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Genomes and GenesSpecies | SbSummaryGene Symbol: Sb Description: Stubble Alias: CG4316, Dmel\CG4316, SP56, Sb-sbd, c-SP56, sbd, st-sb, CG4316-PA, Sb-PA, Stubble-stubbloid, stubble, stubbloid Species: fruit fly Top Publications
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Publications
Weakener of white (Wow), a gene that modifies the expression of the white eye color locus and that suppresses position effect variegation in Drosophila melanogasterJ A Birchler
Division of Biological Sciences, University of Missouri, Columbia 65211
Genetics 137:1057-70. 1994..There are many dosage sensitive suppressors of position effect variegation and many dosage-sensitive modifiers of gene expression. The Wow mutations provide evidence for an overlap between the two types of modifiers...- Genetic modifier screens in Drosophila demonstrate a role for Rho1 signaling in ecdysone-triggered imaginal disc morphogenesisRobert E Ward
Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112 5331, USA
Genetics 165:1397-415. 2003..Rho1, stubbloid, blistered (DSRF), and cytoplasmic Tropomyosin were identified from these screens as br1-interacting genes... - Genetic interactions between the RhoA and Stubble-stubbloid loci suggest a role for a type II transmembrane serine protease in intracellular signaling during Drosophila imaginal disc morphogenesisCynthia A Bayer
Department of Biology, University of Central Florida, Orlando, Florida 32816 2368, USA
Genetics 165:1417-32. 2003..here that mutations affecting the RhoA signaling pathway also interact genetically with mutations in the Stubble-stubbloid (Sb-sbd) locus that encodes an unusual type II transmembrane serine protease required for normal leg and wing .. 
Apical cell shape changes during Drosophila imaginal leg disc elongation: a novel morphogenetic mechanismM L Condic
Department of Molecular and Cell Biology, University of California, Berkeley 94720
Development 111:23-33. 1991..The conversion of a stable population of anisometric cells to isometric dimensions constitutes a novel mechanism for altering the proportions of an epithelial sheet during development...- Rho-LIM kinase signaling regulates ecdysone-induced gene expression and morphogenesis during Drosophila metamorphosisGuang Chao Chen
Massachusetts General Hospital Cancer Center and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
Curr Biol 14:309-13. 2004..genes, including those encoding the ecdysone receptor itself, a downstream transcription factor (Br-C), and Stubble, a transmembrane protease required for proper leg formation... - Three neighboring genes interact with the Broad-Complex and the Stubble-stubbloid locus to affect imaginal disc morphogenesis in DrosophilaP J Gotwals
Department of Molecular and Cellular Biology, University of California, Berkeley 94720
Genetics 127:747-59. 1991..Alleles of the Stubble-stubbloid (Sb-sbd) locus at 89B9-10 act as dominant enhancers of broad alleles of the BR-C... - The endogenous siRNA pathway is involved in heterochromatin formation in DrosophilaDelphine Fagegaltier
Centre National de la Recherche Scientifique, Unité de Recherche Associée 2578, Institut Pasteur, 25 rue du Dr Roux, F75015 Paris, France
Proc Natl Acad Sci U S A 106:21258-63. 2009..Similar effects were observed in dcr2, r2d2, and ago2 mutants. Our findings provide evidence that a nuclear pool of TE-derived endo-siRNAs is involved in heterochromatin formation in somatic tissues in Drosophila... - On the origin of metacentric, attached-X (A-X) chromosomes in Drosophila melanogaster malesM M Green
Section of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA
Proc Natl Acad Sci U S A 97:14484-7. 2000..The inseparabile mutation also affects disjunction of the chromosome 4 in males. We suspect that the mutation was responsible for the original A-X female found by L. V. Morgan in 1921... - The antibacterial arm of the drosophila innate immune response requires an IkappaB kinaseY Lu
Molecular Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
Genes Dev 15:104-10. 2001..The ird5 gene encodes a Drosophila homolog of mammalian IkappaB kinases (IKKs). The ird5 phenotype and sequence suggest that the gene is specifically required for the activation of Relish, a Drosophila NF-kappaB family member... - Mutations in Drosophila heat shock cognate 4 are enhancers of PolycombR Mollaaghababa
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 98:3958-63. 2001..HSC4 might be needed for the proper folding of a component of the Polycomb repression complex, or it may be a functional member of that complex... - Exploring the Caenorhabditis elegans and Drosophila melanogaster genomes to understand neuropeptide and peptidase functionD Coates
School of Biology, University of Leeds, Leeds LS2 9JT, U K
Biochem Soc Trans 28:464-9. 2000.... - Mutational analysis of a histone deacetylase in Drosophila melanogaster: missense mutations suppress gene silencing associated with position effect variegationR Mottus
Department of Zoology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
Genetics 154:657-68. 2000.... - Mutations in the heatshock cognate 70 protein (hsc4) modulate Notch signalingH K Hing
Department of Biological Chemistry, UCLA School of Medicine, Los Angeles, CA USA
Eur J Cell Biol 78:690-7. 1999..We discuss how hsc4, a gene thought to be involved in subcellular trafficking, may affect the number of functional Notch receptors on the cell surface... - The trithorax group gene moira encodes a brahma-associated putative chromatin-remodeling factor in Drosophila melanogasterM A Crosby
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Mol Cell Biol 19:1159-70. 1999..These observations provide a molecular explanation for the phenotypic and genetic relationships among several of the trxG genes by suggesting that they encode evolutionarily conserved components of a chromatin-remodeling complex... - Temperature-sensitive paralytic mutations demonstrate that synaptic exocytosis requires SNARE complex assembly and disassemblyJ T Littleton
Laboratory of Genetics, University of Wisconsin, Madison 53706, USA
Neuron 21:401-13. 1998..These results provide in vivo evidence that cycles of assembly and disassembly of SNARE complexes drive membrane trafficking at synapses... - The bithorax complex: the first fifty yearsE B Lewis
Division of Biology, The California Institute of Technology, Pasadena 91125, USA
Int J Dev Biol 42:403-15. 1998 - Genetic analysis of protein kinase B (AKT) in DrosophilaB E Staveley
Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Canada
Curr Biol 8:599-602. 1998..These data implicate Dakt1 as a cell survival gene in Drosophila, consistent with cell protection studies in mammals... - crooked legs encodes a family of zinc finger proteins required for leg morphogenesis and ecdysone-regulated gene expression during Drosophila metamorphosisP P D'Avino
Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112 5331, USA
Development 125:1733-45. 1998..The genetic criteria described here provide a new direction for identifying regulators of adult tissue development during insect metamorphosis... - The genetic control of arista lateral morphogenesis in DrosophilaBiao He
Biology Department and Cancer Center, University of Virginia, Charlottesville, VA 22903, USA
Dev Genes Evol 212:218-29. 2002..We also found that mutations that lead to lateral splitting typically alter the stereotypic arrangement of actin filament bundles and microtubules in laterals... - Temperature-sensitive paralytic mutants are enriched for those causing neurodegeneration in DrosophilaMichael J Palladino
Laboratory of Genetics, University of Wisconsin, Madison, WI 53706, USA
Genetics 161:1197-208. 2002..Further studies of vacu and the other neurodegenerative mutants isolated should ultimately help dissect the biochemical pathways leading to neurodegeneration... - A second-site noncomplementation screen for modifiers of Rho1 signaling during imaginal disc morphogenesis in DrosophilaKistie Patch
Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA
PLoS ONE 4:e7574. 2009.... - Linker histone H1 is essential for Drosophila development, the establishment of pericentric heterochromatin, and a normal polytene chromosome structureXingwu Lu
Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Genes Dev 23:452-65. 2009..Thus, linker histone H1 is essential in Drosophila and plays a fundamental role in the architecture and activity of chromosomes in vivo... - Mutation of Drosophila Lsd1 disrupts H3-K4 methylation, resulting in tissue-specific defects during developmentLuisa Di Stefano
Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Curr Biol 17:808-12. 2007..Taken together, these results show that dLsd1-mediated H3-K4 demethylation has a significant and specific role in Drosophila development... - How to make a curved Drosophila bristle using straight actin bundlesLewis G Tilney
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 102:18785-92. 2005.... - Mutational analysis of Stubble-stubbloid gene structure and function in Drosophila leg and bristle morphogenesisAnn S Hammonds
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
Genetics 172:1577-93. 2006The Stubble-stubbloid (Sb-sbd) gene is required for ecdysone-regulated epithelial morphogenesis of imaginal tissues during Drosophila metamorphosis... - Regulation of membrane localization of Sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organsFabrice Roegiers
Howard Hughes Medical Institute and Department of Physiology and Biochemistry, University of California San Francisco, San Francisco, CA 94143 0725, USA
Mol Biol Cell 16:3480-7. 2005..This study identifies a hitherto unreported role for Lgl as a regulator of Sanpodo during asymmetric cell division in the adult PNS... - The role actin filaments play in providing the characteristic curved form of Drosophila bristlesLewis G Tilney
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104 6018, USA
Mol Biol Cell 15:5481-91. 2004..Thus, the pattern of bristle curvature is a product of both extrinsic factors-the socket cell and the inner pupal case--and intrinsic factors--actin cytoskeleton assembly... - The varieties of selectional experience in behavioral geneticsRalph J Greenspan
The Neurosciences Institute, San Diego, CA 92121, USA
J Neurogenet 17:241-70. 2003 - Actin filament turnover regulated by cross-linking accounts for the size, shape, location, and number of actin bundles in Drosophila bristlesLewis G Tilney
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6018, USA
Mol Biol Cell 14:3953-66. 2003..As a result, filament turnover plays an important role in regulating cytoskeleton assembly and consequently cell shape... - Orphan nuclear receptor betaFTZ-F1 is required for muscle-driven morphogenetic events at the prepupal-pupal transition in Drosophila melanogasterTina M Fortier
Department of Biological Sciences, Mount Holyoke College, South Hadley, MA 01075, USA
Dev Biol 257:153-65. 2003..Our findings indicate that betaFTZ-F1 directs the muscle contraction events that drive the major morphogenetic processes during the prepupal-pupal transition in Drosophila... - The growth of Drosophila bristles and laterals is not restricted to the tip or baseXiaoyin Fei
Biology Department and Cancer Center, University of Virginia, Charlottesville, VA 22903, USA
J Cell Sci 115:3797-806. 2002..The bristle microtubules are less stable. The retrograde movement of the peripheral actin appears to be counterbalanced by the distally directed movement of cytoplasm in the center of the bristle... - Enhancer of Polycomb is a suppressor of position-effect variegation in Drosophila melanogasterD A Sinclair
IMBB, Simon Fraser University, Burnaby, British Columbia, Canada
Genetics 148:211-20. 1998..in E(Pc), an unusual member of the PcG, suppress PEV of four variegating rearrangements: In(l)wm4, B(SV), T(2;3)Sb(V) and In(2R)bw(VDe2)... - Proximo-distal specification in the wing disc of Drosophila by the nubbin geneF J Cifuentes
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Cantoblanco 28049 Madrid, Spain
Proc Natl Acad Sci U S A 94:11405-10. 1997..We discuss the role of nub in the wing's proximo-distal axis and in the formation of compartment boundaries... - Morphogenesis of denticles and hairs in Drosophila embryos: involvement of actin-associated proteins that also affect adult structuresW J Dickinson
Department of Biology, University of Utah, Salt Lake City 84112, USA
Cell Motil Cytoskeleton 38:9-21. 1997..We suggest that interactions between these and other actin-associated proteins are important in generating the diverse shapes of the cuticular specializations seen in both larvae and adults... - Information for the dorsal--ventral pattern of the Drosophila embryo is stored as maternal mRNAK V Anderson
Nature 311:223-7. 1984..Injection of RNA isolated from wild-type embryos into mutants at six loci partially restores dorsal-ventral polarity. For the mutant snake, injection of poly(A)+ RNA restores a complete dorsal-ventral pattern... - Genetic analysis of a meiotic mutant resulting in precocious sister-centromere separation in Drosophila melanogasterB K Davis
Mol Gen Genet 113:251-72. 1971 - Interaction of the Stubble-stubbloid locus and the Broad-complex of Drosophila melanogasterA H Beaton
Department of Genetics, University of California, Berkeley 94720
Genetics 120:453-64. 1988..The Stubble-stubbloid (Sb-sbd) locus at 89B9-10 is best known for the effects of its mutants on bristle structure... - Characterization of mutations that enhance position-effect variegation in Drosophila melanogasterD A Sinclair
Department of Zoology, University of British Columbia, Vancouver, Canada
Mol Gen Genet 216:328-33. 1989..Based on the results of these studies, various hypothetical functions of the E(var)+ products are suggested... - The relationship between P elements and male recombination in Drosophila melanogasterA Duttaroy
Department of Molecular and Cell Biology, University of Connecticut, Storrs 06268
Genetics 124:317-29. 1990..We suggest that this region is measured in terms of chromosomal segments rather than limited to P element sequences... - Two types of genetic interaction implicate the whirligig gene of Drosophila melanogaster in microtubule organization in the flagellar axonemeL L Green
Department of Molecular, University of Colorado, Boulder 80309 0347
Genetics 126:961-73. 1990..However, in post-meiotic stages, flagellar axonemes show loss of the accessory microtubule on the B-subfiber of outer doublet microtubules, outer triplet instead of outer doublet microtubules, and missing central pair microtubules... - The choice of cell fate in the epidermis of DrosophilaP Heitzler
Unité 184 de Biologie Moléculaire, Génie Génétique de l INSERM, Faculte de Medecine, Strasbourg, France
Cell 64:1083-92. 1991..It also suggests that N acts as a receptor for an inhibitory signal emanating from the neural precursors... - A cytogenetic and genetic characterization of a group of closely linked second chromosome mutations that suppress position-effect variegation in Drosophila melanogasterD A Sinclair
Department of Zoology, University of British Columbia, Canada
Genetics 130:333-44. 1992..We also report that two previously isolated mutants located in 31E and 31F-32A act as recessive suppressors of PEV... - Evidence for intrinsic differences in the formation of chromatin domains in Drosophila melanogasterC P Bishop
Department of Biology, Clarkson University, Potsdam, New York 13676
Genetics 132:1063-9. 1992..These results are discussed with regard to spreading heterochromatin and the role this process may play in regulating gene expression... - Cytogenetic analysis of chromosome region 89A of Drosophila melanogaster: isolation of deficiencies and mapping of Po, Aldox-1 and transposon insertionsC R Nelson
Department of Biological Chemistry, Milton S Hershey Medical Center, Pennsylvania State University, Hershey 17033
Mol Gen Genet 235:11-21. 1992..loci Po and Aldox-1, the indirect flight muscle genes Tm2 and act88F, the morphological mutations jvl, sbd2 and Sb, the vital loci srp, pnr and mor, and a newly described vital locus l(3)89Aa... - Cytogenic analysis of chromosome 3 in Drosophila melanogaster: mapping of the proximal portion of the right armI W Duncan
Genetics 80:733-52. 1975.... - Studies of l(3)c43hs1 a polyphasic, temperature-sensitive mutant of Drosophila melanogaster with a variety of imaginal disc defectsP Martin
Dev Biol 55:213-32. 1977 - [Interaction between genes Mos and mwh expressed in somatic cells of Drosophila melanogaster]N Ia Vaĭsman
Genetika 31:358-62. 1995Gene Mosaic (Mos) of chromosome 3 of Drosophila melanogaster was located by means of dominant markers Ly, Sb, and Dr. This gene was shown to be located between Ly and Sb in the centromeric region (45-50 map units)... - The making of a fly leg: a model for epithelial morphogenesisL von Kalm
University of California at Berkeley, Dept of Molecular and Cell Biology 94720 3200, USA
Bioessays 17:693-702. 1995..All of these products are required for the execution of normal changes in leg cell shape... - The Drosophila Stubble-stubbloid gene encodes an apparent transmembrane serine protease required for epithelial morphogenesisL F Appel
Department of Molecular and Cell Biology, University of California, Berkeley 94720
Proc Natl Acad Sci U S A 90:4937-41. 1993The Stubble-stubbloid (Sb-sbd) gene is required for hormone-dependent epithelial morphogenesis of imaginal discs of Drosophila, including the formation of bristles, legs, and wings... - Germ-line effects of a mutator, mu2, in Drosophila melanogasterJ M Mason
Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 2233, USA
Genetics 146:1381-97. 1997..We propose that mu2 affects chromosomal structure during oogenesis, thereby modulating DNA repair... - IMP-L3, A 20-hydroxyecdysone-responsive gene encodes Drosophila lactate dehydrogenase: structural characterization and developmental studiesR L Abu-Shumays
Graduate Group in Endocrinology, University of California, Berkeley 94720, USA
Dev Genet 20:11-22. 1997..Embryos deficient for the 65A-b region lack LDH activity. We conclude that IMP-L3 is the only gene that encodes LDH in Drosophila... - Competition between different variegating rearrangements for limited heterochromatic factors in Drosophila melanogasterV K Lloyd
Department of Zoology, University of British Columbia, Vancouver, Canada
Genetics 145:945-59. 1997..Consequently, even nonvariegation portions of the genome will be disrupted by re-allocation of heterochromatic proteins associated with PEV. These results have implications for models of PEV... - A genetic analysis of pannier, a gene necessary for viability of dorsal tissues and bristle positioning in DrosophilaP Heitzler
Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
Genetics 143:1271-86. 1996..A large number of alleles have been studied and reveal that pannier may have opposing effects on the expression of achaete and scute leading to a loss or a gain of bristles... - Characterization of the mus308 gene in Drosophila melanogasterE A Leonhardt
Department of Genetics, University of California, Davis 95616
Genetics 133:87-96. 1993..In addition, observations of elevated embryo mortality are potentially explained by an aberrant distribution of nuclear material in early embryos which is similar to that seen in the mutant giant nuclei... - Expansions of transgene repeats cause heterochromatin formation and gene silencing in DrosophilaD R Dorer
Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
Cell 77:993-1002. 1994..We propose that pairing of repeats underlies heterochromatin formation and is responsible for diverse gene silencing phenomena in animals and plants... - Drosophila P element transposase induces male recombination additively and without a requirement for P element excision or insertionM McCarron
Department of Molecular and Cell Biology, University of Connecticut, Storrs 06269 2131
Genetics 136:1013-23. 1994..Crossovers increased 58-fold in the immediate region of the P element target... - The Lighten up (Lip) gene of Drosophila melanogaster, a modifier of retroelement expression, position effect variegation and white locus insertion allelesA K Csink
Division of Biological Sciences, University of Missouri, Columbia 65211
Genetics 138:153-63. 1994..Additionally, Lip modifies the total transcript abundance of both the blood and copia retrotransposons, having an inverse effect on the steady state level of blood transcripts, while showing a non-additive effect on copia RNA... - Developmental regulation of expression and activity of multiple forms of the Drosophila RAC protein kinaseM Andjelkovic
Friedrich Miescher Institut, Basel, Switzerland
J Biol Chem 270:4066-75. 1995..DRAC-PK possesses an intrinsic kinase activity that is approximately 8-fold higher in adult flies than in 0-3-h embryos undergoing rapid mitotic cycles... - Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindlesD M Glover
Department of Anatomy and Physiology, University of Dundee, Scotland
Cell 81:95-105. 1995..The size of the single centrosomal body in these circular figures suggests that loss of function of the serine-threonine protein kinase encoded by aur leads to a failure of the centrosomes to separate and form a bipolar spindle... - Harnessing the power of Drosophila geneticsM F Wolfner
Section of Genetics and Development, Cornell University, Ithaca, New York 14853
Methods Cell Biol 44:33-80. 1994 - Spontaneous unequal exchange in the rosy region of Drosophila melanogasterW M Gelbart
Genetics 92:849-59. 1979....
Research Grants
- Endocytic Control of Notch-Mediated Cell Fate Decisions in NeurogenesisFABRICE J ROEGIERS; Fiscal Year: 2010....