Gene Symbol: sei
Description: seizure
Alias: CG3182, Derg, Dmel\CG3182, erg, seizure, CG3182-PA, CG3182-PB, CG3182-PC, Ether-a-go-go-related, Seizure/HERG, eag related gene, sei-PA, sei-PB, sei-PC, seizure potassium channel
Species: fruit fly

Top Publications

  1. Salkoff L, Butler A, Wei A, Scavarda N, Giffen K, Ifune C, et al. Genomic organization and deduced amino acid sequence of a putative sodium channel gene in Drosophila. Science. 1987;237:744-9 pubmed
    ..This position does not coincide with any known mutations that confer behavioral phenotypes, but is close to the seizure locus (60A-B), which has been hypothesized to code for a voltage-sensitive sodium channel.
  2. O Dowd D, Aldrich R. Voltage-clamp analysis of sodium channels in wild-type and mutant Drosophila neurons. J Neurosci. 1988;8:3633-43 pubmed
    ..Physiological and biochemical evidence has led to the suggestion that mutations in the nap, seizure, and tip-E loci of Drosophila may affect voltage-dependent sodium channels...
  3. Fergestad T, Sale H, Bostwick B, Schaffer A, Ho L, Robertson G, et al. A Drosophila behavioral mutant, down and out (dao), is defective in an essential regulator of Erg potassium channels. Proc Natl Acad Sci U S A. 2010;107:5617-21 pubmed publisher
    ..This phenotype closely resembles that of seizure mutations, which impair activity of ether-a-go-go-related gene (Erg)-type potassium channels...
  4. Titus S, Warmke J, Ganetzky B. The Drosophila erg K+ channel polypeptide is encoded by the seizure locus. J Neurosci. 1997;17:875-81 pubmed
    ..We show that it corresponds with the previously identified seizure (sei) locus, mutations of which cause a temperature-sensitive paralytic phenotype associated with hyperactivity ..
  5. Wang X, Reynolds E, Deak P, Hall L. The seizure locus encodes the Drosophila homolog of the HERG potassium channel. J Neurosci. 1997;17:882-90 pubmed
    Mutations in the seizure (sei) locus cause temperature-induced hyperactivity, followed by paralysis...
  6. Kasbekar D, Nelson J, Hall L. Enhancer of seizure: a new genetic locus in Drosophila melanogaster defined by interactions with temperature-sensitive paralytic mutations. Genetics. 1987;116:423-31 pubmed
    Mutations in the enhancer of seizure (e(sei] locus have been isolated on the basis of their ability to cause temperature-induced paralysis of alleles at the seizure (sei) locus at temperatures at which these mutations ordinarily do not ..
  7. Lucey B, Leahy A, Rosas R, Shaw P. A new model to study sleep deprivation-induced seizure. Sleep. 2015;38:777-85 pubmed publisher
    ..Using Drosophila melanogaster mutants with seizure phenotypes, we demonstrate that seizure activity can be modified by sleep deprivation...
  8. Fogle K, Baik L, Houl J, Tran T, Roberts L, Dahm N, et al. CRYPTOCHROME-mediated phototransduction by modulation of the potassium ion channel β-subunit redox sensor. Proc Natl Acad Sci U S A. 2015;112:2245-50 pubmed publisher
    ..Light activation of CRY is transduced to membrane depolarization, increased firing rate, and acute behavioral responses by the Kvβ subunit redox sensor. ..
  9. Tolar L, Pallanck L. NSF function in neurotransmitter release involves rearrangement of the SNARE complex downstream of synaptic vesicle docking. J Neurosci. 1998;18:10250-6 pubmed

More Information


  1. Huang Q, Wu Y, Wei X, He W, Liu X, Ye J. Evolutionary analysis of voltage-gated potassium channels by Bayes method. J Mol Neurosci. 2014;53:41-9 pubmed publisher
  2. Ocorr K, Zambon A, Nudell Y, PINEDA S, Diop S, Tang M, et al. Age-dependent electrical and morphological remodeling of the Drosophila heart caused by hERG/seizure mutations. PLoS Genet. 2017;13:e1006786 pubmed publisher
    ..of these channels plays a major role in adult mouse heart function; however, we show here that the hERG homolog seizure (sei), along with KCNQ, both contribute significantly to adult heart function as they do in humans...
  3. Warmke J, Ganetzky B. A family of potassium channel genes related to eag in Drosophila and mammals. Proc Natl Acad Sci U S A. 1994;91:3438-42 pubmed
  4. Jackson F, Wilson S, Strichartz G, Hall L. Two types of mutants affecting voltage-sensitive sodium channels in Drosophila melanogaster. Nature. 1984;308:189-91 pubmed
    ..The second, no-action-potential (napts) (refs 5, 6), reduces the number of saxitoxin-binding sites, but appears not to alter the receptor structure. ..
  5. Amichot M, Castella C, Berge J, Pauron D. Transcription analysis of the para gene by in situ hybridization and immunological characterization of its expression product in wild-type and mutant strains of Drosophila. Insect Biochem Mol Biol. 1993;23:381-90 pubmed
    ..Immunohistochemistry was also performed on napts and seits1, two mutant Drosophila strains known to be defective in sodium channel activity. Only napts flies displayed a decrease in the expression of the para protein. ..
  6. Pavlidis P, Tanouye M. Seizures and failures in the giant fiber pathway of Drosophila bang-sensitive paralytic mutants. J Neurosci. 1995;15:5810-9 pubmed
    ..that in easily shocked (eas), a typical bang-sensitive mutant, electrical shocks delivered to the brain cause seizure-like activity in the dorsal longitudinal flight motor neurons (DLMmns), and failure of giant fiber (GF) ..
  7. Babcock D, Shen W, Ganetzky B. A neuroprotective function of NSF1 sustains autophagy and lysosomal trafficking in Drosophila. Genetics. 2015;199:511-22 pubmed publisher
  8. Palladino M, Bower J, Kreber R, Ganetzky B. Neural dysfunction and neurodegeneration in Drosophila Na+/K+ ATPase alpha subunit mutants. J Neurosci. 2003;23:1276-86 pubmed
    ..Our data show that maintenance of neuronal viability is dependent on normal sodium pump activity and establish Drosophila as a useful model for investigating the role of the pump in human neurodegenerative and seizure disorders.
  9. McCormack T. Comparison of K+-channel genes within the genomes of Anopheles gambiae and Drosophila melanogaster. Genome Biol. 2003;4:R58 pubmed
  10. Barber C, Jorquera R, Melom J, Littleton J. Postsynaptic regulation of synaptic plasticity by synaptotagmin 4 requires both C2 domains. J Cell Biol. 2009;187:295-310 pubmed publisher
    ..These data suggest that Syt 4 regulates activity-dependent release of postsynaptic retrograde signals that promote synaptic plasticity, similar to the role of Syt 1 as a Ca(2+) sensor for presynaptic vesicle fusion. ..
  11. Jarecki J, Keshishian H. Role of neural activity during synaptogenesis in Drosophila. J Neurosci. 1995;15:8177-90 pubmed
    ..Our experiments suggest that neural activity may function during development by preventing inappropriate connections and thereby maintaining the precise connectivity achieved during nerve outgrowth and target selection. ..
  12. Buhl L, Jorquera R, Akbergenova Y, Huntwork Rodriguez S, Volfson D, Littleton J. Differential regulation of evoked and spontaneous neurotransmitter release by C-terminal modifications of complexin. Mol Cell Neurosci. 2013;52:161-72 pubmed publisher
  13. Germeraad S, O DOWD D, Aldrich R. Functional assay of a putative Drosophila sodium channel gene in homozygous deficiency neurons. J Neurogenet. 1992;8:1-16 pubmed
    ..The morphological development of both neurons and myotubes in these cultures was similar to wildtype, making it feasible to compare the properties of normal diploid cells and cells completely lacking a putative sodium channel gene. ..
  14. Wu C, Ganetzky B. Neurogenetic studies of ion channels in Drosophila. Ion Channels. 1992;3:261-314 pubmed
  15. Islam R, Nakamura M, Scott H, Repnikova E, Carnahan M, Pandey D, et al. The role of Drosophila cytidine monophosphate-sialic acid synthetase in the nervous system. J Neurosci. 2013;33:12306-15 pubmed publisher
    ..Genetic interactions between CSAS, DSiaT, and voltage-gated channel genes paralytic and seizure were consistent with the hypothesis that CSAS and DSiaT function within the same pathway regulating neural ..
  16. Frolov R, Bagati A, Casino B, Singh S. Potassium channels in Drosophila: historical breakthroughs, significance, and perspectives. J Neurogenet. 2012;26:275-90 pubmed
    ..Drosophila has also helped in discovering other K(+) channels, such as Shab, Shaw, Shal, Eag, Sei, Elk, and also Slo, a Ca(2+) - and voltage-dependent K(+) channel...
  17. Lee J, Wu C. Orchestration of stepwise synaptic growth by K+ and Ca2+ channels in Drosophila. J Neurosci. 2010;30:15821-33 pubmed publisher
    ..We found striking synaptic overgrowth caused by Drosophila K(+)-channel mutations of the seizure and slowpoke genes, encoding Erg and Ca(2+)-activated large-conductance (BK) channels, respectively...
  18. Fergestad T, Ganetzky B, Palladino M. Neuropathology in Drosophila membrane excitability mutants. Genetics. 2006;172:1031-42 pubmed
    ..Disruption of these signaling mechanisms in any of a variety of ways increases the incidence of neurodegeneration. ..
  19. Jackson F, Gitschier J, Strichartz G, Hall L. Genetic modifications of voltage-sensitive sodium channels in Drosophila: gene dosage studies of the seizure locus. J Neurosci. 1985;5:1144-51 pubmed
    ..This locus, designated seizure, is defined by two temperature-sensitive alleles (seits-1 and seits-2), each of which causes convulsive seizures ..
  20. Elkins T, Ganetzky B. Conduction in the giant nerve fiber pathway in temperature-sensitive paralytic mutants of Drosophila. J Neurogenet. 1990;6:207-19 pubmed
    ..In contrast, analysis of sei mutants showed enhanced spontaneous activity at elevated temperatures in at least some neurons of the CGF pathway...
  21. Ocorr K, Akasaka T, Bodmer R. Age-related cardiac disease model of Drosophila. Mech Ageing Dev. 2007;128:112-6 pubmed
    ..The fly heart is thus emerging as a promising genetic model for studying the age-dependent decline in organ function. ..
  22. Ghezzi A, Al Hasan Y, Larios L, Bohm R, Atkinson N. slo K(+) channel gene regulation mediates rapid drug tolerance. Proc Natl Acad Sci U S A. 2004;101:17276-81 pubmed
    ..It is the sedative phase that stimulates slo gene expression and induces tolerance. We demonstrate that the expression level of slo is a predictor of drug sensitivity...
  23. Hoeffer C, Sanyal S, Ramaswami M. Acute induction of conserved synaptic signaling pathways in Drosophila melanogaster. J Neurosci. 2003;23:6362-72 pubmed
    ..The effect of "seizure-stimulation" on ERK activation requires neural activity and is mediated through activation of MEK (MAPK/erk ..
  24. Peixoto A, Hall J. Analysis of temperature-sensitive mutants reveals new genes involved in the courtship song of Drosophila. Genetics. 1998;148:827-38 pubmed
    ..The implications of these findings from the perspective of interspecific lovesong variations in Drosophila are discussed. ..
  25. Zheng X, Valakh V, DiAntonio A, Ben Shahar Y. Natural antisense transcripts regulate the neuronal stress response and excitability. elife. 2014;3:e01849 pubmed publisher
    ..seizures by acting as a natural antisense transcript (NAT) that regulates the neuronal mRNA levels of seizure (sei), the Drosophila homolog of the human Ether-à-go-go Related Gene (hERG) potassium channel...