Gene Symbol: RyR
Description: Ryanodine receptor
Alias: CG10844, D-RyR, DRR, DRY, Dmel\CG10844, RYR, RyRs, Rya-44F, Rya-R44F, Rya-r44F, Rya-r76CD, Ryr, dRyR, dRyr, dry, dya, l(2)k00424, l(2)k04913, rya-r44F, ryr, ryanodine receptor, CG10844-PA, CG10844-PB, CG10844-PC, CG10844-PD, CG10844-PE, CG10844-PF, CG10844-PG, CG10844-PH, CG10844-PI, CG10844-PJ, RyR-PA, RyR-PB, RyR-PC, RyR-PD, RyR-PE, RyR-PF, RyR-PG, RyR-PH, RyR-PI, RyR-PJ, ryanodine receptor 44F
Species: fruit fly

Top Publications

  1. Wang B, Sullivan K, Beckingham K. Drosophila calmodulin mutants with specific defects in the musculature or in the nervous system. Genetics. 2003;165:1255-68 pubmed
    ..Genetic interaction studies suggest that failed regulation of the muscle calcium release channel, the ryanodine receptor, is the major defect underlying the Cam7 phenotype.
  2. Murmu M, Stinnakre J, Martin J. Presynaptic Ca2+ stores contribute to odor-induced responses in Drosophila olfactory receptor neurons. J Exp Biol. 2010;213:4163-73 pubmed publisher
    ..For example in vertebrates, presynaptic Ca(2+) stores relying on either the ryanodine receptor (RyR) or the inositol (1,4,5)-trisphosphate receptor (InsP(3)R) have been reported to participate in ..
  3. Cuttell L, Vaughan A, Silva E, Escaron C, Lavine M, Van Goethem E, et al. Undertaker, a Drosophila Junctophilin, links Draper-mediated phagocytosis and calcium homeostasis. Cell. 2008;135:524-34 pubmed publisher
    ..We place Draper, its adaptor drCed-6, UTA, the Ryanodine receptor Rya-r44F, the ER Ca2+ sensor dSTIM, and the Ca2+-release-activated Ca2+ channel dOrai in the same pathway ..
  4. Gao Z, Joseph E, Ruden D, Lu X. Drosophila Pkd2 is haploid-insufficient for mediating optimal smooth muscle contractility. J Biol Chem. 2004;279:14225-31 pubmed
    ..Consistent with this, Pkd2 interacted strongly with a ryanodine receptor mutation, causing a synergistic reduction of larval body wall contraction rate that is normally regulated ..
  5. Sullivan K, Scott K, Zuker C, Rubin G. The ryanodine receptor is essential for larval development in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2000;97:5942-7 pubmed
    ..We identified a P element insertion in the Drosophila ryanodine receptor gene, Ryanodine receptor 44F (Ryr), and used it to generate the hypomorphic allele Ryr(16)...
  6. Vázquez Martínez O, Cañedo Merino R, Díaz Muñoz M, Riesgo Escovar J. Biochemical characterization, distribution and phylogenetic analysis of Drosophila melanogaster ryanodine and IP3 receptors, and thapsigargin-sensitive Ca2+ ATPase. J Cell Sci. 2003;116:2483-94 pubmed
    ..b>Ryanodine receptor was expressed mainly in the digestive tract and parts of the nervous system...
  7. Bi J, Wang W, Liu Z, Huang X, Jiang Q, Liu G, et al. Seipin promotes adipose tissue fat storage through the ER Ca²?-ATPase SERCA. Cell Metab. 2014;19:861-71 pubmed publisher
    ..Adipose tissue-specific knockdown of the ER-to-cytosol calcium release channel ryanodine receptor (RyR) partially restores fat storage in dSeipin mutants...
  8. Hasan G, Rosbash M. Drosophila homologs of two mammalian intracellular Ca(2+)-release channels: identification and expression patterns of the inositol 1,4,5-triphosphate and the ryanodine receptor genes. Development. 1992;116:967-75 pubmed
    ..of two Drosophila genes homologous to two classes of mammalian intracellular Ca(2+)-release channels, the ryanodine receptor and the inositol 1,4,5-triphosphate (IP3) receptor...
  9. Lin N, Badie N, Yu L, Abraham D, Cheng H, Bursac N, et al. A method to measure myocardial calcium handling in adult Drosophila. Circ Res. 2011;108:1306-15 pubmed publisher
    ..3) Hearts from hdp(2) mutants had reductions in caffeine-induced Ca(2+) increases and reductions in ryanodine receptor (RyR) without changes in L-type Ca(2+) channel transcripts in comparison with w(1118)...

More Information


  1. Terada S, Matsubara D, Onodera K, Matsuzaki M, Uemura T, Usui T. Neuronal processing of noxious thermal stimuli mediated by dendritic Ca(2+) influx in Drosophila somatosensory neurons. elife. 2016;5: pubmed publisher
    ..The precipitous fluctuation of firing rate in Class IV neurons enhanced the robust heat avoidance. We hypothesize that the Ca(2+) influx can be a key signal encoding a specific modality. ..
  2. Dockendorff T, Robertson S, Faulkner D, Jongens T. Genetic characterization of the 44D-45B region of the Drosophila melanogaster genome based on an F2 lethal screen. Mol Gen Genet. 2000;263:137-43 pubmed
    ..This screen may have uncovered mutant alleles of these genes. The results of complementation tests with previously identified genes in 44D-45B suggests that over half of the complementation groups identified in this screen may be novel. ..
  3. Abraham D, Wolf M. Disruption of sarcoendoplasmic reticulum calcium ATPase function in Drosophila leads to cardiac dysfunction. PLoS ONE. 2013;8:e77785 pubmed publisher
    ..Thus, we present a cardiac phenotype associated with Drosophila SERCA dysfunction that would serve as additional phenotyping for further large-scale genetic screens for novel modifiers of SERCA function. ..
  4. Xu X, Bhat M, Nishi M, Takeshima H, Ma J. Molecular cloning of cDNA encoding a drosophila ryanodine receptor and functional studies of the carboxyl-terminal calcium release channel. Biophys J. 2000;78:1270-81 pubmed
    ..To study the function and regulation of the ryanodine receptor (RyR) from insect cells, we have cloned the entire cDNA sequence of RyR from the fruit fly Drosophila ..
  5. Mensch J, Serra F, Lavagnino N, Dopazo H, Hasson E. Positive selection in nucleoporins challenges constraints on early expressed genes in Drosophila development. Genome Biol Evol. 2013;5:2231-41 pubmed publisher
    ..Understanding these exceptions to the broad evolutionary conservation of early expressed developmental genes can shed light into relevant processes driving the evolution of species divergence. ..
  6. Wilczynski B, Liu Y, Yeo Z, Furlong E. Predicting spatial and temporal gene expression using an integrative model of transcription factor occupancy and chromatin state. PLoS Comput Biol. 2012;8:e1002798 pubmed publisher
    ..While this is, to our knowledge, the first genome-wide approach to predict tissue-specific gene expression in metazoan development, our results suggest that integrative models of this type will become more prevalent in the future. ..
  7. Li A, Zhou C, Moore J, Zhang P, Tsai T, Lee H, et al. Changes in the expression of the Alzheimer’s disease-associated presenilin gene in drosophila heart leads to cardiac dysfunction. Curr Alzheimer Res. 2011;8:313-22 pubmed
    ..Silencing of dPsn elevated dIP3R expression, and reduced dSERCA expression; overexprerssion of dPsn led to reduced dRyR expression...
  8. Mohr S, Boswell R. Genetic analysis of Drosophila melanogaster polytene chromosome region 44D-45F: loci required for viability and fertility. Genetics. 2002;160:1503-10 pubmed
    ..Mutations in sine prole disrupt spermatogenesis at or before individualization of spermatozoa and cause multiple defects in oogenesis, including inappropriate division of the germline cyst and arrest of oogenesis at stage 4. ..
  9. Razzaq A, Robinson I, McMahon H, Skepper J, Su Y, Zelhof A, et al. Amphiphysin is necessary for organization of the excitation-contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in Drosophila. Genes Dev. 2001;15:2967-79 pubmed
    ..We therefore propose that muscle amphiphysin is not involved in clathrin-mediated endocytosis, but in the structural organization of the membrane-bound compartments of the excitation-contraction coupling machinery of muscles. ..
  10. Michno K, Knight D, Campusano J, Campussano J, van de Hoef D, Boulianne G. Intracellular calcium deficits in Drosophila cholinergic neurons expressing wild type or FAD-mutant presenilin. PLoS ONE. 2009;4:e6904 pubmed publisher
    ..Our data support a model whereby presenilin plays a role in regulating intracellular calcium stores and demonstrate that Drosophila can be used to study the link between presenilin and calcium deregulation. ..
  11. Mortimer N, Goecks J, Kacsoh B, Mobley J, Bowersock G, Taylor J, et al. Parasitoid wasp venom SERCA regulates Drosophila calcium levels and inhibits cellular immunity. Proc Natl Acad Sci U S A. 2013;110:9427-32 pubmed publisher
    ..Our characterization of parasitoid wasp venom proteins led us to identify plasmatocyte cytoplasmic calcium bursts as an important aspect of fly cellular immunity. ..
  12. Casas Tinto S, Zhang Y, Sanchez Garcia J, Gomez Velazquez M, Rincon Limas D, Fernandez Funez P. The ER stress factor XBP1s prevents amyloid-beta neurotoxicity. Hum Mol Genet. 2011;20:2144-60 pubmed publisher
    ..In support of this observation, a mutation in the only ryanodine receptor (RyR) in flies also suppresses A? neurotoxicity, indicating the conserved mechanisms between the two AD ..
  13. Van Goethem E, Silva E, Xiao H, Franc N. The Drosophila TRPP cation channel, PKD2 and Dmel/Ced-12 act in genetically distinct pathways during apoptotic cell clearance. PLoS ONE. 2012;7:e31488 pubmed publisher
    ..Similarly to its C. elegans homologue, Dmel\Ced-12 appears to function in a genetically distinct pathway. ..
  14. Cassar M, Issa A, Riemensperger T, Petitgas C, Rival T, Coulom H, et al. A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila. Hum Mol Genet. 2015;24:197-212 pubmed publisher
    ..Fourthly, a mutation in the Drosophila ryanodine receptor (RyR), which inhibits activity-induced increase in cytosolic Ca(2+), also strongly enhanced PQ resistance...
  15. Tao Y, Gutteridge S, Benner E, Wu L, Rhoades D, Sacher M, et al. Identification of a critical region in the Drosophila ryanodine receptor that confers sensitivity to diamide insecticides. Insect Biochem Mol Biol. 2013;43:820-8 pubmed publisher
    ..Expression of a full-length Drosophila melanogaster ryanodine receptor in an insect cell line confers sensitivity to the receptor agents, caffeine and ryanodine along with ..
  16. Takeshima H, Nishi M, Iwabe N, Miyata T, Hosoya T, Masai I, et al. Isolation and characterization of a gene for a ryanodine receptor/calcium release channel in Drosophila melanogaster. FEBS Lett. 1994;337:81-7 pubmed
    ..The nucleotide sequence of a 25.7 kilobase Drosophila melanogaster genomic DNA segment containing a gene for a ryanodine receptor/calcium release channel homologue has been determined...
  17. Wang B, Martin S, Newman R, Hamilton S, Shea M, Bayley P, et al. Biochemical properties of V91G calmodulin: A calmodulin point mutation that deregulates muscle contraction in Drosophila. Protein Sci. 2004;13:3285-97 pubmed
    ..In particular, defective regulation of ryanodine receptor (RyR) channels was indicated by genetic interaction analysis...
  18. Gao S, Sandstrom D, Smith H, High B, Marsh J, Nash H. Drosophila ryanodine receptors mediate general anesthesia by halothane. Anesthesiology. 2013;118:587-601 pubmed publisher
    ..The mammalian ryanodine receptor (Ryr) is a known halothane target, and the authors hypothesized that it has a central role in anesthesia...
  19. Shakiryanova D, Morimoto T, Zhou C, Chouhan A, Sigrist S, Nose A, et al. Differential control of presynaptic CaMKII activation and translocation to active zones. J Neurosci. 2011;31:9093-100 pubmed publisher
    ..activation is slow, reflecting T286 autophosphorylation and the function of presynaptic ER ryanodine receptors (RyRs) and inositol trisphosphate receptors (IP3Rs)...
  20. An S, Wang S, Gilbert L, Beerntsen B, Ellersieck M, Song Q. Global identification of bursicon-regulated genes in Drosophila melanogaster. BMC Genomics. 2008;9:424 pubmed publisher
    ..The data obtained here will form the basis for future studies aimed at elucidating the exact mechanisms upstream from the secretion of bursicon and its binding to target cells. ..
  21. Wong M, Shakiryanova D, Levitan E. Presynaptic ryanodine receptor-CamKII signaling is required for activity-dependent capture of transiting vesicles. J Mol Neurosci. 2009;37:146-50 pubmed publisher
    ..mobilization requires Ca(2+)-induced Ca2+ release by presynaptic endoplasmic reticulum (ER) ryanodine receptors (RyRs) that in turn stimulates Ca2+/calmodulin-dependent kinase II (CamKII)...
  22. Ponting C. Novel repeats in ryanodine and IP3 receptors and protein O-mannosyltransferases. Trends Biochem Sci. 2000;25:48-50 pubmed
  23. Baker D, Meadows L, Wang J, Dow J, Russell S. Variable sexually dimorphic gene expression in laboratory strains of Drosophila melanogaster. BMC Genomics. 2007;8:454 pubmed
    ..Much of this variation reflects sex-specific challenges associated with divergent physiological trade-offs, morphology and regulatory pathways operating within males and females. ..
  24. Blumenthal E. Characterization of transepithelial potential oscillations in the Drosophila Malpighian tubule. J Exp Biol. 2001;204:3075-84 pubmed
    ..Transcripts encoding two calcium-release channels, the ryanodine receptor and the inositol trisphosphate receptor, are detectable in the tubule by reverse transcription-polymerase ..
  25. Baumann O. Distribution of ryanodine receptor Ca(2+) channels in insect photoreceptor cells. J Comp Neurol. 2000;421:347-61 pubmed
    Physiological studies have provided evidence for the existence of ryanodine receptor (RyR) Ca(2+) channels in compound eyes of insects...
  26. Xu C, Luo J, He L, Montell C, Perrimon N. Oxidative stress induces stem cell proliferation via TRPA1/RyR-mediated Ca2+ signaling in the Drosophila midgut. elife. 2017;6: pubmed publisher
    ..identified two regulators of cytosolic Ca2+ levels, transient receptor potential A1 (TRPA1) and ryanodine receptor (RyR)...
  27. Shakiryanova D, Zettel G, Gu T, Hewes R, Levitan E. Synaptic neuropeptide release induced by octopamine without Ca2+ entry into the nerve terminal. Proc Natl Acad Sci U S A. 2011;108:4477-81 pubmed publisher
    ..Octopamine-evoked neuropeptide release also requires endoplasmic reticulum Ca(2+) mobilization by the ryanodine receptor and the inositol trisphosphate receptor...
  28. Klose M, Dason J, Atwood H, Boulianne G, Mercier A. Peptide-induced modulation of synaptic transmission and escape response in Drosophila requires two G-protein-coupled receptors. J Neurosci. 2010;30:14724-34 pubmed publisher
    ..stores or by interfering with Ca(2+) release from the endoplasmic reticulum through disruption of either the ryanodine receptor or the inositol 1,4,5-trisphosphate receptor. The peptide also altered behavior...
  29. Shakiryanova D, Klose M, Zhou Y, Gu T, Deitcher D, Atwood H, et al. Presynaptic ryanodine receptor-activated calmodulin kinase II increases vesicle mobility and potentiates neuropeptide release. J Neurosci. 2007;27:7799-806 pubmed
    ..However, this ryanodine receptor (RyR)-mediated effect is short-lived and only initiates signaling...
  30. Shim J, Mukherjee T, Mondal B, Liu T, Young G, Wijewarnasuriya D, et al. Olfactory control of blood progenitor maintenance. Cell. 2013;155:1141-53 pubmed publisher
    ..This study links sensory perception and the effects of its deprivation on the integrity of the hematopoietic and innate immune systems in Drosophila. PAPERCLIP: ..
  31. Murmu M, Stinnakre J, Real E, Martin J. Calcium-stores mediate adaptation in axon terminals of olfactory receptor neurons in Drosophila. BMC Neurosci. 2011;12:105 pubmed publisher