Gene Symbol: RpL38
Description: Ribosomal protein L38
Alias: 41Af, 41Ag, BcDNA:RE42506, CG18001, CG40278, Dmel\CG18001, E-2b, GroupIV, M(2)41A, M(2)S2, M(2)S3, Rp L38, l(2)41Af, l(2)41Ag, l(2)41Ai, l(2)EMS4-72, l(2)EMS45-72, l(2R)A', ribosomal protein L38, CG18001-PA, CG18001-PB, Minute(2)41A, RpL38-PA, RpL38-PB, enhancer on chromosome 2, complementation group b, lethal(2)41Af, nipped, ribosomal protein 38
Species: fruit fly

Top Publications

  1. Ganetzky B. On the components of segregation distortion in Drosophila melanogaster. Genetics. 1977;86:321-55 pubmed
    ..The results of these studies allow a reinterpretation of results from earlier analyses of the SD system and serve to limit the possible mechanisms to account for segregation distortion. ..
  2. Dimitri P, Corradini N, Rossi F, Vernì F, Cenci G, Belloni G, et al. Vital genes in the heterochromatin of chromosomes 2 and 3 of Drosophila melanogaster. Genetica. 2003;117:209-15 pubmed
    ..Repetitive loci, such as Responder and the ABO elements, which are also located in the heterochromatin of chromosome 2, are not discussed here because they have been reviewed in detail elsewhere. ..
  3. Hilliker A. Genetic analysis of the centromeric heterochromatin of chromosome 2 of Drosophila melanogaster: deficiency mapping of EMS-induced lethal complementation groups. Genetics. 1976;83:765-82 pubmed
    ..Thus functional genetic loci are found in heterochromatin, albeit at a very low density relative to euchromatin. ..
  4. Lyttle T. The effect of novel chromosome position and variable dose on the genetic behavior of the Responder (Rsp) element of the Segregation distorter (SD) system of Drosophila melanogaster. Genetics. 1989;121:751-63 pubmed
    ..Possible explanations for such behavior are discussed. ..
  5. Kongsuwan K, Yu Q, Vincent A, Frisardi M, Rosbash M, Lengyel J, et al. A Drosophila Minute gene encodes a ribosomal protein. Nature. 1985;317:555-8 pubmed
    ..This activity is specific to the 99D Minute as it does not suppress other Minute loci elsewhere in the genome. This result provides direct evidence that the Minute locus at the 99D interval encodes the ribosomal protein 49. ..
  6. Duttagupta A, Shellenbarger D. Genetics of minute locus in Drosophila melanogaster. Basic Life Sci. 1980;16:25-33 pubmed
  7. Coulthard A, Alm C, Cealiac I, Sinclair D, Honda B, Rossi F, et al. Essential loci in centromeric heterochromatin of Drosophila melanogaster. I: the right arm of chromosome 2. Genetics. 2010;185:479-95 pubmed publisher
  8. Cenci G, Belloni G, Dimitri P. 1(2)41Aa, a heterochromatic gene of Drosophila melanogaster, is required for mitotic and meiotic chromosome condensation. Genet Res. 2003;81:15-24 pubmed
    ..Taken together, these findings indicate that 1(2)41Aa is a novel cell cycle gene required for proper chromosome condensation in both somatic and germ line cells. ..
  9. Lin J, Mitchell N, Kalcina M, Tchoubrieva E, Stewart M, Marygold S, et al. Drosophila ribosomal protein mutants control tissue growth non-autonomously via effects on the prothoracic gland and ecdysone. PLoS Genet. 2011;7:e1002408 pubmed publisher
    ..They also demonstrate how Rp mutants can affect growth and development cell non-autonomously. ..

More Information


  1. Dimitri P. Cytogenetic analysis of the second chromosome heterochromatin of Drosophila melanogaster. Genetics. 1991;127:553-64 pubmed
    ..Extensive cell death during imaginal disc development was observed in individuals hemizygous for either the EMS 31 and rolled mutations, leading to a pattern of phenotypic defects of adult structures. ..
  2. Lindsley D, Sandler L, Baker B, Carpenter A, Denell R, Hall J, et al. Segmental aneuploidy and the genetic gross structure of the Drosophila genome. Genetics. 1972;71:157-84 pubmed
    ..Moreover, except for the single triplo-lethal locus, the effects of hyperploidy are much less pronounced than those of the corresponding hypoploidy. ..
  3. Dimitri P, Arca B, Berghella L, Mei E. High genetic instability of heterochromatin after transposition of the LINE-like I factor in Drosophila melanogaster. Proc Natl Acad Sci U S A. 1997;94:8052-7 pubmed
    ..Together, these data indicate that I factors transpose with high frequency into pericentric regions of chromosome 2 and may play a role in the evolution of constitutive heterochromatin. ..
  4. Rasmuson Lestander A, Larsson J, Rasmuson B. Position-effect variegation and z1 mediated white repression in the In(1)wis system in Drosophila melanogaster. Hereditas. 1993;119:209-18 pubmed
    ..We propose that nonhomologous chromosome pairing between X and Y is important for the synapsis-dependent z1-mediated repression of white transcription activity in this system. ..
  5. Duffy J, Wells J, Gergen J. Dosage-sensitive maternal modifiers of the drosophila segmentation gene runt. Genetics. 1996;142:839-52 pubmed
    ..Furthermore, the effects of one of these loci, M(1)1B, is indirect and mediated through effects on the transcriptional regulation of posterior gap genes. ..
  6. Eberl D, Duyf B, Hilliker A. The role of heterochromatin in the expression of a heterochromatic gene, the rolled locus of Drosophila melanogaster. Genetics. 1993;134:277-92 pubmed
  7. Presgraves D. A fine-scale genetic analysis of hybrid incompatibilities in Drosophila. Genetics. 2003;163:955-72 pubmed
    ..Finally, I estimate that a total of approximately 191 hybrid-lethal incompatibilities separate D. melanogaster and D. simulans, indicating extensive functional divergence between these species' genomes. ..
  8. Rollins R, Morcillo P, Dorsett D. Nipped-B, a Drosophila homologue of chromosomal adherins, participates in activation by remote enhancers in the cut and Ultrabithorax genes. Genetics. 1999;152:577-93 pubmed
    ..in the Notch receptor pathway in the wing margin, including scalloped, vestigial, mastermind, Chip, and the Nipped locus...
  9. Hilliker A, Holm D. Genetic analysis of the proximal region of chromosome 2 of Drosophila melanogaster. I. Detachment products of compound autosomes. Genetics. 1975;81:705-21 pubmed
    ..The data further demonstrate that rolled, and probably light, are located within the proximal heterochromatin. Thus, functional genetic loci are found in heterochromatin, albeit at low density. ..