Gene Symbol: RpL14
Description: Ribosomal protein L14
Alias: CG6253, Dmel\CG6253, L14, M(3)66, M(3)66D, M66D, RPL14, Rp L14, anon-EST:Posey193U, anon-EST:Posey6, rpl14, ribosomal protein L14, 60 S ribosomal protein L14, CG6253-PA, Minute(3)66D, RpL14-PA, minute (3)66D
Species: fruit fly
Products:     RpL14

Top Publications

  1. Saeb√łe Larssen S, Urbanczyk Mohebi B, Lambertsson A. The Drosophila ribosomal protein L14-encoding gene, identified by a novel Minute mutation in a dense cluster of previously undescribed genes in cytogenetic region 66D. Mol Gen Genet. 1997;255:141-51 pubmed
    ..Quantitative Northern blot analyses showed the mutation to affect RPL14 mRNA levels only...
  2. Enerly E, Larsson J, Lambertsson A. Silencing the Drosophila ribosomal protein L14 gene using targeted RNA interference causes distinct somatic anomalies. Gene. 2003;320:41-8 pubmed
    ..RNAi) in combination with the yeast GAL4/UAS binary system to spatiotemporally knock down the ribosomal protein L14 (RpL14) gene...
  3. Lyamouri M, Enerly E, Kress H, Lambertsson A. Conservation of gene order, structure and sequence between three closely linked genes in Drosophila melanogaster and Drosophila virilis. Gene. 2002;282:199-206 pubmed
    In Drosophila melanogaster, the apparently unrelated genes anon-66Da, RpL14, and anon-66Db (from telomere to centromere) are located on a 5547 bp genomic fragment on chromosome arm 3L at cytological position 66D8...
  4. Lyamouri M, Enerly E, Lambertsson A. Organization, sequence, and phylogenetic analysis of the ribosomal protein S3 gene from Drosophila virilis. Gene. 2002;294:147-56 pubmed
    ..Finally, electrophoretic mobility shift assays indicate that an upstream element binds a nuclear protein(s). ..
  5. de la Cova C, Abril M, Bellosta P, Gallant P, Johnston L. Drosophila myc regulates organ size by inducing cell competition. Cell. 2004;117:107-16 pubmed
    ..Modulating dmyc levels to create cell competition and hid-dependent cell death may be a mechanism used during normal development to control organ size. ..
  6. Moberg K, Schelble S, Burdick S, Hariharan I. Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth. Dev Cell. 2005;9:699-710 pubmed
    ..Activation of JAK-STAT signaling in surrounding wild-type cells correlates with their overgrowth. These findings define a pathway by which changes in endocytic trafficking can regulate tissue growth in a non-cell-autonomous manner. ..
  7. Beam C, MOBERG K. The gang of four gene regulates growth and patterning of the developing Drosophila eye. Fly (Austin). 2010;4:104-16 pubmed
    ..Genetic reduction of bru-3 suppresses phenotypes caused by gfr alleles, and like gfr alleles, overexpression of bru-3 depresses levels of Cic protein, indicating that overexpression of bru-3 is central to gfr mutant phenotypes. ..
  8. Coolon J, Webb W, Wittkopp P. Sex-specific effects of cis-regulatory variants in Drosophila melanogaster. Genetics. 2013;195:1419-22 pubmed publisher
    ..Here we show that sex-specific effects of cis-regulatory variants are common in Drosophila...
  9. Reeves R, Bryk J, Altrock P, Denton J, Reed F. First steps towards underdominant genetic transformation of insect populations. PLoS ONE. 2014;9:e97557 pubmed publisher
    ..The described genetic construct {Ud} is composed of two genes; (1) a UAS-RpL14.dsRNA targeting RNAi to a haploinsufficient gene RpL14 and (2) an RNAi insensitive RpL14 rescue...

More Information


  1. Coelho C, Kolevski B, Bunn C, Walker C, Dahanukar A, Leevers S. Growth and cell survival are unevenly impaired in pixie mutant wing discs. Development. 2005;132:5411-24 pubmed
    ..We propose a model in which a balance of growth inhibitors and promoters determines tissue growth rates and cell survival. An alteration in this balance slows growth before final disc size is reached...
  2. Pinnola A, Naumova N, Shah M, Tulin A. Nucleosomal core histones mediate dynamic regulation of poly(ADP-ribose) polymerase 1 protein binding to chromatin and induction of its enzymatic activity. J Biol Chem. 2007;282:32511-9 pubmed
    ..Therefore, our data collectively suggests a model in which both the regulation of PARP1 protein binding to chromatin and the enzymatic activation of PARP1 protein depend on the dynamics of nucleosomal core histone mediation. ..
  3. Haynes S. Primary structure of Drosophila ribosomal protein L14 and identification of conserved protein motifs. DNA Seq. 1997;8:105-8 pubmed
    ..I have sequenced a cDNA that encodes a Drosophila homolog of the rat ribosomal protein L14. The cDNA sequence was 601 nucleotides long, with an open reading frame encoding a protein of 166 amino ..
  4. Montagne J, Stewart M, Stocker H, Hafen E, Kozma S, Thomas G. Drosophila S6 kinase: a regulator of cell size. Science. 1999;285:2126-9 pubmed
    ..Thus, the dS6K gene product regulates cell size in a cell-autonomous manner without impinging on cell number. ..
  5. McDermott S, Meignin C, Rappsilber J, Davis I. Drosophila Syncrip binds the gurken mRNA localisation signal and regulates localised transcripts during axis specification. Biol Open. 2012;1:488-97 pubmed publisher
    ..We propose that Syncrip/SYNCRIP is part of a conserved complex associated with localised transcripts and required for their correct translational regulation in flies and mammals. ..
  6. Xun Z, Sowell R, Kaufman T, Clemmer D. Quantitative proteomics of a presymptomatic A53T alpha-synuclein Drosophila model of Parkinson disease. Mol Cell Proteomics. 2008;7:1191-203 pubmed publisher
    ..J. Proteome Res. 6, 3729-3738) that defects in cellular components such as actin cytoskeleton and mitochondria may contribute to the development of later symptoms. ..
  7. Jacobsson L, Kronhamn J, Rasmuson Lestander A. The Drosophila Pax6 paralogs have different functions in head development but can partially substitute for each other. Mol Genet Genomics. 2009;282:217-31 pubmed publisher
    ..We therefore conclude that Toy and Ey, to some extent, can substitute for each other. Nevertheless, the phenotypes of the rescued flies indicate that the two Pax6 genes are specialized to regulate defined structures of the fly head. ..