Gene Symbol: Rrp40
Description: Ribosomal RNA processing 40
Alias: CG31938, Dmel\CG31938, dRrp40, ribosomal RNA processing 40, CG31938-PA, CG31938-PB, Rrp40-PA, Rrp40-PB
Species: fruit fly
Products:     Rrp40

Top Publications

  1. Andrulis E, Werner J, Nazarian A, Erdjument Bromage H, Tempst P, Lis J. The RNA processing exosome is linked to elongating RNA polymerase II in Drosophila. Nature. 2002;420:837-41 pubmed
    ..These data provide a physical basis for the hypothesis that exosome-mediated pre-mRNA surveillance accompanies transcription elongation. ..
  2. Graham A, Kiss D, Andrulis E. Differential distribution of exosome subunits at the nuclear lamina and in cytoplasmic foci. Mol Biol Cell. 2006;17:1399-409 pubmed
    ..These different distribution patterns presumably reflect distinct exosome subunit subcomplexes with correspondingly specialized functions...
  3. Graham A, Kiss D, Andrulis E. Core exosome-independent roles for Rrp6 in cell cycle progression. Mol Biol Cell. 2009;20:2242-53 pubmed publisher
    ..culture cells, dRrp6 is required for cell proliferation and error-free mitosis, but the core exosome subunit Rrp40 is not...
  4. Kiss D, Andrulis E. Genome-wide analysis reveals distinct substrate specificities of Rrp6, Dis3, and core exosome subunits. RNA. 2010;16:781-91 pubmed publisher
    ..We conclude that individual exosome subunits are largely functionally independent at the transcript level, but are interdependent on a transcriptomic level. ..
  5. Graham A, Davis S, Andrulis E. Interdependent nucleocytoplasmic trafficking and interactions of Dis3 with Rrp6, the core exosome and importin-alpha3. Traffic. 2009;10:499-513 pubmed publisher
    ..We propose that the movement and deposition of this complex is important for the subcellular compartmentalization and regulation of the exosome core. ..
  6. Hödl M, Basler K. Transcription in the absence of histone H3.3. Curr Biol. 2009;19:1221-6 pubmed publisher
    ..2. Together, these data suggest that in Drosophila, presence of H3.3K4me in the chromatin of active genes is dispensable for successful transcription in most cells and only plays an important role in reproductive tissues. ..
  7. Kiss D, Hou D, Gross R, Andrulis E. Dis3- and exosome subunit-responsive 3' mRNA instability elements. Biochem Biophys Res Commun. 2012;423:461-6 pubmed publisher
    ..RNAi-based depletion of Dis3, Rrp6, Rrp4, Rrp40, or Rrp46 diminished the efficacy of cassette-mediated destabilization...
  8. Lim S, Boyle P, Chinen M, Dale R, Lei E. Genome-wide localization of exosome components to active promoters and chromatin insulators in Drosophila. Nucleic Acids Res. 2013;41:2963-80 pubmed publisher
    ..Taken together, our results reveal a novel positive relationship between exosome and chromatin insulators throughout the genome. ..
  9. Mondal B, Shim J, Evans C, Banerjee U. Pvr expression regulators in equilibrium signal control and maintenance of Drosophila blood progenitors. elife. 2014;3:e03626 pubmed publisher
    ..We show that the products of these genes along with the Bip1-interacting protein RpS8 (Ribosomal protein S8) are required for the proper expression of Pvr. ..

More Information


  1. Freibaum B, Lu Y, López González R, Kim N, Almeida S, Lee K, et al. GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport. Nature. 2015;525:129-33 pubmed publisher
    ..These studies show that a primary consequence of G4C2 repeat expansion is the compromise of nucleocytoplasmic transport through the nuclear pore, revealing a novel mechanism of neurodegeneration. ..
  2. Forler D, Kocher T, Rode M, Gentzel M, Izaurralde E, Wilm M. An efficient protein complex purification method for functional proteomics in higher eukaryotes. Nat Biotechnol. 2003;21:89-92 pubmed
    ..This strategy allows the determination of the functionality of the tagged protein and increases the specificity and the efficiency of the purification. ..
  3. Mamolen M, Smith A, Andrulis E. Drosophila melanogaster Dis3 N-terminal domains are required for ribonuclease activities, nuclear localization and exosome interactions. Nucleic Acids Res. 2010;38:5507-17 pubmed publisher
    ..Taken together, our data suggest that the dDis3 N-terminus is a dynamic and complex hub for RNA metabolism and exosome interactions. ..