RpL32

Summary

Gene Symbol: RpL32
Description: Ribosomal protein L32
Alias: 143250_at, BcDNA:RH03940, CG7939, Dmel\CG7939, L32, M(3)99D, RP-49, RP49, RPL32, Rp-49, Rp49, Rp49/RpL32, Rpl32, bs30a02.y1, rp49, rp49/RpL32, CG7939-PA, CG7939-PB, CG7939-PC, CG7939-PD, Minute(3)99D, RpL32-PA, RpL32-PB, RpL32-PC, RpL32-PD, r-protein 49, ribosomal protein 49, ribosomal protein 49/L32, ribosomal protein L32
Species: fruit fly

Top Publications

  1. doi Myosin-V regulates oskar mRNA localization in the Drosophila oocyte
    Jana Krauss
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Spemannstrasse 35, 72076 Tubingen, Germany
    Curr Biol 19:1058-63. 2009
  2. ncbi Molecular evolution of the ocnus and janus genes in the Drosophila melanogaster species subgroup
    J Parsch
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138 2020, USA
    Mol Biol Evol 18:801-11. 2001
  3. pmc Fcp1 dephosphorylation of the RNA polymerase II C-terminal domain is required for efficient transcription of heat shock genes
    Nicholas J Fuda
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA
    Mol Cell Biol 32:3428-37. 2012
  4. pmc Identification and characterization of a juvenile hormone response element and its binding proteins
    Yiping Li
    Department of Entomology, University of Kentucky, Lexington, KY 40546, USA
    J Biol Chem 282:37605-17. 2007
  5. ncbi Decreased expression of the GABAA receptor in fragile X syndrome
    Charlotte D'Hulst
    Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
    Brain Res 1121:238-45. 2006
  6. doi In situ visualization of gene expression using polymer-coated quantum-dot-DNA conjugates
    Youngseon Choi
    Nano Bio Chemistry Group, Institut Pasteur Korea, Seongnam, South Korea
    Small 5:2085-91. 2009
  7. doi On the possible role of tRNA base modifications in the evolution of codon usage: queuosine and Drosophila
    Ylenia Chiari
    Department of Ecology and Evolutionary Biology, Yale University, 21 Sachem St, New Haven, CT 06520 8106, USA
    J Mol Evol 70:339-45. 2010
  8. doi Evaluation of potential reference genes for reverse transcription-qPCR studies of physiological responses in Drosophila melanogaster
    Fleur Ponton
    School of Biological Sciences, Heydon Laurence Building A08, The University of Sydney, NSW 2006, Australia
    J Insect Physiol 57:840-50. 2011
  9. pmc Separation of stem cell maintenance and transposon silencing functions of Piwi protein
    Mikhail S Klenov
    Department of Molecular Genetics of the Cell, Institute of Molecular Genetics, Russian Academy of Science, Moscow 123182, Russia
    Proc Natl Acad Sci U S A 108:18760-5. 2011
  10. pmc Sex chromosome-specific regulation in the Drosophila male germline but little evidence for chromosomal dosage compensation or meiotic inactivation
    Colin D Meiklejohn
    Department of Biology, University of Rochester, Rochester, New York, United States of America
    PLoS Biol 9:e1001126. 2011

Research Grants

Scientific Experts

  • Jeffrey Powell
  • Fleur Ponton
  • Marcio Alves-Ferreira
  • J Parsch
  • Laura Fanti
  • Pier Paolo Pompa
  • Colin D Meiklejohn
  • Anne Ephrussi
  • Nicholas J Fuda
  • Bruna P Matta
  • Mikhail S Klenov
  • Shih Jung Fan
  • François Juge
  • Ylenia Chiari
  • Virginie Marchand
  • Florence Besse
  • Youngseon Choi
  • Sonia López de Quinto
  • Xingwu Lu
  • Jana Krauss
  • Akiko Sakai
  • Wouter Bossuyt
  • M V Frolov
  • J Rozas
  • Bassem A Hassan
  • Natalie De Geest
  • Yiping Li
  • Weronika Fic
  • M Aguade
  • B Lemaitre
  • Hirofumi Furuhashi
  • James B Earl
  • J A Birchler
  • Charlotte D'Hulst
  • Manika Pal Bhadra
  • Hadas Millo
  • Fiona M Pyke
  • J A Hoffmann
  • Cheng Yu Lee
  • Alexei Tulin
  • C S Thummel
  • Colin T Waters
  • Danny Reinberg
  • John T Lis
  • Wenxiang Wei
  • Leighton J Core
  • Martin S Buckley
  • A Herold
  • C Segarra
  • Olesya A Sokolova
  • Sergey A Lavrov
  • Evgeny Y Yakushev
  • Anastasia D Stolyarenko
  • Blanche C Bitner-Mathé
  • Elena A Mikhaleva
  • Vladimir A Gvozdev
  • T Hock
  • P P D'Avino
  • Aristeidis Parmakelis
  • A Bernal
  • U Bhadra
  • R Farkas
  • I E Clark
  • A Basset
  • S P Koushika
  • James Colborn
  • Kirstin Dion
  • Ji Young Ryu
  • B M Mechler
  • Alexander Y Konev
  • Christiane Nüsslein-Volhard
  • Suk Min Hong
  • Dmitry V Fyodorov
  • Iris Leenaerts
  • Rita Song
  • Alvar Trucco
  • Patrick Morcillo
  • Peter Marynen
  • Sandeep N Wontakal
  • Brian E Schwartz
  • Sung Jun Han
  • Kami Ahmad
  • Sara Goldstein
  • Alexander V Emelyanov
  • Hwa Pyung Kim
  • Stein Aerts
  • Arthur I Skoultchi
  • G Lam
  • P Manfruelli
  • A Vincent

Detail Information

Publications74

  1. doi Myosin-V regulates oskar mRNA localization in the Drosophila oocyte
    Jana Krauss
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Spemannstrasse 35, 72076 Tubingen, Germany
    Curr Biol 19:1058-63. 2009
    ..Our findings reveal that a balance of microtubule- and actin-based motor activities regulates oskar mRNA localization in the Drosophila oocyte...
  2. ncbi Molecular evolution of the ocnus and janus genes in the Drosophila melanogaster species subgroup
    J Parsch
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138 2020, USA
    Mol Biol Evol 18:801-11. 2001
    ..These results are consistent with previous studies that have detected an increased rate of evolution in genes with reproductive function...
  3. pmc Fcp1 dephosphorylation of the RNA polymerase II C-terminal domain is required for efficient transcription of heat shock genes
    Nicholas J Fuda
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA
    Mol Cell Biol 32:3428-37. 2012
    ..Our results indicate that Fcp1 is required to maintain the pool of initiation-competent unphosphorylated Pol II, and this function is particularly important for the highly transcribed heat shock genes...
  4. pmc Identification and characterization of a juvenile hormone response element and its binding proteins
    Yiping Li
    Department of Entomology, University of Kentucky, Lexington, KY 40546, USA
    J Biol Chem 282:37605-17. 2007
    ....
  5. ncbi Decreased expression of the GABAA receptor in fragile X syndrome
    Charlotte D'Hulst
    Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
    Brain Res 1121:238-45. 2006
    ....
  6. doi In situ visualization of gene expression using polymer-coated quantum-dot-DNA conjugates
    Youngseon Choi
    Nano Bio Chemistry Group, Institut Pasteur Korea, Seongnam, South Korea
    Small 5:2085-91. 2009
    ..Importantly, multiplex FISH of Ribosomal protein 49 and Actin 5C using green and red QD-DNA conjugates allows the observation of cellular distribution of the ..
  7. doi On the possible role of tRNA base modifications in the evolution of codon usage: queuosine and Drosophila
    Ylenia Chiari
    Department of Ecology and Evolutionary Biology, Yale University, 21 Sachem St, New Haven, CT 06520 8106, USA
    J Mol Evol 70:339-45. 2010
    ..willistoni is in young females producing eggs. Because tRNAs laid down in eggs persist through the early stages of development, this implies that Q modification occurs earlier in development in D. willistoni than in other Drosophila...
  8. doi Evaluation of potential reference genes for reverse transcription-qPCR studies of physiological responses in Drosophila melanogaster
    Fleur Ponton
    School of Biological Sciences, Heydon Laurence Building A08, The University of Sydney, NSW 2006, Australia
    J Insect Physiol 57:840-50. 2011
    ..We analyzed the expression levels of seven candidate reference genes (Actin, EF1, Mnf, Rps20, Rpl32, Tubulin and 18S) in flies that were injured, heat-stressed, or fed different diets...
  9. pmc Separation of stem cell maintenance and transposon silencing functions of Piwi protein
    Mikhail S Klenov
    Department of Molecular Genetics of the Cell, Institute of Molecular Genetics, Russian Academy of Science, Moscow 123182, Russia
    Proc Natl Acad Sci U S A 108:18760-5. 2011
    ..We suggest that the Piwi function in GSC self-renewal is independent of transposon repression and is normally realized in the cytoplasm of GSC niche cells...
  10. pmc Sex chromosome-specific regulation in the Drosophila male germline but little evidence for chromosomal dosage compensation or meiotic inactivation
    Colin D Meiklejohn
    Department of Biology, University of Rochester, Rochester, New York, United States of America
    PLoS Biol 9:e1001126. 2011
    ..These findings help to resolve several previously conflicting reports and have implications for patterns of genome evolution and speciation in Drosophila...
  11. pmc Drosophila Ge-1 promotes P body formation and oskar mRNA localization
    Shih Jung Fan
    Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
    PLoS ONE 6:e20612. 2011
    ..Our findings suggest an important role of dGe-1 in optimization of the osk mRNA localization process required for patterning the Drosophila embryo...
  12. ncbi Analysis of a shift in codon usage in Drosophila
    Jeffrey R Powell
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520 8106, USA
    J Mol Evol 57:S214-25. 2003
    ..However, we do not argue that this shift was adaptive in nature, rather it may be an example of a "frozen accident."..
  13. doi Getting real with real-time qPCR: a case study of reference gene selection for morphological variation in Drosophila melanogaster wings
    Bruna P Matta
    Laboratório de Evolução de Caracteres Complexos, Departamento de Genetica, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rua Professor Rodolpho Paulo Rocco, s n Prédio do CCS, Bloco A, sala A2 075 Cidade Universitária, Rio de Janeiro, 21941 617, RJ, Brazil
    Dev Genes Evol 221:49-57. 2011
    ..Overall, we identified and validated a pair of genes (RpL32 and Tbp) as being stably expressed in both experimental comparisons...
  14. pmc Control of poly(A) polymerase level is essential to cytoplasmic polyadenylation and early development in Drosophila
    François Juge
    Génétique du Développement de la Drosophile, Institut de Genetique Humaine, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    EMBO J 21:6603-13. 2002
    ..This demonstrates that regulation of the PAP level is essential for controlled cytoplasmic polyadenylation and early development...
  15. ncbi Steroid regulation of midgut cell death during Drosophila development
    Cheng Yu Lee
    Center for Biosystems Research, University of Maryland Biotechnology Institute, University of Maryland, College Park, Maryland 20742, USA
    Dev Biol 250:101-11. 2002
    ..These studies indicate that ecdysone triggers a two-step hierarchy composed of steroid-induced regulatory genes and apoptosis genes that, in turn, regulate the autophagic death of midgut cells during development...
  16. pmc Histone acetylation and gene expression analysis of sex lethal mutants in Drosophila
    U Bhadra
    Division of Biological Sciences, University of Missouri, Columbia 65211, USA
    Genetics 155:753-63. 2000
    ..In both cases we find relatively little effect upon X chromosomal gene expression...
  17. pmc The Drosophila heterochromatic gene encoding poly(ADP-ribose) polymerase (PARP) is required to modulate chromatin structure during development
    Alexei Tulin
    Howard Hughes Medical Research Laboratories, Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    Genes Dev 16:2108-19. 2002
    ..We propose that PARP-e autoregulates Parp transcription by influencing the chromatin structure of its heterochromatic environment. Our results indicate that Parp plays a fundamental role organizing the structure of Drosophila chromatin...
  18. pmc NXF1/p15 heterodimers are essential for mRNA nuclear export in Drosophila
    A Herold
    European Molecular Biology Laboratory, Heidelberg, Germany
    RNA 7:1768-80. 2001
    ..We conclude that Dm NXF1/p15 heterodimers only (but not NXF2-NXF4) mediate the export of the majority of mRNAs in Drosophila cells and that the other members of the NXF family play more specialized or different roles...
  19. pmc DNA variation at the rp49 gene region of Drosophila simulans: evolutionary inferences from an unusual haplotype structure
    J Rozas
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, 08071 Barcelona, Spain
    Genetics 158:1147-55. 2001
    An approximately 1.3-kb region including the rp49 gene plus its 5' and 3' flanking regions was sequenced in 24 lines of Drosophila simulans (10 from Spain and 14 from Mozambique)...
  20. pmc The E23 early gene of Drosophila encodes an ecdysone-inducible ATP-binding cassette transporter capable of repressing ecdysone-mediated gene activation
    T Hock
    Department of Biological Science and Program in Medical Sciences, Florida State University, Tallahassee 32306 4370, USA
    Proc Natl Acad Sci U S A 97:9519-24. 2000
    ..Our results suggest the existence of a previously unrecognized regulatory mechanism for modulating steroid hormone signaling in Drosophila...
  21. pmc The oxen gene of Drosophila encodes a homolog of subunit 9 of yeast ubiquinol-cytochrome c oxidoreductase complex: evidence for modulation of gene expression in response to mitochondrial activity
    M V Frolov
    University of Missouri, Columbia, Missouri 65211, USA
    Genetics 156:1727-36. 2000
    ..The oxen mutation provides a model for the genetic analysis in multicellular organisms of the effect of mitochondrial activity on nuclear gene expression...
  22. ncbi Synthesis of the posterior determinant Nanos is spatially restricted by a novel cotranslational regulatory mechanism
    I E Clark
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Curr Biol 10:1311-4. 2000
    ..Thus, synthesis of ectopic Nos protein is inhibited by a novel regulatory mechanism that does not involve a stable arrest of the translation cycle...
  23. pmc Drosophila Thor participates in host immune defense and connects a translational regulator with innate immunity
    A Bernal
    Department of Biochemistry and Cell Biology, Rice University, 6100 Main Street, Houston, TX 77005, USA
    Proc Natl Acad Sci U S A 97:6019-24. 2000
    ..Our results suggest either a role for translational regulation in humoral immunity or a new, nontranslational function for 4E-BP type genes...
  24. ncbi The genetic basis of resistance to diazinon in natural populations of Drosophila melanogaster
    Fiona M Pyke
    Department of Genetics, Centre for Environmental Stress and Adaptation Research University of Melbourne, Melbourne, VIC 3010, Australia
    Genetica 121:13-24. 2004
    ..Larval resistance levels, due to single genes (or gene complexes) on chromosomes II and III, were significant (15-fold). Evidence indicates that the gene on chromosome II is Cyp6g1...
  25. ncbi Myosin VI plays a role in cell-cell adhesion during epithelial morphogenesis
    Hadas Millo
    Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh EH9 3JR, UK
    Mech Dev 121:1335-51. 2004
    ..Some embryos hatch into larvae, containing detached cells loose in the haemolymph. Myosin VI is crucial for correct cell morphology and maintenance of adhesive cellular contacts within epithelial cell layers...
  26. doi Physical assessment of toxicology at nanoscale: nano dose-metrics and toxicity factor
    P P Pompa
    Center for Bio Molecular Nanotechnology, Italian Institute of Technology, Via Barsanti 1, 73010 Arnesano, Lecce, Italy
    Nanoscale 3:2889-97. 2011
    ..This approach may pave the way to a systematic classification of nanomaterials, leading to important developments in risk assessment and regulatory approval, as well as in a wide range of nanomedicine applications...
  27. pmc Transcriptional and developmental functions of the H3.3 histone variant in Drosophila
    Akiko Sakai
    Department of BCMP, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Curr Biol 19:1816-20. 2009
    ..Our results imply that the H3.3 variant plays an essential role in chromatin transitions in the male germline...
  28. ncbi Sequence and structure of the serendipity locus of Drosophila melanogaster. A densely transcribed region including a blastoderm-specific gene
    A Vincent
    J Mol Biol 186:149-66. 1985
    ..The predicted beta and delta polypeptides show partial amino acid sequence homology, suggesting a common evolutionary origin...
  29. pmc The atonal proneural transcription factor links differentiation and tumor formation in Drosophila
    Wouter Bossuyt
    Laboratory of Neurogenetics, Department of Molecular and Developmental Genetics, VIB, Leuven, Belgium
    PLoS Biol 7:e40. 2009
    ..Combined with evidence that atonal's mammalian homolog, ATOH1, is a tumor suppressor gene, our data support a critical, evolutionarily conserved, function for ato in oncogenesis...
  30. pmc Linker histone H1 is essential for Drosophila development, the establishment of pericentric heterochromatin, and a normal polytene chromosome structure
    Xingwu Lu
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Genes Dev 23:452-65. 2009
    ..Thus, linker histone H1 is essential in Drosophila and plays a fundamental role in the architecture and activity of chromosomes in vivo...
  31. pmc Drosophila PTB promotes formation of high-order RNP particles and represses oskar translation
    Florence Besse
    Developmental Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Genes Dev 23:195-207. 2009
    ..Thus, PTB is a key structural component of oskar RNP complexes that dually controls formation of high-order RNP particles and translational silencing...
  32. ncbi The trithorax group and Pc group proteins are differentially involved in heterochromatin formation in Drosophila
    Laura Fanti
    Istituto Pasteur, Fondazione Cenci Bolognetti, Dipartimento di Genetica e Biologia Molecolare, Universita La Sapienza, 00185, Rome, Italy
    Chromosoma 117:25-39. 2008
    ..These results strongly suggest that trx-G proteins, along with some Pc-G proteins, play an active role in heterochromatin formation in Drosophila...
  33. pmc Eye development under the control of SRp55/B52-mediated alternative splicing of eyeless
    Weronika Fic
    Institut de Génétique Moléculaire de Montpellier IGMM, UMR 5535, Universite de Montpellier II, Centre National de Recherche Scientifique CNRS, Montpellier, France
    PLoS ONE 2:e253. 2007
    ..Our results suggest that B52/SRp55 splicing activity is used during normal eye development to control eye organogenesis and size through regulation of eyeless alternative splicing...
  34. ncbi DNA supercoiling factor contributes to dosage compensation in Drosophila
    Hirofumi Furuhashi
    Department of Developmental Genetics, National Institute of Genetics, SOKENDAI, Mishima, Shizuoka ken 411 8540, Japan
    Development 133:4475-83. 2006
    ..These findings demonstrate that SCF plays a role in transcriptional activation via alteration of chromatin structure and provide evidence that SCF contributes to dosage compensation...
  35. ncbi Expression of Drosophila rhodopsins during photoreceptor cell differentiation: insights into R7 and R8 cell subtype commitment
    James B Earl
    Department of Cell and Developmental Biology, University of Colorado at Denver and Health Sciences Center, School of Medicine, RC1 South, Aurora, 80045, USA
    Gene Expr Patterns 6:687-94. 2006
    ..This sequence mimics the model for how R7 and R8 photoreceptor cells are specified, and defines the timing of photoreceptor cell fate decisions with respect to other events in eye development...
  36. pmc Gene expression analysis of the function of the male-specific lethal complex in Drosophila
    Manika Pal Bhadra
    Division of Biological Sciences, University of Missouri, Columbia, 65211, USA
    Genetics 169:2061-74. 2005
    ....
  37. ncbi The ecdysone regulatory pathway controls wing morphogenesis and integrin expression during Drosophila metamorphosis
    P P D'Avino
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, 15N 2030E, Room 5100, Salt Lake City, Utah 84112 5331, USA
    Dev Biol 220:211-24. 2000
    ..We also propose that ecdysone modulation of integrin expression might be widely used to control multiple aspects of adult development...
  38. pmc The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response
    A Basset
    Centre de Genetique Moleculaire, Centre National de la Recherche Scientifique, F 91198 Gif sur Yvette Cedex, France
    Proc Natl Acad Sci U S A 97:3376-81. 2000
    ....
  39. ncbi The timing of drosophila salivary gland apoptosis displays an l(2)gl-dose response
    R Farkas
    Department of Developmental Genetics, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Cell Death Differ 7:89-101. 2000
    ....
  40. ncbi Separate cis-regulatory sequences control expression of serendipity beta and janus A, two immediately adjacent Drosophila genes
    C Yanicostas
    Institut Jacques Monod, CNRS et Université Paris 7, France
    Mol Gen Genet 246:549-60. 1995
    ..Together these data indicate that in spite of the physical proximity of the jan A and sry beta genes, their transcription is regulated by separate cis-acting sequences...
  41. ncbi The Drosophila E93 gene from the 93F early puff displays stage- and tissue-specific regulation by 20-hydroxyecdysone
    E H Baehrecke
    Howard Hughes Medical Institute, University of Utah, Salt Lake City 84112
    Dev Biol 171:85-97. 1995
    ..We propose that E93 acts in a stage-specific regulatory hierarchy in the salivary gland to direct its histolysis in response to the prepupal ecdysteroid pulse...
  42. ncbi Degradation of maternal string mRNA is controlled by proteins encoded on maternally contributed transcripts
    F A Myers
    Biophysics Laboratory, University of Portsmouth, UK
    Mech Dev 51:217-26. 1995
    ..Therefore, the proteins required to activate the degradation of string mRNA are encoded on a maternally contributed mRNA. We discuss possible models to explain the degradation pathway...
  43. pmc Genetic analysis of B2t, the structural gene for a testis-specific beta-tubulin subunit in Drosophila melanogaster
    K J Kemphues
    Genetics 105:345-56. 1983
    ..All four mutant genes encode beta 2-tubulin subunits that are synthesized at normal rates but do not accumulate. All mutants are completely male sterile as homozygotes...
  44. pmc Drosophila maternal and embryo mRNAs transcribed from a single transcription unit use alternate combinations of exons
    A Vincent
    EMBO J 3:1003-13. 1984
    ..Multiple mRNAs, transcribed from genes which lie adjacent to a ribosomal protein ( rp49 ) gene, are present during oogenesis, embryogenesis, or both...
  45. pmc Sequence, structure, and codon preference of the Drosophila ribosomal protein 49 gene
    P O O'Connell
    Nucleic Acids Res 12:5495-513. 1984
    In this communication, we describe several features of the D. melanogaster gene which codes for ribosomal protein 49 (rp49)...
  46. ncbi A Drosophila Minute gene encodes a ribosomal protein
    K Kongsuwan
    Nature 317:555-8. 1985
    ..3-kilobase (kb) region containing the gene encoding the large subunit ribosomal protein 49 (rp49) suppresses the dominant phenotypes of Minute (3)99D, a previously undescribed Minute associated with ..
  47. ncbi Translational regulation of mRNAs for ribosomal proteins during early Drosophila development
    G R Al-Atia
    Biochemistry 24:5798-803. 1985
    ..Coordination between r-protein and rRNA synthesis appears to be achieved by regulating translation of r-protein mRNAs in early embryos and by decreasing their abundance in adult tissues...
  48. ncbi Nucleotide sequence comparison of the rp49 gene region between Drosophila subobscura and D. melanogaster
    M Aguade
    Department de Genetica, Facultat de Biologia, Universitat de Barcelona, Spain
    Mol Biol Evol 5:433-41. 1988
    A 1.6-kb fragment encompassing the rp49 gene, which codes for a ribosomal protein, has been cloned and sequenced in Drosophila subobscura. The rp49 coding region has accumulated 46 nucleotide differences out of 402 bp since D...
  49. pmc Transcriptional and posttranscriptional regulation contributes to the sex-regulated expression of two sequence-related genes at the janus locus of Drosophila melanogaster
    C Yanicostas
    Institut Jacques Monod, Centre National de la Recherche Scientifique, Paris, France
    Mol Cell Biol 9:2526-35. 1989
    ..The janA gene displayed a much more complex expression; one of the major mRNAs was found in both sexes and at all stages, whereas the two other janA transcripts were expressed only in males...
  50. ncbi Left hemispheric interference with nonverbal performance in aphasics: comparison with data from split-brain studies
    W Hartje
    Abteilung Neurologie, RWTH Aachen, West Germany
    Brain Cogn 8:137-46. 1988
    ....
  51. ncbi Overproduction and translational regulation of rp49 ribosomal protein mRNA in transgenic Drosophila carrying extra copies of the gene
    H B Tamate
    Department of Genetics, Case Western Reserve University, Cleveland, OH 44106
    Mol Gen Genet 221:171-5. 1990
    ..In this study we assayed for changes of ribosomal protein rp49 gene expression in flies transformed with extra copies of the gene...
  52. ncbi The serendipity alpha gene encodes a membrane-associated protein required for the cellularization of the Drosophila embryo
    F Schweisguth
    Institut Jacques Monod, Centre National de la Recherche Scientifique et Université Paris, France
    Genes Dev 4:922-31. 1990
    ..The sry alpha protein is associated with the invaginating plasma membrane and colocalizes with F-actin. We propose that sry alpha is involved in the localization of membrane furrows within the syncytial blastoderm...
  53. ncbi Dosage compensation in Drosophila melanogaster male and female embryos generated by segregation distortion of the sex chromosomes
    C Polito
    Department of Genetics, General and Molecular Biology, University of Naples, Italy
    Dev Genet 11:249-53. 1990
    ..We have used this scheme to determine that the steady-state levels of transcripts of X-linked genes are the same in early male and female embryos, establishing that these genes are dosage compensated...
  54. ncbi Effect of dietary carbohydrates and ethanol on expression of genes encoding sn-glycerol-3-phosphate dehydrogenase, aldolase, and phosphoglycerate kinase in Drosophila larvae
    J L Lissemore
    Department of Biology, Syracuse University, New York 13244 1220
    Biochem Genet 28:615-30. 1990
    ....
  55. pmc Single amino acid exchanges in separate domains of the Drosophila serendipity delta zinc finger protein cause embryonic and sex biased lethality
    M Crozatier
    Centre de Recherche de Biochimie et de Génétique Cellulaires du CNRS 118, Toulouse, France
    Genetics 131:905-16. 1992
    ..The fourth mutation is located in the NH2-proximal part of the protein, in a domain proposed to be involved in specific protein-protein interactions...
  56. pmc Effects of the maleless mutation on X and autosomal gene expression in Drosophila melanogaster
    J C Hiebert
    Biological Laboratories, Harvard University, Cambridge, Massachusetts 02138
    Genetics 136:913-26. 1994
    ..These observations suggest that if mle plays a role in the discrimination of the X and the autosomes, it may do so by modification of the effects of dosage sensitive regulatory genes...
  57. ncbi Interspecific comparison of Drosophila serendipity delta and beta: multimodular structure of these C2H2 zinc finger proteins
    P Ferrer
    Centre de Biologie du Developpement, Scientifique Université Paul Sabatier, Toulouse, France
    J Mol Evol 38:263-73. 1994
    ..pseudoobscura sry delta gene rescues the sry delta mutant phenotype. Convergence of genetic and structural data on the sry proteins supports a multimodular function and mode of evolution of these C2H2 finger proteins...
  58. pmc The neuron-enriched splicing pattern of Drosophila erect wing is dependent on the presence of ELAV protein
    S P Koushika
    Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    Mol Cell Biol 20:1836-45. 2000
    ..Additionally, we report that ELAV promotes a neuron-enriched splice isoform of Drosophila armadillo transcript. ELAV, however, is not involved in all neuron-enriched splice events...
  59. ncbi The RRM protein NonA from Drosophila forms a complex with the RRM proteins Hrb87F and S5 and the Zn finger protein PEP on hnRNA
    I Reim
    Institut für Biologie Abt Zytogenetik, Humboldt Universitat zu Berlin, Berlin, D 10115, Germany
    Exp Cell Res 253:573-86. 1999
    ..Like NonA, X4/PEP, S5, and P11/Hrb87F are present on active sites on polytene chromosomes. The precipitated NonA complex is enriched for certain protein encoding RNAs, notably, histone H3 and H4 RNA...
  60. pmc Targeted expression of the DNA binding domain of DRE-binding factor, a Drosophila transcription factor, attenuates DNA replication of the salivary gland and eye imaginal disc
    F Hirose
    Laboratory of Cell Biology, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya, 464 8681, Japan
    Mol Cell Biol 19:6020-8. 1999
    ..The lines of evidence suggest that the N-terminal fragment can impede the endogenous DREF function in a dominant negative manner and that DREF is required for normal DNA replication in both mitotic cell cycle and endo cycle...
  61. ncbi DHR3 is required for the prepupal-pupal transition and differentiation of adult structures during Drosophila metamorphosis
    G Lam
    Howard Hughes Medical Institute, University of Utah, 15 N 2030 E Rm 5100, Salt Lake City, Utah, 84112 5331, USA
    Dev Biol 212:204-16. 1999
    ....
  62. pmc A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF
    P Manfruelli
    Institut de Biologie Moleculaire et Cellulaire, UPR 9022 du Centre National de la Recherche Scientifique, 15, rue René Descartes, F 67084 Strasbourg CEDEX, France
    EMBO J 18:3380-91. 1999
    ..Finally, we have used fat body cell clones homozygous for various mutations to show that a linear activation cascade Spaetzle--> Toll-->Cactus-->Dorsal/DIF leads to the induction of the drosomycin gene in larval fat body cells...
  63. pmc Down-regulation of RpS21, a putative translation initiation factor interacting with P40, produces viable minute imagos and larval lethality with overgrown hematopoietic organs and imaginal discs
    I Torok
    Department of Developmental Genetics, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
    Mol Cell Biol 19:2308-21. 1999
    ..These data demonstrate a strong interaction between components of the translation machinery and showed that their underexpression impairs the control of cell proliferation in both hematopoietic organs and imaginal discs...
  64. pmc Mutation in P0, a dual function ribosomal protein/apurinic/apyrimidinic endonuclease, modifies gene expression and position effect variegation in Drosophila
    M V Frolov
    University of Missouri, Columbia, Missouri 65211, USA
    Genetics 150:1487-95. 1998
    ..Recent work revealed that Drosophila ribosomal protein P0 contains an apurinic/apyrimidinic endonuclease activity. Our results suggest that this multifunctional protein is also involved in regulation of gene expression in Drosophila...
  65. ncbi Molecular and chromosomal phylogeny in the obscura group of Drosophila inferred from sequences of the rp49 gene region
    S Ramos-Onsins
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Spain
    Mol Phylogenet Evol 9:33-41. 1998
    A region of approximately 1.6 kb encompassing the ribosomal protein 49 gene (rp49) has been sequenced and compared in nine species of the obscura group of Drosophila: four species belonging to the obscura subgroup, three to the ..
  66. pmc Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms
    B Lemaitre
    Institut de Biologie Moleculaire et Cellulaire, Unité Propre de Recherche 9022 du Centre National de la Recherche Scientifique, 15 rue Rene Descartes, 67084 Strasbourg Cedex, France
    Proc Natl Acad Sci U S A 94:14614-9. 1997
    ..This response is mediated through the selective activation of the Toll pathway...
  67. pmc Divergence of the yellow gene between Drosophila melanogaster and D. subobscura: recombination rate, codon bias and synonymous substitutions
    A Munte
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Spain
    Genetics 147:165-75. 1997
    ..melanogaster...
  68. ncbi Changes in the expression of genes involved in protein synthesis during Drosophila aging
    N Shikama
    Department of Cell Biology, Biozentrum University Basel, Switzerland
    Gerontology 42:123-36. 1996
    ..Our data suggest that down-regulation of RNA polymerase I-, II-, and III-mediated transcription may contribute to an age-related decrease in protein synthesis or other homeostatic functions...
  69. ncbi A combined molecular and cytogenetic approach to genome evolution in Drosophila using large-fragment DNA cloning
    E R Lozovskaya
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138
    Chromosoma 102:253-66. 1993
    ..melanogaster. The materials and methods described will make it possible to carry out a direct study of molecular evolution at the level of chromosome structure and organization as well as at the level of individual genes...
  70. ncbi Nucleotide divergence of the rp49 gene region between Drosophila melanogaster and two species of the Obscura group of Drosophila
    C Segarra
    Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138
    J Mol Evol 36:243-8. 1993
    A 2.1-kb SstI fragment including the rp49 gene and the 3' end of the delta-serendipity gene has been cloned and sequenced in Drosophila pseudoobscura. rp49 maps at region 62 on the tip of chromosome II of this species...
  71. pmc Transfer of genetic information in the rp49 region of Drosophila subobscura between different chromosomal gene arrangements
    J Rozas
    Department de Genetica, Facultat de Biologia, Universitat de Barcelona, Spain
    Proc Natl Acad Sci U S A 90:8083-7. 1993
    Nucleotide variation in the region including the ribosomal protein 49 (rp49) gene was investigated by direct sequencing of 10 alleles of Drosophila subobscura from chromosomes differing in gene arrangements...
  72. pmc Compositional heterogeneity and patterns of molecular evolution in the Drosophila genome
    J P Carulli
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110
    Genetics 134:837-45. 1993
    ....
  73. ncbi Puffs and PCR: the in vivo dynamics of early gene expression during ecdysone responses in Drosophila
    F Huet
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Faculte de Medecine, Strasbourg, France
    Development 118:613-27. 1993
    ..As these molecules have homologues in vertebrates, our analysis may have general implications for the organisation of hormonal responses in vivo...
  74. ncbi Generation of Minute phenotypes by a transformed antisense ribosomal protein gene
    R Patel
    Department of Genetics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4955
    Dev Genet 13:256-63. 1992
    ..the effects of antisense r-protein 49 expression, a gene known to correspond to a Minute mutation An antisense rp49 gene driven by a strong and inducible promoter was transformed into the Drosophila germ line...

Research Grants12

  1. Genetic Studies of African Anopheles Vectors of Malaria
    Jeffrey Powell; Fiscal Year: 2009
    ..Replacing natural vector populations with such strains require that the strain have high fitness. ..
  2. Genetic Studies of African Anopheles Vectors of Malaria
    Jeffrey Powell; Fiscal Year: 2007
    ..Replacing natural vector populations with such strains require that the strain have high fitness. ..
  3. GENE EXCHANGE BETWEEN AFRICAN MALARIA VECTORS
    Jeffrey Powell; Fiscal Year: 2003
    ..Understanding whether the two most important vectors of malaria in the world (An. gambiae and An. arabiensis) are exchanging genes is vitally important to control measures aimed at these species. ..
  4. Evolution of codon usage bias in the genus Drosophila
    Jeffrey Powell; Fiscal Year: 2009
    ..willistoni, one of the species being sequenced. ..