rhino

Summary

Gene Symbol: rhino
Description: rhino
Alias: CG10683, Dmel\CG10683, HP1, HP1D, HP1d, RHI, Rhi, rno, rhino, CG10683-PA, heterochromatin protein 1, rhi-PA
Species: fruit fly

Top Publications

  1. Volpe A, Horowitz H, Grafer C, Jackson S, Berg C. Drosophila rhino encodes a female-specific chromo-domain protein that affects chromosome structure and egg polarity. Genetics. 2001;159:1117-34 pubmed
    Here we describe our analyses of Rhino, a novel member of the Heterochromatin Protein 1(HP1) subfamily of chromo box proteins...
  2. Levine M, McCoy C, Vermaak D, Lee Y, Hiatt M, Matsen F, et al. Phylogenomic analysis reveals dynamic evolutionary history of the Drosophila heterochromatin protein 1 (HP1) gene family. PLoS Genet. 2012;8:e1002729 pubmed publisher
    ..heterochromatin function and evolution, we conducted a comprehensive phylogenomic analysis of the Heterochromatin Protein 1 gene family across 40 million years of Drosophila evolution...
  3. Khurana J, Xu J, Weng Z, Theurkauf W. Distinct functions for the Drosophila piRNA pathway in genome maintenance and telomere protection. PLoS Genet. 2010;6:e1001246 pubmed publisher
    ..Here we show that mutations in the Drosophila piRNA pathway genes, armi, aub, ago3, and rhi, lead to extensive fragmentation of the zygotic genome during the cleavage stage of embryonic divisions...
  4. Kolaczkowski B, Hupalo D, Kern A. Recurrent adaptation in RNA interference genes across the Drosophila phylogeny. Mol Biol Evol. 2011;28:1033-42 pubmed publisher
    ..Our observations suggest a predictive model of how selective pressures generated by evolutionary arms race scenarios may affect multiple genes across protein interaction networks and other biochemical pathways. ..
  5. Klattenhoff C, Xi H, Li C, Lee S, Xu J, Khurana J, et al. The Drosophila HP1 homolog Rhino is required for transposon silencing and piRNA production by dual-strand clusters. Cell. 2009;138:1137-49 pubmed publisher
    ..We show that the HP1 homolog Rhino is required for nuage organization, transposon silencing, and ping-pong amplification of piRNAs...
  6. Molla Herman A, Vallés A, Ganem Elbaz C, Antoniewski C, Huynh J. tRNA processing defects induce replication stress and Chk2-dependent disruption of piRNA transcription. EMBO J. 2015;34:3009-27 pubmed publisher
    ..Our data thus link tRNA processing, DNA replication, and genome defense by small RNAs. This unexpected connection reveals constraints that could shape genome organization during evolution. ..
  7. Hermant C, Boivin A, Teysset L, Delmarre V, Asif Laidin A, van den Beek M, et al. Paramutation in Drosophila Requires Both Nuclear and Cytoplasmic Actors of the piRNA Pathway and Induces Cis-spreading of piRNA Production. Genetics. 2015;201:1381-96 pubmed publisher
    ..here that piRNA production and trans-silencing capacities of the paramutated cluster depend on the function of the rhino, cutoff, and zucchini genes involved in primary piRNA biogenesis in the germline, as well as on that of the ..
  8. Zhang F, Wang J, Xu J, Zhang Z, Koppetsch B, Schultz N, et al. UAP56 couples piRNA clusters to the perinuclear transposon silencing machinery. Cell. 2012;151:871-884 pubmed publisher
    ..We show that UAP56 colocalizes with the cluster-associated HP1 variant Rhino, that nuage granules containing Vasa localize directly across the nuclear envelope from cluster foci containing ..
  9. Pane A, Jiang P, Zhao D, Singh M, Schupbach T. The Cutoff protein regulates piRNA cluster expression and piRNA production in the Drosophila germline. EMBO J. 2011;30:4601-15 pubmed publisher
    ..Consistent with this observation, Cuff physically interacts with the Heterochromatin Protein 1 (HP1) variant Rhino (Rhi)...

More Information

Publications34

  1. Mohn F, Handler D, Brennecke J. Noncoding RNA. piRNA-guided slicing specifies transcripts for Zucchini-dependent, phased piRNA biogenesis. Science. 2015;348:812-817 pubmed publisher
    ..Our data uncover an evolutionarily conserved piRNA biogenesis mechanism in which Zucchini plays a central role in defining piRNA 5' and 3' ends. ..
  2. Yu B, Cassani M, Wang M, Liu M, Ma J, Li G, et al. Structural insights into Rhino-mediated germline piRNA cluster formation. Cell Res. 2015;25:525-8 pubmed publisher
  3. Levine M, Malik H. A rapidly evolving genomic toolkit for Drosophila heterochromatin. Fly (Austin). 2013;7:137-41 pubmed publisher
    ..This paper reported over 20 new members of what was traditionally believed to be a small and static Heterochromatin Protein 1 (HP1) gene family...
  4. Pek J, Kai T. Non-coding RNAs enter mitosis: functions, conservation and implications. Cell Div. 2011;6:6 pubmed publisher
    ..We also highlight relevant studies implicating mitotic roles for RNAs and/or nuage in other model systems and their implications for cancer development. ..
  5. Zhang Z, Wang J, Schultz N, Zhang F, Parhad S, Tu S, et al. The HP1 homolog rhino anchors a nuclear complex that suppresses piRNA precursor splicing. Cell. 2014;157:1353-63 pubmed publisher
    ..The Drosophila HP1 homolog Rhino is required for germline piRNA production...
  6. Mohn F, Sienski G, Handler D, Brennecke J. The rhino-deadlock-cutoff complex licenses noncanonical transcription of dual-strand piRNA clusters in Drosophila. Cell. 2014;157:1364-79 pubmed publisher
    ..Here, we show that a complex composed of Rhino, Deadlock, and Cutoff (RDC) defines dual-strand piRNA clusters genome-wide in Drosophila ovaries...
  7. Neuman Silberberg F. Drosophila female sterile mutation spoonbill interferes with multiple pathways in oogenesis. Genesis. 2007;45:369-81 pubmed
    ..Based on the previous data and the results presented here, it is anticipated that spoonbill may encode a multifunctional protein that perhaps coordinately regulated the activity of multiple signaling pathways during oogenesis. ..
  8. Kumar M, Chen K. Evolution of animal Piwi-interacting RNAs and prokaryotic CRISPRs. Brief Funct Genomics. 2012;11:277-88 pubmed publisher
  9. Morgunova V, Akulenko N, Radion E, Olovnikov I, Abramov Y, Olenina L, et al. Telomeric repeat silencing in germ cells is essential for early development in Drosophila. Nucleic Acids Res. 2015;43:8762-73 pubmed publisher
    ..Our data demonstrate that Ccr4-Not, Woc, Trf2 and Ars2, components of different regulatory pathways, are required for telomere protection in the germline in order to guarantee normal development. ..
  10. Tao Y, Christiansen A, Schulz R. Second chromosome genes required for heart development in Drosophila melanogaster. Genesis. 2007;45:607-17 pubmed
    ..Several of these sequences have known vertebrate homologues, further supporting a conserved genetic basis for heart formation in Drosophila and higher eukaryotes. ..
  11. Olivieri D, Sykora M, Sachidanandam R, Mechtler K, Brennecke J. An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in Drosophila. EMBO J. 2010;29:3301-17 pubmed publisher
    ..Loss of Zucchini leads to an accumulation of Piwi and Armitage in Yb bodies, indicating that Yb bodies are sites of primary piRNA biogenesis. ..
  12. Ryazansky S, Radion E, Mironova A, Akulenko N, Abramov Y, Morgunova V, et al. Natural variation of piRNA expression affects immunity to transposable elements. PLoS Genet. 2017;13:e1006731 pubmed publisher
    ..remnants of I-elements shows increased expression of the piRNA precursors and enrichment by the Heterochromatin Protein 1 homolog, Rhino, in weak R strains, which is in accordance with stronger piRNA expression by these ..
  13. Brideau N, Barbash D. Functional conservation of the Drosophila hybrid incompatibility gene Lhr. BMC Evol Biol. 2011;11:57 pubmed publisher
    ..We conclude that evolution of the hybrid lethality properties of Lhr between D. melanogaster and D. simulans did not involve extensive loss or gain of functions associated with protein interactions or localization to heterochromatin...
  14. Beck E, Llopart A. Widespread Positive Selection Drives Differentiation of Centromeric Proteins in the Drosophila melanogaster subgroup. Sci Rep. 2015;5:17197 pubmed publisher
  15. Lavrenov A, Nefedova L, Romanova N, Kim A. Expression of hp1 family genes and their plausible role in formation of flamenco phenotype in D. melanogaster. Biochemistry (Mosc). 2014;79:1267-72 pubmed publisher
    ..RNA interference system genes ago3, zuc, aub, and HP1 heterochromatin protein family genes hp1a, hp1b, hp1c, hp1d (rhino), and hp1e in D. melanogaster SS strain mutant on the flamenco gene are presented...
  16. Vermaak D, Henikoff S, Malik H. Positive selection drives the evolution of rhino, a member of the heterochromatin protein 1 family in Drosophila. PLoS Genet. 2005;1:96-108 pubmed publisher
    ..One of the best markers for heterochromatin is the heterochromatin protein 1 (HP1), which is an essential, nonhistone chromosomal protein...
  17. Hur J, Luo Y, Moon S, Ninova M, Marinov G, Chung Y, et al. Splicing-independent loading of TREX on nascent RNA is required for efficient expression of dual-strand piRNA clusters in Drosophila. Genes Dev. 2016;30:840-55 pubmed publisher
    ..Finally, we show that TREX is required for accumulation of nascent piRNA precursors. Our study reveals a novel splicing-independent mechanism for TREX loading on nascent RNA and its importance in piRNA biogenesis. ..
  18. Lee Y, Langley C. Long-term and short-term evolutionary impacts of transposable elements on Drosophila. Genetics. 2012;192:1411-32 pubmed publisher
  19. Han B, Zamore P. piRNAs. Curr Biol. 2014;24:R730-3 pubmed publisher
  20. Le Thomas A, Stuwe E, Li S, Du J, Marinov G, Rozhkov N, et al. Transgenerationally inherited piRNAs trigger piRNA biogenesis by changing the chromatin of piRNA clusters and inducing precursor processing. Genes Dev. 2014;28:1667-80 pubmed publisher
    ..The heterochromatin protein 1 (HP1) homolog Rhino binds to the H3K9me3 mark through its chromodomain and is enriched over piRNA ..
  21. Simkin A, Wong A, Poh Y, Theurkauf W, Jensen J. Recurrent and recent selective sweeps in the piRNA pathway. Evolution. 2013;67:1081-90 pubmed publisher
    ..Using a variety of molecular evolutionary and population genetic approaches, we find that the piRNA pathway genes rhino, krimper, and aubergine show patterns suggestive of extensive recurrent positive selection across Drosophila ..
  22. Kelleher E, Edelman N, Barbash D. Drosophila interspecific hybrids phenocopy piRNA-pathway mutants. PLoS Biol. 2012;10:e1001428 pubmed publisher
    ..We suggest that TE derepression in interspecific hybrids largely reflects adaptive divergence of piRNA pathway genes rather than species-specific differences in TE-derived piRNAs. ..
  23. Andersen P, Tirián L, Vunjak M, Brennecke J. A heterochromatin-dependent transcription machinery drives piRNA expression. Nature. 2017;549:54-59 pubmed publisher
    ..factor IIA (TFIIA) subunit, which is recruited to piRNA clusters via the heterochromatin protein-1 variant Rhino. Moonshiner triggers transcription initiation within piRNA clusters by recruiting the TATA-box binding protein (..
  24. Chen Y, Aravin A. Non-Coding RNAs in Transcriptional Regulation: The review for Current Molecular Biology Reports. Curr Mol Biol Rep. 2015;1:10-18 pubmed
    ..Furthermore, a rapidly growing number long non-coding RNAs (lncRNAs) have been implicated as important players in transcription regulation. We will discuss current models for long non-coding RNA-mediated gene regulation. ..
  25. Baxley R, Soshnev A, Koryakov D, Zhimulev I, Geyer P. The role of the Suppressor of Hairy-wing insulator protein in Drosophila oogenesis. Dev Biol. 2011;356:398-410 pubmed publisher
    ..2 and CP190, these proteins are not essential for oogenesis. These studies represent the first molecular investigations of Su(Hw) function in the germline, which uncover distinct requirements for Su(Hw) insulator and ovary functions. ..