Gene Symbol: RpS18
Description: Ribosomal protein S18
Alias: BcDNA:RH43343, CG8900, Dmel\CG8900, M(2)56F, RS18_DROME, Rps18, S18, anon-56Fa, anon-EST:Posey27, anon-EST:fe2D3, rpS18, ribosomal protein S18, CG8900-PA, CG8900-PB, RpS18-PA, RpS18-PB, anon-fast-evolving-2D3, transcription unit B
Species: fruit fly

Top Publications

  1. Burns D, Stark B, Macklin M, Chooi W. Isolation and characterization of cloned DNA sequences containing ribosomal protein genes of Drosophila melanogaster. Mol Cell Biol. 1984;4:2643-52 pubmed
    ..Three clones containing the genes for r proteins 7/8, S18, and L12 were positively identified by electrophoresis of the translation products in one-dimensional and two-..
  2. Ponton F, Chapuis M, Pernice M, Sword G, Simpson S. Evaluation of potential reference genes for reverse transcription-qPCR studies of physiological responses in Drosophila melanogaster. J Insect Physiol. 2011;57:840-50 pubmed publisher
    ..The differences between the experimental treatments suggest that assessing the stability of reference gene expression patterns, determining candidates and testing their suitability is required for each experimental investigation. ..
  3. Al Jubran K, Wen J, Abdullahi A, Roy Chaudhury S, Li M, Ramanathan P, et al. Visualization of the joining of ribosomal subunits reveals the presence of 80S ribosomes in the nucleus. RNA. 2013;19:1669-83 pubmed publisher
    ..Furthermore, we detected rapid puromycin incorporation in the nucleolus and at transcription sites, providing an independent indication of functional 80S in the nucleolus and 80S association with nascent transcripts. ..
  4. Renault A, Axton J. Identification of plu genes and cis-acting elements of PCNA in the Drosophila genus using conservation of gene order. Gene. 2003;307:77-86 pubmed
    In Drosophila melanogaster, the cell cycle control gene, plutonium (plu), is located between the PCNA and RpS18 genes at position 56F on chromosome arm 2R...
  5. Eggert U, Kiger A, Richter C, Perlman Z, Perrimon N, Mitchison T, et al. Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol. 2004;2:e379 pubmed
    ..Our study shows that parallel RNA interference and small molecule screening is a generally useful approach to identifying active small molecules and their target pathways...
  6. Sakai A, Schwartz B, Goldstein S, Ahmad K. Transcriptional and developmental functions of the H3.3 histone variant in Drosophila. Curr Biol. 2009;19:1816-20 pubmed publisher
    ..Our results imply that the H3.3 variant plays an essential role in chromatin transitions in the male germline. ..
  7. Killip L, Grewal S. DREF is required for cell and organismal growth in Drosophila and functions downstream of the nutrition/TOR pathway. Dev Biol. 2012;371:191-202 pubmed publisher
    ..Given that DREF is conserved, this role may also be important in the control of growth in other animals. ..
  8. Kale A, Li W, Lee C, Baker N. Apoptotic mechanisms during competition of ribosomal protein mutant cells: roles of the initiator caspases Dronc and Dream/Strica. Cell Death Differ. 2015;22:1300-12 pubmed publisher
    ..Independence of p53 and unusual dependence on Dream/Strica distinguish competitive cell death from noncompetitive apoptosis of Rp/Rp cells and from many other examples of cell death. ..
  9. Garwood J, Lepesant J. The Drosophila melanogaster homolog of ribosomal protein S18. Gene. 1994;141:231-5 pubmed
    ..the cDNA encoding the Drosophila melanogaster homolog of the human and rat small-subunit ribosomal protein, S18 (rpS18), is presented...

More Information


  1. Trachtulec Z, Forejt J. Synteny of orthologous genes conserved in mammals, snake, fly, nematode, and fission yeast. Mamm Genome. 2001;12:227-31 pubmed
    ..Such a distribution of transcription units is nonrandom and could indicate a long-range cis-acting relationship among the genes within the conserved syntenic group. ..
  2. Spain M, Caruso J, Swaminathan A, Pile L. Drosophila SIN3 isoforms interact with distinct proteins and have unique biological functions. J Biol Chem. 2010;285:27457-67 pubmed publisher
    ..Together our findings suggest that SIN3 isoforms serve distinct roles in transcriptional regulation by partnering with different histone-modifying enzymes. ..
  3. Rugjee K, Roy Chaudhury S, Al Jubran K, Ramanathan P, Matina T, Wen J, et al. Fluorescent protein tagging confirms the presence of ribosomal proteins at Drosophila polytene chromosomes. Peerj. 2013;1:e15 pubmed publisher
    ..sites in Drosophila, we have generated several transgenic flies expressing RPs (RpS2, RpS5a, RpS9, RpS11, RpS13, RpS18, RpL8, RpL11, RpL32, and RpL36) tagged with either green or red fluorescent protein...
  4. Axton J, Shamanski F, Young L, Henderson D, Boyd J, Orr Weaver T. The inhibitor of DNA replication encoded by the Drosophila gene plutonium is a small, ankyrin repeat protein. EMBO J. 1994;13:462-70 pubmed
    ..plu encodes a protein with two ankyrin-like repeats, a domain for protein-protein interaction. plu is immediately adjacent to, but distinct from, the PCNA gene. ..