Gene Symbol: sd
Description: scalloped
Alias: CG8544, DROEXO, DROEXO2, Dmel\CG8544, EP(X)1088, EP1088, TEAD, anon-EST:Liang-2.14, clone 2.14, l(1)G0239, l(1)G0262, l(1)G0309, l(1)G0315, l(1)G0483, l(1)HF394, l(1)III, scalloped, CG8544-PA, CG8544-PB, CG8544-PC, CG8544-PD, CG8544-PE, CG8544-PF, CG8544-PG, CG8544-PH, CG8544-PI, CG8544-PJ, CG8544-PK, CG8544-PL, CG8544-PM, CG8544-PN, CG8544-PO, CG8544-PP, CG8544-PQ, CG8544-PR, CG8544-PS, CG8544-PT, CG8544-PU, sd-PA, sd-PB, sd-PC, sd-PD, sd-PE, sd-PF, sd-PG, sd-PH, sd-PI, sd-PJ, sd-PK, sd-PL, sd-PM, sd-PN, sd-PO, sd-PP, sd-PQ, sd-PR, sd-PS, sd-PT, sd-PU, spatula
Species: fruit fly
Products:     sd

Top Publications

  1. Garg A, Srivastava A, Davis M, O Keefe S, Chow L, Bell J. Antagonizing scalloped with a novel vestigial construct reveals an important role for scalloped in Drosophila melanogaster leg, eye and optic lobe development. Genetics. 2007;175:659-69 pubmed
    b>Scalloped (SD), a TEA/ATTS-domain-containing protein, is required for the proper development of Drosophila melanogaster...
  2. Campbell S, Duttaroy A, Katzen A, Chovnick A. Cloning and characterization of the scalloped region of Drosophila melanogaster. Genetics. 1991;127:367-80 pubmed
    Viable mutants of the scalloped gene (sd) of Drosophila melanogaster exhibit defects that can include gapping of the wing margin and ectopic bristle formation on the wing...
  3. Sen A, Stultz B, Lee H, Hursh D. Odd paired transcriptional activation of decapentaplegic in the Drosophila eye/antennal disc is cell autonomous but indirect. Dev Biol. 2010;343:167-77 pubmed publisher
    ..These data suggest that while Opa can function in vivo as a sequence specific transcriptional regulator, it does not require DNA binding for transcriptional activation. ..
  4. Koontz L, Liu Chittenden Y, Yin F, Zheng Y, Yu J, Huang B, et al. The Hippo effector Yorkie controls normal tissue growth by antagonizing scalloped-mediated default repression. Dev Cell. 2013;25:388-401 pubmed publisher
    ..Although Sd has been implicated as a DNA-binding transcription factor partner for Yki and can genetically account for gain-of-..
  5. Ren F, Wang B, Yue T, Yun E, Ip Y, Jiang J. Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways. Proc Natl Acad Sci U S A. 2010;107:21064-9 pubmed publisher
    ..Finally, we show that the Hpo pathway mediator Yorkie (Yki) is also required in precursor cells for injury-induced ISC proliferation in response to tissue-damaging reagent DSS. ..
  6. Oh H, Irvine K. Cooperative regulation of growth by Yorkie and Mad through bantam. Dev Cell. 2011;20:109-22 pubmed publisher
    ..Our results indicate that in promoting the growth of Drosophila tissues, Fat-Hippo and Dpp signaling contribute distinct subunits of a shared transcriptional activation complex, Yorkie:Mad...
  7. Roy S, Shashidhara L, Vijayraghavan K. Muscles in the Drosophila second thoracic segment are patterned independently of autonomous homeotic gene function. Curr Biol. 1997;7:222-7 pubmed
  8. Poon C, Lin J, Zhang X, Harvey K. The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway. Dev Cell. 2011;21:896-906 pubmed publisher
    ..Given that SWH pathway activity is subverted in many human cancers, our findings identify human TAO kinases as potential tumor suppressor genes. ..
  9. Nagaraj R, Gururaja Rao S, Jones K, Slattery M, Negre N, Braas D, et al. Control of mitochondrial structure and function by the Yorkie/YAP oncogenic pathway. Genes Dev. 2012;26:2027-37 pubmed publisher
    ..Thus, mitochondrial fusion is an essential and direct target of the Yorkie/YAP pathway in the regulation of organ size control during development and could play a similar role in the genesis of cancer. ..

More Information


  1. Simmonds A, Liu X, Soanes K, Krause H, Irvine K, Bell J. Molecular interactions between Vestigial and Scalloped promote wing formation in Drosophila. Genes Dev. 1998;12:3815-20 pubmed
    b>Scalloped (Sd) and Vestigial (Vg) are each needed for Drosophila wing development. We show that Sd is required for Vg function and that altering their relative cellular levels inhibits wing formation...
  2. Bernard F, Kasherov P, Grenetier S, Dutriaux A, Zider A, Silber J, et al. Integration of differentiation signals during indirect flight muscle formation by a novel enhancer of Drosophila vestigial gene. Dev Biol. 2009;332:258-72 pubmed publisher
    ..Moreover, we show that this enhancer is activated by Drosophila Myocyte enhancing factor 2 (MEF2), Scalloped (SD) and VG but repressed by Twist, demonstrating a sensitivity to differentiation in vivo...
  3. Ren F, Zhang L, Jiang J. Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms. Dev Biol. 2010;337:303-12 pubmed publisher
    ..consisting of the transcriptional coactivator Yorkie (Yki) and the TEAD/TEF family of transcription factor Scalloped (Sd)...
  4. Grimaud C, Bantignies F, Pal Bhadra M, Ghana P, Bhadra U, Cavalli G. RNAi components are required for nuclear clustering of Polycomb group response elements. Cell. 2006;124:957-71 pubmed
    ..This suggests a novel role for the RNAi machinery in regulating the nuclear organization of PcG chromatin targets. ..
  5. Yu T, Bachman J, Lai Z. Evidence for a tumor suppressor role for the large tumor suppressor genes LATS1 and LATS2 in human cancer. Genetics. 2013;195:1193-6 pubmed publisher
    ..hLATS1/2 mutants exhibit a decreased activity in inhibiting YAP and tissue growth. Therefore, hLATS1/2 alleles from human cancer can be loss-of-function mutations. ..
  6. Robinson B, Huang J, Hong Y, Moberg K. Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded. Curr Biol. 2010;20:582-90 pubmed publisher
  7. Zhang L, Ren F, Zhang Q, Chen Y, Wang B, Jiang J. The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control. Dev Cell. 2008;14:377-87 pubmed publisher
    ..Here we provide evidence that the TEAD/TEF family transcription factor Scalloped (Sd) acts together with the coactivator Yorkie (Yki) to regulate Hpo pathway-responsive genes...
  8. Ribeiro P, Josué F, Wepf A, Wehr M, Rinner O, Kelly G, et al. Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling. Mol Cell. 2010;39:521-34 pubmed publisher
    ..dSTRIPAK depletion leads to increased Hpo activatory phosphorylation and repression of Yki target genes in vivo, suggesting this phosphatase complex prevents Hpo activation during development. ..
  9. Halder G, Polaczyk P, Kraus M, Hudson A, Kim J, Laughon A, et al. The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene expression in Drosophila. Genes Dev. 1998;12:3900-9 pubmed
    ..Here, we show that Vestigial requires the function of the Scalloped protein, a member of the TEA family of transcriptional regulators, to directly activate the expression of genes ..
  10. Cavalli G, Paro R. The Drosophila Fab-7 chromosomal element conveys epigenetic inheritance during mitosis and meiosis. Cell. 1998;93:505-18 pubmed
    ..Thus, Fab-7 is a switchable chromosomal element, which can convey memory of epigenetically determined active and repressed chromatin states...
  11. Delanoue R, Legent K, Godefroy N, Flagiello D, Dutriaux A, Vaudin P, et al. The Drosophila wing differentiation factor vestigial-scalloped is required for cell proliferation and cell survival at the dorso-ventral boundary of the wing imaginal disc. Cell Death Differ. 2004;11:110-22 pubmed
    ..In the Drosophila wing disc, the vestigial (vg) and the scalloped (sd) gene products dimerize to form a functional transcription factor...
  12. Jin Y, Dong L, Lu Y, Wu W, Hao Q, Zhou Z, et al. Dimerization and cytoplasmic localization regulate Hippo kinase signaling activity in organ size control. J Biol Chem. 2012;287:5784-96 pubmed publisher
  13. Goulev Y, Fauny J, Gonzalez Marti B, Flagiello D, Silber J, Zider A. SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila. Curr Biol. 2008;18:435-41 pubmed publisher
    In Drosophila, SCALLOPED (SD) belongs to a family of evolutionarily conserved proteins characterized by the presence of a TEA/ATTS DNA-binding domain [1, 2]...
  14. Wu S, Liu Y, Zheng Y, Dong J, Pan D. The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway. Dev Cell. 2008;14:388-98 pubmed publisher
    ..Here we identify the TEAD/TEF family protein Scalloped (Sd) as a DNA-binding transcription factor that partners with Yki to mediate the transcriptional output of the ..
  15. Inamdar M, Vijayraghavan K, Rodrigues V. The Drosophila homolog of the human transcription factor TEF-1, scalloped, is essential for normal taste behavior. J Neurogenet. 1993;9:123-39 pubmed
    The scalloped (sd) locus of Drosophila melanogaster encodes a protein with a novel DNA binding domain bearing a high degree of similarity to the human transcription factor TEF-1 (Campbell et al., 1992)...
  16. Verghese S, Waghmare I, Kwon H, Hanes K, Kango Singh M. Scribble acts in the Drosophila fat-hippo pathway to regulate warts activity. PLoS ONE. 2012;7:e47173 pubmed publisher
    ..We show that Ft requires Scrib to interact with Expanded (Ex) and Dachs (D), and for regulating Warts (Wts) levels and stability, thus placing Scrib in the Hippo pathway network. ..
  17. McVey M, Larocque J, Adams M, Sekelsky J. Formation of deletions during double-strand break repair in Drosophila DmBlm mutants occurs after strand invasion. Proc Natl Acad Sci U S A. 2004;101:15694-9 pubmed
    ..This model explains how RecQ helicases can promote homologous recombination while preventing illegitimate recombination. ..
  18. Cho E, Irvine K. Action of fat, four-jointed, dachsous and dachs in distal-to-proximal wing signaling. Development. 2004;131:4489-500 pubmed
  19. Campbell S, Inamdar M, Rodrigues V, Raghavan V, Palazzolo M, Chovnick A. The scalloped gene encodes a novel, evolutionarily conserved transcription factor required for sensory organ differentiation in Drosophila. Genes Dev. 1992;6:367-79 pubmed
    The scalloped (sd) gene of Drosophila melanogaster was initially characterized by mutants affecting structures on the wing of the adult fly...
  20. Zhao B, Ye X, Yu J, Li L, Li W, Li S, et al. TEAD mediates YAP-dependent gene induction and growth control. Genes Dev. 2008;22:1962-71 pubmed publisher
    ..Moreover, the functional relationship between YAP and TEAD is conserved in Drosophila Yki (the YAP homolog) and Scalloped (the TEAD homolog)...
  21. Adams M, McVey M, Sekelsky J. Drosophila BLM in double-strand break repair by synthesis-dependent strand annealing. Science. 2003;299:265-7 pubmed
    ..These results suggest a model in which BLM maintains genomic stability by promoting efficient repair DNA synthesis and thereby prevents double-strand break repair by less precise pathways. ..
  22. Oh H, Irvine K. In vivo analysis of Yorkie phosphorylation sites. Oncogene. 2009;28:1916-27 pubmed publisher
    ..We also identify two potential sites of phosphorylation by an unknown kinase, which could influence phosphorylation of Ser168 by Wts, suggesting that there are additional mechanisms for regulating Yki/YAP activity. ..
  23. Zhang T, Zhou Q, Pignoni F. Yki/YAP, Sd/TEAD and Hth/MEIS control tissue specification in the Drosophila eye disc epithelium. PLoS ONE. 2011;6:e22278 pubmed publisher
    ..RNAi-mediated inactivation of Yki, or its partner Scalloped (Sd), or increased activity of the upstream negative regulators of Yki cause a dramatic reorganization of the ..
  24. Chow L, Berube J, Fromont A, Bell J. Ability of scalloped deletion constructs to rescue sd mutant wing phenotypes in Drosophila melanogaster. Genome. 2004;47:849-59 pubmed
    b>Scalloped (SD) and Vestigial (VG) proteins physically interact to form a selector complex that activates genes involved in wing development in Drosophila melanogaster...
  25. Bernard F, Lalouette A, Gullaud M, Jeantet A, Cossard R, Zider A, et al. Control of apterous by vestigial drives indirect flight muscle development in Drosophila. Dev Biol. 2003;260:391-403 pubmed
    ..We show that vg and scalloped (sd), the only known VG transcriptional coactivator, are coexpressed during IFM development...
  26. Srivastava A, Bell J. Further developmental roles of the Vestigial/Scalloped transcription complex during wing development in Drosophila melanogaster. Mech Dev. 2003;120:587-96 pubmed
    The Drosophila homologue of the human TEF-1 gene, scalloped (sd), is required for wing development...
  27. Halder G, Carroll S. Binding of the Vestigial co-factor switches the DNA-target selectivity of the Scalloped selector protein. Development. 2001;128:3295-305 pubmed
    ..It is not understood how the target selectivity of most selector proteins is determined in vivo. The Scalloped selector protein controls wing development in Drosophila by regulating the expression of numerous target genes ..
  28. Srivastava A, Simmonds A, Garg A, Fossheim L, Campbell S, Bell J. Molecular and functional analysis of scalloped recessive lethal alleles in Drosophila melanogaster. Genetics. 2004;166:1833-43 pubmed
    The Drosophila melanogaster scalloped (sd) gene is a homolog of the human TEF-1 gene and is a member of the TEA/ATTS domain-containing family of transcription factors...
  29. Bantignies F, Grimaud C, Lavrov S, Gabut M, Cavalli G. Inheritance of Polycomb-dependent chromosomal interactions in Drosophila. Genes Dev. 2003;17:2406-20 pubmed
    ..This suggests that transmission of nuclear architecture through cell division might contribute to inheritance of chromatin states in eukaryotes. ..
  30. Neto Silva R, de Beco S, Johnston L. Evidence for a growth-stabilizing regulatory feedback mechanism between Myc and Yorkie, the Drosophila homolog of Yap. Dev Cell. 2010;19:507-20 pubmed publisher
    ..We propose that the codependent regulatory relationship functionally coordinates the cellular activities of Yki and Myc and provides a mechanism of growth control that regulates organ size and has broad implications for cancer. ..
  31. Deng H, Hughes S, Bell J, Simmonds A. Alternative requirements for Vestigial, Scalloped, and Dmef2 during muscle differentiation in Drosophila melanogaster. Mol Biol Cell. 2009;20:256-69 pubmed publisher
    ..In Drosophila there is a single mef2 (Dmef2) gene as well single homologues of TEF-1 and vestigial-like, scalloped (sd), and vestigial (vg), respectively...
  32. Doggett K, Grusche F, Richardson H, Brumby A. Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling. BMC Dev Biol. 2011;11:57 pubmed publisher
    ..defective Hippo signaling and can be rescued by knockdown of either the TEAD/TEF family transcription factor Scalloped or the transcriptional coactivator Yorkie in the eye disc, or reducing levels of Yorkie in the wing disc...
  33. Vaudin P, Delanoue R, Davidson I, Silber J, Zider A. TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation. Development. 1999;126:4807-16 pubmed
    The mammalian TEF and the Drosophila scalloped genes belong to a conserved family of transcriptional factors that possesses a TEA/ATTS DNA-binding domain...
  34. Oh H, Slattery M, Ma L, Crofts A, White K, Mann R, et al. Genome-wide association of Yorkie with chromatin and chromatin-remodeling complexes. Cell Rep. 2013;3:309-18 pubmed publisher
    ..Our studies suggest a widespread role for Yorkie as a regulator of transcription and identify recruitment of the chromatin-modifying GAF protein and BRM complex as a molecular mechanism for transcriptional activation by Yorkie. ..
  35. Gerlitz O, Nellen D, Ottiger M, Basler K. A screen for genes expressed in Drosophila imaginal discs. Int J Dev Biol. 2002;46:173-6 pubmed
    ..The procedure has been optimized for high-throughput. 2'000 P-element insertions have been established which exhibit expression in imaginal discs. ..
  36. Tsai C, Anderson A, Burra S, Jo J, Galko M. Yorkie regulates epidermal wound healing in Drosophila larvae independently of cell proliferation and apoptosis. Dev Biol. 2017;427:61-71 pubmed publisher
    ..Here we show that Yki and Scalloped (Sd) are required for epidermal wound closure in the Drosophila larval epidermis...
  37. Singer R, Atar S, Atias O, Oron E, Segal D, Hirsch J, et al. Drosophila COP9 signalosome subunit 7 interacts with multiple genomic loci to regulate development. Nucleic Acids Res. 2014;42:9761-70 pubmed publisher
  38. Salah Z, Aqeilan R. WW domain interactions regulate the Hippo tumor suppressor pathway. Cell Death Dis. 2011;2:e172 pubmed publisher
    ..We further discuss new insights and future directions on the emerging role of such regulation. ..
  39. Sebé Pedrós A, Zheng Y, Ruiz Trillo I, Pan D. Premetazoan origin of the hippo signaling pathway. Cell Rep. 2012;1:13-20 pubmed publisher
    ..pathway components, such as the kinases Hippo and Warts, the coactivator Yorkie, and the transcription factor Scalloped, were already present in the unicellular ancestors of animals...
  40. Kulkarni S, Steinlauf A, Hall J. The dissonance mutant of courtship song in Drosophila melanogaster: isolation, behavior and cytogenetics. Genetics. 1988;118:267-85 pubmed
  41. Pflugfelder G. Genetic lesions in Drosophila behavioural mutants. Behav Brain Res. 1998;95:3-15 pubmed
    ..Various mutagens are reviewed as to their suitability in inducing selective regulatory mutations. ..
  42. Pimmett V, Deng H, Haskins J, Mercier R, LaPointe P, Simmonds A. The activity of the Drosophila Vestigial protein is modified by Scalloped-dependent phosphorylation. Dev Biol. 2017;425:58-69 pubmed publisher
    ..Vestigial is part of a multi-protein transcription factor complex, which includes Scalloped, a TEAD-class DNA binding protein...
  43. Caine C, Kasherov P, Silber J, Lalouette A. Mef2 interacts with the Notch pathway during adult muscle development in Drosophila melanogaster. PLoS ONE. 2014;9:e108149 pubmed publisher
    ..Furthermore, the Myocyte Enhancing Factor 2 (Mef2), Vestigial (Vg) and Scalloped (Sd) transcription factors are necessary for IFM development and that Vg is required for Notch pathway ..
  44. Miotto B, Sagnier T, Bérenger H, Bohmann D, Pradel J, Graba Y. Chameau HAT and DRpd3 HDAC function as antagonistic cofactors of JNK/AP-1-dependent transcription during Drosophila metamorphosis. Genes Dev. 2006;20:101-12 pubmed
    ..This study establishes a direct link among JNK signaling, DFos phosphorylation, chromatin modification, and AP-1-dependent transcription and its importance in a developing organism. ..
  45. Guo T, Lu Y, Li P, Yin M, Lv D, Zhang W, et al. A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity. Cell Res. 2013;23:1201-14 pubmed publisher
    ..regulating the activity of transcriptional co-activator Yorkie (Yki), which associates with transcription factor Scalloped (Sd) in the nucleus to promote downstream target gene expression...
  46. Zhang X, Milton C, Poon C, Hong W, Harvey K. Wbp2 cooperates with Yorkie to drive tissue growth downstream of the Salvador-Warts-Hippo pathway. Cell Death Differ. 2011;18:1346-55 pubmed publisher
    ..together with Yorkie to drive transcription and tissue growth are beginning to be revealed and include the Scalloped (Sd), Teashirt (Tsh) and Homothorax (Hth) transcription factors...
  47. Curtiss J, Halder G, Mlodzik M. Selector and signalling molecules cooperate in organ patterning. Nat Cell Biol. 2002;4:E48-51 pubmed
    ..Such enhancers include autoregulatory enhancers of the selector genes themselves, which drive the refinement of expression patterns of selector genes. ..
  48. Affolter M, Mann R. Development. Legs, eyes, or wings--selectors and signals make the difference. Science. 2001;292:1080-1 pubmed
  49. Schönbauer C, Distler J, Jährling N, Radolf M, Dodt H, Frasch M, et al. Spalt mediates an evolutionarily conserved switch to fibrillar muscle fate in insects. Nature. 2011;479:406-9 pubmed publisher
    ..We propose that Spalt proteins switch myofibres from tubular to fibrillar fate during development, a function potentially conserved in the vertebrate heart--a stretch-activated muscle sharing features with insect flight muscle. ..
  50. Ray A, Van der Goes van Naters W, Carlson J. A regulatory code for neuron-specific odor receptor expression. PLoS Biol. 2008;6:e125 pubmed
    ..We identified a transcription factor, Scalloped, that mediates repression...
  51. González I, Simón R, Busturia A. The Polyhomeotic protein induces hyperplastic tissue overgrowth through the activation of the JAK/STAT pathway. Cell Cycle. 2009;8:4103-11 pubmed
    ..Our results show a functional relationship between the PcG gene expression and the JAK/STAT pathway, both of which are found to be perturbed in tumorigenesis. ..
  52. Levis R, Hazelrigg T, Rubin G. Separable cis-acting control elements for expression of the white gene of Drosophila. EMBO J. 1985;4:3489-99 pubmed
    ..1 to 1.9 kb upstream from the 5' end of the white transcript which are required for expression in the testes and interaction of white and zeste-1. The same or other elements in this region appear to augment the pigmentation of the eye. ..
  53. Wandler A, Guillemin K. Transgenic expression of the Helicobacter pylori virulence factor CagA promotes apoptosis or tumorigenesis through JNK activation in Drosophila. PLoS Pathog. 2012;8:e1002939 pubmed publisher
    ..These data suggest a potential role for CagA-mediated JNK pathway activation in promoting gastric cancer progression. ..
  54. Bray S. Drosophila development: Scalloped and Vestigial take wing. Curr Biol. 1999;9:R245-7 pubmed
    The proteins Scalloped and Vestigial are known from genetic studies to play a part in Drosophila wing development...
  55. Pastor Pareja J, Xu T. Shaping cells and organs in Drosophila by opposing roles of fat body-secreted Collagen IV and perlecan. Dev Cell. 2011;21:245-56 pubmed publisher
    ..Our results uncover incorporation of Collagen IV and Perlecan into BMs as a major determinant of organ shape and animal form. ..
  56. Kavi H, Fernandez H, Xie W, Birchler J. Polycomb, pairing and PIWI--RNA silencing and nuclear interactions. Trends Biochem Sci. 2006;31:485-7 pubmed
    ..These Pc-associated sequences are involved with the control of the proper expression of developmental HOX genes. ..
  57. Seppa M, Johnson R, Bao S, Cagan R. Polychaetoid controls patterning by modulating adhesion in the Drosophila pupal retina. Dev Biol. 2008;318:1-16 pubmed publisher
    ..Our results suggest that Pyd modulates adherens junction strength and Roughest-mediated preferential cell adhesion. ..
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    ..In light of the shibire phenotype, we suggest that these proteins provide the motor for vesicular transport during endocytosis. ..
  59. Schug M, Mackay T, Aquadro C. Low mutation rates of microsatellite loci in Drosophila melanogaster. Nat Genet. 1997;15:99-102 pubmed
    ..3 x 10(-6), a mutation rate considerably lower than reported for various mammals. We propose that the comparatively low mutation rate is primarily a function of short microsatellite repeat lengths in the D. melanogaster genome. ..
  60. Varadarajan S, Vijayraghavan K. scalloped functions in a regulatory loop with vestigial and wingless to pattern the Drosophila wing. Dev Genes Evol. 1999;209:10-7 pubmed
    ..Notch-mediated signalling is required for the expression of the genes vestigial and scalloped in the presumptive wing blade...
  61. Moehring A, Li J, Schug M, Smith S, deAngelis M, Mackay T, et al. Quantitative trait loci for sexual isolation between Drosophila simulans and D. mauritiana. Genetics. 2004;167:1265-74 pubmed publisher
    ..The observation of a few QTL with moderate to large effects will facilitate positional cloning of genes underlying sexual isolation...
  62. Huang H, Li J, Hu L, Ge L, Ji H, Zhao Y, et al. Bantam is essential for Drosophila intestinal stem cell proliferation in response to Hippo signaling. Dev Biol. 2014;385:211-9 pubmed publisher
  63. Canudas S, Perez S, Fanti L, Pimpinelli S, Singh N, Hanes S, et al. dSAP18 and dHDAC1 contribute to the functional regulation of the Drosophila Fab-7 element. Nucleic Acids Res. 2005;33:4857-64 pubmed
    ..These results indicate a contribution of GAGA, dSAP18 and dRPD3/HDAC1 to the regulation of Fab-7 function. ..
  64. Gaspar P, Holder M, Aerne B, Janody F, Tapon N. Zyxin antagonizes the FERM protein expanded to couple F-actin and Yorkie-dependent organ growth. Curr Biol. 2015;25:679-689 pubmed publisher
    ..promotes the interaction between the transcriptional co-activator Yorkie (Yki) and the transcription factor Scalloped (Sd), leading to activation of Yki target gene expression and promoting tissue growth...
  65. Delanoue R, Zider A, Cossard R, Dutriaux A, Silber J. Interaction between apterous and early expression of vestigial in formation of the dorso-ventral compartments in the Drosophila wing disc. Genes Cells. 2002;7:1255-66 pubmed
    ..Normal cell proliferation is necessary for ap expression at the level of the D/V boundary. This would be mediated by vg, which interacts in a dose-dependent way with ap. ..
  66. Ghazi A, Paul L, Vijayraghavan K. Prepattern genes and signaling molecules regulate stripe expression to specify Drosophila flight muscle attachment sites. Mech Dev. 2003;120:519-28 pubmed
    ..The Wg signal differentially influences the formation of different sr domains. These results identify the multiple regulatory elements involved in the positioning of Drosophila flight muscle attachment sites. ..
  67. Hing H, Bangalore L, Sun X, Artavanis Tsakonas S. Mutations in the heatshock cognate 70 protein (hsc4) modulate Notch signaling. Eur J Cell Biol. 1999;78:690-7 pubmed
    ..the known Notch signaling modulators Notch, Delta and mastermind we isolated alleles in vestigial, wingless, scalloped and clipped, genes known to affect wing morphogenesis...
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    ..The sterility was efficiently rescued by an autosomal copy of the wild-type Chc gene reintroduced on a P element. These findings suggest a specialized role for clathrin in spermatogenesis. ..
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