sav

Summary

Gene Symbol: sav
Description: salvador
Alias: CG13831, CG13832, CG33193, Dmel\CG33193, Salvador/Shar-pei, Sav, anon-WO0172774.152, shar-pei, salvador, CG33193-PA, CG33193-PB, salvador/shar-pei, sav-PA, sav-PB
Species: fruit fly

Top Publications

  1. Zhang L, Ren F, Zhang Q, Chen Y, Wang B, Jiang J. The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control. Dev Cell. 2008;14:377-87 pubmed publisher
    ..Finally, Sd recruits Yki to the enhancer of the pathway-responsive gene diap1, suggesting that diap1 is a direct transcriptional target of the Hpo pathway. ..
  2. Harvey K, Pfleger C, Hariharan I. The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell. 2003;114:457-67 pubmed
    ..growth, proliferation, and apoptosis in Drosophila are warts (wts), encoding a serine/threonine kinase, and salvador (sav), encoding a WW domain containing Wts-interacting protein...
  3. Fernández B, Gaspar P, Bras Pereira C, Jezowska B, Rebelo S, Janody F. Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila. Development. 2011;138:2337-46 pubmed publisher
    ..Taken together, these findings indicate a novel interplay between Hippo pathway activity and actin filament dynamics that is essential for normal growth control. ..
  4. Edgar B. From cell structure to transcription: Hippo forges a new path. Cell. 2006;124:267-73 pubmed
    ..Merlin and Expanded, which play a role in cell adhesion and structure, control the activation of the Hippo/Salvador kinase complex, which in turn activates the Warts/Mats kinase complex...
  5. Robinson B, Huang J, Hong Y, Moberg K. Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded. Curr Biol. 2010;20:582-90 pubmed publisher
    ..We find that Crb-driven growth is dependent upon the Salvador/Warts/Hippo (SWH) pathway and its transcriptional effector Yorkie (Yki)...
  6. Hamaratoglu F, Willecke M, Kango Singh M, Nolo R, Hyun E, Tao C, et al. The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol. 2006;8:27-36 pubmed
    ..Our genetic and biochemical data place Merlin and Expanded upstream of Hippo and identify a pathway through which they act as tumour-suppressor genes. ..
  7. Polesello C, Huelsmann S, Brown N, Tapon N. The Drosophila RASSF homolog antagonizes the hippo pathway. Curr Biol. 2006;16:2459-65 pubmed
    ..Expanded (Ex) and Merlin (Mer), two serine/threonine kinases, Hpo and Warts (Wts), the scaffold proteins Salvador (Sav) and Mats, and the transcriptional coactivator Yorkie (Yki)...
  8. Zhai B, Villen J, Beausoleil S, Mintseris J, Gygi S. Phosphoproteome analysis of Drosophila melanogaster embryos. J Proteome Res. 2008;7:1675-82 pubmed publisher
    ..63% at the peptide level. Because of the large size of the data set, both novel and known phosphorylation motifs were extracted using the Motif-X algorithm, including those representative of potential ordered phosphorylation events. ..
  9. Silva E, Tsatskis Y, Gardano L, Tapon N, McNeill H. The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway. Curr Biol. 2006;16:2081-9 pubmed
    ..The Hippo pathway consists of the Ste20 family kinase Hippo, the WW adaptor protein Salvador, and the NDR kinase Warts...

More Information

Publications77

  1. Yu J, Poulton J, Huang Y, Deng W. The hippo pathway promotes Notch signaling in regulation of cell differentiation, proliferation, and oocyte polarity. PLoS ONE. 2008;3:e1761 pubmed publisher
    ..Disruption of the Hippo pathway, including major components Hippo, Salvador, and Warts, results in aberrant follicle-cell differentiation and proliferation and dramatic disruption of the ..
  2. Genevet A, Wehr M, Brain R, Thompson B, Tapon N. Kibra is a regulator of the Salvador/Warts/Hippo signaling network. Dev Cell. 2010;18:300-8 pubmed publisher
    The Salvador (Sav)/Warts (Wts)/Hippo (Hpo) (SWH) network controls tissue growth by inhibiting cell proliferation and promoting apoptosis...
  3. Colombani J, Polesello C, Josué F, Tapon N. Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage. Curr Biol. 2006;16:1453-8 pubmed
    ..The Hippo (Hpo) pathway comprises the kinases Hpo and Warts/Lats (Wts), the adaptors Salvador (Sav) and Mob1 as a tumor suppressor (Mats), the cytoskeletal proteins Expanded and Merlin, and the ..
  4. Grzeschik N, Parsons L, Allott M, Harvey K, Richardson H. Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms. Curr Biol. 2010;20:573-81 pubmed publisher
    ..of lgl in eye epithelial tissue, where polarity is maintained, results in upregulation of targets of the Salvador/Warts/Hippo (SWH) tumor suppressor pathway...
  5. Huang J, Wu S, Barrera J, Matthews K, Pan D. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell. 2005;122:421-34 pubmed
    ..Thus, Yki is a critical target of the Wts/Lats protein kinase and a potential oncogene. ..
  6. Tapon N, Harvey K, Bell D, Wahrer D, Schiripo T, Haber D, et al. salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell. 2002;110:467-78 pubmed
    ..In a screen for Drosophila mutations that result in tissue overgrowth, we identified salvador (sav), a gene that promotes both cell cycle exit and cell death...
  7. Meignin C, Alvarez Garcia I, Davis I, Palacios I. The salvador-warts-hippo pathway is required for epithelial proliferation and axis specification in Drosophila. Curr Biol. 2007;17:1871-8 pubmed
    ..We show that the Salvador Warts Hippo (SWH) tumor-suppressor pathway is required in the follicle cells in order to induce their Gurken- and ..
  8. Ribeiro P, Josué F, Wepf A, Wehr M, Rinner O, Kelly G, et al. Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling. Mol Cell. 2010;39:521-34 pubmed publisher
    ..MST1/2 in mammals) and a downstream kinase Warts (Wts, Lats1/2 in mammals), as well as several scaffold proteins, Sav, dRASSF, and Mats...
  9. Jia J, Zhang W, Wang B, Trinko R, Jiang J. The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. Genes Dev. 2003;17:2514-9 pubmed
    ..dMST forms a complex with Sav and Wts, two tumor suppressors also implicated in regulating both cell proliferation and apoptosis, suggesting that ..
  10. Ryoo H, Steller H. Hippo and its mission for growth control. Nat Cell Biol. 2003;5:853-5 pubmed
  11. Boggiano J, Vanderzalm P, Fehon R. Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway. Dev Cell. 2011;21:888-95 pubmed publisher
    Recent studies have shown that the Hippo-Salvador-Warts (HSW) pathway restrains tissue growth by phosphorylating and inactivating the oncoprotein Yorkie. How growth-suppressive signals are transduced upstream of Hippo remains unclear...
  12. Wu S, Huang J, Dong J, Pan D. hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell. 2003;114:445-56 pubmed
    ..hpo encodes a Ste-20 family protein kinase that binds to and phosphorylates the tumor suppressor protein Salvador (Sav), which is known to interact with the Warts (Wts) protein kinase...
  13. Kango Singh M, Nolo R, Tao C, Verstreken P, Hiesinger P, Bellen H, et al. Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila. Development. 2002;129:5719-30 pubmed
    ..shar-pei encodes a WW-domain-containing protein that has homologs in worms, mice and humans, suggesting that mechanisms of organ growth control are evolutionarily conserved. ..
  14. Dong J, Feldmann G, Huang J, Wu S, Zhang N, Comerford S, et al. Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell. 2007;130:1120-33 pubmed
    ..These results uncover a universal size-control mechanism in metazoan. ..
  15. Shaw R, Kohlmaier A, Polesello C, Veelken C, Edgar B, Tapon N. The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration. Development. 2010;137:4147-58 pubmed publisher
    ..Our results suggest that the Hpo pathway is a mediator of the regenerative response in the Drosophila midgut. ..
  16. Jin Y, Dong L, Lu Y, Wu W, Hao Q, Zhou Z, et al. Dimerization and cytoplasmic localization regulate Hippo kinase signaling activity in organ size control. J Biol Chem. 2012;287:5784-96 pubmed publisher
  17. Yu J, Zheng Y, Dong J, Klusza S, Deng W, Pan D. Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded. Dev Cell. 2010;18:288-99 pubmed publisher
    ..Central to this pathway is a kinase cascade wherein Hippo (Hpo), in complex with Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) ..
  18. Bennett F, Harvey K. Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway. Curr Biol. 2006;16:2101-10 pubmed
    ..A newly emerging signaling pathway that controls organ size during development is the Salvador/Warts/Hippo pathway...
  19. Polesello C, Tapon N. Salvador-warts-hippo signaling promotes Drosophila posterior follicle cell maturation downstream of notch. Curr Biol. 2007;17:1864-70 pubmed
    The Salvador Warts Hippo (SWH) network limits tissue size in Drosophila and vertebrates [1]. Decreased SWH pathway activity gives rise to excess proliferation and reduced apoptosis...
  20. Poon C, Lin J, Zhang X, Harvey K. The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway. Dev Cell. 2011;21:896-906 pubmed publisher
    The Salvador-Warts-Hippo (SWH) pathway is a complex signaling network that controls both developmental and regenerative tissue growth...
  21. Cho E, Feng Y, Rauskolb C, Maitra S, Fehon R, Irvine K. Delineation of a Fat tumor suppressor pathway. Nat Genet. 2006;38:1142-50 pubmed
    ..The tumor suppressors Merlin, expanded, hippo, salvador and mob as tumor suppressor also share multiple Fat pathway phenotypes but regulate Warts activity independently...
  22. Wei X, Shimizu T, Lai Z. Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila. EMBO J. 2007;26:1772-81 pubmed
    ..Our results support a model in which Mats is activated by Hpo through phosphorylation for growth inhibition, and this regulatory mechanism is conserved from flies to mammals. ..
  23. Oh H, Irvine K. In vivo regulation of Yorkie phosphorylation and localization. Development. 2008;135:1081-8 pubmed publisher
    ..These results identify modulation of subcellular localization as a mechanism of Yki regulation, and establish that this regulation occurs in vivo through multiple sites of Warts-dependent phosphorylation on Yki. ..
  24. Hariharan I. Growth regulation: a beginning for the hippo pathway. Curr Biol. 2006;16:R1037-9 pubmed
    ..A signaling pathway involving two protein kinases, Hippo and Warts, restricts the growth of imaginal discs in Drosophila. Four recent studies taken together show that the protocadherin Fat can regulate Warts in two different ways. ..
  25. Udan R, Kango Singh M, Nolo R, Tao C, Halder G. Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nat Cell Biol. 2003;5:914-20 pubmed
    ..of warts (wts), which encodes a serine/threonine kinase of the myotonic dystrophy protein kinase family, and salvador (sav), which encodes a WW domain protein that binds to Wts...
  26. Pantalacci S, Tapon N, Leopold P. The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila. Nat Cell Biol. 2003;5:921-7 pubmed
    Tissue growth during animal development is tightly controlled so that the organism can develop harmoniously. The salvador (sav) gene, which encodes a scaffold protein, has been shown to restrict cell number by coordinating cell-cycle exit ..
  27. Wang L, Baker N. Salvador-Warts-Hippo pathway in a developmental checkpoint monitoring helix-loop-helix proteins. Dev Cell. 2015;32:191-202 pubmed publisher
    ..in Drosophila, we show that the Id protein Extramacrochaetae enables growth by suppressing activation of the Salvador-Warts-Hippo pathway of tumor suppressors, activation that requires transcriptional activation of the expanded ..
  28. Zhang X, Milton C, Poon C, Hong W, Harvey K. Wbp2 cooperates with Yorkie to drive tissue growth downstream of the Salvador-Warts-Hippo pathway. Cell Death Differ. 2011;18:1346-55 pubmed publisher
    The Salvador-Warts-Hippo (SWH) pathway is a key controller of tissue growth in both flies and mammals, and deregulation of pathway activity contributes to tumour formation...
  29. Robbins R, Gbur S, Beitel G. Non-canonical roles for Yorkie and Drosophila Inhibitor of Apoptosis 1 in epithelial tube size control. PLoS ONE. 2014;9:e101609 pubmed publisher
    ..regulated in unexpected ways by the transcription factor Yorkie (Yki, homolog of mammalian YAP and TAZ) and the Salvador/Warts/Hippo (SWH) kinase pathway...
  30. Poon C, Zhang X, Lin J, Manning S, Harvey K. Homeodomain-interacting protein kinase regulates Hippo pathway-dependent tissue growth. Curr Biol. 2012;22:1587-94 pubmed publisher
    The Salvador-Warts-Hippo (SWH) pathway is an evolutionarily conserved regulator of tissue growth that is deregulated in human cancer...
  31. Richter C, Oktaba K, Steinmann J, Muller J, Knoblich J. The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements. Nat Cell Biol. 2011;13:1029-39 pubmed publisher
    ..from overproliferation of neuroepithelial cells in the optic lobes caused by derepression of target genes in the Salvador-Warts-Hippo (SWH) pathway...
  32. Wu D, Wu S. A conserved serine residue regulates the stability of Drosophila Salvador and human WW domain-containing adaptor 45 through proteasomal degradation. Biochem Biophys Res Commun. 2013;433:538-41 pubmed publisher
    ..Drosophila Salvador (Sav), which limits organ size, is a core component of the Hpo pathway...
  33. Huang H, Wang S, Yin M, Dong L, Wang C, Wu W, et al. Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association. PLoS Biol. 2013;11:e1001620 pubmed publisher
    ..We demonstrated that par-1 functioned downstream of fat and expanded and upstream of hpo and salvador (sav)...
  34. Fausti F, Di Agostino S, Sacconi A, Strano S, Blandino G. Hippo and rassf1a Pathways: A Growing Affair. Mol Biol Int. 2012;2012:307628 pubmed publisher
    ..Recently, the impact of RASSF proteins on Hippo signaling potentiating its proapoptotic activity has been addressed, thus, providing further evidence for Hippo's key role in mammalian tumorigenesis as well as other important diseases. ..
  35. Abrams J. Competition and compensation: coupled to death in development and cancer. Cell. 2002;110:403-6 pubmed
    ..Recent insights from the Drosophila system implicate new determinants that specify "winners" and "losers" in this process. ..
  36. Sousa Guimarães S, Sunkel C, Malmanche N. polo Is Identified as a Suppressor of bubR1 Nondisjunction in a Deficiency Screen of the Third Chromosome in Drosophila melanogaster. G3 (Bethesda). 2011;1:161-9 pubmed publisher
    ..Overall, our genetic screening strategy proved to be highly sensitive for the identification of modifiers of BubR1 kinase activity in both meiosis and mitosis. ..
  37. Rauskolb C, Sun S, Sun G, Pan Y, Irvine K. Cytoskeletal tension inhibits Hippo signaling through an Ajuba-Warts complex. Cell. 2014;158:143-156 pubmed publisher
    ..Our observations delineate a mechanism that links cytoskeletal tension to regulation of Hippo pathway activity, providing a molecular understanding of how mechanical forces can modulate organ growth. ..
  38. Jukam D, Xie B, Rister J, TERRELL D, Charlton Perkins M, Pistillo D, et al. Opposite feedbacks in the Hippo pathway for growth control and neural fate. Science. 2013;342:1238016 pubmed publisher
    ..Altering feedback architecture provides an efficient mechanism to co-opt conserved signaling networks for diverse purposes in development and evolution. ..
  39. Zhang L, Yang S, Wennmann D, Chen Y, Kremerskothen J, Dong J. KIBRA: In the brain and beyond. Cell Signal. 2014;26:1392-9 pubmed publisher
    ..At the biochemical level, KIBRA protein is highly phosphorylated by various kinases in epithelial cells. Here, we discuss the updates concerning the function and regulation of KIBRA in the brain and beyond. ..
  40. Rhiner C, Diaz B, Portela M, Poyatos J, Fernández Ruíz I, López Gay J, et al. Persistent competition among stem cells and their daughters in the Drosophila ovary germline niche. Development. 2009;136:995-1006 pubmed publisher
    ..Moreover, competitive interactions among stem cells may be relevant for the successful application of stem cell therapies in humans. ..
  41. Menut L, Vaccari T, Dionne H, Hill J, Wu G, Bilder D. A mosaic genetic screen for Drosophila neoplastic tumor suppressor genes based on defective pupation. Genetics. 2007;177:1667-77 pubmed
    ..The isolation of additional loci that affect hyperplastic as well as neoplastic growth indicates the utility of this screening strategy for studying epithelial growth control. ..
  42. Vissers J, Manning S, Kulkarni A, Harvey K. A Drosophila RNAi library modulates Hippo pathway-dependent tissue growth. Nat Commun. 2016;7:10368 pubmed publisher
    ..To enhance the use of the VDRC KK RNAi library, we have generated a D. melanogaster strain that will allow researchers to test, in a single cross, whether their genetic screen of interest will be affected by ectopic tio expression. ..
  43. Guo T, Lu Y, Li P, Yin M, Lv D, Zhang W, et al. A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity. Cell Res. 2013;23:1201-14 pubmed publisher
    ..Collectively, we identify SdBP as a novel component of the Hpo pathway, negatively regulating the transcriptional activity of Sd-Yki to restrict tissue growth. ..
  44. Laprise P. Emerging role for epithelial polarity proteins of the Crumbs family as potential tumor suppressors. J Biomed Biotechnol. 2011;2011:868217 pubmed publisher
    ..Thereby, these studies provide a molecular basis explaining how regulation of epithelial polarity is coupled to tumorogenesis. ..
  45. Hafezi Y, Bosch J, Hariharan I. Differences in levels of the transmembrane protein Crumbs can influence cell survival at clonal boundaries. Dev Biol. 2012;368:358-69 pubmed publisher
    ..lesions alter Crb levels, including loss-of-function mutations in hyperplastic tumour suppressors in the Hippo-Salvador-Warts pathway and in neoplastic tumour suppressor genes, such as scribble...
  46. Aerne B, Gailite I, Sims D, Tapon N. Hippo Stabilises Its Adaptor Salvador by Antagonising the HECT Ubiquitin Ligase Herc4. PLoS ONE. 2015;10:e0131113 pubmed publisher
    ..In particular, the stability of scaffold protein Salvador (Sav), which is believed to promote Hpo/Wts association, is crucially dependent on its binding partner Hpo...
  47. Das Thakur M, Feng Y, Jagannathan R, Seppa M, Skeath J, Longmore G. Ajuba LIM proteins are negative regulators of the Hippo signaling pathway. Curr Biol. 2010;20:657-62 pubmed publisher
    ..In mammalian and Drosophila cells, Ajuba LIM proteins/dJub interact with LATS/Warts (Wts) and WW45/Sav to inhibit phosphorylation of YAP/Yki...
  48. Bateman J, McNeill H. Seeing in color--warts and all. Dev Cell. 2005;9:441-2 pubmed
    ..show that cell fate decisions needed for color vision are dependent on a bistable negative feedback loop between genes previously implicated in cell proliferation (warts) and growth (melted). ..
  49. Hevia C, López Varea A, Esteban N, de Celis J. A Search for Genes Mediating the Growth-Promoting Function of TGFβ in the Drosophila melanogaster Wing Disc. Genetics. 2017;206:231-249 pubmed publisher
    ..between TGFβ signaling and other pathways regulating wing disc growth, such as the Insulin and Hippo/Salvador/Warts pathways, as well as cell cycle regulators...
  50. Napoletano F, Occhi S, Calamita P, Volpi V, Blanc E, Charroux B, et al. Polyglutamine Atrophin provokes neurodegeneration in Drosophila by repressing fat. EMBO J. 2011;30:945-58 pubmed publisher
    ..Our data thus provide a crucial insight into the specific mechanism of a polyQ disease and reveal an unexpected neuroprotective role of the Fat/Hippo pathway. ..
  51. Salah Z, Aqeilan R. WW domain interactions regulate the Hippo tumor suppressor pathway. Cell Death Dis. 2011;2:e172 pubmed publisher
    ..We further discuss new insights and future directions on the emerging role of such regulation. ..
  52. Tyler D, Baker N. Expanded and fat regulate growth and differentiation in the Drosophila eye through multiple signaling pathways. Dev Biol. 2007;305:187-201 pubmed
    ..During disc growth, ex was largely epistatic to ft, and the Warts pathway mutation hippo largely epistatic to ex. Our data suggest that ft and ex act partially through the Warts pathway. ..
  53. Firth L, Baker N. Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye. Dev Cell. 2005;8:541-51 pubmed
    ..These studies identify the specific extracellular signals that pattern the retinal cell cycles and show how differentiation can be uncoupled from cell cycle exit. ..
  54. Yin F, Yu J, Zheng Y, Chen Q, Zhang N, Pan D. Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2. Cell. 2013;154:1342-55 pubmed publisher
    ..Membrane recruitment, in turn, promotes Wts phosphorylation by the Hpo-Sav kinase complex...
  55. Huang H, Li J, Hu L, Ge L, Ji H, Zhao Y, et al. Bantam is essential for Drosophila intestinal stem cell proliferation in response to Hippo signaling. Dev Biol. 2014;385:211-9 pubmed publisher
  56. Oh H, Irvine K. In vivo analysis of Yorkie phosphorylation sites. Oncogene. 2009;28:1916-27 pubmed publisher
    ..We also identify two potential sites of phosphorylation by an unknown kinase, which could influence phosphorylation of Ser168 by Wts, suggesting that there are additional mechanisms for regulating Yki/YAP activity. ..
  57. Emoto K, Parrish J, Jan L, Jan Y. The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance. Nature. 2006;443:210-3 pubmed
  58. Liu B, Zheng Y, Yin F, Yu J, Silverman N, Pan D. Toll Receptor-Mediated Hippo Signaling Controls Innate Immunity in Drosophila. Cell. 2016;164:406-19 pubmed publisher
  59. Dutta S, Baehrecke E. Warts is required for PI3K-regulated growth arrest, autophagy, and autophagic cell death in Drosophila. Curr Biol. 2008;18:1466-75 pubmed publisher
    ..Our data indicate that the Wts-pathway components Yki, Sd, and bantam fail to function in salivary glands and that Wts regulates salivary gland cell death in a PI3K-dependent manner. ..
  60. Wehr M, Holder M, Gailite I, Saunders R, Maile T, Ciirdaeva E, et al. Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila. Nat Cell Biol. 2013;15:61-71 pubmed
    ..The pathway core is a kinase cassette, comprising the kinases Hpo and Warts (Wts) and the scaffold proteins Salvador (Sav) and Mats, which inactivates the pro-growth transcriptional co-activator Yorkie (Yki)...
  61. Rothenberg M, Jan Y. salvador--The persistence of proliferation. Cancer Cell. 2002;2:171-3 pubmed
    ..Using an elegant genetic screen in the fly eye, have identified a gene, salvador, which is especially significant, because it not only regulates and coordinates both exit from the cell cycle and ..
  62. Zaessinger S, Zhou Y, Bray S, Tapon N, Djiane A. Drosophila MAGI interacts with RASSF8 to regulate E-Cadherin-based adherens junctions in the developing eye. Development. 2015;142:1102-12 pubmed publisher
    ..We propose that, by controlling the proper localization of Baz to remodeling junctions, Magi and the RASSF8-ASPP complex promote the recruitment or stabilization of E-Cad complexes at junction sites. ..
  63. Sun S, Reddy B, Irvine K. Localization of Hippo signalling complexes and Warts activation in vivo. Nat Commun. 2015;6:8402 pubmed publisher
    ..wing imaginal discs are organized into distinct junctional complexes, including separate distributions for Salvador, Expanded, Warts and Hippo...
  64. Sun S, Zhao S, Wang Z. Genes of Hippo signaling network act unconventionally in the control of germline proliferation in Drosophila. Dev Dyn. 2008;237:270-5 pubmed
    ..Surprisingly, when we generated germline mutant clones of Hippo-network genes such as fat, expanded, hippo, salvador, and warts, we did not observe any overgrowth of these mutant cells...
  65. Chung H, Augustine G, Choi K. Drosophila Schip1 Links Expanded and Tao-1 to Regulate Hippo Signaling. Dev Cell. 2016;36:511-24 pubmed publisher
    ..This study provides insights into the mechanism of Tao-1 regulation and a potential growth control function for SCHIP1 in mammals. ..
  66. Ohsawa S, Sugimura K, Takino K, Xu T, Miyawaki A, Igaki T. Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila. Dev Cell. 2011;20:315-28 pubmed publisher
    ..Our data indicate that JNK-mediated cell engulfment could be an evolutionarily conserved intrinsic tumor-suppression mechanism that eliminates premalignant cells from epithelia. ..
  67. Delalle I, Pfleger C, Buff E, Lueras P, Hariharan I. Mutations in the Drosophila orthologs of the F-actin capping protein alpha- and beta-subunits cause actin accumulation and subsequent retinal degeneration. Genetics. 2005;171:1757-65 pubmed
    ..In its absence, cells progressively accumulate actin filaments and eventually die. A possible role for their human orthologs in neurodegenerative disease merits further investigation. ..
  68. Hafen E, Stocker H. How are the sizes of cells, organs, and bodies controlled?. PLoS Biol. 2003;1:E86 pubmed