Gene Symbol: SelD
Description: Selenide,water dikinase
Alias: 142926_at, CG8553, Dm SelD, Dm-SelD, Dmel\CG8553, SPS1, SeS, anon-WO0172774.145, anon-WO0172774.146, dSPS1, dsps1, l(2)SH1599, l(2)SH2 1599, l(2)k12303, ptf1, ptuf, ptuf1, selD, selD/sps1, Selenide,water dikinase, CG8553-PA, CG8553-PB, SelD-PA, SelD-PB, lethal (2) SH1599, patufet, selD-like, selenide,water dikinase, selenophosphate synthetase, selenophosphate synthetase 1
Species: fruit fly

Top Publications

  1. Alsina B, Corominas M, Berry M, Baguna J, Serras F. Disruption of selenoprotein biosynthesis affects cell proliferation in the imaginal discs and brain of Drosophila melanogaster. J Cell Sci. 1999;112 ( Pt 17):2875-84 pubmed
    The patufet gene encodes the Drosophila melanogaster homologue of selenophosphate synthetase, an enzyme required for selenoprotein synthesis, and appears to have a role in cell proliferation...
  2. Lobanov A, Hatfield D, Gladyshev V. Selenoproteinless animals: selenophosphate synthetase SPS1 functions in a pathway unrelated to selenocysteine biosynthesis. Protein Sci. 2008;17:176-82 pubmed
    ..These insects also lost the Sec biosynthesis and insertion machinery, but selenophosphate synthetase 1 (SPS1), an enzyme previously implicated in Sec biosynthesis, is present in all insects, including T...
  3. Shim M, Kim J, Jung H, Lee K, Xu X, Carlson B, et al. Elevation of glutamine level by selenophosphate synthetase 1 knockdown induces megamitochondrial formation in Drosophila cells. J Biol Chem. 2009;284:32881-94 pubmed publisher
    Although selenophosphate synthetase 1 (SPS1/SelD) is an essential gene in Drosophila, its function has not been determined...
  4. Alsina B, Serras F, Baguna J, Corominas M. patufet, the gene encoding the Drosophila melanogaster homologue of selenophosphate synthetase, is involved in imaginal disc morphogenesis. Mol Gen Genet. 1998;257:113-23 pubmed
    ..We have cloned the ptuf gene of Drosophila melanogaster and found that it encodes a selenophosphate synthetase, which is the first identified in insects...
  5. Morey M, Corominas M, Serras F. DIAP1 suppresses ROS-induced apoptosis caused by impairment of the selD/sps1 homolog in Drosophila. J Cell Sci. 2003;116:4597-604 pubmed
    ..In Drosophila, a null mutation in the selD gene (homologous to the human selenophosphate synthetase type 1) causes an impairment of selenoprotein biosynthesis, a ROS burst and lethality...
  6. Persson B, Bock A, Jackle H, Vorbr├╝ggen G. SelD homolog from Drosophila lacking selenide-dependent monoselenophosphate synthetase activity. J Mol Biol. 1997;274:174-80 pubmed
    The isolation and molecular characterization of an invertebrate gene that encodes a homolog of the human selenophosphate synthetase 1 is described...
  7. Morey M, Serras F, Baguna J, Hafen E, Corominas M. Modulation of the Ras/MAPK signalling pathway by the redox function of selenoproteins in Drosophila melanogaster. Dev Biol. 2001;238:145-56 pubmed
    ..of the redox balance caused by patufet (selD(ptuf)), a null mutation in the Drosophila melanogaster selenophosphate synthetase 1 (sps1) gene, which codes for the SelD enzyme of the selenoprotein biosynthesis, affects the Ras/MAPK ..
  8. Pedersen K, Kristensen T, Loeschcke V, Petersen B, Duus J, Nielsen N, et al. Metabolomic signatures of inbreeding at benign and stressful temperatures in Drosophila melanogaster. Genetics. 2008;180:1233-43 pubmed publisher
  9. Morey M, Serras F, Corominas M. Halving the selenophosphate synthetase gene dose confers hypersensitivity to oxidative stress in Drosophila melanogaster. FEBS Lett. 2003;534:111-4 pubmed oxidative stress (paraquat and hydrogen peroxide) between wild type and heterozygous flies for the selenophosphate synthetase selD(ptuf) mutation...

More Information


  1. Chapple C, Guigo R. Relaxation of selective constraints causes independent selenoprotein extinction in insect genomes. PLoS ONE. 2008;3:e2968 pubmed publisher
    ..The dispensability of selenoproteins in insects may be related to the fundamental differences in antioxidant defense between these animals and other metazoans. ..
  2. Alsina B, Serras F, Baguna J, Corominas M. Characterisation of a selenophosphate synthetase from a collection of P-lacW insertion mutants in Drosophila. Int J Dev Biol. 1996;Suppl 1:85S pubmed
  3. Hirosawa Takamori M, Jackle H, Vorbr├╝ggen G. The class 2 selenophosphate synthetase gene of Drosophila contains a functional mammalian-type SECIS. EMBO Rep. 2000;1:441-6 pubmed
    ..the selenium donor required for the synthesis of selenocysteine (Sec) is catalyzed by the enzyme selenophosphate synthetase (SPS), first described in Escherichia coli...
  4. Doumanis J, Wada K, Kino Y, Moore A, Nukina N. RNAi screening in Drosophila cells identifies new modifiers of mutant huntingtin aggregation. PLoS ONE. 2009;4:e7275 pubmed publisher
    ..Newly identified modifiers including genes related to nuclear transport, nucleotide processes, and signaling, may be involved in polyglutamine aggregate formation and Huntington disease cascades. ..
  5. Tang L, Reddy M, Rasheva V, Lee T, Lin M, Hung M, et al. The eukaryotic DNMT2 genes encode a new class of cytosine-5 DNA methyltransferases. J Biol Chem. 2003;278:33613-6 pubmed
    ..These data provide solid evidence that the fly and mouse DNMT2 gene products are genuine cytosine-5 DNA methyltransferases. ..
  6. Martin Romero F, Kryukov G, Lobanov A, Carlson B, Lee B, Gladyshev V, et al. Selenium metabolism in Drosophila: selenoproteins, selenoprotein mRNA expression, fertility, and mortality. J Biol Chem. 2001;276:29798-804 pubmed
    ..characterization of selenoprotein mRNA expression resulted in identification of three selenoproteins: selenophosphate synthetase 2 and novel G-rich and BthD selenoproteins that had no homology to known proteins...
  7. Jin J, Baek S, Lee H, Oh M, Koo Y, Shim M, et al. A DNA replication-related element downstream from the initiation site of Drosophila selenophosphate synthetase 2 gene is essential for its transcription. Nucleic Acids Res. 2004;32:2482-93 pubmed
    b>Selenophosphate synthetase catalyzes the synthesis of selenophosphate which is a selenium donor for Sec biosynthesis...
  8. Samsonova A, Niranjan M, Russell S, Brazma A. Prediction of gene expression in embryonic structures of Drosophila melanogaster. PLoS Comput Biol. 2007;3:e144 pubmed
    ..Our novel organism-independent method will be of considerable utility in enriching the annotation of gene function and expression in complex multicellular organisms. ..
  9. Swanson L, Yu M, Nelson K, Laprise P, Tepass U, Beitel G. Drosophila convoluted/dALS is an essential gene required for tracheal tube morphogenesis and apical matrix organization. Genetics. 2009;181:1281-90 pubmed publisher
    ..Moreover, we present evidence indicating that Conv/dALS has a novel, IGF-signaling independent function in tracheal morphogenesis. ..
  10. Lee K, Shim M, Kim J, Jung H, Lee E, Carlson B, et al. Drosophila selenophosphate synthetase 1 regulates vitamin B6 metabolism: prediction and confirmation. BMC Genomics. 2011;12:426 pubmed publisher
    There are two selenophosphate synthetases (SPSs) in higher eukaryotes, SPS1 and SPS2. Of these two isotypes, only SPS2 catalyzes selenophosphate synthesis...