Gene Symbol: Sema5c
Description: Semaphorin 5c
Alias: BEST:CK02567, BG01245, CG5661, CK02567, CT17880, Dmel\CG5661, Dsema3a, Sema 5c, Sema-3a, Sema-5C, Sema-5c, Sema3A, sema 5c, sema-5c, semaphorin 5c, CG5661-PA, CG5661-PB, Sema-3a, Sema-5c, Sema5c-PA, Sema5c-PB, Semaphorin-5c, semaphorin, semaphorin 5C, semiphorin
Species: fruit fly

Top Publications

  1. Khare N, Fascetti N, DaRocha S, Chiquet Ehrismann R, Baumgartner S. Expression patterns of two new members of the Semaphorin family in Drosophila suggest early functions during embryogenesis. Mech Dev. 2000;91:393-7 pubmed
    We report the sequence and expression analysis of two new Drosophila members of the Semaphorin family. Both proteins show the presence of Semaphorin domains and transmembrane domains...
  2. Harbison S, Sehgal A. Quantitative genetic analysis of sleep in Drosophila melanogaster. Genetics. 2008;178:2341-60 pubmed publisher
    ..The large mutational target that we observed implicates genes functioning in a variety of biological processes, suggesting that sleep may serve a number of different functions rather than a single purpose. ..
  3. Rau A, Buttgereit D, Holz A, Fetter R, Doberstein S, Paululat A, et al. rolling pebbles (rols) is required in Drosophila muscle precursors for recruitment of myoblasts for fusion. Development. 2001;128:5061-73 pubmed
    ..Transplantation assays of rols mutant mesodermal cells into wild-type embryos show that Rols is required in muscle precursor cells and is essential to recruit fusion-competent myoblasts for myotube formation. ..
  4. Bahri S, Chia W, Yang X. Characterization and mutant analysis of the Drosophila sema 5c gene. Dev Dyn. 2001;221:322-30 pubmed
    ..glycoproteins characterised by the presence of thrombospondin type I (Tsp) repeats linked to their extracellular semaphorin domain. Sema 5C is the only class V semaphorin found in Drosophila...
  5. Seong K, Ogashiwa T, Matsuo T, Fuyama Y, Aigaki T. Application of the gene search system to screen for longevity genes in Drosophila. Biogerontology. 2001;2:209-17 pubmed
    ..This is the first demonstration that a systematic gain-of-function screen could efficiently detect longevity genes. ..
  6. Woodhouse E, Fisher A, Bandle R, Bryant Greenwood B, Charboneau L, Petricoin E, et al. Drosophila screening model for metastasis: Semaphorin 5c is required for l(2)gl cancer phenotype. Proc Natl Acad Sci U S A. 2003;100:11463-8 pubmed
    ..b>Semaphorin 5c (Sema 5c) is required for tumorigenicity, apontic overexpression suppresses metastasis but not tumorigenicity, ..
  7. Hou H, Heffer A, Anderson W, Liu J, Bowler T, Pick L. Stripy Ftz target genes are coordinately regulated by Ftz-F1. Dev Biol. 2009;335:442-53 pubmed publisher
  8. Hughes S, Salinas P. Control of muscle fibre and motoneuron diversification. Curr Opin Neurobiol. 1999;9:54-64 pubmed
    ..We propose a model in which four classes of decision control the patterning of both motoneurons and muscles. ..
  9. Castellani V, Rougon G. Control of semaphorin signaling. Curr Opin Neurobiol. 2002;12:532-41 pubmed
    Receptor complexes for the chemorepellent factors of the semaphorin family activate intracellular pathways that trigger actin rearrangements underlying growth cone collapse and repellent behavior...

More Information


  1. Yamamoto A, Zwarts L, Callaerts P, Norga K, Mackay T, Anholt R. Neurogenetic networks for startle-induced locomotion in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2008;105:12393-8 pubmed publisher
    ..We find that behavioral and neuroanatomical phenotypes are determined by a common set of genes that are organized as partially overlapping genetic networks. ..
  2. Marinho J, Martins T, Neto M, Casares F, Pereira P. The nucleolar protein Viriato/Nol12 is required for the growth and differentiation progression activities of the Dpp pathway during Drosophila eye development. Dev Biol. 2013;377:154-65 pubmed publisher
    ..vito would act genetically downstream of Dpp, playing an important role in maintaining a sufficient level of Dpp activity for the promotion of eye disc growth and regulation of photoreceptor differentiation in eye development. ..
  3. Yamamoto A, Anholt R, Mackay T. Epistatic interactions attenuate mutations affecting startle behaviour in Drosophila melanogaster. Genet Res (Camb). 2009;91:373-82 pubmed publisher
  4. Swarup S, Harbison S, Hahn L, Morozova T, Yamamoto A, Mackay T, et al. Extensive epistasis for olfactory behaviour, sleep and waking activity in Drosophila melanogaster. Genet Res (Camb). 2012;94:9-20 pubmed publisher a wild-derived Drosophila melanogaster population on the mutational effects of P-element insertions in Semaphorin-5C (Sema-5c) and Calreticulin (Crc), pleiotropic genes that affect olfactory behaviour and startle behaviour and,..