Sb

Summary

Gene Symbol: Sb
Description: Stubble
Alias: CG4316, Dmel\CG4316, SP56, Sb-sbd, c-SP56, sbd, st-sb, CG4316-PA, Sb-PA, Stubble-stubbloid, stubble, stubbloid
Species: fruit fly

Top Publications

  1. pmc Weakener of white (Wow), a gene that modifies the expression of the white eye color locus and that suppresses position effect variegation in Drosophila melanogaster
    J A Birchler
    Division of Biological Sciences, University of Missouri, Columbia 65211
    Genetics 137:1057-70. 1994
  2. pmc Genetic modifier screens in Drosophila demonstrate a role for Rho1 signaling in ecdysone-triggered imaginal disc morphogenesis
    Robert E Ward
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112 5331, USA
    Genetics 165:1397-415. 2003
  3. doi Mating density and the strength of sexual selection against deleterious alleles in Drosophila melanogaster
    Nathaniel P Sharp
    Department of Ecology and Evolutionary Biology, University of Toronto, 25 Harbord Street, Toronto, ON, Canada, M5S 3G5
    Evolution 62:857-67. 2008
  4. ncbi Apical cell shape changes during Drosophila imaginal leg disc elongation: a novel morphogenetic mechanism
    M L Condic
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Development 111:23-33. 1991
  5. ncbi Rho-LIM kinase signaling regulates ecdysone-induced gene expression and morphogenesis during Drosophila metamorphosis
    Guang Chao Chen
    Massachusetts General Hospital Cancer Center and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Curr Biol 14:309-13. 2004
  6. pmc Three neighboring genes interact with the Broad-Complex and the Stubble-stubbloid locus to affect imaginal disc morphogenesis in Drosophila
    P J Gotwals
    Department of Molecular and Cellular Biology, University of California, Berkeley 94720
    Genetics 127:747-59. 1991
  7. pmc Genetic interactions between the RhoA and Stubble-stubbloid loci suggest a role for a type II transmembrane serine protease in intracellular signaling during Drosophila imaginal disc morphogenesis
    Cynthia A Bayer
    Department of Biology, University of Central Florida, Orlando, Florida 32816 2368, USA
    Genetics 165:1417-32. 2003
  8. ncbi The Drosophila jumonji gene encodes a JmjC-containing nuclear protein that is required for metamorphosis
    Nobuhiro Sasai
    Venture Laboratory, Kyoto Institute of Technology, Japan
    FEBS J 274:6139-51. 2007
  9. doi Selection, epistasis, and parent-of-origin effects on deleterious mutations across environments in Drosophila melanogaster
    Alethea D Wang
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario M5S3B2, Canada
    Am Nat 174:863-74. 2009
  10. pmc Overlapping roles of Drosophila Drak and Rok kinases in epithelial tissue morphogenesis
    Dagmar Neubueser
    Institut de Recherches Cliniques de Montreal, Montreal, QC, Canada
    Mol Biol Cell 21:2869-79. 2010

Research Grants

Scientific Experts

  • J M Mason
  • Sean C A Clark
  • Alethea D Wang
  • Nathaniel P Sharp
  • Ralph J Greenspan
  • FABRICE J ROEGIERS
  • W J Dickinson
  • E B Lewis
  • Pascal Heitzler
  • Michael J Palladino
  • David Coates
  • Lewis G Tilney
  • Robert E Ward
  • Azadeh Laffafian
  • Dagmar Neubueser
  • Xingwu Lu
  • Kistie Patch
  • Delphine Fagegaltier
  • Biao He
  • Luisa Di Stefano
  • Nobuhiro Sasai
  • Ann S Hammonds
  • James W Fristrom
  • D A Sinclair
  • Guang Chao Chen
  • T A Grigliatti
  • Gregory M Guild
  • Patricia S Connelly
  • Linda Ruggiero
  • Kelly A Vranich
  • Tina M Fortier
  • Cynthia A Bayer
  • Paul N Adler
  • Xiaoyin Fei
  • Y Lu
  • R Mollaaghababa
  • R Mottus
  • Aneil F Agrawal
  • James D King
  • David R Hipfner
  • M M Green
  • Alexander Y Konev
  • Bassam Berry
  • Anne Laure Bouge
  • Dmitry V Fyodorov
  • Laurent Théodore
  • Patrick Morcillo
  • Emilie Poisot
  • Christophe Antoniewski
  • Jean Yves Coppee
  • Odile Sismeiro
  • Olivier Voinnet
  • Shannon R Stewart
  • Sandeep N Wontakal
  • Alexander V Emelyanov
  • Aaron Welch
  • Arthur I Skoultchi
  • M A Crosby
  • H K Hing
  • Takashi Takeuchi
  • Yasuko Kato
  • Jun Yuan Ji
  • Gaku Kimura
  • Masamitsu Yamaguchi
  • Nicholas Dyson
  • Anabel Herr
  • Nam Sung Moon
  • V K Lloyd
  • P P D'Avino
  • B E Staveley
  • J T Littleton
  • David J Derosier
  • Jeffrey Settleman
  • David Derosier
  • R L Abu-Shumays
  • Patrycja Gajowniczek
  • F J Cifuentes
  • Priya P Vasa
  • K V Anderson
  • Susan R Halsell
  • Craig T Woodard
  • Laurence von Kalm
  • Daniel P Kiehart
  • Janelle Evans
  • Carl S Thummel
  • J A Birchler
  • L P Wu
  • L Sipos
  • J A Armstrong
  • S Y Tiong

Detail Information

Publications67

  1. pmc Weakener of white (Wow), a gene that modifies the expression of the white eye color locus and that suppresses position effect variegation in Drosophila melanogaster
    J A Birchler
    Division of Biological Sciences, University of Missouri, Columbia 65211
    Genetics 137:1057-70. 1994
    ..There are many dosage sensitive suppressors of position effect variegation and many dosage-sensitive modifiers of gene expression. The Wow mutations provide evidence for an overlap between the two types of modifiers...
  2. pmc Genetic modifier screens in Drosophila demonstrate a role for Rho1 signaling in ecdysone-triggered imaginal disc morphogenesis
    Robert E Ward
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112 5331, USA
    Genetics 165:1397-415. 2003
    ..Rho1, stubbloid, blistered (DSRF), and cytoplasmic Tropomyosin were identified from these screens as br1-interacting genes...
  3. doi Mating density and the strength of sexual selection against deleterious alleles in Drosophila melanogaster
    Nathaniel P Sharp
    Department of Ecology and Evolutionary Biology, University of Toronto, 25 Harbord Street, Toronto, ON, Canada, M5S 3G5
    Evolution 62:857-67. 2008
    ..In most cases, sexual selection is as strong or stronger than these other forms of selection...
  4. ncbi Apical cell shape changes during Drosophila imaginal leg disc elongation: a novel morphogenetic mechanism
    M L Condic
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Development 111:23-33. 1991
    ..The conversion of a stable population of anisometric cells to isometric dimensions constitutes a novel mechanism for altering the proportions of an epithelial sheet during development...
  5. ncbi Rho-LIM kinase signaling regulates ecdysone-induced gene expression and morphogenesis during Drosophila metamorphosis
    Guang Chao Chen
    Massachusetts General Hospital Cancer Center and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Curr Biol 14:309-13. 2004
    ..genes, including those encoding the ecdysone receptor itself, a downstream transcription factor (Br-C), and Stubble, a transmembrane protease required for proper leg formation...
  6. pmc Three neighboring genes interact with the Broad-Complex and the Stubble-stubbloid locus to affect imaginal disc morphogenesis in Drosophila
    P J Gotwals
    Department of Molecular and Cellular Biology, University of California, Berkeley 94720
    Genetics 127:747-59. 1991
    ..Alleles of the Stubble-stubbloid (Sb-sbd) locus at 89B9-10 act as dominant enhancers of broad alleles of the BR-C...
  7. pmc Genetic interactions between the RhoA and Stubble-stubbloid loci suggest a role for a type II transmembrane serine protease in intracellular signaling during Drosophila imaginal disc morphogenesis
    Cynthia A Bayer
    Department of Biology, University of Central Florida, Orlando, Florida 32816 2368, USA
    Genetics 165:1417-32. 2003
    ..here that mutations affecting the RhoA signaling pathway also interact genetically with mutations in the Stubble-stubbloid (Sb-sbd) locus that encodes an unusual type II transmembrane serine protease required for normal leg and wing ..
  8. ncbi The Drosophila jumonji gene encodes a JmjC-containing nuclear protein that is required for metamorphosis
    Nobuhiro Sasai
    Venture Laboratory, Kyoto Institute of Technology, Japan
    FEBS J 274:6139-51. 2007
    ..Furthermore, mutation in djmj suppresses position effect variegation of the T(2;3)Sb(V) rearrangement...
  9. doi Selection, epistasis, and parent-of-origin effects on deleterious mutations across environments in Drosophila melanogaster
    Alethea D Wang
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario M5S3B2, Canada
    Am Nat 174:863-74. 2009
    ..e., epistasis becomes more positive). In addition, we find a high incidence of indirect genetic effects whereby the strength of selection against the alleles carried by offspring is dependent on the genotypes of their parents...
  10. pmc Overlapping roles of Drosophila Drak and Rok kinases in epithelial tissue morphogenesis
    Dagmar Neubueser
    Institut de Recherches Cliniques de Montreal, Montreal, QC, Canada
    Mol Biol Cell 21:2869-79. 2010
    ..These results provide the first evidence that DAPK family kinases regulate actin dynamics in vivo and identify Drak as a novel component of the signaling networks that shape epithelial tissues...
  11. doi Variation in the strength and softness of selection on deleterious mutations
    Azadeh Laffafian
    Department of Ecology and Evolutionary Biology, University of Toronto, 25 Willcocks Street, Toronto, Ontario M5S 3B2, Canada
    Evolution 64:3232-41. 2010
    ..A model is presented showing that the sensitivities of mutants and wild types to local competitors differentially affect equilibrium mutation frequency and measures of load...
  12. pmc Relative effectiveness of mating success and sperm competition at eliminating deleterious mutations in Drosophila melanogaster
    Sean C A Clark
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 7:e37351. 2012
    ..Establishing whether the various stages of sexual selection affect deleterious mutations differently, and to what extent, remains an important issue to resolve...
  13. pmc Temperature-sensitive paralytic mutants are enriched for those causing neurodegeneration in Drosophila
    Michael J Palladino
    Laboratory of Genetics, University of Wisconsin, Madison, WI 53706, USA
    Genetics 161:1197-208. 2002
    ..Further studies of vacu and the other neurodegenerative mutants isolated should ultimately help dissect the biochemical pathways leading to neurodegeneration...
  14. ncbi The genetic control of arista lateral morphogenesis in Drosophila
    Biao He
    Biology Department and Cancer Center, University of Virginia, Charlottesville, VA 22903, USA
    Dev Genes Evol 212:218-29. 2002
    ..We also found that mutations that lead to lateral splitting typically alter the stereotypic arrangement of actin filament bundles and microtubules in laterals...
  15. pmc Mutations in Drosophila heat shock cognate 4 are enhancers of Polycomb
    R Mollaaghababa
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:3958-63. 2001
    ..HSC4 might be needed for the proper folding of a component of the Polycomb repression complex, or it may be a functional member of that complex...
  16. pmc The antibacterial arm of the drosophila innate immune response requires an IkappaB kinase
    Y Lu
    Molecular Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Genes Dev 15:104-10. 2001
    ..The ird5 gene encodes a Drosophila homolog of mammalian IkappaB kinases (IKKs). The ird5 phenotype and sequence suggest that the gene is specifically required for the activation of Relish, a Drosophila NF-kappaB family member...
  17. pmc On the origin of metacentric, attached-X (A-X) chromosomes in Drosophila melanogaster males
    M M Green
    Section of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 97:14484-7. 2000
    ..The inseparabile mutation also affects disjunction of the chromosome 4 in males. We suspect that the mutation was responsible for the original A-X female found by L. V. Morgan in 1921...
  18. ncbi Exploring the Caenorhabditis elegans and Drosophila melanogaster genomes to understand neuropeptide and peptidase function
    D Coates
    School of Biology, University of Leeds, Leeds LS2 9JT, U K
    Biochem Soc Trans 28:464-9. 2000
    ....
  19. pmc Mutational analysis of a histone deacetylase in Drosophila melanogaster: missense mutations suppress gene silencing associated with position effect variegation
    R Mottus
    Department of Zoology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
    Genetics 154:657-68. 2000
    ..We propose that the missense mutations reported here are acting as antimorphic mutations that "poison" the deacetylase complex and propose a model that accounts for the various phenotypes associated with lesions in the deacetylase locus...
  20. ncbi Mutations in the heatshock cognate 70 protein (hsc4) modulate Notch signaling
    H K Hing
    Department of Biological Chemistry, UCLA School of Medicine, Los Angeles, CA USA
    Eur J Cell Biol 78:690-7. 1999
    ..We discuss how hsc4, a gene thought to be involved in subcellular trafficking, may affect the number of functional Notch receptors on the cell surface...
  21. pmc The trithorax group gene moira encodes a brahma-associated putative chromatin-remodeling factor in Drosophila melanogaster
    M A Crosby
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Mol Cell Biol 19:1159-70. 1999
    ..These observations provide a molecular explanation for the phenotypic and genetic relationships among several of the trxG genes by suggesting that they encode evolutionarily conserved components of a chromatin-remodeling complex...
  22. ncbi Temperature-sensitive paralytic mutations demonstrate that synaptic exocytosis requires SNARE complex assembly and disassembly
    J T Littleton
    Laboratory of Genetics, University of Wisconsin, Madison 53706, USA
    Neuron 21:401-13. 1998
    ..These results provide in vivo evidence that cycles of assembly and disassembly of SNARE complexes drive membrane trafficking at synapses...
  23. ncbi The growth of Drosophila bristles and laterals is not restricted to the tip or base
    Xiaoyin Fei
    Biology Department and Cancer Center, University of Virginia, Charlottesville, VA 22903, USA
    J Cell Sci 115:3797-806. 2002
    ..The bristle microtubules are less stable. The retrograde movement of the peripheral actin appears to be counterbalanced by the distally directed movement of cytoplasm in the center of the bristle...
  24. ncbi Orphan nuclear receptor betaFTZ-F1 is required for muscle-driven morphogenetic events at the prepupal-pupal transition in Drosophila melanogaster
    Tina M Fortier
    Department of Biological Sciences, Mount Holyoke College, South Hadley, MA 01075, USA
    Dev Biol 257:153-65. 2003
    ..Our findings indicate that betaFTZ-F1 directs the muscle contraction events that drive the major morphogenetic processes during the prepupal-pupal transition in Drosophila...
  25. pmc Actin filament turnover regulated by cross-linking accounts for the size, shape, location, and number of actin bundles in Drosophila bristles
    Lewis G Tilney
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6018, USA
    Mol Biol Cell 14:3953-66. 2003
    ..As a result, filament turnover plays an important role in regulating cytoskeleton assembly and consequently cell shape...
  26. pmc The endogenous siRNA pathway is involved in heterochromatin formation in Drosophila
    Delphine Fagegaltier
    Centre National de la Recherche Scientifique, Unité de Recherche Associée 2578, Institut Pasteur, 25 rue du Dr Roux, F75015 Paris, France
    Proc Natl Acad Sci U S A 106:21258-63. 2009
    ..Similar effects were observed in dcr2, r2d2, and ago2 mutants. Our findings provide evidence that a nuclear pool of TE-derived endo-siRNAs is involved in heterochromatin formation in somatic tissues in Drosophila...
  27. pmc A second-site noncomplementation screen for modifiers of Rho1 signaling during imaginal disc morphogenesis in Drosophila
    Kistie Patch
    Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA
    PLoS ONE 4:e7574. 2009
    ....
  28. pmc Linker histone H1 is essential for Drosophila development, the establishment of pericentric heterochromatin, and a normal polytene chromosome structure
    Xingwu Lu
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Genes Dev 23:452-65. 2009
    ..Thus, linker histone H1 is essential in Drosophila and plays a fundamental role in the architecture and activity of chromosomes in vivo...
  29. pmc Spontaneous unequal exchange in the rosy region of Drosophila melanogaster
    W M Gelbart
    Genetics 92:849-59. 1979
    ....
  30. pmc Mutation of Drosophila Lsd1 disrupts H3-K4 methylation, resulting in tissue-specific defects during development
    Luisa Di Stefano
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Curr Biol 17:808-12. 2007
    ..Taken together, these results show that dLsd1-mediated H3-K4 demethylation has a significant and specific role in Drosophila development...
  31. pmc How to make a curved Drosophila bristle using straight actin bundles
    Lewis G Tilney
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 102:18785-92. 2005
    ....
  32. pmc Mutational analysis of Stubble-stubbloid gene structure and function in Drosophila leg and bristle morphogenesis
    Ann S Hammonds
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Genetics 172:1577-93. 2006
    The Stubble-stubbloid (Sb-sbd) gene is required for ecdysone-regulated epithelial morphogenesis of imaginal tissues during Drosophila metamorphosis...
  33. pmc Regulation of membrane localization of Sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs
    Fabrice Roegiers
    Howard Hughes Medical Institute and Department of Physiology and Biochemistry, University of California San Francisco, San Francisco, CA 94143 0725, USA
    Mol Biol Cell 16:3480-7. 2005
    ..This study identifies a hitherto unreported role for Lgl as a regulator of Sanpodo during asymmetric cell division in the adult PNS...
  34. pmc The role actin filaments play in providing the characteristic curved form of Drosophila bristles
    Lewis G Tilney
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104 6018, USA
    Mol Biol Cell 15:5481-91. 2004
    ..Thus, the pattern of bristle curvature is a product of both extrinsic factors-the socket cell and the inner pupal case--and intrinsic factors--actin cytoskeleton assembly...
  35. ncbi The varieties of selectional experience in behavioral genetics
    Ralph J Greenspan
    The Neurosciences Institute, San Diego, CA 92121, USA
    J Neurogenet 17:241-70. 2003
  36. ncbi The bithorax complex: the first fifty years
    E B Lewis
    Division of Biology, The California Institute of Technology, Pasadena 91125, USA
    Int J Dev Biol 42:403-15. 1998
  37. ncbi Genetic analysis of protein kinase B (AKT) in Drosophila
    B E Staveley
    Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Canada
    Curr Biol 8:599-602. 1998
    ..These data implicate Dakt1 as a cell survival gene in Drosophila, consistent with cell protection studies in mammals...
  38. pmc The Drosophila Stubble-stubbloid gene encodes an apparent transmembrane serine protease required for epithelial morphogenesis
    L F Appel
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Proc Natl Acad Sci U S A 90:4937-41. 1993
    The Stubble-stubbloid (Sb-sbd) gene is required for hormone-dependent epithelial morphogenesis of imaginal discs of Drosophila, including the formation of bristles, legs, and wings...
  39. ncbi The making of a fly leg: a model for epithelial morphogenesis
    L von Kalm
    University of California at Berkeley, Dept of Molecular and Cell Biology 94720 3200, USA
    Bioessays 17:693-702. 1995
    ..All of these products are required for the execution of normal changes in leg cell shape...
  40. ncbi [Interaction between genes Mos and mwh expressed in somatic cells of Drosophila melanogaster]
    N Ia Vaĭsman
    Genetika 31:358-62. 1995
    Gene Mosaic (Mos) of chromosome 3 of Drosophila melanogaster was located by means of dominant markers Ly, Sb, and Dr. This gene was shown to be located between Ly and Sb in the centromeric region (45-50 map units)...
  41. ncbi Information for the dorsal--ventral pattern of the Drosophila embryo is stored as maternal mRNA
    K V Anderson
    Nature 311:223-7. 1984
    ..Injection of RNA isolated from wild-type embryos into mutants at six loci partially restores dorsal-ventral polarity. For the mutant snake, injection of poly(A)+ RNA restores a complete dorsal-ventral pattern...
  42. ncbi Genetic analysis of a meiotic mutant resulting in precocious sister-centromere separation in Drosophila melanogaster
    B K Davis
    Mol Gen Genet 113:251-72. 1971
  43. pmc Interaction of the Stubble-stubbloid locus and the Broad-complex of Drosophila melanogaster
    A H Beaton
    Department of Genetics, University of California, Berkeley 94720
    Genetics 120:453-64. 1988
    ..The Stubble-stubbloid (Sb-sbd) locus at 89B9-10 is best known for the effects of its mutants on bristle structure...
  44. ncbi Characterization of mutations that enhance position-effect variegation in Drosophila melanogaster
    D A Sinclair
    Department of Zoology, University of British Columbia, Vancouver, Canada
    Mol Gen Genet 216:328-33. 1989
    ..Based on the results of these studies, various hypothetical functions of the E(var)+ products are suggested...
  45. pmc The relationship between P elements and male recombination in Drosophila melanogaster
    A Duttaroy
    Department of Molecular and Cell Biology, University of Connecticut, Storrs 06268
    Genetics 124:317-29. 1990
    ..We suggest that this region is measured in terms of chromosomal segments rather than limited to P element sequences...
  46. pmc Two types of genetic interaction implicate the whirligig gene of Drosophila melanogaster in microtubule organization in the flagellar axoneme
    L L Green
    Department of Molecular, University of Colorado, Boulder 80309 0347
    Genetics 126:961-73. 1990
    ..However, in post-meiotic stages, flagellar axonemes show loss of the accessory microtubule on the B-subfiber of outer doublet microtubules, outer triplet instead of outer doublet microtubules, and missing central pair microtubules...
  47. ncbi The choice of cell fate in the epidermis of Drosophila
    P Heitzler
    Unité 184 de Biologie Moléculaire, Génie Génétique de l INSERM, Faculte de Medecine, Strasbourg, France
    Cell 64:1083-92. 1991
    ..It also suggests that N acts as a receptor for an inhibitory signal emanating from the neural precursors...
  48. pmc A cytogenetic and genetic characterization of a group of closely linked second chromosome mutations that suppress position-effect variegation in Drosophila melanogaster
    D A Sinclair
    Department of Zoology, University of British Columbia, Canada
    Genetics 130:333-44. 1992
    ..We also report that two previously isolated mutants located in 31E and 31F-32A act as recessive suppressors of PEV...
  49. pmc Evidence for intrinsic differences in the formation of chromatin domains in Drosophila melanogaster
    C P Bishop
    Department of Biology, Clarkson University, Potsdam, New York 13676
    Genetics 132:1063-9. 1992
    ..These results are discussed with regard to spreading heterochromatin and the role this process may play in regulating gene expression...
  50. ncbi Cytogenetic analysis of chromosome region 89A of Drosophila melanogaster: isolation of deficiencies and mapping of Po, Aldox-1 and transposon insertions
    C R Nelson
    Department of Biological Chemistry, Milton S Hershey Medical Center, Pennsylvania State University, Hershey 17033
    Mol Gen Genet 235:11-21. 1992
    ..loci Po and Aldox-1, the indirect flight muscle genes Tm2 and act88F, the morphological mutations jvl, sbd2 and Sb, the vital loci srp, pnr and mor, and a newly described vital locus l(3)89Aa...
  51. pmc Cytogenic analysis of chromosome 3 in Drosophila melanogaster: mapping of the proximal portion of the right arm
    I W Duncan
    Genetics 80:733-52. 1975
    ....
  52. ncbi Harnessing the power of Drosophila genetics
    M F Wolfner
    Section of Genetics and Development, Cornell University, Ithaca, New York 14853
    Methods Cell Biol 44:33-80. 1994
  53. ncbi Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles
    D M Glover
    Department of Anatomy and Physiology, University of Dundee, Scotland
    Cell 81:95-105. 1995
    ..The size of the single centrosomal body in these circular figures suggests that loss of function of the serine-threonine protein kinase encoded by aur leads to a failure of the centrosomes to separate and form a bipolar spindle...
  54. ncbi crooked legs encodes a family of zinc finger proteins required for leg morphogenesis and ecdysone-regulated gene expression during Drosophila metamorphosis
    P P D'Avino
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112 5331, USA
    Development 125:1733-45. 1998
    ..The genetic criteria described here provide a new direction for identifying regulators of adult tissue development during insect metamorphosis...
  55. pmc Enhancer of Polycomb is a suppressor of position-effect variegation in Drosophila melanogaster
    D A Sinclair
    IMBB, Simon Fraser University, Burnaby, British Columbia, Canada
    Genetics 148:211-20. 1998
    ..in E(Pc), an unusual member of the PcG, suppress PEV of four variegating rearrangements: In(l)wm4, B(SV), T(2;3)Sb(V) and In(2R)bw(VDe2)...
  56. pmc Proximo-distal specification in the wing disc of Drosophila by the nubbin gene
    F J Cifuentes
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Cantoblanco 28049 Madrid, Spain
    Proc Natl Acad Sci U S A 94:11405-10. 1997
    ..We discuss the role of nub in the wing's proximo-distal axis and in the formation of compartment boundaries...
  57. ncbi Morphogenesis of denticles and hairs in Drosophila embryos: involvement of actin-associated proteins that also affect adult structures
    W J Dickinson
    Department of Biology, University of Utah, Salt Lake City 84112, USA
    Cell Motil Cytoskeleton 38:9-21. 1997
    ..We suggest that interactions between these and other actin-associated proteins are important in generating the diverse shapes of the cuticular specializations seen in both larvae and adults...
  58. pmc Germ-line effects of a mutator, mu2, in Drosophila melanogaster
    J M Mason
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 2233, USA
    Genetics 146:1381-97. 1997
    ..We propose that mu2 affects chromosomal structure during oogenesis, thereby modulating DNA repair...
  59. ncbi IMP-L3, A 20-hydroxyecdysone-responsive gene encodes Drosophila lactate dehydrogenase: structural characterization and developmental studies
    R L Abu-Shumays
    Graduate Group in Endocrinology, University of California, Berkeley 94720, USA
    Dev Genet 20:11-22. 1997
    ..Embryos deficient for the 65A-b region lack LDH activity. We conclude that IMP-L3 is the only gene that encodes LDH in Drosophila...
  60. pmc Competition between different variegating rearrangements for limited heterochromatic factors in Drosophila melanogaster
    V K Lloyd
    Department of Zoology, University of British Columbia, Vancouver, Canada
    Genetics 145:945-59. 1997
    ..Consequently, even nonvariegation portions of the genome will be disrupted by re-allocation of heterochromatic proteins associated with PEV. These results have implications for models of PEV...
  61. pmc A genetic analysis of pannier, a gene necessary for viability of dorsal tissues and bristle positioning in Drosophila
    P Heitzler
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
    Genetics 143:1271-86. 1996
    ..A large number of alleles have been studied and reveal that pannier may have opposing effects on the expression of achaete and scute leading to a loss or a gain of bristles...
  62. pmc Characterization of the mus308 gene in Drosophila melanogaster
    E A Leonhardt
    Department of Genetics, University of California, Davis 95616
    Genetics 133:87-96. 1993
    ..In addition, observations of elevated embryo mortality are potentially explained by an aberrant distribution of nuclear material in early embryos which is similar to that seen in the mutant giant nuclei...
  63. ncbi Expansions of transgene repeats cause heterochromatin formation and gene silencing in Drosophila
    D R Dorer
    Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Cell 77:993-1002. 1994
    ..We propose that pairing of repeats underlies heterochromatin formation and is responsible for diverse gene silencing phenomena in animals and plants...
  64. pmc Drosophila P element transposase induces male recombination additively and without a requirement for P element excision or insertion
    M McCarron
    Department of Molecular and Cell Biology, University of Connecticut, Storrs 06269 2131
    Genetics 136:1013-23. 1994
    ..Crossovers increased 58-fold in the immediate region of the P element target...
  65. pmc The Lighten up (Lip) gene of Drosophila melanogaster, a modifier of retroelement expression, position effect variegation and white locus insertion alleles
    A K Csink
    Division of Biological Sciences, University of Missouri, Columbia 65211
    Genetics 138:153-63. 1994
    ..Additionally, Lip modifies the total transcript abundance of both the blood and copia retrotransposons, having an inverse effect on the steady state level of blood transcripts, while showing a non-additive effect on copia RNA...
  66. ncbi Developmental regulation of expression and activity of multiple forms of the Drosophila RAC protein kinase
    M Andjelkovic
    Friedrich Miescher Institut, Basel, Switzerland
    J Biol Chem 270:4066-75. 1995
    ..DRAC-PK possesses an intrinsic kinase activity that is approximately 8-fold higher in adult flies than in 0-3-h embryos undergoing rapid mitotic cycles...
  67. ncbi Studies of l(3)c43hs1 a polyphasic, temperature-sensitive mutant of Drosophila melanogaster with a variety of imaginal disc defects
    P Martin
    Dev Biol 55:213-32. 1977

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