Gene Symbol: Sec8
Description: Secretory 8
Alias: CG2095, Dmel\CG2095, Sec8p, dsec8, fun, sec8, secretory 8, CG2095-PA, Sec8 ortholog, Sec8-PA, funnel cakes, sec8
Species: fruit fly

Top Publications

  1. Giansanti M, Farkas R, Bonaccorsi S, Lindsley D, Wakimoto B, Fuller M, et al. Genetic dissection of meiotic cytokinesis in Drosophila males. Mol Biol Cell. 2004;15:2509-22 pubmed
  2. Murthy M, Ranjan R, Denef N, Higashi M, Schupbach T, Schwarz T. Sec6 mutations and the Drosophila exocyst complex. J Cell Sci. 2005;118:1139-50 pubmed
    ..We also find that Sec5 is mislocalized in sec6 mutants. Additionally, we have generated an epitope-tagged Sec8 that localized with Sec5 on oocyte membranes and was mislocalized in sec5 and sec6 germ-line clones...
  3. Mehta S, Hiesinger P, Beronja S, Zhai R, Schulze K, Verstreken P, et al. Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components. Neuron. 2005;46:219-32 pubmed
    ..Additionally, sec15 mutant neurons fail to localize other exocyst members like Sec5 and Sec8, but not Sec6, to neuronal terminals...
  4. Beronja S, Laprise P, Papoulas O, Pellikka M, Sisson J, Tepass U. Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells. J Cell Biol. 2005;169:635-46 pubmed
    ..In developing photoreceptor cells (PRCs), Sec6 but not Sec5 or Sec8 shows accumulation at adherens junctions...
  5. Murthy M, Garza D, Scheller R, Schwarz T. Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists. Neuron. 2003;37:433-47 pubmed
    ..In this regard, sec5 differs from the homologs of other yeast exocytosis genes that are required for both neuronal trafficking pathways. ..
  6. Jones T, Nikolova L, Schjelderup A, Metzstein M. Exocyst-mediated membrane trafficking is required for branch outgrowth in Drosophila tracheal terminal cells. Dev Biol. 2014;390:41-50 pubmed publisher
    ..Together, our results suggest a model where exocyst mediated vesicle trafficking facilitates branch outgrowth, while de novo branching requires cooperation between the PAR and exocyst complexes. ..
  7. Jiu Y, Hasygar K, Tang L, Liu Y, Holmberg C, B rglin T, et al. par-1, atypical pkc, and PP2A/B55 sur-6 are implicated in the regulation of exocyst-mediated membrane trafficking in Caenorhabditis elegans. G3 (Bethesda). 2014;4:173-83 pubmed publisher
  8. Heider M, Munson M. Exorcising the exocyst complex. Traffic. 2012;13:898-907 pubmed publisher
    ..In this review, we discuss current knowledge of exocyst architecture, assembly, regulation and its roles in a variety of cellular trafficking pathways. ..
  9. Tracy K, Velentzas P, Baehrecke E. Ral GTPase and the exocyst regulate autophagy in a tissue-specific manner. EMBO Rep. 2016;17:110-21 pubmed publisher
    ..These data indicate that Ral and the exocyst regulate autophagy in a context-dependent manner, and that in dying salivary glands, Ral mediates autophagy, at least in part, by regulation of Notch. ..

More Information


  1. Assaker G, Ramel D, Wculek S, Gonzalez Gaitan M, Emery G. Spatial restriction of receptor tyrosine kinase activity through a polarized endocytic cycle controls border cell migration. Proc Natl Acad Sci U S A. 2010;107:22558-63 pubmed publisher
    ..Together, our data demonstrate a fundamental role for a plasma membrane-endosome trafficking cycle in the maintenance of active RTK at the leading edge of border cells during their migration. ..
  2. Venken K, He Y, Hoskins R, Bellen H. P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster. Science. 2006;314:1747-51 pubmed
    ..This transgenesis platform should greatly facilitate structure/function analyses of most Drosophila genes...
  3. Rodriguez Fernandez I, Dell Angelica E. A data-mining approach to rank candidate protein-binding partners-The case of biogenesis of lysosome-related organelles complex-1 (BLOC-1). J Inherit Metab Dis. 2009;32:190-203 pubmed publisher
    ..The data-mining approach described herein can be customized to study candidate binding partners for other proteins or possibly candidates derived from other types of 'omics' data. ..
  4. Liebl F, Chen K, Karr J, Sheng Q, Featherstone D. Increased synaptic microtubules and altered synapse development in Drosophila sec8 mutants. BMC Biol. 2005;3:27 pubmed
    b>Sec8 is highly expressed in mammalian nervous systems and has been proposed to play a role in several aspects of neural development and function, including neurite outgrowth, calcium-dependent neurotransmitter secretion, trafficking of ..
  5. Portela M, Parsons L, Grzeschik N, Richardson H. Regulation of Notch signaling and endocytosis by the Lgl neoplastic tumor suppressor. Cell Cycle. 2015;14:1496-506 pubmed publisher
    ..In this extraview, we provide additional data on the regulation of Notch signaling and endocytosis by Lgl, and discuss possible mechanisms by which Lgl depletion contributes to signaling pathway defects and tumorigenesis. ..
  6. Lee S, Cooley L. Jagunal is required for reorganizing the endoplasmic reticulum during Drosophila oogenesis. J Cell Biol. 2007;176:941-52 pubmed
    ..We propose that ER reorganization is an important mechanism used by cells to prepare for an increased demand for membrane traffic, and Jagunal facilitates this process through ER clustering. ..
  7. Langevin J, Morgan M, Sibarita J, Aresta S, Murthy M, Schwarz T, et al. Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane. Dev Cell. 2005;9:365-76 pubmed
    ..Our results support a model whereby the exocyst regulates DE-Cadherin trafficking, from recycling endosomes to sites on the epithelial cell membrane where Armadillo is located. ..
  8. Gervais L, Casanova J. In vivo coupling of cell elongation and lumen formation in a single cell. Curr Biol. 2010;20:359-66 pubmed publisher
    ..Given the similarities in the formation of fine respiratory tubes and capillaries, we propose that an inward membrane growth model could account for lumen formation in both processes. ..
  9. Fabian L, Wei H, Rollins J, Noguchi T, Blankenship J, Bellamkonda K, et al. Phosphatidylinositol 4,5-bisphosphate directs spermatid cell polarity and exocyst localization in Drosophila. Mol Biol Cell. 2010;21:1546-55 pubmed publisher
    ..Moreover, the exocyst is required for polarity, as partial loss of function of the exocyst subunit Sec8 results in bipolar cysts...
  10. Michel M, Raabe I, Kupinski A, Pérez Palencia R, Bökel C. Local BMP receptor activation at adherens junctions in the Drosophila germline stem cell niche. Nat Commun. 2011;2:415 pubmed publisher
    ..We, therefore, propose that local generation of the BMP signal is achieved through shared use of the Cadherin transport machinery. ..
  11. Yashiro H, Loza A, Skeath J, Longmore G. Rho1 regulates adherens junction remodeling by promoting recycling endosome formation through activation of myosin II. Mol Biol Cell. 2014;25:2956-69 pubmed publisher
    ..This work identifies spatially distinct functions for Rho1 in the regulation of DE-cadherin-containing vesicular trafficking during AJ remodeling in live epithelia. ..
  12. Chabu C, Xu T. Oncogenic Ras stimulates Eiger/TNF exocytosis to promote growth. Development. 2014;141:4729-39 pubmed publisher
    ..Our findings highlight important cell-intrinsic and cell-extrinsic roles of exocytosis during oncogenic growth and provide a new class of synthetic suppressors for targeted therapy approaches. ..
  13. Giansanti M, Vanderleest T, Jewett C, Sechi S, Frappaolo A, Fabian L, et al. Exocyst-Dependent Membrane Addition Is Required for Anaphase Cell Elongation and Cytokinesis in Drosophila. PLoS Genet. 2015;11:e1005632 pubmed publisher
    ..We show that onion rings (onr) and funnel cakes (fun) encode the Drosophila homologs of the Exo84 and Sec8 exocyst subunits, respectively...