Gene Symbol: ric8a
Alias: CG15797, DmRic8, Dmel\CG15797, RIC-8, Ric-8, l(1)G0397, ric-8, ric-8a, ric8a, CG15797-PA, CG15797-PB, ric8a-PA, ric8a-PB
Species: fruit fly
Hampoelz B, Hoeller O, Bowman S, Dunican D, Knoblich J. Drosophila Ric-8 is essential for plasma-membrane localization of heterotrimeric G proteins. Nat Cell Biol. 2005;7:1099-105 pubmed
..Our results indicate a model in which both receptor-dependent and receptor-independent G-protein functions are executed at the plasma membrane and require the Ric-8 protein. ..
Wang H, Ng K, Qian H, Siderovski D, Chia W, Yu F. Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins. Nat Cell Biol. 2005;7:1091-8 pubmed
..In addition, Gbetagamma acts to restrict Galphai (and GoLoco proteins) to the apical cortex, where Galphai (and Pins) can mediate asymmetric spindle geometry. ..
David N, Martin C, Segalen M, Rosenfeld F, Schweisguth F, Bellaiche Y. Drosophila Ric-8 regulates Galphai cortical localization to promote Galphai-dependent planar orientation of the mitotic spindle during asymmetric cell division. Nat Cell Biol. 2005;7:1083-90 pubmed
..Thus, Frizzled and heterotrimeric G-protein signalling act in opposition to ensure that the spindle aligns both in the plane of the epithelium and along the tissue polarity axis. ..
Kanesaki T, Hirose S, Grosshans J, Fuse N. Heterotrimeric G protein signaling governs the cortical stability during apical constriction in Drosophila gastrulation. Mech Dev. 2013;130:132-42 pubmed publisher
..We propose that the organisation of cortical actin by HGP is required to reinforce the cortex so that the cells can endure hydrostatic stress during tissue folding. ..
Peters K, Rogers S. Drosophila Ric-8 interacts with the G?12/13 subunit, Concertina, during activation of the Folded gastrulation pathway. Mol Biol Cell. 2013;24:3460-71 pubmed publisher
..We also use this system to conduct a structure-function analysis of Ric-8 and identify key residues required for both Cta interaction and cellular contractility. ..
Matsuzaki F. Drosophila G-protein signalling: intricate roles for Ric-8?. Nat Cell Biol. 2005;7:1047-9 pubmed
Romero Pozuelo J, Dason J, Mansilla A, Baños Mateos S, Sardina J, Chaves Sanjuan A, et al
. The guanine-exchange factor Ric8a binds to the Ca²? sensor NCS-1 to regulate synapse number and neurotransmitter release. J Cell Sci. 2014;127:4246-59 pubmed publisher
..We show here that Drosophila Ric8a (a homolog of mammalian synembryn, which is also known as Ric8a), a receptor-independent activator of G protein ..
Mansilla A, Chaves Sanjuan A, Campillo N, Semelidou O, MartÃnez GonzÃ¡lez L, Infantes L, et al
. Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome. Proc Natl Acad Sci U S A. 2017;114:E999-E1008 pubmed publisher
..formed by the Ca2+ sensor neuronal calcium sensor 1 (NCS-1) and the guanine exchange factor protein Ric8a coregulates synapse number and probability of neurotransmitter release, emerging as a potential therapeutic target ..