Gene Symbol: Scox
Description: Synthesis of cytochrome c oxidase
Alias: CG8885, Dmel\CG8885, SCO, SCO1, SCOX, dSco1, l(2)SH1783, l(2)SH2 1783, scox, synthesis of cytochrome c oxidase, CG8885-PA, SCO1 protein homolog, Scox-PA, lethal (2) SH1783, synthesis of cytochrome c oxidase X
Species: fruit fly
Southon A, Burke R, Norgate M, Batterham P, Camakaris J. Copper homoeostasis in Drosophila melanogaster S2 cells. Biochem J. 2004;383:303-9 pubmed
..of yeast ATX1), CCS (copper chaperone for superoxide dismutase), COX17 (a human orthologue of yeast COX17), and SCO1 and SCO2, did not significantly respond transcriptionally to increased Cu levels, whereas MtnA, MtnB and MtnD (..
Porcelli D, Oliva M, Duchi S, Latorre D, Cavaliere V, Barsanti P, et al
. Genetic, functional and evolutionary characterization of scox, the Drosophila melanogaster ortholog of the human SCO1 gene. Mitochondrion. 2010;10:433-48 pubmed publisher
..Mutations in the two human SCO-encoding genes, SCO1 and SCO2, produce tissue-specific COX deficiencies associated with distinct clinical phenotypes...
Nguyen T, Ida H, Shimamura M, Kitazawa D, Akao S, Yoshida H, et al
. Role of SCOX in determination of Drosophila melanogaster lifespan. Am J Cancer Res. 2014;4:325-36 pubmed
..b>Synthesis of cytochrome c oxidase X (SCOX) is a Drosophila orthologue of human SCO2...
MartÃnez Morentin L, MartÃnez L, Piloto S, Yang H, Schon E, Garesse R, et al
. Cardiac deficiency of single cytochrome oxidase assembly factor scox induces p53-dependent apoptosis in a Drosophila cardiomyopathy model. Hum Mol Genet. 2015;24:3608-22 pubmed publisher
..mechanisms that underlie the cardiomyopathy associated with Sco deficiency, we have heart specifically interfered scox expression, the single Drosophila Sco orthologue...
Huang Y, Xie J, Wang T. A Fluorescence-Based Genetic Screen to Study Retinal Degeneration in Drosophila. PLoS ONE. 2015;10:e0144925 pubmed publisher
..Our findings demonstrate that this "Rh1::GFP ey-flp/hid" method enables high-throughput F1 genetic screens to rapidly and precisely identify mutations of retinal degeneration. ..
Binks T, Lye J, Camakaris J, Burke R. Tissue-specific interplay between copper uptake and efflux in Drosophila. J Biol Inorg Chem. 2010;15:621-8 pubmed publisher
..We also find that the copper chaperone dSco1 appears necessary for supplying the mitochondria with copper in these tissues...
de la Cova C, Senoo Matsuda N, Ziosi M, Wu D, Bellosta P, Quinzii C, et al
. Supercompetitor status of Drosophila Myc cells requires p53 as a fitness sensor to reprogram metabolism and promote viability. Cell Metab. 2014;19:470-83 pubmed publisher
..Our findings suggest that the initial confrontation between precancerous and WT cells could enhance cancer cell fitness and promote tumor progression. ..