Gene Symbol: Sac1
Description: Sac1 phosphatase
Alias: CG9128, Dmel\CG9128, dsac1, impatent, l(3)2107, sac1, Sac1 phosphatase, CG9128-PA, CG9128-PB, Sac1-PA, Sac1-PB, impatent, suppressor of actin-1
Species: fruit fly
Wei H, Sanny J, Shu H, Baillie D, Brill J, Price J, et al
. The Sac1 lipid phosphatase regulates cell shape change and the JNK cascade during dorsal closure in Drosophila. Curr Biol. 2003;13:1882-7 pubmed
The Sac1 lipid phosphatase dephosphorylates several phosphatidylinositol (PtdIns) phosphates and, in yeast, regulates a diverse range of cellular processes including organization of the actin cytoskeleton and secretion...
Yavari A, Nagaraj R, Owusu Ansah E, Folick A, Ngo K, Hillman T, et al
. Role of lipid metabolism in smoothened derepression in hedgehog signaling. Dev Cell. 2010;19:54-65 pubmed publisher
..which is required for the generation of PI4P, exhibits hh loss-of-function phenotypes, whereas loss of Sac1 phosphatase, which is required for the degradation of PI4P, results in hh gain-of-function phenotypes in multiple ..
Wei H, Shu H, Price J. Functional genomic analysis of the 61D-61F region of the third chromosome of Drosophila melanogaster. Genome. 2003;46:1049-58 pubmed
..AC005847). Six essential complementation groups were assigned to specific genes, including genes encoding a porphobilinogen deaminase and a Sac1-like protein.
Lee S, Kim S, Nahm M, Kim E, Kim T, Yoon J, et al
. The phosphoinositide phosphatase Sac1 is required for midline axon guidance. Mol Cells. 2011;32:477-82 pubmed publisher
b>Sac1 phosphoinositide (PI) phosphatases are important regulators of PtdIns(4)P turnover at the ER, Golgi, and plasma membrane (PM) and are involved in diverse cellular processes including cytoskeletal organization and vesicular ..
Forrest S, Chai A, Sanhueza M, Marescotti M, Parry K, Georgiev A, et al
. Increased levels of phosphoinositides cause neurodegeneration in a Drosophila model of amyotrophic lateral sclerosis. Hum Mol Genet. 2013;22:2689-704 pubmed publisher
..We identified the conserved phosphoinositide phosphatase Sac1 as a Drosophila VAP (DVAP)-binding partner and showed that DVAP is required to maintain normal levels of ..
Jiang K, Liu Y, Fan J, Zhang J, Li X, Evers B, et al
. PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail. PLoS Biol. 2016;14:e1002375 pubmed publisher