  91. ncbi Polarized exocytosis and transcytosis of Notch during its apical localization in Drosophila epithelial cells
    Nobuo Sasaki
    Department of Biological Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278 8510, Japan
    Genes Cells 12:89-103. 2007
    Notch (N) and its ligands, Delta (Dl) and Serrate (Ser), are transmembrane proteins that mediate the cell-cell interactions necessary for many cell-fate decisions...
  92. ncbi Control of blood cell homeostasis in Drosophila larvae by the posterior signalling centre
    Joanna Krzemien
    Centre de Biologie du Developpement, UMR 5547 and IFR 109, CNRS and Université Paul Sabatier, Toulouse III, 118 route de Narbonne, 31062 Toulouse Cedex 09, France
    Nature 446:325-8. 2007
    ..b>Serrate-mediated Notch signalling from the PSC is required to maintain normal levels of col transcription...
  93. pmc Adherens junction remodeling by the Notch pathway in Drosophila melanogaster oogenesis
    Muriel Grammont
    Institut National de la Sante et de la Recherche Medicale, Unité 384, Clermont Ferrand F 63001, France
    J Cell Biol 177:139-50. 2007
    ..of AJ disassembly between the StCs is affected in follicles with somatic clones mutant for fringe or Delta and Serrate. This results in abnormal StC flattening and delayed MBFC displacement...
  94. ncbi In vitro reconstitution of the modulation of Drosophila Notch-ligand binding by Fringe
    Aiguo Xu
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA
    J Biol Chem 282:35153-62. 2007
    ..in vitro is sufficient both to enhance Notch binding to the Delta ligand and to inhibit Notch binding to the Serrate ligand. Further elongation by galactose does not detectably influence Notch-ligand binding in vitro...
  95. pmc Both inhibition and activation of Notch signaling rely on a conserved Neuralized-binding motif in Bearded proteins and the Notch ligand Delta
    Joseph R Fontana
    Division of Biological Sciences, Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA
    Dev Biol 333:373-85. 2009
    ..Our results illuminate the mechanism of an important regulatory event in Notch signaling that appears to be conserved between insects and crustaceans...
  96. doi A role of receptor Notch in ligand cis-inhibition in Drosophila
    Isabelle Becam
    Institute for Research in Biomedicine IRB Barcelona, Parc Cientific de Barcelona, Baldiri Reixac 10 12, 08028 Barcelona, Spain
    Curr Biol 20:554-60. 2010
    ..wing primordium with cell culture assays, we present evidence here that Notch promotes the clearance of Serrate ligand from the cell surface and exerts an inhibitory effect on the activity of Serrate expressed in the same ..
  97. pmc Interaction between Notch and Hif-alpha in development and survival of Drosophila blood cells
    Tina Mukherjee
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Science 332:1210-3. 2011
    ..Studies in vertebrate myeloid cells have shown a similar up-regulation of Hif-α protein in well-oxygenated environments. This study provides a mechanistic paradigm for Hif-α/Notch interaction that may be conserved in mammals...
  98. pmc Multiple O-glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling
    Jessica Leonardi
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 138:3569-78. 2011
    ....
  99. ncbi The phenogenetics of a super-suppressor in Drosophila melanogaster. II. Suppression and back-mutation
    G L Lee
    Aust J Biol Sci 26:189-99. 1973
  100. ncbi Notch signaling
    S Artavanis-Tsakonas
    Howard Hughes Medical Institute, Boyer Center for Molecular Medicine, Yale University, New Haven, CT 06536, USA
    Science 268:225-32. 1995
    ..Several vertebrate Notch receptors have also been discovered recently and play important roles in normal development and tumorigenesis...
  101. ncbi Modulation of wingless signaling by Notch in Drosophila
    H K Hing
    Howard Hughes Medical Institute, Yale University, School of Medicine, New Haven, CT 06536 0812
    Mech Dev 47:261-8. 1994
    ..We discuss the possibility that Notch is directly involved in the reception of Wingless in the light of current models for the developmental action of Notch...

Research Grants12

  1. A novel Dlg isoform and identification of its interacting proteins
    Kyung Ok Cho; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  2. The enhancer of rudimentary gene
    STUART TSUBOTA; Fiscal Year: 2002
    ..The expression data of e(r) suggest that mutants may be embryonic lethals. If this is the case, the mutants will be analyzed for cellular defects in the embryo that that will help uncover the normal function of e(r). ..
  3. SPECTRAL CONFOCAL MICROSCOPE
    Peter Bryant; Fiscal Year: 2002
    ..abstract_text> ..
  4. NOTCH SIGNALING IN HEMATOPOIETIC CELLS
    THOMAS KADESCH; Fiscal Year: 2002
    ..Experiments are proposed to characterize signaling through Deltex. ..
  5. TRANSCRIPTIONAL DETERMINANTS OF B LYMPHOCYTES
    THOMAS KADESCH; Fiscal Year: 2002
    ....
  6. Signaling Mechanisms of the Drosophila JAK/STAT Pathway
    Hong Luo; Fiscal Year: 2003
    ..abstract_text> ..
  7. Analysis of fringe-dependent cell-signaling
    Kenneth Irvine; Fiscal Year: 2004
    ..biologically relevant targets of Fringe by altering consensus sites for addition of 0-linked fucose within Notch, Serrate, and Delta, and assaying the activity of these mutant proteins in Drosophila...
  8. Molecular Mechanisms of Segmentation
    Cordelia Rauskolb; Fiscal Year: 2005
    ..abstract_text> ..
  9. Molecular Genetics of Drosophila MAGUK's
    Peter Bryant; Fiscal Year: 2005
    ..The work will provide a genetic approach to understanding the functions of Dlg and its mammalian homologs, some of which are strongly implicated in a variety of human cancers. ..
  10. Left/right asymmetric neuronal cell fate specification
    Oliver Hobert; Fiscal Year: 2006
    ..These studies may reveal fundamental principles of neuronal development and may shed light onto the elusive mechanisms of generating L/R asymmetry in the nervous system...
  11. Genome-wide expression profiling of miRNAs with single cell resolution
    Oliver Hobert; Fiscal Year: 2006
    ..Moreover, it will (4) validate the "sensor strategy" to determine miRNA expression profiles in C. elegans, and (5) build a toolkit of potentially useful gfp cell fate markers. [unreadable] [unreadable]..