Gene Symbol: Rh3
Description: Rhodopsin 3
Alias: CG10888, DMELRH3, Dm Rh3, Dmel\CG10888, FBgn0003249, RH3, rh3, rhodopsin 3, CG10888-PA, Rh3-PA, Rhodopsin3, rhodopsin
Species: fruit fly

Top Publications

  1. Britt S, Feiler R, Kirschfeld K, Zuker C. Spectral tuning of rhodopsin and metarhodopsin in vivo. Neuron. 1993;11:29-39 pubmed
    Color vision is dependent upon the expression of spectrally distinct forms of rhodopsin in different photoreceptor cells...
  2. Hudson R, Kaplan N. Deleterious background selection with recombination. Genetics. 1995;141:1605-17 pubmed
    ..If considerably smaller selection coefficients are assumed, the low observed levels of variation at the tips of the third chromosome are consistent with the background selection model. ..
  3. Cook T. Cell diversity in the retina: more than meets the eye. Bioessays. 2003;25:921-5 pubmed
    ..As Prospero, the Drosophila homolog of Prox1, also participates in retinal cell specification, these data provide a forum for asking new questions concerning pathways that may regulate retinogenesis across evolution. ..
  4. Domingos P, Brown S, Barrio R, Ratnakumar K, Frankfort B, Mardon G, et al. Regulation of R7 and R8 differentiation by the spalt genes. Dev Biol. 2004;273:121-33 pubmed
    ..Final photoreceptor differentiation, including rhabdomere formation and rhodopsin expression, is completed during pupal life...
  5. Vasiliauskas D, Mazzoni E, Sprecher S, Brodetskiy K, Johnston R, Lidder P, et al. Feedback from rhodopsin controls rhodopsin exclusion in Drosophila photoreceptors. Nature. 2011;479:108-12 pubmed publisher
    ..Here we show that the green-light sensing receptor rhodopsin 6 (Rh6) acts to exclude an alternative blue-sensitive rhodopsin 5 (Rh5) from a subset of Drosophila R8 ..
  6. Mikeladze Dvali T, Wernet M, Pistillo D, Mazzoni E, Teleman A, Chen Y, et al. The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors. Cell. 2005;122:775-87 pubmed
    ..This represents an unexpected postmitotic role for genes controlling cell proliferation (warts and its partner hippo and salvador) and cell growth (melted). ..
  7. Salcedo E, Huber A, Henrich S, Chadwell L, Chou W, Paulsen R, et al. Blue- and green-absorbing visual pigments of Drosophila: ectopic expression and physiological characterization of the R8 photoreceptor cell-specific Rh5 and Rh6 rhodopsins. J Neurosci. 1999;19:10716-26 pubmed
  8. Bell M, Earl J, Britt S. Two types of Drosophila R7 photoreceptor cells are arranged randomly: a model for stochastic cell-fate determination. J Comp Neurol. 2007;502:75-85 pubmed
  9. Wernet M, VELEZ M, Clark D, Baumann Klausener F, Brown J, Klovstad M, et al. Genetic dissection reveals two separate retinal substrates for polarization vision in Drosophila. Curr Biol. 2012;22:12-20 pubmed publisher
    ..This work establishes a behavioral paradigm that will enable genetic dissection of the circuits underlying polarization vision. ..

More Information


  1. McDonald E, Xie B, Workman M, Charlton Perkins M, Terrell D, Reischl J, et al. Separable transcriptional regulatory domains within Otd control photoreceptor terminal differentiation events. Dev Biol. 2010;347:122-32 pubmed publisher
    ..In the fly retina, Otd controls rhabdomere morphogenesis of all photoreceptors and regulates distinct Rhodopsin-encoding genes in a photoreceptor subtype-specific manner...
  2. Johnston R, Otake Y, Sood P, Vogt N, Behnia R, Vasiliauskas D, et al. Interlocked feedforward loops control cell-type-specific Rhodopsin expression in the Drosophila eye. Cell. 2011;145:956-68 pubmed publisher
    ..for the transcription factor gene defective proventriculus (dve) as a critical node in the network regulating Rhodopsin expression. dve is a shared component of two opposing, interlocked feedforward loops (FFLs)...
  3. Mazzoni E, Celik A, Wernet M, Vasiliauskas D, Johnston R, Cook T, et al. Iroquois complex genes induce co-expression of rhodopsins in Drosophila. PLoS Biol. 2008;6:e97 pubmed publisher
    ..The exclusive expression of one rhodopsin per photoreceptor is a widespread phenomenon, although exceptions exist...
  4. Earl J, Britt S. Expression of Drosophila rhodopsins during photoreceptor cell differentiation: insights into R7 and R8 cell subtype commitment. Gene Expr Patterns. 2006;6:687-94 pubmed
    ..We examined the onset of expression of the rhodopsin genes to determine the latest time point by which photoreceptor subtype commitment must have occurred...
  5. Hardie R, Raghu P. Visual transduction in Drosophila. Nature. 2001;413:186-93 pubmed
    ..Analysis in Drosophila has revealed many of the underlying molecular strategies, leading to the discovery and characterization of signalling molecules of widespread importance. ..
  6. Fortini M, Rubin G. Analysis of cis-acting requirements of the Rh3 and Rh4 genes reveals a bipartite organization to rhodopsin promoters in Drosophila melanogaster. Genes Dev. 1990;4:444-63 pubmed
    The rhodopsin genes of Drosophila melanogaster are expressed in nonoverlapping subsets of photoreceptor cells within the insect visual system...
  7. Chou W, Huber A, Bentrop J, Schulz S, Schwab K, Chadwell L, et al. Patterning of the R7 and R8 photoreceptor cells of Drosophila: evidence for induced and default cell-fate specification. Development. 1999;126:607-16 pubmed
    ..specific Rh5 and Rh6 opsins are expressed in non-overlapping sets of R8 cells, in a precise pairwise fashion with Rh3 and Rh4 in the R7 cells of individual ommatidia...
  8. Wernet M, Labhart T, Baumann F, Mazzoni E, Pichaud F, Desplan C. Homothorax switches function of Drosophila photoreceptors from color to polarized light sensors. Cell. 2003;115:267-79 pubmed
    ..Homothorax expression is induced by the iroquois complex and the wingless (wg) pathway. However, crucial wg pathway components are not required, suggesting that additional signals are involved. ..
  9. Papatsenko D, Sheng G, Desplan C. A new rhodopsin in R8 photoreceptors of Drosophila: evidence for coordinate expression with Rh3 in R7 cells. Development. 1997;124:1665-73 pubmed
    ..All cells of the primary system, R1-R6, express the same rhodopsin and are functionally identical. In contrast, the R7 and R8 photoreceptors are different from each other...
  10. Yamaguchi S, Wolf R, Desplan C, Heisenberg M. Motion vision is independent of color in Drosophila. Proc Natl Acad Sci U S A. 2008;105:4910-5 pubmed publisher
    ..Under these conditions, mutant flies lacking functional rhodopsin in R1-R6 cells do not respond at all...
  11. Tahayato A, Sonneville R, Pichaud F, Wernet M, Papatsenko D, Beaufils P, et al. Otd/Crx, a dual regulator for the specification of ommatidia subtypes in the Drosophila retina. Dev Cell. 2003;5:391-402 pubmed
    ..in the two classes of ommatidia depends on a series of highly conserved homeodomain binding sites present in the rhodopsin promoters...
  12. TERRELL D, Xie B, Workman M, Mahato S, Zelhof A, Gebelein B, et al. OTX2 and CRX rescue overlapping and photoreceptor-specific functions in the Drosophila eye. Dev Dyn. 2012;241:215-28 pubmed publisher
    ..Our findings have important implications for understanding how Otx proteins have subfunctionalized during evolution, and cement Drosophila as an effective tool to unravel the molecular bases of photoreceptor pathogenesis. ..
  13. Mishra M, Oke A, Lebel C, McDonald E, Plummer Z, Cook T, et al. Pph13 and orthodenticle define a dual regulatory pathway for photoreceptor cell morphogenesis and function. Development. 2010;137:2895-904 pubmed publisher
    ..Rh2 and Rh6, and other phototransduction genes, demonstrating that Pph13 and Otd control a distinct subset of Rhodopsin-encoding genes in adult visual systems...
  14. Wernet M, Mazzoni E, Celik A, Duncan D, Duncan I, Desplan C. Stochastic spineless expression creates the retinal mosaic for colour vision. Nature. 2006;440:174-80 pubmed publisher
    ..The fly retina contains two types of ommatidia, called 'pale' and 'yellow', defined by different rhodopsin pairs expressed in R7 and R8 cells...
  15. Sprecher S, Pichaud F, Desplan C. Adult and larval photoreceptors use different mechanisms to specify the same Rhodopsin fates. Genes Dev. 2007;21:2182-95 pubmed
    ..Therefore, even though the larval PRs and adult R8 PRs express the same rhodopsins (rh5 and rh6), they use very distinct mechanisms for their specification. ..
  16. Wernet M, Desplan C. Building a retinal mosaic: cell-fate decision in the fly eye. Trends Cell Biol. 2004;14:576-84 pubmed
    ..Notably, several of the factors used in generating the retinal mosaic of the fruitfly have corresponding functions in vertebrates that are likely to have similar roles. ..
  17. Wardill T, List O, Li X, Dongre S, McCulloch M, Ting C, et al. Multiple spectral inputs improve motion discrimination in the Drosophila visual system. Science. 2012;336:925-31 pubmed publisher
    ..Our results demonstrate that inputs from photoreceptors of different spectral sensitivities improve motion discrimination, increasing robustness of perception. ..
  18. Zuker C, Montell C, Jones K, Laverty T, Rubin G. A rhodopsin gene expressed in photoreceptor cell R7 of the Drosophila eye: homologies with other signal-transducing molecules. J Neurosci. 1987;7:1550-7 pubmed
    ..Amino acid homologies between these different opsins and other signal-transducing molecules suggest an important role for the conserved domains of rhodopsin in the transduction of extracellular signals.
  19. Pichaud F, Desplan C. A new visualization approach for identifying mutations that affect differentiation and organization of the Drosophila ommatidia. Development. 2001;128:815-26 pubmed
    ..We illustrate the power of this detection system using known genetic backgrounds and new mutations that affect ommatidial differentiation, morphology or chirality. ..
  20. Cook T, Pichaud F, Sonneville R, Papatsenko D, Desplan C. Distinction between color photoreceptor cell fates is controlled by Prospero in Drosophila. Dev Cell. 2003;4:853-64 pubmed
    ..Furthermore, this study provides transcriptional targets for pros that may lend insight into its role in regulating neuronal development in flies and vertebrates. ..
  21. Pollock J, Benzer S. Transcript localization of four opsin genes in the three visual organs of Drosophila; RH2 is ocellus specific. Nature. 1988;333:779-82 pubmed
    ..Four opsin genes have been identified thus far in Drosophila; Rh1, Rh2, Rh3 and Rh4 (refs 6-11)...
  22. Shen W, Kwon Y, Adegbola A, Luo J, Chess A, Montell C. Function of rhodopsin in temperature discrimination in Drosophila. Science. 2011;331:1333-6 pubmed publisher
    ..We report that mutation of the gene (ninaE) encoding a classical G protein-coupled receptor (GPCR), Drosophila rhodopsin, eliminates thermotactic discrimination in the comfortable temperature range...
  23. Xie B, Charlton Perkins M, McDonald E, Gebelein B, Cook T. Senseless functions as a molecular switch for color photoreceptor differentiation in Drosophila. Development. 2007;134:4243-53 pubmed
    ..and Sens function together with the transcription factor Orthodenticle (Otd) to oppositely regulate R7 and R8 PR Rhodopsin gene expression in vitro...
  24. Fryxell K, Meyerowitz E. An opsin gene that is expressed only in the R7 photoreceptor cell of Drosophila. EMBO J. 1987;6:443-51 pubmed
    ..The predicted protein structure contains many characteristics that are common to all rhodopsins, and the sequence differences help to identify four domains of the rhodopsin molecule that have been conserved in evolution.
  25. Fortini M, Rubin G. The optic lobe projection pattern of polarization-sensitive photoreceptor cells in Drosophila melanogaster. Cell Tissue Res. 1991;265:185-91 pubmed
    Histological staining of wild-type and sevenless transgenic Drosophila melanogaster bearing Rh3-lacZ fusion genes permits the selective visualization of polarization-sensitive R7 and R8 photoreceptor cells located along the dorsal ..
  26. Papatsenko D, Nazina A, Desplan C. A conserved regulatory element present in all Drosophila rhodopsin genes mediates Pax6 functions and participates in the fine-tuning of cell-specific expression. Mech Dev. 2001;101:143-53 pubmed
    The Drosophila rhodopsin genes (rh's) represent a unique family of highly regulated cell-specific genes, where each member has its own expression pattern in the visual system...
  27. Feiler R, Bjornson R, Kirschfeld K, Mismer D, Rubin G, Smith D, et al. Ectopic expression of ultraviolet-rhodopsins in the blue photoreceptor cells of Drosophila: visual physiology and photochemistry of transgenic animals. J Neurosci. 1992;12:3862-8 pubmed
    ..We show that the Rh3 and Rh4 opsin genes encode UV-sensitive opsins with similar spectral properties (lambda max = 345 nm and 375 nm), ..
  28. Townson S, Chang B, Salcedo E, Chadwell L, Pierce N, Britt S. Honeybee blue- and ultraviolet-sensitive opsins: cloning, heterologous expression in Drosophila, and physiological characterization. J Neurosci. 1998;18:2412-22 pubmed
    ..The UV opsin cDNA encodes a protein of 371 amino acids that is most closely related to the UV-sensitive Drosophila Rh3 and Rh4 opsins...
  29. Shetty K, Kurada P, O Tousa J. Rab6 regulation of rhodopsin transport in Drosophila. J Biol Chem. 1998;273:20425-30 pubmed
    ..N125I) Rab6 protein in Drosophila photoreceptors to assess the in vivo role of Rab6 in the trafficking of rhodopsin and other proteins...
  30. Schnaitmann C, Garbers C, Wachtler T, Tanimoto H. Color discrimination with broadband photoreceptors. Curr Biol. 2013;23:2375-82 pubmed publisher
    ..Our findings show that receptors with a complex and broad spectral sensitivity can contribute to color vision and reveal that chromatic and achromatic circuits in the fly share common photoreceptors. ..
  31. Randall A, Liu C, Chu B, Zhang Q, Dongre S, Juusola M, et al. Speed and sensitivity of phototransduction in Drosophila depend on degree of saturation of membrane phospholipids. J Neurosci. 2015;35:2731-46 pubmed publisher
    ..The results are consistent with mechanosensitive gating and provide a striking example of how dietary fatty acids can profoundly influence sensory performance in a classical G-protein-coupled signaling cascade. ..
  32. Lee R, Thomas C, Marietta R, Stark W. Vitamin A, visual pigments, and visual receptors in Drosophila. Microsc Res Tech. 1996;35:418-30 pubmed
    ..suggest that retinoic acid-rearing stimulates membrane export and rhabdomere buildup, even though functional rhodopsin is missing...
  33. Alvarez C, Robison K, Gilbert W. Novel Gq alpha isoform is a candidate transducer of rhodopsin signaling in a Drosophila testes-autonomous pacemaker. Proc Natl Acad Sci U S A. 1996;93:12278-82 pubmed
    DGq is the alpha subunit of the heterotrimeric GTPase (G alpha), which couples rhodopsin to phospholipase C in Drosophila vision...
  34. Carulli J, Krane D, Hartl D, Ochman H. Compositional heterogeneity and patterns of molecular evolution in the Drosophila genome. Genetics. 1993;134:837-45 pubmed
  35. Rosenbaum E, Brehm K, Vasiljevic E, Liu C, Hardie R, Colley N. XPORT-dependent transport of TRP and rhodopsin. Neuron. 2011;72:602-15 pubmed publisher
    ..Here, we identify XPORT (exit protein of rhodopsin and TRP) as a critical chaperone for TRP and its G protein-coupled receptor (GPCR), rhodopsin (Rh1)...
  36. Ranganathan R, Harris W, Zuker C. The molecular genetics of invertebrate phototransduction. Trends Neurosci. 1991;14:486-93 pubmed
    ..The results of a combination of molecular, genetic, physiological and biochemical studies are beginning to produce a clearer model for the complex mechanisms involved in invertebrate visual transduction. ..
  37. Aoyagi N, Wassarman D. Developmental and transcriptional consequences of mutations in Drosophila TAF(II)60. Mol Cell Biol. 2001;21:6808-19 pubmed
    ..Finally, TAF(II)60 plays roles in developmental regulation of gene expression that are distinct from those of other TAF(II) proteins. ..
  38. Salcedo E, Zheng L, Phistry M, Bagg E, Britt S. Molecular basis for ultraviolet vision in invertebrates. J Neurosci. 2003;23:10873-8 pubmed
    ..UV: lysine vs blue:asparagine or glutamate) corresponds to amino acid position glycine 90 (G90) in bovine rhodopsin, a site affected in autosomal dominant human congenital night blindness...
  39. Palazzolo M, Hyde D, Vijayraghavan K, Mecklenburg K, Benzer S, Meyerowitz E. Use of a new strategy to isolate and characterize 436 Drosophila cDNA clones corresponding to RNAs detected in adult heads but not in early embryos. Neuron. 1989;3:527-39 pubmed
    ..Many of these genes are likely to encode eye- and nervous system-specific products. ..
  40. Benchabane H, Hughes E, Takacs C, Baird J, Ahmed Y. Adenomatous polyposis coli is present near the minimal level required for accurate graded responses to the Wingless morphogen. Development. 2008;135:963-71 pubmed publisher
    ..We conclude that Apc activity is not present in vast excess, but instead is near the minimal level required for accurate graded responses to the Wg morphogen. ..
  41. Kunduri G, Yuan C, Parthibane V, Nyswaner K, Kanwar R, Nagashima K, et al. Phosphatidic acid phospholipase A1 mediates ER-Golgi transit of a family of G protein-coupled receptors. J Cell Biol. 2014;206:79-95 pubmed publisher
    ..phospholipase A1 (PAPLA1) interacts with COPII protein family members and is required for the transport of Rh1 (rhodopsin 1), an N-glycosylated G protein-coupled receptor (GPCR), from the ER to the Golgi complex...
  42. Weir P, Henze M, Bleul C, Baumann Klausener F, Labhart T, Dickinson M. Anatomical Reconstruction and Functional Imaging Reveal an Ordered Array of Skylight Polarization Detectors in Drosophila. J Neurosci. 2016;36:5397-404 pubmed publisher
    ..Behavioral experiments have shown that many species use the polarization pattern in the sky to direct locomotion. Here we describe the input stage of the fly's polarization-vision system. ..
  43. Sun H, Gilbert D, Copeland N, Jenkins N, Nathans J. Peropsin, a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epithelium. Proc Natl Acad Sci U S A. 1997;94:9893-8 pubmed
    ..These observations suggest that peropsin may play a role in RPE physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds. ..
  44. Ayala F, Chang B, Hartl D. Molecular evolution of the Rh3 gene in Drosophila. Genetica. 1993;92:23-32 pubmed
    ..of the Drosophila opsin gene family are extended by inter- and intraspecific DNA sequence comparisons of the Rh3 locus in the melanogaster subgroup and D. pseudoobscura...
  45. Begun D. Population genetics of silent and replacement variation in Drosophila simulans and D. melanogaster: X/autosome differences?. Mol Biol Evol. 1996;13:1405-7 pubmed
  46. Schlichting M, Grebler R, Peschel N, Yoshii T, Helfrich Forster C. Moonlight detection by Drosophila's endogenous clock depends on multiple photopigments in the compound eyes. J Biol Rhythms. 2014;29:75-86 pubmed publisher
    ..The increase in relative nocturnal activity in response to moonlight is mainly mediated by the rhodopsin 6-expressing inner photoreceptor cell R8 together with the rhodopsin 1-expressing outer receptor cells (R1-R6), ..
  47. Rosenbaum E, Hardie R, Colley N. Calnexin is essential for rhodopsin maturation, Ca2+ regulation, and photoreceptor cell survival. Neuron. 2006;49:229-41 pubmed
    ..Here, we demonstrate a multifunctional role for calnexin as both a molecular chaperone uniquely required for rhodopsin maturation and a regulator of Ca2+ that enters photoreceptor cells during light stimulation...
  48. Pichaud F, Briscoe A, Desplan C. Evolution of color vision. Curr Opin Neurobiol. 1999;9:622-7 pubmed
    ..Interesting new findings suggest that animals have evolved a strategy to achieve specific sensitivity through the mutually exclusive expression of different opsin genes in photoreceptors. ..
  49. Zuker C. Phototransduction in Drosophila: a paradigm for the genetic dissection of sensory transduction cascades. Curr Opin Neurobiol. 1992;2:622-7 pubmed
    ..The availability of Drosophila mutants with defects in visual physiology allows for an in vivo dissection of this complex sensory signal transduction process. ..
  50. Schlichting M, Grebler R, Menegazzi P, Helfrich Förster C. Twilight dominates over moonlight in adjusting Drosophila's activity pattern. J Biol Rhythms. 2015;30:117-28 pubmed publisher
    ..To adjust nocturnal activity levels to a wild-type manner, all photoreceptor cells work together in a complex way, with rhodopsin 6 having a prominent role.
  51. Landry C, Castillo Davis C, Ogura A, Liu J, Hartl D. Systems-level analysis and evolution of the phototransduction network in Drosophila. Proc Natl Acad Sci U S A. 2007;104:3283-8 pubmed
    ..These results provide a preliminary quantification of variation and divergence of gene expression between species in a known gene network and provide a foundation for a system-level understanding of functional and evolutionary change. ..
  52. Borst A. Fly visual course control: behaviour, algorithms and circuits. Nat Rev Neurosci. 2014;15:590-9 pubmed publisher
    ..By focusing on fly visual course control, I highlight what has been learned about the neuronal circuit modules that control visual guidance in Drosophila melanogaster through the use of these techniques. ..
  53. Wernet M, Meier K, Baumann Klausener F, Dorfman R, Weihe U, Labhart T, et al. Genetic dissection of photoreceptor subtype specification by the Drosophila melanogaster zinc finger proteins elbow and no ocelli. PLoS Genet. 2014;10:e1004210 pubmed publisher
    ..that Elb/Noc specifically interact with the transcription factor Orthodenticle (Otd)/Otx, a crucial regulator of rhodopsin gene transcription...
  54. Hsiao H, Johnston R, Jukam D, Vasiliauskas D, Desplan C, Rister J. Dissection and immunohistochemistry of larval, pupal and adult Drosophila retinas. J Vis Exp. 2012;:4347 pubmed publisher
    ..R7 and R8 PRs stochastically express different combinations of Rhs in two main subtypes: In the 'p' subtype, Rh3 in pR7s is coupled with Rh5 in pR8s, whereas in the 'y' subtype, Rh4 in yR7s is associated with Rh6 in yR8s...
  55. Przeworski M, Charlesworth B, Wall J. Genealogies and weak purifying selection. Mol Biol Evol. 1999;16:246-52 pubmed
    ..We caution, however, that the effect of weak selection on the genealogy is specific to the model; a (more realistic) model of multiple linked sites could lead to a more distorted genealogy than is observed for a single site. ..
  56. Xu X, Choudhury A, Li X, Montell C. Coordination of an array of signaling proteins through homo- and heteromeric interactions between PDZ domains and target proteins. J Cell Biol. 1998;142:545-55 pubmed
    ..The INAD signaling complex also includes rhodopsin, protein kinase C (PKC), and calmodulin, though it is not known whether these proteins bind to INAD...
  57. Hyde D, Mecklenburg K, Pollock J, Vihtelic T, Benzer S. Twenty Drosophila visual system cDNA clones: one is a homolog of human arrestin. Proc Natl Acad Sci U S A. 1990;87:1008-12 pubmed
    ..Vertebrate arrestin interacts with rhodopsin in phototransduction and has been associated with an autoimmune form of uveitis in primates...
  58. BIRKHOLZ D, Chou W, Phistry M, Britt S. rhomboid mediates specification of blue- and green-sensitive R8 photoreceptor cells in Drosophila. J Neurosci. 2009;29:2666-75 pubmed publisher
    ..This suggests that rhomboid may function in R8 cells to activate Epidermal growth factor receptor signaling in R7 cells and promote their differentiation to a signaling competent state. ..
  59. Baker E, Colley N, Zuker C. The cyclophilin homolog NinaA functions as a chaperone, forming a stable complex in vivo with its protein target rhodopsin. EMBO J. 1994;13:4886-95 pubmed
    In Drosophila, biogenesis of the major rhodopsin, Rh1, is dependent on the presence of a photoreceptor cell-specific cyclophilin, NinaA...
  60. Hakeda Suzuki S, Suzuki T. Cell surface control of the layer specific targeting in the Drosophila visual system. Genes Genet Syst. 2014;89:9-15 pubmed
    ..Fundamental and comprehensive understanding of the crosstalk of growing axons and target regions in the Drosophila optic lobe will elucidate the general principles applicable to more complex nervous systems. ..
  61. BIRKHOLZ D, Chou W, Phistry M, Britt S. Disruption of photoreceptor cell patterning in the Drosophila Scutoid mutant. Fly (Austin). 2009;3:253-62 pubmed
    ..Our detailed analysis of this unusual dominant gain-of-function neomorphic phenotype suggests that the induction of Rh5 expression in Scutoid mutants is partially rhomboid independent. ..
  62. Rosenbaum E, Brehm K, Vasiljevic E, Gajeski A, Colley N. Drosophila GPI-mannosyltransferase 2 is required for GPI anchor attachment and surface expression of chaoptin. Vis Neurosci. 2012;29:143-56 pubmed publisher
    ..Our findings on GPI-MT2 provide a mechanistic link between GPI anchor biosynthesis and protein trafficking in Drosophila and shed light on a novel mechanism for inherited retinal degeneration. ..
  63. Posnien N, Hopfen C, Hilbrant M, Ramos Womack M, Murat S, Schönauer A, et al. Evolution of eye morphology and rhodopsin expression in the Drosophila melanogaster species subgroup. PLoS ONE. 2012;7:e37346 pubmed publisher
    ..Intriguingly, this dorsal enlargement is associated with enhanced expression of rhodopsin 3 in D. mauritiana...
  64. Zhu Y. The Drosophila visual system: From neural circuits to behavior. Cell Adh Migr. 2013;7:333-44 pubmed publisher
  65. Miller A, Seymour H, King C, Herman T. Loss of seven-up from Drosophila R1/R6 photoreceptors reveals a stochastic fate choice that is normally biased by Notch. Development. 2008;135:707-15 pubmed publisher
    ..We show that N specifies the R7 fate by a novel branched pathway: N represses Svp expression, thereby exposing an underlying stochastic choice between the R7 and R8 fates, and then tips this choice towards the R7 fate. ..
  66. Karpilow J, Pimentel A, Shamloula H, Venkatesh T. Neuronal development in the Drosophila compound eye: photoreceptor cells R1, R6, and R7 fail to differentiate in the retina aberrant in pattern (rap) mutant. J Neurobiol. 1996;31:149-65 pubmed
    ..These results suggest that the rap gene encodes an R8-specific function that plays a role in the determination of the photoreceptor cells R1, R6, and R7. ..
  67. Fanning A, Anderson J. Protein modules as organizers of membrane structure. Curr Opin Cell Biol. 1999;11:432-9 pubmed
    ..The organization of these proteins into discreet structures has functional consequences for downstream signaling. ..
  68. Charlton Perkins M, Whitaker S, Fei Y, Xie B, Li Kroeger D, Gebelein B, et al. Prospero and Pax2 combinatorially control neural cell fate decisions by modulating Ras- and Notch-dependent signaling. Neural Dev. 2011;6:20 pubmed publisher
  69. Edwards T, Meinertzhagen I. Photoreceptor neurons find new synaptic targets when misdirected by overexpressing runt in Drosophila. J Neurosci. 2009;29:828-41 pubmed publisher
    ..This uniformity indicates the cell-autonomous determination of the architecture of its synaptic organelles by the presynaptic photoreceptor terminal. ..
  70. Xiang Y, Yuan Q, Vogt N, Looger L, Jan L, Jan Y. Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall. Nature. 2010;468:921-6 pubmed publisher
    ..These novel photoreceptors use phototransduction machinery distinct from other photoreceptors in Drosophila and enable larvae to sense light exposure over their entire bodies and move out of danger. ..