Gene Symbol: SdhB
Description: Succinate dehydrogenase, subunit B (iron-sulfur)
Alias: CG3283, CII-SDHB, DHSB, Dmel\CG3283, SDH, SDH-B, SDH-IP, SDH-Ip, SDHb, sdhB, succinate dehydrogenase, subunit B (iron-sulfur), CG3283-PA, COMPLEX II: iron-sulfur subunit, SdhB-PA, iron-sulfur protein subunit of succinate dehydrogenase, succinate dehydrogenase, succinate dehydrogenase B, succinate dehydrogenase Iron-sulfur, succinate dehydrogenase Iron-sulfur protein, succinate dehydrogenase [ubiquinone] iron-sulfur protein, succinate dehydrogenase iron protein, succinate dehydrogenase subunit b
Species: fruit fly

Top Publications

  1. Surdej P, Richman L, Kühn L. Differential translational regulation of IRE-containing mRNAs in Drosophila melanogaster by endogenous IRP and a constitutive human IRP1 mutant. Insect Biochem Mol Biol. 2008;38:891-4 pubmed publisher
    ..Two mRNAs, an unspliced form of ferritin H mRNA and succinate dehydrogenase subunit b (SDHb) mRNA, are known to comprise an iron responsive element (IRE) in their 5'-untranslated region ..
  2. Jasper H. Exploring the physiology and pathology of aging in the intestine of Drosophila melanogaster. Invertebr Reprod Dev. 2015;59:51-58 pubmed
    ..Here, I review recent studies exploring age-related changes in the fly intestine, and their insight into the regulation of health and lifespan of the animal. ..
  3. Au H, Scheffler I. Characterization of the gene encoding the iron-sulfur protein subunit of succinate dehydrogenase from Drosophila melanogaster. Gene. 1994;149:261-5 pubmed
    The iron-sulfur protein (Ip) subunit of succinate dehydrogenase (and complex II of the electron transport chain) is highly conserved in evolution [Gould et al., Proc. Natl. Acad. Sci. USA 86 (1989) 1934-1938]...
  4. Scialò F, Sriram A, Fernández Ayala D, Gubina N, Lõhmus M, Nelson G, et al. Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan. Cell Metab. 2016;23:725-34 pubmed publisher
    ..These results illustrate that the source of a ROS signal is vital in determining its effects on cellular physiology and establish that manipulation of ubiquinone redox state is a valid strategy to delay aging. ..
  5. Prasad S, Muralidhara -. Neuroprotective effect of geraniol and curcumin in an acrylamide model of neurotoxicity in Drosophila melanogaster: relevance to neuropathy. J Insect Physiol. 2014;60:7-16 pubmed publisher
    ..Interestingly, ACR induced mitochondrial dysfunctions (MTT reduction, activities of SDH and citrate synthase enzymes) were alleviated by both phytoconstituents...
  6. Uhrigshardt H, Rouault T, Missirlis F. Insertion mutants in Drosophila melanogaster Hsc20 halt larval growth and lead to reduced iron-sulfur cluster enzyme activities and impaired iron homeostasis. J Biol Inorg Chem. 2013;18:441-9 pubmed publisher
    ..insertion mutants in Drosophila Hsc20 that display larval growth arrest and deficiencies in aconitase and succinate dehydrogenase activities, but not in isocitrate dehydrogenase activity; phenotypes also observed with ubiquitous ..
  7. Melefors O. Translational regulation in vivo of the Drosophila melanogaster mRNA encoding succinate dehydrogenase iron protein via iron responsive elements. Biochem Biophys Res Commun. 1996;221:437-41 pubmed
    ..We here describe the drosophila melanogaster succinate dehydrogenase iron protein (SDH-IP) as a fourth example of an mRNA species being translationally regulated by an IRE, based on ..
  8. Bharathi V, Pallavi S, Bajpai R, Emerald B, Shashidhara L. Genetic characterization of the Drosophila homologue of coronin. J Cell Sci. 2004;117:1911-22 pubmed
    ..Our results provide a genetic link between endocytosis/exocytosis events involving F actin-coated vesicles and the establishment of morphogen gradient. ..
  9. Kohler S, Henderson B, Kuhn L. Succinate dehydrogenase b mRNA of Drosophila melanogaster has a functional iron-responsive element in its 5'-untranslated region. J Biol Chem. 1995;270:30781-6 pubmed
    ..Here we describe a new IRE in the 5'-UTR of succinate dehydrogenase subunit b (SDHb) mRNA of Drosophila melanogaster...

More Information


  1. Na U, Yu W, Cox J, Bricker D, Brockmann K, Rutter J, et al. The LYR factors SDHAF1 and SDHAF3 mediate maturation of the iron-sulfur subunit of succinate dehydrogenase. Cell Metab. 2014;20:253-66 pubmed publisher
    Disorders arising from impaired assembly of succinate dehydrogenase (SDH) result in a myriad of pathologies, consistent with its unique role in linking the citric acid cycle and electron transport chain...
  2. Van Vranken J, Bricker D, Dephoure N, Gygi S, Cox J, Thummel C, et al. SDHAF4 promotes mitochondrial succinate dehydrogenase activity and prevents neurodegeneration. Cell Metab. 2014;20:241-52 pubmed publisher
    b>Succinate dehydrogenase (SDH) occupies a central place in cellular energy production, linking the tricarboxylic cycle with the electron transport chain...
  3. Walker D, Hajek P, Muffat J, Knoepfle D, Cornelison S, Attardi G, et al. Hypersensitivity to oxygen and shortened lifespan in a Drosophila mitochondrial complex II mutant. Proc Natl Acad Sci U S A. 2006;103:16382-7 pubmed
    ..Here, we report the isolation and characterization of a Drosophila mutant with a defect in subunit b of succinate dehydrogenase (SDH; mitochondrial complex II)...
  4. Gould S, Subramani S, Scheffler I. Use of the DNA polymerase chain reaction for homology probing: isolation of partial cDNA or genomic clones encoding the iron-sulfur protein of succinate dehydrogenase from several species. Proc Natl Acad Sci U S A. 1989;86:1934-8 pubmed
    ..We used this technique to clone the gene encoding the iron protein subunit (27 kDa) of succinate dehydrogenase (EC 1.3.5...
  5. Tufi R, Gandhi S, de Castro I, Lehmann S, Angelova P, Dinsdale D, et al. Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease. Nat Cell Biol. 2014;16:157-66 pubmed publisher
    ..We propose that targeting strategies enhancing nucleotide synthesis pathways may reverse mitochondrial dysfunction and rescue neurodegeneration in PD and, potentially, other diseases linked to mitochondrial impairment. ..
  6. Rera M, Clark R, Walker D. Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila. Proc Natl Acad Sci U S A. 2012;109:21528-33 pubmed publisher
    ..Our findings suggest that intestinal barrier dysfunction may be an important factor in the pathophysiology of aging in other species as well, including humans. ..
  7. Celotto A, Chiu W, Van Voorhies W, Palladino M. Modes of metabolic compensation during mitochondrial disease using the Drosophila model of ATP6 dysfunction. PLoS ONE. 2011;6:e25823 pubmed publisher
    ..However, succinate dehydrogenase activity is reduced and mitochondrial supercomplex formation is severely disrupted contributing to the ..
  8. Schwarze S, Weindruch R, Aiken J. Decreased mitochondrial RNA levels without accumulation of mitochondrial DNA deletions in aging Drosophila melanogaster. Mutat Res. 1998;382:99-107 pubmed
    ..No difference, however, was apparent in the nuclear-encoded beta-ATPase RNA level, suggesting only mitochondrial RNA (mtRNA) declines are associated with life expectancy. ..
  9. Zhan M, Yamaza H, Sun Y, Sinclair J, Li H, Zou S. Temporal and spatial transcriptional profiles of aging in Drosophila melanogaster. Genome Res. 2007;17:1236-43 pubmed
    ..The spatial and temporal transcriptome data presented in this study provide a basis and a valuable resource for further genetic and genomic investigation of tissue-specific regulation of aging. ..
  10. Gray N, Pantopoulos K, Dandekar T, Ackrell B, Hentze M. Translational regulation of mammalian and Drosophila citric acid cycle enzymes via iron-responsive elements. Proc Natl Acad Sci U S A. 1996;93:4925-30 pubmed an IRE in the 5' untranslated region of the mRNA encoding the iron-sulfur protein (Ip) subunit of succinate dehydrogenase (SDH). This interaction is developmentally regulated during Drosophila embryogenesis...
  11. Lim D, Lee L, Oh C, Kim N, Hwang S, Han S, et al. Microarray analysis of Drosophila dicer-2 mutants reveals potential regulation of mitochondrial metabolism by endogenous siRNAs. J Cell Biochem. 2013;114:418-27 pubmed publisher
    ..Our data support a potential role for the endo-siRNA pathway in energy homeostasis through regulation of mitochondrial metabolism. ..
  12. Tiefenböck S, Baltzer C, Egli N, Frei C. The Drosophila PGC-1 homologue Spargel coordinates mitochondrial activity to insulin signalling. EMBO J. 2010;29:171-83 pubmed publisher
    ..Taken together, our data place Spargel at a nodal point for the integration of mitochondrial activity to tissue and organismal metabolism and growth. ..
  13. Navarro J, Botella J, Metzendorf C, Lind M, Schneuwly S. Mitoferrin modulates iron toxicity in a Drosophila model of Friedreich's ataxia. Free Radic Biol Med. 2015;85:71-82 pubmed publisher
  14. Scialò F, Sriram A, Naudí A, Ayala V, Jové M, Pamplona R, et al. Target of rapamycin activation predicts lifespan in fruit flies. Cell Cycle. 2015;14:2949-58 pubmed publisher
    ..Our results, dissociate metabolic rate and lifespan in wild type flies and instead link nutrient sensing signaling with longevity as predicted by the hyperfunction theory. ..