Gene Symbol: SdhA
Description: Succinate dehydrogenase, subunit A (flavoprotein)
Alias: CG17246, DHSA, Dmel\CG17246, SDH, Scs-fp, Sdh, Sdh A, Sdha, scs-fp, sdh, succinate dehydrogenase, subunit A (flavoprotein), CG17246-PA, CG17246-PB, CG17246-PC, COMPLEX II: flavoprotein subunit, SUCCINYL COENZIME A SYNTHETASE FLAVOPROTEIN SUBUNIT, SdhA-PA, SdhA-PB, SdhA-PC, succinate dehydrogenase, succinate dehydrogenase A, succinate dehydrogenase [ubiquinone] flavoprotein subunit, succinate dehydrogenase flavoprotein, succinate dehydrogenase flavoprotein subunit, succinyl CoA synthetase flavoprotein subunit of complex II, succinyl coenzyme A synthetase flavoprotein subunit
Species: fruit fly

Top Publications

  1. Caggese C, Ragone G, Perrini B, Moschetti R, De Pinto V, Caizzi R, et al. Identification of nuclear genes encoding mitochondrial proteins: isolation of a collection of D. melanogaster cDNAs homologous to sequences in the Human Gene Index database. Mol Gen Genet. 1999;261:64-70 pubmed
    ..Our experimental strategy represents an efficient approach to the identification and interspecies comparison of genes encoding products targeted to the mitochondrion. ..
  2. Blair S. Genetic mosaic techniques for studying Drosophila development. Development. 2003;130:5065-72 pubmed
    ..Variations on these techniques can also be used to screen for novel genes that are involved in non-embryonic patterning and growth. ..
  3. Lerner I, Bartok O, Wolfson V, Menet J, Weissbein U, Afik S, et al. Clk post-transcriptional control denoises circadian transcription both temporally and spatially. Nat Commun. 2015;6:7056 pubmed publisher
    ..Overall our results demonstrate a key role of Clk post-transcriptional control in stabilizing circadian transcription, which is essential for proper development and maintenance of circadian rhythms in Drosophila. ..
  4. Fyrberg E, Bernstein S, Vijayraghavan K. Basic methods for Drosophila muscle biology. Methods Cell Biol. 1994;44:237-58 pubmed
  5. Wolfner M, Goldberg M. Harnessing the power of Drosophila genetics. Methods Cell Biol. 1994;44:33-80 pubmed
  6. Tiefenböck S, Baltzer C, Egli N, Frei C. The Drosophila PGC-1 homologue Spargel coordinates mitochondrial activity to insulin signalling. EMBO J. 2010;29:171-83 pubmed publisher
    ..Taken together, our data place Spargel at a nodal point for the integration of mitochondrial activity to tissue and organismal metabolism and growth. ..
  7. Kanda H, Igaki T, Okano H, Miura M. Conserved metabolic energy production pathways govern Eiger/TNF-induced nonapoptotic cell death. Proc Natl Acad Sci U S A. 2011;108:18977-82 pubmed publisher
    ..This result suggests a link between sensitivity to cell death and metabolic activity in cancer. ..
  8. Prasad S, Muralidhara -. Neuroprotective effect of geraniol and curcumin in an acrylamide model of neurotoxicity in Drosophila melanogaster: relevance to neuropathy. J Insect Physiol. 2014;60:7-16 pubmed publisher
    ..Interestingly, ACR induced mitochondrial dysfunctions (MTT reduction, activities of SDH and citrate synthase enzymes) were alleviated by both phytoconstituents...
  9. Navarro J, Botella J, Metzendorf C, Lind M, Schneuwly S. Mitoferrin modulates iron toxicity in a Drosophila model of Friedreich's ataxia. Free Radic Biol Med. 2015;85:71-82 pubmed publisher

More Information


  1. Lawrence P. A general cell marker for clonal analysis of Drosophila development. J Embryol Exp Morphol. 1981;64:321-32 pubmed
    The mitochondrial enzyme, succinate dehydrogenase, can be localized by specific histochemical stains. A naturally occurring variant which gives heat-labile enzyme is used to map a gene responsible for succinate dehydrogenase...
  2. Denholm B, Sudarsan V, Pasalodos Sanchez S, Artero R, Lawrence P, Maddrell S, et al. Dual origin of the renal tubules in Drosophila: mesodermal cells integrate and polarize to establish secretory function. Curr Biol. 2003;13:1052-7 pubmed
    ..Strikingly, the normal incorporation of stellate cells and the later physiological activity of the mature tubules depend on the activity of hibris, an ortholog of mammalian NEPHRIN. ..
  3. Comas D, Petit F, Preat T. Drosophila long-term memory formation involves regulation of cathepsin activity. Nature. 2004;430:460-3 pubmed
    ..In wild-type flies, cer expression transiently decreases after LTM conditioning, indicating that cysteine proteinases are activated early in LTM formation. ..
  4. Mast J, Tomalty K, Vogel H, Clandinin T. Reactive oxygen species act remotely to cause synapse loss in a Drosophila model of developmental mitochondrial encephalopathy. Development. 2008;135:2669-79 pubmed publisher
    ..Thus, alterations in electron transport chain function explain many of the neurodegenerative changes seen in both early- and late-onset disorders. ..
  5. Celotto A, Chiu W, Van Voorhies W, Palladino M. Modes of metabolic compensation during mitochondrial disease using the Drosophila model of ATP6 dysfunction. PLoS ONE. 2011;6:e25823 pubmed publisher
    ..However, succinate dehydrogenase activity is reduced and mitochondrial supercomplex formation is severely disrupted contributing to the ..
  6. Na U, Yu W, Cox J, Bricker D, Brockmann K, Rutter J, et al. The LYR factors SDHAF1 and SDHAF3 mediate maturation of the iron-sulfur subunit of succinate dehydrogenase. Cell Metab. 2014;20:253-66 pubmed publisher
    Disorders arising from impaired assembly of succinate dehydrogenase (SDH) result in a myriad of pathologies, consistent with its unique role in linking the citric acid cycle and electron transport chain...
  7. Van Vranken J, Bricker D, Dephoure N, Gygi S, Cox J, Thummel C, et al. SDHAF4 promotes mitochondrial succinate dehydrogenase activity and prevents neurodegeneration. Cell Metab. 2014;20:241-52 pubmed publisher
    b>Succinate dehydrogenase (SDH) occupies a central place in cellular energy production, linking the tricarboxylic cycle with the electron transport chain...