Gene Symbol: rpk
Description: ripped pocket
Alias: CG1058, Dmel\CG1058, GNaC1, RPK, dGNaC1, ppk2, ripped pocket, CG1058-PA, CG1058-PB, gonad-specific amiloride-sensitive sodium channel 1, rpk-PA, rpk-PB
Species: fruit fly

Top Publications

  1. Horner V, Wolfner M. Mechanical stimulation by osmotic and hydrostatic pressure activates Drosophila oocytes in vitro in a calcium-dependent manner. Dev Biol. 2008;316:100-9 pubmed publisher
    ..This will allow exploitation of Drosophila genetics to dissect molecular pathways involving Ca(2+) and the activation of development. ..
  2. Bono J, Matzkin L, Kelleher E, Markow T. Postmating transcriptional changes in reproductive tracts of con- and heterospecifically mated Drosophila mojavensis females. Proc Natl Acad Sci U S A. 2011;108:7878-83 pubmed publisher
  3. Tsubouchi A, Caldwell J, Tracey W. Dendritic filopodia, Ripped Pocket, NOMPC, and NMDARs contribute to the sense of touch in Drosophila larvae. Curr Biol. 2012;22:2124-34 pubmed publisher
    ..Through a genome-wide RNAi screen of ion channels, we identified Ripped Pocket (rpk), No Mechanoreceptor Potential C (nompC), and NMDA Receptors 1 and 2 (Nmdars) as playing critical roles ..
  4. Hunter G, Crawford J, Genkins J, Kiehart D. Ion channels contribute to the regulation of cell sheet forces during Drosophila dorsal closure. Development. 2014;141:325-34 pubmed publisher
    ..We identify two channel subunits, ripped pocket and dtrpA1 (TrpA1), that play a role in closure and other morphogenetic events...
  5. Mutsuddi M, Nambu J. Neural disease: Drosophila degenerates for a good cause. Curr Biol. 1998;8:R809-11 pubmed
    ..Recent studies suggest that molecular genetic approaches in Drosophila may shed important new light on conserved mechanisms underlying such disorders. ..
  6. Mano I, Driscoll M. DEG/ENaC channels: a touchy superfamily that watches its salt. Bioessays. 1999;21:568-78 pubmed
    ..We discuss working understanding of DEG/ENaC functions, channel properties, structure/activity correlations and possible evolutionary relationship to other channel classes. ..
  7. Guo Y, Wang Y, Wang Q, Wang Z. The role of PPK26 in Drosophila larval mechanical nociception. Cell Rep. 2014;9:1183-90 pubmed
    ..Our work indicates that PPK26 and PPK might form heteromeric DEG/ENaC channels that are essential for mechanotransduction in class IV da neurons. ..
  8. Adams C, Anderson M, Motto D, Price M, Johnson W, Welsh M. Ripped pocket and pickpocket, novel Drosophila DEG/ENaC subunits expressed in early development and in mechanosensory neurons. J Cell Biol. 1998;140:143-52 pubmed
    ..We identified two novel Drosophila DEG/ ENaC proteins, Pickpocket (PPK) and Ripped Pocket (RPK). Both appear to be ion channel subunits...
  9. Darboux I, Lingueglia E, Champigny G, Coscoy S, Barbry P, Lazdunski M. dGNaC1, a gonad-specific amiloride-sensitive Na+ channel. J Biol Chem. 1998;273:9424-9 pubmed
    ..We have now identified a gene called dGNaC1 that is specifically expressed in the gonads and early embryo in Drosophila melanogaster...

More Information


  1. Darboux I, Lingueglia E, Pauron D, Barbry P, Lazdunski M. A new member of the amiloride-sensitive sodium channel family in Drosophila melanogaster peripheral nervous system. Biochem Biophys Res Commun. 1998;246:210-6 pubmed
    ..They could function as stretch or touch receptors, raising the possibility that this Drosophila gene product, called dmdNaC1, could also be involved in mechanotransduction. ..
  2. Liu L, Leonard A, Motto D, Feller M, Price M, Johnson W, et al. Contribution of Drosophila DEG/ENaC genes to salt taste. Neuron. 2003;39:133-46 pubmed
    ..In contrast, the response of larvae to sucrose, pH 3, and several odors remained intact. These results indicate that the DEG/ENaC channels PPK11 and PPK19 play a key role in detecting Na(+) and K(+) salts. ..
  3. Krüger J, Bohrmann J. Bioelectric patterning during oogenesis: stage-specific distribution of membrane potentials, intracellular pH and ion-transport mechanisms in Drosophila ovarian follicles. BMC Dev Biol. 2015;15:1 pubmed publisher
    ..Characteristic stage-specific changes of bioelectric activity in specialized cell types are correlated with various developmental processes. ..