Genomes and Genes
Gene Symbol: Rho1
Description: CG8416 gene product from transcript CG8416-RB
Alias: 8416, AAF01186, CG8416, D-Rho1, DRho, DRho1, DRhoA, Dm Rho1, DmRHO-A, Dmel\CG8416, Drho1, DrhoA, E3.10/J3.8, RHO, RHO1, Rho, Rho A, Rho GTPase, Rho kinase, RhoA, RhoN19, dRho1, dRhoA, dnRho, l(2)52Fa, l(2)k02107b, n(2)k07236, rho, rho1, rhoA, CG8416-PA, CG8416-PB, CG8416-PC, CG8416-PD, CG8416-PE, CG8416-PF, CG8416-PG, Rho GTPase, Rho1-PA, Rho1-PB, Rho1-PC, Rho1-PD, Rho1-PE, Rho1-PF, Rho1-PG, RhoA, RhoA kinase, rho kinase, rho1, rho1 kinase
Species: fruit fly
Publications118 found, 100 shown here
- Genetic analysis demonstrates a direct link between rho signaling and nonmuscle myosin function during Drosophila morphogenesisS R Halsell
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Genetics 155:1253-65. 2000..we show that two EMS-induced mutations, previously shown to interact genetically with zipper(Ebr), disrupt the RhoA locus...
- Regulation of rho family GTPases is required to prevent axons from crossing the midlineJanice L Fritz
Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
Dev Biol 252:46-58. 2002..Heterozygous loss of Roundabout enhances the ctDrac phenotype and causes errors in embryos expressing dnRho or ctRho...
- Cellular functions of the Spir actin-nucleation factorsEugen Kerkhoff
Institut für medizinsche Strahlenkunde und Zellforschung MSZ, Universitat Wurzburg, Versbacher Strasse 5, 97078 Wurzburg, Germany
Trends Cell Biol 16:477-83. 2006..Phosphorylation by mitogen-activated protein kinases and interaction with Rho GTPases have been proposed as regulatory mechanisms.
- Gastrulation in Drosophila: the logic and the cellular mechanismsM Leptin
Institut fur Genetik, Universitat zu Koln, Weyertal 121, D 50931 Köln, Germany
EMBO J 18:3187-92. 1999....
- Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in DrosophilaT P Newsome
Research Institute of Molecular Pathology, Vienna, Austria
Cell 101:283-94. 2000..We propose that distinct signals transduced via Trio and Dock act combinatorially to activate Pak in spatially restricted domains within the growth cone, thereby controlling the direction of axon extension...
- Suppression of Drosophila cellular immunity by directed expression of the ExoS toxin GAP domain of Pseudomonas aeruginosaAmelie Avet-Rochex
CEA Grenoble, Departement de Reponse et Dynamique Cellulaires, UMR5092 CEA CNRS UJF, 17, Rue des Martyrs 38054 Grenoble Cedex 9, France
Cell Microbiol 7:799-810. 2005..It contains a N-terminal GTPase activating (GAP) domain that prevents cytoskeleton reorganization by Rho family of GTPases in cell culture...
- Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosisPetra Sekyrova
Biology Center, Czech Academy of Sciences and Department of Molecular Biology, University of South Bohemia, Ceske Budejovice 37005, Czech Republic
Development 137:141-50. 2010..This closure defect can be either mimicked and further enhanced by knockdown of the small GTPase Rho1 or, conversely, alleviated by stimulating ecdysone steroid hormone signaling...
- The Drosophila Pkn protein kinase is a Rho/Rac effector target required for dorsal closure during embryogenesisY Lu
Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Genes Dev 13:1168-80. 1999The PKN family of PKC-related protein kinases constitutes the major Rho GTPase-associated protein kinase activities detected in mammalian tissues. However, the biological functions of these kinases are unknown...
- The guanine nucleotide exchange factor trio mediates axonal development in the Drosophila embryoJ Bateman
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Neuron 26:93-106. 2000Recent analysis of Rho subfamily GTPases in Drosophila revealed roles for Rac and Cdc42 during axonogenesis...
- The RhoGEF Pebble is required for cell shape changes during cell migration triggered by the Drosophila FGF receptor HeartlessSabine Schumacher
Institut fur Genetik, Heinrich Heine Universitat, Dusseldorf, Germany
Development 131:2631-40. 2004..pbl encodes a guanyl nucleotide exchange factor (GEF) for RHO1 and is known as an essential regulator of cytokinesis...
- Csk-deficient boundary cells are eliminated from normal Drosophila epithelia by exclusion, migration, and apoptosisMarcos Vidal
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, Missouri 63110, USA
Dev Cell 10:33-44. 2006..These latter phenotypes required sharp differences in dCsk activity between neighbors; dE-cadherin, P120-catenin, Rho1, JNK, and MMP2 mediated this signal...
- The role of RhoA in tissue polarity and Frizzled signallingD I Strutt
Developmental Biology Programme, EMBL, Heidelberg, Germany
Nature 387:292-5. 1997..We have identified mutations in the Drosophila homologue of RhoA p21 GTPase, and by analysis of their phenotype show that RhoA is required for the generation of tissue polarity...
- The Cdc42-selective GAP rich regulates postsynaptic development and retrograde BMP transsynaptic signalingMinyeop Nahm
Interdisplinary Program in Brain Science, Seoul National University, Seoul, Republic of Korea
J Cell Biol 191:661-75. 2010..Importantly, dRich increases Gbb release and elevates presynaptic phosphorylated Mad levels. We propose that dRich coordinates the Gbb-dependent modulation of synaptic growth and function with postsynaptic development...
- Drosophila RhoGAP68F is a putative GTPase activating protein for RhoA participating in gastrulationJustina Sanny
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada
Dev Genes Evol 216:543-50. 2006..despite the strong similarities between RhoGAP68F and p50RhoGAP/Cdc42GAP, RhoGAP68F is most effective as a GAP for RhoA. These in vitro data are supported by the in vivo analysis of mutants in RhoGAP68F...
- The role of the actomyosin cytoskeleton in coordination of tissue growth during Drosophila oogenesisYing Wang
Institut fur Entwicklungsbiologie, Universitat zu Koln, Gyrhofstrasse 17, D 50931 Köln, Germany
Curr Biol 17:1349-55. 2007..Myosin is activated at the apical cortex by localized Rho kinase and inhibited at the basolateral cortex by PP1beta9C...
- Rho1 regulates Drosophila adherens junctions independently of p120ctnDonald T Fox
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Development 132:4819-31. 2005..Further, Rho1 localization is not obviously altered by loss of p120 or by reduction of core AJ proteins...
- RhoGEF2 and the formin Dia control the formation of the furrow canal by directed actin assembly during Drosophila cellularisationJörg Grosshans
ZMBH, Universitat Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
Development 132:1009-20. 2005..Biochemical analysis shows that Rho1 interacts with both RhoGEF2 and Dia, and that Dia nucleates actin filaments...
- Moesin functions antagonistically to the Rho pathway to maintain epithelial integrityOlga Speck
DCMB Group, Department of Biology, Duke University, Box 91000, Durham, North Carolina 27708, USA
Nature 421:83-7. 2003..not by providing an essential structural function, but rather by antagonizing activity of the small GTPase Rho. Thus, Moesin functions in maintaining epithelial integrity by regulating cell-signalling events that affect actin ..
- Drosophila RhoA regulates the cytoskeleton and cell-cell adhesion in the developing epidermisJames W Bloor
Developmental, Cell and Molecular Biology Group, Department of Biology, B330 LSRC Building, Duke University, Durham, NC 27708 1000, USA
Development 129:3173-83. 2002..By expressing the dominant negative DRhoA(N19) construct in stripes of epidermal cells, we confirm that Rho function is required for dorsal closure and ..
- Rho1 interacts with p120ctn and alpha-catenin, and regulates cadherin-based adherens junction components in DrosophilaCraig R Magie
Division of Basic Sciences and Program in Developmental Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Development 129:3771-82. 2002..Here we show interactions between Drosophila Rho1 and the adherens junction components alpha-catenin and p120(ctn)...
- Moesin contributes an essential structural role in Drosophila photoreceptor morphogenesisSue A Karagiosis
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
Development 131:725-32. 2004..Our results show an essential structural role for Moesin in photoreceptor morphology...
- Nuclear signaling by Rac and Rho GTPases is required in the establishment of epithelial planar polarity in the Drosophila eyeM Fanto
EMBL, Developmental Biology Programme, Heidelberg, Germany
Curr Biol 10:979-88. 2000..In the fruit fly Drosophila, RhoA participates in the establishment of planar polarity, a process mediated by the receptor Frizzled (Fz)...
- Drosophila RhoGEF2 associates with microtubule plus ends in an EB1-dependent mannerStephen L Rogers
Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94107, USA
Curr Biol 14:1827-33. 2004..as a model system, we show that DRhoGEF2 induces contractile cell shape changes by stimulating myosin II via the Rho1 pathway...
- IrreC/rst-mediated cell sorting during Drosophila pupal eye development depends on proper localisation of DE-cadherinNicola A Grzeschik
Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstrasse 1, 40225 Dusseldorf, Germany
Development 132:2035-45. 2005..overexpression of DE-cadherin, the intracellular domain of Crumbs, or by a dominant version of the monomeric GTPase Rho1 prevents localisation of the transmembrane protein IrreC-rst to the border between primary pigment cells and IOCs...
- Mutations in sticky lead to defective organization of the contractile ring during cytokinesis and are enhanced by Rho and suppressed by RacPier Paolo D'Avino
Cancer Research UK Cell Cycle Genetics Research Group, Department of Genetics, University of Cambridge, Downing Site, CB2 3EH
J Cell Biol 166:61-71. 2004..sti shows opposite genetic interactions with Rho and Rac genes suggesting that these GTPases antagonistically regulate STICKY functions...
- Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural developmentT Lee
Department of Cell and Structural Biology, University of Illinois, Urbana Champaign, Urbana, IL 61801, USA
Trends Neurosci 24:251-4. 2001....
- Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsionHailan Hu
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 102:4613-8. 2005The regulators of the Rho-family GTPases, GTPase-activating proteins (GAPs) and guanine exchange factors (GEFs), play important roles in axon guidance...
- Plexin B mediates axon guidance in Drosophila by simultaneously inhibiting active Rac and enhancing RhoA signalingH Hu
Howard Hughes Medical Institute, Division of Neurobiology, Department of Molecular and Cell Biology, 519 LSA, University of California, Berkeley, CA 94720, USA
Neuron 32:39-51. 2001..A different region of PlexB binds to RhoA. Dosage-sensitive genetic interactions suggest that PlexB suppresses Rac activity and enhances RhoA activity...
- Citron kinase is an essential effector of the Pbl-activated Rho signalling pathway in Drosophila melanogasterTetyana Shandala
ARC Special Research Centre for the Molecular Genetics of Development, Adelaide University, Adelaide, SA 5005, Australia
Development 131:5053-63. 2004Pebble (Pbl)-activated RhoA signalling is essential for cytokinesis in Drosophila melanogaster. Here we report that the Drosophila citron gene encodes an essential effector kinase of Pbl-RhoA signalling in vivo...
- Rho1 regulates signaling events required for proper Drosophila embryonic developmentCraig R Magie
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, A1 162, PO Box 19024, Seattle, WA 98109 1024, USA
Dev Biol 278:144-54. 2005..Here we report that in Drosophila, reduction of maternal Rho1 compromises signaling pathways consistent with defects in membrane trafficking events...
- Participation of small GTPases in dorsal closure of the Drosophila embryo: distinct roles for Rho subfamily proteins in epithelial morphogenesisN Harden
Glaxo IMCB and Drosophila Neurobiology Laboratories, Institute of Molecular and Cell Biology, Singapore 117609, Republic of Singapore
J Cell Sci 112:273-84. 1999..We now show that two other Rho subfamily proteins, Dcdc42 and RhoA, as well as Ras1 are also required for dorsal closure...
- Second-site noncomplementation identifies genomic regions required for Drosophila nonmuscle myosin function during morphogenesisS R Halsell
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Genetics 148:1845-63. 1998..10/J3.8, for leg morphogenesis and viability...
- Drosophila RhoGEF4 encodes a novel RhoA-specific guanine exchange factor that is highly expressed in the embryonic central nervous systemMinyeop Nahm
Interdisciplinary Program in Brain Science, School of Natural Sciences, Seoul National University, Seoul 151 742, Republic of Korea
Gene 384:139-44. 2006..In this study, the DH-PH motif is shown to enhance the dissociation of GDP from either RhoA or Rac1 but not from Cdc42 in vitro...
- Dystroglycan and perlecan provide a basal cue required for epithelial polarity during energetic stressVincent Mirouse
The Gurdon Institute and the Department of Genetics, University of Cambridge, Cambridge, UK
Dev Cell 16:83-92. 2009..Since Dystroglycan is often downregulated in tumors, loss of this pathway may play a role in cancer progression...
- Convergent use of RhoGAP toxins by eukaryotic parasites and bacterial pathogensDominique Colinet
UMR 1112 UNSA INRA Résponses des Organismes aux Stress Environnementaux, Sophia Antipolis, France
PLoS Pathog 3:e203. 2007..Some bacterial toxins mimic eukaryotic Rho GTPase-activating proteins (GAPs) to inactivate mammalian GTPases, probably as a result of evolutionary convergence...
- The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulationK Barrett
Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown 02129, USA
Cell 91:905-15. 1997..due to a defect in cell shape changes required for tissue invagination, and expression of a dominant-negative Rho GTPase in early embryos results in similar defects...
- Rho-LIM kinase signaling regulates ecdysone-induced gene expression and morphogenesis during Drosophila metamorphosisGuang Chao Chen
Massachusetts General Hospital Cancer Center and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
Curr Biol 14:309-13. 2004..The Rho GTPase, which mediates cell shape change and migration, is also an essential regulator of tissue morphogenesis during ..
- Genetic interactions between the RhoA and Stubble-stubbloid loci suggest a role for a type II transmembrane serine protease in intracellular signaling during Drosophila imaginal disc morphogenesisCynthia A Bayer
Department of Biology, University of Central Florida, Orlando, Florida 32816 2368, USA
Genetics 165:1417-32. 2003The Drosophila RhoA (Rho1) GTPase is essential for postembryonic morphogenesis of leg and wing imaginal discs...
- Genetic modifier screens in Drosophila demonstrate a role for Rho1 signaling in ecdysone-triggered imaginal disc morphogenesisRobert E Ward
Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112 5331, USA
Genetics 165:1397-415. 2003..b>Rho1, stubbloid, blistered (DSRF), and cytoplasmic Tropomyosin were identified from these screens as br1-interacting ..
- Drosophila nonmuscle myosin II promotes the asymmetric segregation of cell fate determinants by cortical exclusion rather than active transportClaudia S Barros
Wellcome Trust Cancer Research UK Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
Dev Cell 5:829-40. 2003..Myosin II is activated by Rho kinase and restricted to the apical cortex by the tumor suppressor Lethal (2) giant larvae...
- Moesin and its activating kinase Slik are required for cortical stability and microtubule organization in mitotic cellsSebastien Carreno
Centre de Biologie du Developpement, Université Toulouse III Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5547, 31062 Toulouse Cedex 09, France
J Cell Biol 180:739-46. 2008..We propose that the spatiotemporal control of moesin activation at the mitotic cortex provides localized cues to coordinate cortical contractility and microtubule interactions during cell division...
- Distinct functions for Rho1 in maintaining adherens junctions and apical tension in remodeling epitheliaStephen J Warner
Department of Medicine, Washington University, St Louis, MO 63110, USA
J Cell Biol 185:1111-25. 2009..Using clonal analysis in the postmitotic Drosophila melanogaster pupal eye epithelium, we demonstrate that Rho1 is required to maintain AJ integrity independent of its role in sustaining apical cell tension...
- The essential role of PP1beta in Drosophila is to regulate nonmuscle myosinNatalia Vereshchagina
Department of Zoology, University of Oxford, Oxford OX1 3PS, United Kingdom
Mol Biol Cell 15:4395-405. 2004..The similarity between fly and human PP1beta and MYPT genes suggests this role may be conserved...
- Cellular behavior in the developing Drosophila pupal retinaDavid E Larson
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8103, Saint Louis, MO 63110, USA
Mech Dev 125:223-32. 2008..Based upon our live visualization of the P120-Catenin mutant as well as genetic data, we conclude that P120-Catenin is acting to stabilize E-cadherin and adherens junction integrity during eye development...
- Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targetsUlrike S Eggert
Department of Systems Biology, Harvard Medical School Boston, Massachusetts, USA
PLoS Biol 2:e379. 2004..Our study shows that parallel RNA interference and small molecule screening is a generally useful approach to identifying active small molecules and their target pathways...
- D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cellsOlga P Ryabinina
Department of Cell and Developmental Biology, Oregon Health and Science University, Portland, Oregon 97239, USA
BMC Cell Biol 7:7. 2006..The study of mammalian signaling pathways to JNK is complicated by the significant degree of redundancy among upstream JNK regulators, especially at the level of JNK kinase kinases (JNKKK)...
- The Drosophila formin DAAM regulates the tracheal cuticle pattern through organizing the actin cytoskeletonTamás Matusek
Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, H 6726 Szeged, Temesvari krt 62, Hungary
Development 133:957-66. 2006..Our results indicate that although DAAM is regulated by RhoA, it functions upstream or parallel to the non-receptor tyrosine kinases Src42A and Tec29 to organize the actin ..
- Distinct pathways control recruitment and maintenance of myosin II at the cleavage furrow during cytokinesisSara O Dean
Department of Biochemistry, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 102:13473-8. 2005..Three genes in the rho1 signaling pathway, pebble (a Rho guanidine nucleotide exchange factor), rho1, and rho kinase, are required for the initial recruitment of myosin II to the equatorial cortex...
- Mutations in the Drosophila orthologs of the F-actin capping protein alpha- and beta-subunits cause actin accumulation and subsequent retinal degenerationIvana Delalle
Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
Genetics 171:1757-65. 2005..In its absence, cells progressively accumulate actin filaments and eventually die. A possible role for their human orthologs in neurodegenerative disease merits further investigation...
- Rho-kinase regulates tissue morphogenesis via non-muscle myosin and LIM-kinase during Drosophila developmentValerie Verdier
Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA
BMC Dev Biol 6:38. 2006The Rho-kinases (ROCKs) are major effector targets of the activated Rho GTPase that have been implicated in many of the Rho-mediated effects on cell shape and movement via their ability to affect acto-myosin contractility...
- Genetic analysis of slipper/mixed lineage kinase reveals requirements in multiple Jun-N-terminal kinase-dependent morphogenetic events during Drosophila developmentStephanie Polaski
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
Genetics 174:719-33. 2006..Finally, we demonstrate that SLPR overexpression can induce ectopic JNK signaling and that the SLPR protein is enriched at the epithelial cell cortex...
- Asymmetric Rab 11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous systemGregory Emery
Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
Cell 122:763-73. 2005..Our results suggest that cells can regulate signaling pathways and influence their developmental fate by inhibiting the formation of individual endocytic compartments...
- Cleavage furrow formation and ingression during animal cytokinesis: a microtubule legacyPier Paolo D'Avino
Cancer Research UK Cell Cycle Genetics Research Group, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
J Cell Sci 118:1549-58. 2005..The same mechanism might be conserved in other organisms...
- Independent roles of Drosophila Moesin in imaginal disc morphogenesis and hedgehog signallingCristina Molnar
Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, Madrid 28049, Spain
Mech Dev 123:337-51. 2006..Some aspects of Drosophila Moe are related to the activity of the small GTPase RhoA, because the reduction of RhoA activity corrects many phenotypes of moe mutant embryos and imaginal discs...
- Rho kinase's role in myosin recruitment to the equatorial cortex of mitotic Drosophila S2 cells is for myosin regulatory light chain phosphorylationSara O Dean
Department of Biochemistry, Stanford University, Stanford, California, United States of America
PLoS ONE 1:e131. 2006..S2 cells, we previously showed that myosin II is recruited to the furrow independently of F-actin, and that Rho1 and Rok are essential for this recruitment ...
- Dynamic decapentaplegic signaling regulates patterning and adhesion in the Drosophila pupal retinaJulia B Cordero
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
Development 134:1861-71. 2007..Importantly, we identify a similar functional connection between Dpp activity and DE-cadherin and Rho1 during cell fate determination in the wing, suggesting a broader link between Dpp function and junctional integrity ..
- Diaphanous regulates myosin and adherens junctions to control cell contractility and protrusive behavior during morphogenesisCatarina C F Homem
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
Development 135:1005-18. 2008..Diaphanous-related formins, the best-known subclass, are activated by Rho and play essential roles in cytokinesis...
- Rho GTPases regulate axon growth through convergent and divergent signaling pathwaysJulian Ng
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Neuron 44:779-93. 2004b>Rho GTPases are essential regulators of cytoskeletal reorganization, but how they do so during neuronal morphogenesis in vivo is poorly understood...
- Slik Sterile-20 kinase regulates Moesin activity to promote epithelial integrity during tissue growthDavid R Hipfner
European Molecular Biology Laboratory, 69117 Heidelberg, Germany
Genes Dev 18:2243-8. 2004..behavior of slik mutant cells is due to failure to phosphorylate and activate Moesin, which leads to excess Rho1 activity. This is distinct from Slik's effects on cell proliferation, which are mediated by Raf...
- The degradation of two mitotic cyclins contributes to the timing of cytokinesisArnaud Echard
Department of Biochemistry and Biophysics, University of California, San Francisco, Genentech Hall, 600 16th Street, San Francisco, CA 94143, USA
Curr Biol 13:373-83. 2003..We examined the interface between mitotic cyclin destruction and the timing of cytokinesis...
- Molecular dissection of cytokinesis by RNA interference in Drosophila cultured cellsMaria Patrizia Somma
Istituto Pasteur Fondazione Cenci Bolognetti and Centro di Genetica Evoluzionistica del Consiglio Nazionale delle Richerche, Dipartimento di Genetica e Biologia Molecolare, Universita di Roma La Sapienza, 00185 Rome, Italy
Mol Biol Cell 13:2448-60. 2002..We show that double-stranded RNAs for anillin, acGAP, pavarotti, rho1, pebble, spaghetti squash, syntaxin1A, and twinstar all disrupt cytokinesis in S2 tissue culture cells, causing ..
- Frizzled signaling and the developmental control of cell polarityJ M Shulman
Wellcome CRC Institute, UK
Trends Genet 14:452-8. 1998..Recently described examples from the nematode and frog suggest that the developmental control of cell polarity by FZ receptors might represent a functionally conserved signaling mechanism...
- The genetics of cell migration in Drosophila melanogaster and Caenorhabditis elegans developmentD J Montell
Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
Development 126:3035-46. 1999..link between membrane receptor signaling and regulation of the actin cytoskeleton is that provided by the Rho family of small GTPases...
- A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in DrosophilaS N Prokopenko
Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030 USA
Genes Dev 13:2301-14. 1999..pbl interacts genetically with Rho1, but not with Rac1 or Cdc42, and Pbl and Rho1 proteins interact in vivo in yeast...
- Drosophila myosin phosphatase and its role in dorsal closureTomoaki Mizuno
Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
Development 129:1215-23. 2002..Similar defects were seen in embryos overexpressing Rho-kinase, suggesting that myosin phosphatase and Rho-kinase function antagonistically...
- Identification and characterization of Drosophila homolog of Rho-kinaseT Mizuno
Division of Biological Science, Graduate School of Science, Nagoya University, Japan
Gene 238:437-44. 1999..A two-hybrid analysis demonstrated that DRho-kinase interacts with the GTP-bound form of the Drosophila Rho. Drho1, at the conserved Rho-binding site...
- Argosomes: a potential vehicle for the spread of morphogens through epitheliaV Greco
Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307, Dresden, Germany
Cell 106:633-45. 2001..Wingless protein colocalizes with argosomes derived from Wingless-producing cells. The properties of argosomes are consistent with their being a vehicle for the spread of Wingless protein...
- Essential roles of Drosophila RhoA in the regulation of neuroblast proliferation and dendritic but not axonal morphogenesisT Lee
Department of Biological Sciences, Stanford University, California 94305, USA
Neuron 25:307-16. 2000..report here the use of the MARCM (mosaic analysis with a repressible cell marker) system to analyze the function of RhoA in the developing Drosophila brain...
- Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeletonC G Winter
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Cell 105:81-91. 2001..Here, we show that Drosophila Rho-associated kinase (Drok) works downstream of Fz/Dsh to mediate a branch of the planar polarity pathway involved in ..
- Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signalingM Boutros
European Molecular Biology Laboratory, Developmental Biology Programme, Heidelberg, Germany
Cell 94:109-18. 1998..Our results indicate that different Wnt/Fz signals activate distinct intracellular pathways, and Dishevelled discriminates among them by distinct domain interactions...
- JNK signaling and morphogenesis in DrosophilaS Noselli
Centre de Biologie du Developpement, UMR 5547 CNRS, Toulouse, France
Trends Genet 14:33-8. 1998
- Roles of myosin phosphatase during Drosophila developmentChange Tan
Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Development 130:671-81. 2003..Our results indicate that the regulation of the phosphorylation of myosin regulatory light chains, or dynamic activation and inactivation of myosin II, is essential for its various functions during many developmental processes...
- Stimulus-specific requirements for MAP3 kinases in activating the JNK pathwayWei Chen
Departments of Pharmacology and Cell Biology and Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9041, USA
J Biol Chem 277:49105-10. 2002..On the other hand, sorbitol requires expression of four MAP3Ks to cause maximal JNK activation. Thus, we demonstrate that specific stimuli use different mechanisms to recruit distinct MAP3Ks to regulate the JNK pathway...
- Dystroglycan is required for polarizing the epithelial cells and the oocyte in DrosophilaWu Min Deng
Department of Biochemistry, Box 357350, University of Washington, Seattle, WA 98195, USA
Development 130:173-84. 2003..These data suggest that the primary function of Dystroglycan in oogenesis is to organize cellular polarity; and this study sets the stage for analyzing the Dystroglycan complex by using the power of Drosophila molecular genetics...
- A RhoGEF and Rho family GTPase-activating protein complex links the contractile ring to cortical microtubules at the onset of cytokinesisW Gregory Somers
Centre for the Molecular Genetics of Development, Research School of Biological Sciences, Australian National University, Canberra, ACT 0200, Australia
Dev Cell 4:29-39. 2003..We show that an interaction between the Rho GTP exchange factor, Pebble, and the Rho family GTPase-activating protein, RacGAP50C, connects the contractile ring ..
- DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape changes during gastrulation in DrosophilaU Hacker
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115 USA
Genes Dev 12:274-84. 1998..Expression of dominant-negative DRhoA during gastrulation results in phenocopies of the DRhoGEF2 mutant, suggesting that a signaling cascade involving ..
- Planar polarization of Drosophila and vertebrate epitheliaS Eaton
Cell Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
Curr Opin Cell Biol 9:860-6. 1997..Three different Rho family proteins have been shown to mediate polarization in the wing and the eye of Drosophila...
- DRhoGEF2 regulates actin organization and contractility in the Drosophila blastoderm embryoMojgan Padash Barmchi
Department of Cell and Molecular Biology, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, BMC B13, 22184 Lund, Sweden
J Cell Biol 168:575-85. 2005..Often, Rho1 controls different aspects of cytoskeletal function in parallel, requiring a complex level of regulation...
- Untying the Gordian knot of cytokinesis. Role of small G proteins and their regulatorsS N Prokopenko
Program in Developmental Biology, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
J Cell Biol 148:843-8. 2000
- Characterization of rho GTPase family homologues in Drosophila melanogaster: overexpressing Rho1 in retinal cells causes a late developmental defectI K Hariharan
MGH Cancer Center, Harvard Medical School, Charlestown, MA 02129
EMBO J 14:292-302. 1995..We have cloned three widely expressed members of this family from Drosophila melanogaster; a rho homologue (Rho1) and two rac homologues (Rac1 and Rac2)...
- Rasputin, the Drosophila homologue of the RasGAP SH3 binding protein, functions in ras- and Rho-mediated signalingC Pazman
LMG, NICHD, NIH, MSC 2785, Bethesda, MD 20892, USA
Development 127:1715-25. 2000..The ommatidial polarity phenotypes of rin are similar to those of RhoA and the polarity genes, e.g. fz and dsh...
- The Drosophila tumor suppressor expanded regulates growth, apoptosis, and patterning during developmentC M Blaumueller
Developmental Biology Programme, EMBL, Meyerhofstrasse 1, 69117, Heidelberg, Germany
Mech Dev 92:251-62. 2000..Taken together, our data suggest that Ex is a versatile molecule that plays a role in most of the processes that govern disc development...
- Spiny legs and prickled bodies: new insights and complexities in planar polarity establishmentM Mlodzik
EMBL, Developmental Biology Program, Heidelberg, Germany
Bioessays 22:311-5. 2000..Pk might serve a scaffolding function involved in assembling a protein complex required for planar polarity establishment...
- CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entryM Vig
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Science 312:1220-3. 2006..Although overexpression of CRACM1 did not affect CRAC currents, RNAi-mediated knockdown disrupted its activation. CRACM1 could be the CRAC channel itself, a subunit of it, or a component of the CRAC signaling machinery...
- Regulation of cell differentiation by the Drosophila Jun kinase cascadeE Martin-Blanco
Department of Zoology, University of Cambridge, UK
Curr Opin Genet Dev 7:666-71. 1997....
- Wash functions downstream of Rho and links linear and branched actin nucleation factorsRaymond Liu
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Development 136:2849-60. 2009..We show that Drosophila Wash interacts genetically with Arp2/3, and also functions downstream of Rho1 with Spire and the formin Cappuccino to control actin and microtubule dynamics during Drosophila oogenesis...
- The PDZ-GEF dizzy regulates cell shape of migrating macrophages via Rap1 and integrins in the Drosophila embryoSven Huelsmann
Interfakultäres Institut für Zellbiologie, Abteilung Genetik der Tiere, Fakultat fur Biologie, Universitat Tubingen, Auf der Morgenstelle 28, D 72076 Tubingen, Germany
Development 133:2915-24. 2006..These data provide the first link between a PDZ-GEF, the corresponding small GTPase and integrin-dependent cell adhesion during cell migration in embryonic development...
- Cell biology: polarity bitesRichard Fehon
Nature 442:519-20. 2006
- Cell biology. Which way is up?M Peifer
Nature 403:611-2. 2000
- Migration of the Drosophila primordial midgut cells requires coordination of diverse PS integrin functionsM D Martin-Bermudo
Wellcome CRC Institute and Department of Anatomy, Cambridge University, Tennis Court Road, Cambridge CB2 1QR, UK cam ac uk
Development 126:5161-9. 1999..N17) versions of Rac and Cdc42 cause a very similar defect in migration as loss of integrins, while those of Rho and Ras have no effect...
- The Drosophila Ral GTPase regulates developmental cell shape changes through the Jun NH(2)-terminal kinase pathwayK Sawamoto
Division of Neuroanatomy, Department of Neuroscience, Biomedical Research Center, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
J Cell Biol 146:361-72. 1999..These results indicate that DRal regulates developmental cell shape changes through the JNK pathway...
- Roles of type I myosins in Drosophila handednessKiichiro Taniguchi
Department of Biological Science and Technology, Tokyo University of Science, Noda, Chiba, Japan
Fly (Austin) 1:287-90. 2007..We propose that the actin-based functions of type I Myosins play critical roles in generating LR asymmetry in invertebrates...
- Wingless signaling: the inconvenient complexities of lifeR T Cox
Department of Biology, University of North Carolina at Chapel Hill 27599 3280, USA
Curr Biol 8:R140-4. 1998
- Snail/slug family of repressors: slowly going into the fast lane of development and cancerK Hemavathy
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Gene 257:1-12. 2000..Moreover, the studies may enable us to trace the evolution of this gene family...
- Axon guidance: the cytoplasmic tailBharatkumar N Patel
Program in Neuroscience, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Curr Opin Cell Biol 14:221-9. 2002..Many of these axon guidance receptors, including Plexin B, EphA, ephrin B and Robo, regulate the Rho family of GTPases, to effect changes in motility...
- EGF signaling and ommatidial rotation in the Drosophila eyeHelen Strutt
Centre for Developmental Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
Curr Biol 13:1451-7. 2003..Secondly, reducing EGF signaling can specifically affect ommatidial rotation without showing transformation of the mystery cells or defects in polarity protein localization...
- A role for moesin in polarityKathryn G Miller
Department of Biology, Campus Box 1229, Washington University, 1 Brookings Drive, St Louis MO 63130, USA
Trends Cell Biol 13:165-8. 2003..Localization of informational molecules at the oocyte posterior is strongly affected, thus indicating a role for moesin in anchoring these determinants...
- Dynamic analysis of actin cable function during Drosophila dorsal closureAntonio Jacinto
Department of Anatomy andDevelopmental Biology, University College London, United Kingdom
Curr Biol 12:1245-50. 2002..of this cable by live analysis of GFP-actin-expressing embryos in which the cable is disrupted by modulating Rho1 signaling or by loss of non-muscle myosin (Zipper) function...
- Dendritic development: lessons from Drosophila and related branchesWesley B Grueber
Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, 533 Parnassus Avenue, Box 0725, San Francisco CA 94143, USA
Curr Opin Neurobiol 14:74-82. 2004..Here, we review some recent advances in our understanding of dendritic development in insects, focusing primarily on insights that have been gained from studies of Drosophila...
- Increasingly complex: new players enter the Wnt signaling networkPetra Pandur
Abt Biochemie, Universitat Ulm, Germany
Bioessays 24:881-4. 2002....
- Myosins motor MirandaDaniel P Kiehart
Developmental, Cell and Molecular Biology Group, Department of Biology, Duke University, Durham, NC 27708, USA
Mol Cell 12:1346-7. 2003..New evidence shows that myosin motors drive the spatial segregation of cell fate determinants during asymmetric cell division. How they do so remains a mystery...
- GENETIC CONTROL OF TISSUE POLARITYPaul N Adler; Fiscal Year: 2010..We propose to continue to study a group of planar polarity effector genes to understand how they function at the cellular level and the molecular genetic basis for their control of cell shape and morphology. ..
- Mechanisms of Roundabout Repulsive Axon GuidanceGREG BASHAW; Fiscal Year: 2007..Deciphering the mechanisms that mediate Robo repulsive axon guidance will give important insight into how the nervous system is correctly wired during development and may have implications for nerve regeneration. ..
- REGULATION OF CELL MIGRATION IN DEVELOPMENTDenise Montell; Fiscal Year: 2007..We will also investigate the biochemical mechansims that tether UPD to the cell membrane. ..
- Animal Models For Studying Angelman Syndrome, A Developmental Brain DisorderFen Biao Gao; Fiscal Year: 2007..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page J Description, ..
- Genetic Analysis of Heavy Metals NeurotoxicityFen Biao Gao; Fiscal Year: 2005....
- MYOSIN VI FUNCTION AND MECHANISMKathryn G Miller; Fiscal Year: 2010..Further understanding of how myosin VI works in vivo is likely to enhance our understanding of disease mechanisms and provide for new routes of treatment. ..
- MYOSIN VI FUNCTION AND MECHANISMKathryn Miller; Fiscal Year: 2009....
- Mechanisms of Slit-Roundabout Mediated Axon RepulsionGreg J Bashaw; Fiscal Year: 2010....
- Transciption Factor Codes, Guidance Receptors and Motor Axon GuidanceGreg J Bashaw; Fiscal Year: 2010....
- REGULATION OF CELL MIGRATION IN DEVELOPMENTDenise J Montell; Fiscal Year: 2010..Since cell motility contributes to wound healing and tumor metastasis, these studies could lead to the discovery of new drug targets that could promote healing or inhibit the spread of cancer cells. ..
- Cytoskeleton Dynamics in Developmental Cell MigrationDenise J Montell; Fiscal Year: 2010..Since cell motility contributes to wound healing and tumor metastasis, these studies could lead to the discovery of new drug targets that could promote healing or inhibit the spread of cancer cells. ..
- Transciption Factor Codes, Guidance Receptors and Motor Axon GuidanceGREG BASHAW; Fiscal Year: 2009....
- GENETIC CONTROL OF TISSUE POLARITYPaul Adler; Fiscal Year: 2005..For one of these genes we will determine the relative importance of adhesion versus signal transduction for the mutant phenotype. ..
- GENETIC CONTROL OF TISSUE POLARITYPaul Adler; Fiscal Year: 2001..We will also carry out experiments designed to distinguish between models proposed to explain the function of the fz signaling/signal transduction pathway in the development of tissue polarity. ..
- MYOSIN VI FUNCTION IN INTRACELLULAR TRANSPORT/LOCALIZATIKathryn Miller; Fiscal Year: 2003..abstract_text> ..
- REGULATION OF CELL MIGRATION IN DEVELOPMENTDenise Montell; Fiscal Year: 2003..In addition, the regulated activity of the GTPase Rac, but not Rho or Cdc42, is required during border cell migration...