Gene Symbol: Sep2
Description: Septin 2
Alias: 38961, CG4173, DSep2, Dmel\CG4173, sep2, septin 2, CG4173-PA, CG4173-PB, Sep2-PA, Sep2-PB, Septin2, septin, septin-2
Species: fruit fly

Top Publications

  1. Shih H, Hales K, Pringle J, Peifer M. Identification of septin-interacting proteins and characterization of the Smt3/SUMO-conjugation system in Drosophila. J Cell Sci. 2002;115:1259-71 pubmed
    ..In a two-hybrid screen designed to identify septin-interacting proteins in Drosophila, we isolated several genes, including homologues (Dmuba2 and Dmubc9) of yeast ..
  2. Goldbach P, Wong R, Beise N, Sarpal R, Trimble W, Brill J. Stabilization of the actomyosin ring enables spermatocyte cytokinesis in Drosophila. Mol Biol Cell. 2010;21:1482-93 pubmed publisher
    ..Our results show that the anillin-septin and cadherin-catenin complexes can serve as alternative cassettes to promote tight physical coupling of F-actin ..
  3. Huijbregts R, Svitin A, Stinnett M, Renfrow M, Chesnokov I. Drosophila Orc6 facilitates GTPase activity and filament formation of the septin complex. Mol Biol Cell. 2009;20:270-81 pubmed publisher
    ..smallest subunit of ORC, is essential for both replication and cytokinesis in Drosophila, and interacts with the septin protein Pnut, which is part of the Drosophila septin complex...
  4. Pan F, Malmberg R, Momany M. Analysis of septins across kingdoms reveals orthology and new motifs. BMC Evol Biol. 2007;7:103 pubmed
    ..Comparative sequence alignments revealed septin derivatives of already known G1, G3 and G4 GTPase motifs, four new motifs from two to twelve amino acids long and ..
  5. Mavrakis M, Azou Gros Y, Tsai F, Alvarado J, Bertin A, Iv F, et al. Septins promote F-actin ring formation by crosslinking actin filaments into curved bundles. Nat Cell Biol. 2014;16:322-34 pubmed publisher that septins alone bundle actin filaments into rings, accounting for the defects in actin ring formation in septin mutants...
  6. Adam J, Pringle J, Peifer M. Evidence for functional differentiation among Drosophila septins in cytokinesis and cellularization. Mol Biol Cell. 2000;11:3123-35 pubmed
    ..In Drosophila melanogaster, null mutations in the pnut septin gene are recessive lethal, but homozygous pnut mutants complete embryogenesis and survive until the pupal stage...
  7. Sisson J, Field C, Ventura R, Royou A, Sullivan W. Lava lamp, a novel peripheral golgi protein, is required for Drosophila melanogaster cellularization. J Cell Biol. 2000;151:905-18 pubmed
    ..Our results are consistent with the idea that animal cell cytokinesis depends on both actomyosin-based contraction and Golgi-derived membrane secretion. ..
  8. Silverman Gavrila R, Hales K, Wilde A. Anillin-mediated targeting of peanut to pseudocleavage furrows is regulated by the GTPase Ran. Mol Biol Cell. 2008;19:3735-44 pubmed publisher
    ..We found that Ran was required for the localization of the septin Peanut to the pseudocleavage furrow, but not anillin or actin...
  9. D Avino P, Takeda T, Capalbo L, Zhang W, Lilley K, Laue E, et al. Interaction between Anillin and RacGAP50C connects the actomyosin contractile ring with spindle microtubules at the cell division site. J Cell Sci. 2008;121:1151-8 pubmed publisher
    ..Thus, in addition to its role in activating RhoA signalling, RacGAP50C also controls the proper assembly of the actomyosin ring by interacting with Anillin at the cleavage furrow. ..

More Information


  1. Field C, al Awar O, Rosenblatt J, Wong M, Alberts B, Mitchison T. A purified Drosophila septin complex forms filaments and exhibits GTPase activity. J Cell Biol. 1996;133:605-16 pubmed
    b>Septin proteins are necessary for cytokinesis in budding yeast and Drosophila and are thought to be the subunits of the yeast neck filaments...
  2. Founounou N, Loyer N, Le Borgne R. Septins regulate the contractility of the actomyosin ring to enable adherens junction remodeling during cytokinesis of epithelial cells. Dev Cell. 2013;24:242-55 pubmed publisher
    ..By modulating the strength of tension induced by neighbors, we uncover a mechanical function for septins to overcome the extrinsic tension induced by neighboring interphasic cells. ..
  3. Hime G, Brill J, Fuller M. Assembly of ring canals in the male germ line from structural components of the contractile ring. J Cell Sci. 1996;109 ( Pt 12):2779-88 pubmed
    ..However, at least four proteins present at the contractile ring remain: the three septins (Pnut, Sep1 and Sep2) and anillin...
  4. Miller K, Kiehart D. Fly division. J Cell Biol. 1995;131:1-5 pubmed
  5. Bergner L, Hickman F, Wood K, Wakeman C, Stone H, Campbell T, et al. A novel predicted bromodomain-related protein affects coordination between meiosis and spermiogenesis in Drosophila and is required for male meiotic cytokinesis. DNA Cell Biol. 2010;29:487-98 pubmed publisher
    ..We speculate that Mitoshell may participate in transcriptional regulation of spermatogenesis-specific genes, though perhaps with different ligand specificity compared to traditional bromodomains. ..
  6. O Neill R, Clark D. Evolution of three parent genes and their retrogene copies in Drosophila species. Int J Evol Biol. 2013;2013:693085 pubmed publisher Drosophilidae; in Drosophila melanogaster, these gene pairs are CG8331 and CG4960, CG17734 and CG11825, and Sep2 and Sep5. We investigated the embryonic expression patterns of these gene pairs across multiple Drosophila species...
  7. Robinson D, Cooley L. Stable intercellular bridges in development: the cytoskeleton lining the tunnel. Trends Cell Biol. 1996;6:474-9 pubmed
  8. Field C, Oegema K, Zheng Y, Mitchison T, Walczak C. Purification of cytoskeletal proteins using peptide antibodies. Methods Enzymol. 1998;298:525-41 pubmed
  9. Djagaeva I, Doronkin S, Beckendorf S. Src64 is involved in fusome development and karyosome formation during Drosophila oogenesis. Dev Biol. 2005;284:143-56 pubmed
    ..Our results indicate that Src64 regulates actin dynamics at multiple stages of oogenesis. ..
  10. Menon M, Gaestel M. Sep(t)arate or not – how some cells take septin-independent routes through cytokinesis. J Cell Sci. 2015;128:1877-86 pubmed publisher
    ..we present recent observations that specific cell divisions can proceed in the absence of the core mammalian septin SEPT7 and its Drosophila homolog Peanut (Pnut) and that thus challenge the view that septins have an essential ..
  11. Su J, Chow B, Boulianne G, Wilde A. The BAR domain of amphiphysin is required for cleavage furrow tip-tubule formation during cellularization in Drosophila embryos. Mol Biol Cell. 2013;24:1444-53 pubmed publisher
    ..The tubules are marked by amphiphysin but are otherwise poorly understood. Here we identify the septin family of GTPases as new tubule markers...
  12. Akhmetova K, Balasov M, Huijbregts R, Chesnokov I. Functional insight into the role of Orc6 in septin complex filament formation in Drosophila. Mol Biol Cell. 2015;26:15-28 pubmed publisher
    ..We reconstituted a recombinant Drosophila septin complex and compared activities of the wild-type and several mutant septin complex variants both in vitro and in ..
  13. Fedoseeva D, Tchurikov N. Analysis of insulator proteins binding in reporter genetic constructs transfected into Drosophila S2 cells. Dokl Biochem Biophys. 2013;451:198-202 pubmed publisher
  14. O Neill R, Clark D. Partial Functional Diversification of Drosophila melanogaster Septin Genes Sep2 and Sep5. G3 (Bethesda). 2016;6:1947-57 pubmed publisher
    The septin family of hetero-oligomeric complex-forming proteins can be divided into subgroups, and subgroup members are interchangeable at specific positions in the septin complex...
  15. O Neill R, Clark D. The Drosophila melanogaster septin gene Sep2 has a redundant function with the retrogene Sep5 in imaginal cell proliferation but is essential for oogenesis. Genome. 2013;56:753-8 pubmed publisher
    ..Drosophila melanogaster has five septin genes. Sep5, which is the most recently evolved septin gene in Drosophila, is a retrogene copy of Sep2...
  16. Morais de Sá E, Sunkel C. Adherens junctions determine the apical position of the midbody during follicular epithelial cell division. EMBO Rep. 2013;14:696-703 pubmed publisher
    ..Thus, apical midbody localization is essential to maintain epithelial tissue architecture during proliferation. ..
  17. Ruggiero R, Kale A, Thomas B, Baker N. Mitosis in neurons: Roughex and APC/C maintain cell cycle exit to prevent cytokinetic and axonal defects in Drosophila photoreceptor neurons. PLoS Genet. 2012;8:e1003049 pubmed publisher
  18. Oegema K, Desai A, Wong M, Mitchison T, Field C. Purification and assay of a septin complex from Drosophila embryos. Methods Enzymol. 1998;298:279-95 pubmed
  19. Sechi S, Colotti G, Belloni G, Mattei V, Frappaolo A, Raffa G, et al. GOLPH3 is essential for contractile ring formation and Rab11 localization to the cleavage site during cytokinesis in Drosophila melanogaster. PLoS Genet. 2014;10:e1004305 pubmed publisher
    ..of GOLPH3 enables maintenance of centralspindlin and Rho1 at cell equator and stabilization of Myosin II and Septin rings...
  20. Taniguchi K, Kokuryo A, Imano T, Minami R, Nakagoshi H, Adachi Yamada T. Isoform-specific functions of Mud/NuMA mediate binucleation of Drosophila male accessory gland cells. BMC Dev Biol. 2014;14:46 pubmed publisher
    ..We also propose that Mud(S) is a key regulator triggering cytokinesis skipping in binucleation processes. ..