Gene Symbol: Ref1
Description: RNA and export factor binding protein 1
Alias: ALY, Aly, BcDNA:LD24793, CG1101, DmREF1, Dmel\CG1101, REF1, aly, cg1101, dmREF1, l(3)02267, ref1, RNA and export factor binding protein 1, Aly, CG1101-PA, Ref1-PA
Species: fruit fly

Top Publications

  1. Herold A, Klymenko T, Izaurralde E. NXF1/p15 heterodimers are essential for mRNA nuclear export in Drosophila. RNA. 2001;7:1768-80 pubmed
    ..We conclude that Dm NXF1/p15 heterodimers only (but not NXF2-NXF4) mediate the export of the majority of mRNAs in Drosophila cells and that the other members of the NXF family play more specialized or different roles. ..
  2. Gatfield D, Izaurralde E. REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export. J Cell Biol. 2002;159:579-88 pubmed
    The metazoan proteins UAP56, REF1, and NXF1 are thought to bind sequentially to mRNA to promote its export to the cytoplasm: UAP56 is thought to recruit REF1 to nascent mRNA; REF1 acts as an adaptor protein mediating the association of ..
  3. Stutz F, Bachi A, Doerks T, Braun I, Seraphin B, Wilm M, et al. REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export. RNA. 2000;6:638-50 pubmed
    ..Thus, Yra1p and members of the REF family of hnRNP-like proteins may facilitate the interaction of TAP/Mex67p with cellular mRNAs. ..
  4. Gatfield D, Unterholzner L, Ciccarelli F, Bork P, Izaurralde E. Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways. EMBO J. 2003;22:3960-70 pubmed
    ..Our findings reveal that despite conservation of the NMD machinery, different mechanisms have evolved to discriminate premature from natural stop codons in metazoa. ..
  5. Chen S, Zhang Y, Long M. New genes in Drosophila quickly become essential. Science. 2010;330:1682-5 pubmed publisher
    ..Lethality was attributed to diverse cellular and developmental defects, such as organ formation and patterning defects. These data suggest that new genes frequently and rapidly evolve essential functions and participate in development. ..
  6. Jin Z, Homola E, Goldbach P, Choi Y, Brill J, Campbell S. Drosophila Myt1 is a Cdk1 inhibitory kinase that regulates multiple aspects of cell cycle behavior during gametogenesis. Development. 2005;132:4075-85 pubmed
    ..Based on these observations, we propose that Myt1 serves unique Cdk1 regulatory functions required for efficient coupling of cell differentiation with cell cycle progression. ..
  7. Garcia Lopez A, Monferrer L, Garcia Alcover I, Vicente Crespo M, Alvarez Abril M, Artero R. Genetic and chemical modifiers of a CUG toxicity model in Drosophila. PLoS ONE. 2008;3:e1595 pubmed publisher
    ..identify putative cellular processes unknown to be altered by CUG repeat RNA, and they include mRNA export factor Aly, apoptosis inhibitor Thread, chromatin remodelling factor Nurf-38, and extracellular matrix structural component ..
  8. Buszczak M, Spradling A. The Drosophila P68 RNA helicase regulates transcriptional deactivation by promoting RNA release from chromatin. Genes Dev. 2006;20:977-89 pubmed
    ..Our observations reveal a strong connection between transcript clearance and gene repression. P68 may be needed to rapidly remove transcripts from a gene before its activity can be shut down and its chromatin reset to an inactive state. ..
  9. Kozlova N, Braga J, Lundgren J, Rino J, Young P, Carmo Fonseca M, et al. Studies on the role of NonA in mRNA biogenesis. Exp Cell Res. 2006;312:2619-30 pubmed
    ..Our data suggest that NonA facilitates the intranuclear mobility of mRNP particles. ..

More Information


  1. Hayashi R, Handler D, Ish Horowicz D, Brennecke J. The exon junction complex is required for definition and excision of neighboring introns in Drosophila. Genes Dev. 2014;28:1772-85 pubmed publisher
    ..Based on a transcriptome-wide analysis, we propose that the dependency of splicing on the EJC is exploited as a means to control the temporal order of splicing events. ..
  2. Provost E, Hersperger G, Timmons L, Ho W, Hersperger E, Alcazar R, et al. Loss-of-function mutations in a glutathione S-transferase suppress the prune-Killer of prune lethal interaction. Genetics. 2006;172:207-19 pubmed
    ..These alleles are loss-of-function mutations in CG10065, a gene that is predicted to encode a protein with several zinc finger domains and glutathione S-transferase activity. ..
  3. Palacios I. RNA processing: splicing and the cytoplasmic localisation of mRNA. Curr Biol. 2002;12:R50-2 pubmed
    ..The new findings suggest that recruitment of the Mago Nashi and Y14 proteins upon splicing of oskar mRNA is an essential step in the localisation of the RNA to the posterior pole of the Drosophila oocyte. ..
  4. McClure K, Schubiger G. A screen for genes that function in leg disc regeneration in Drosophila melanogaster. Mech Dev. 2008;125:67-80 pubmed
    ..Of the 97 P-lacZ lines, we identified six genes (Krüppel-homolog-1, rpd3, jing, combgap, Aly and S6 kinase) that met both criteria...
  5. Vicente Crespo M, Pascual M, Fernandez Costa J, Garcia Lopez A, Monferrer L, Miranda M, et al. Drosophila muscleblind is involved in troponin T alternative splicing and apoptosis. PLoS ONE. 2008;3:e1613 pubmed publisher
    ..and 13 dominant enhancers including Drosophila CUG-BP1 homolog aret, exon junction complex components tsunagi and Aly, and pro-apoptotic genes Traf1 and reaper...
  6. Korenjak M, Brehm A. E2F-Rb complexes regulating transcription of genes important for differentiation and development. Curr Opin Genet Dev. 2005;15:520-7 pubmed
  7. Doggett K, Jiang J, Aleti G, White Cooper H. Wake-up-call, a lin-52 paralogue, and Always early, a lin-9 homologue physically interact, but have opposing functions in regulating testis-specific gene expression. Dev Biol. 2011;355:381-93 pubmed publisher
    ..identified wake-up-call (wuc), a lin-52 paralogue, via a physical interaction with the tMAC lin-9-related subunit Aly, and find that Wuc co-localises with known tMAC subunits...
  8. Le Thomas A, Rogers A, Webster A, Marinov G, Liao S, Perkins E, et al. Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state. Genes Dev. 2013;27:390-9 pubmed publisher
    ..Our results indicate that Piwi identifies targets complementary to the associated piRNA and induces transcriptional repression by establishing a repressive chromatin state when correct targets are found. ..
  9. Freibaum B, Lu Y, López González R, Kim N, Almeida S, Lee K, et al. GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport. Nature. 2015;525:129-33 pubmed publisher
    ..These studies show that a primary consequence of G4C2 repeat expansion is the compromise of nucleocytoplasmic transport through the nuclear pore, revealing a novel mechanism of neurodegeneration. ..