Gene Symbol: Scsalpha
Description: Succinyl coenzyme A synthetase alpha subunit
Alias: CG1065, Dmel\CG1065, Scs-alpha, scsalpha, succinyl coenzyme A synthetase alpha subunit, CG1065-PA, CG1065-PB, Scsalpha-PA, Scsalpha-PB, succinyl coenzyme A synthatase, alpha subunit, succinyl-CoA synthetase alpha-subunit
Species: fruit fly
Caggese C, Ragone G, Perrini B, Moschetti R, De Pinto V, Caizzi R, et al
. Identification of nuclear genes encoding mitochondrial proteins: isolation of a collection of D. melanogaster cDNAs homologous to sequences in the Human Gene Index database. Mol Gen Genet. 1999;261:64-70 pubmed
..Our experimental strategy represents an efficient approach to the identification and interspecies comparison of genes encoding products targeted to the mitochondrion. ..
Barry W, Thummel C. The Drosophila HNF4 nuclear receptor promotes glucose-stimulated insulin secretion and mitochondrial function in adults. elife. 2016;5: pubmed publisher
..These findings establish an animal model for MODY1 and define a developmental reprogramming of metabolism to support the energetic needs of the mature animal. ..
Van Buskirk C, Hawkins N, Schupbach T. Encore is a member of a novel family of proteins and affects multiple processes in Drosophila oogenesis. Development. 2000;127:4753-62 pubmed
..We argue that the enc mutant phenotypes reflect a role for Enc in the regulation of several RNA targets. ..
Lim D, Lee L, Oh C, Kim N, Hwang S, Han S, et al
. Microarray analysis of Drosophila dicer-2 mutants reveals potential regulation of mitochondrial metabolism by endogenous siRNAs. J Cell Biochem. 2013;114:418-27 pubmed publisher
..Our data support a potential role for the endo-siRNA pathway in energy homeostasis through regulation of mitochondrial metabolism. ..
Choo A, O Keefe L, Lee C, Gregory S, Shaukat Z, Colella A, et al
. Tumor suppressor WWOX moderates the mitochondrial respiratory complex. Genes Chromosomes Cancer. 2015;54:745-61 pubmed publisher
..Thus, the ability of WWOX to facilitate escape from mitochondrial damage-induced glycolysis (Warburg effect) is, therefore, a plausible mechanism for its tumor suppressor activity. ..
Quan X, Sato Miyata Y, Tsuda M, Muramatsu K, Asano T, Takeo S, et al
. Deficiency of succinyl-CoA synthetase ? subunit delays development, impairs locomotor activity and reduces survival under starvation in Drosophila. Biochem Biophys Res Commun. 2017;483:566-571 pubmed publisher
..To investigate the impact of SCS deficiencies in Drosophila, we generated a null mutation in Scs alpha subunit (Scs?) using the CRISPR/Cas9 system, and characterized their phenotype...