Rdl

Summary

Gene Symbol: Rdl
Description: Resistant to dieldrin
Alias: CG10537, CT29555, DmRDL, DmRdl, Dmel\CG10537, GABA, GABA[[A]], GABA[[A]] receptor, GABA[[A]]R, GABAr, LCCH1, RDL, Rd1, gaba, rdl, CG10537-PA, CG10537-PC, CG10537-PD, CG10537-PE, CG10537-PF, CG10537-PG, GABA A beta-subunit, GABA receptor, GABA[[A]] receptor, Rdl-PA, Rdl-PC, Rdl-PD, Rdl-PE, Rdl-PF, Rdl-PG, resistance to dieldrin, resistant to dieldrin
Species: fruit fly

Top Publications

  1. ncbi Molecular biology of insect neuronal GABA receptors
    A M Hosie
    Babraham Institute, Dept of Zoology, Cambridge, UK
    Trends Neurosci 20:578-83. 1997
  2. doi Gamma-aminobutyric acid (GABA)-mediated neural connections in the Drosophila antennal lobe
    Ryuichi Okada
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Comp Neurol 514:74-91. 2009
  3. ncbi gamma-Aminobutyric acid (GABA) signaling components in Drosophila: immunocytochemical localization of GABA(B) receptors in relation to the GABA(A) receptor subunit RDL and a vesicular GABA transporter
    Lina Enell
    Department of Zoology, Stockholm University, SE 106 91 Stockholm, Sweden
    J Comp Neurol 505:18-31. 2007
  4. ncbi Alternative splicing of a Drosophila GABA receptor subunit gene identifies determinants of agonist potency
    A M Hosie
    Babraham Institute, Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, Downing Street, CB2 3EJ, Cambridge, UK
    Neuroscience 102:709-14. 2001
  5. ncbi Nervous system targets of RNA editing identified by comparative genomics
    Barry Hoopengardner
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Science 301:832-6. 2003
  6. ncbi Putative histamine-gated chloride channel subunits of the insect visual system and thoracic ganglion
    Ines Witte
    Zoologisches Institut, Abteilung Neurophysiologie, Universitat Hamburg, Hamburg, Germany
    J Neurochem 83:504-14. 2002
  7. pmc The effect of a transmembrane amino acid on etomidate sensitivity of an invertebrate GABA receptor
    K A McGurk
    Department of Pharmacology and Neuroscience, Ninewells Hospital and Medical School, Dundee University, Scotland
    Br J Pharmacol 124:13-20. 1998
  8. pmc Glutamate, GABA and acetylcholine signaling components in the lamina of the Drosophila visual system
    Agata Kolodziejczyk
    Department of Zoology, Stockholm University, Stockholm, Sweden
    PLoS ONE 3:e2110. 2008
  9. ncbi Identification of two novel Drosophila melanogaster histamine-gated chloride channel subunits expressed in the eye
    Yingcong Zheng
    Merck Research Laboratories, Merck and Co, Inc, Rahway, New Jersey 07065, USA
    J Biol Chem 277:2000-5. 2002
  10. ncbi Characterization of a putative gamma-aminobutyric acid (GABA) receptor beta subunit gene from Drosophila melanogaster
    J E Henderson
    New York State Agricultural Experiment Station, Cornell University, Geneva 14456
    Biochem Biophys Res Commun 193:474-82. 1993

Research Grants

  1. A TOXIN BASED DROSOPHILA PARKINSON'S DISEASE MODEL
    Geoffrey Stilwell; Fiscal Year: 2005

Scientific Experts

  • Geoff E Stilwell
  • H Xue
  • E Zlotkin
  • F Grolleau
  • Richard R Copley
  • Alfred M Handler
  • Natalia Sánchez-Soriano
  • D Schneider
  • R ffrench-Constant
  • Adrian Rothenfluh
  • CHARLES HOEFFER
  • A M Hosie
  • D B Sattelle
  • James E C Jepson
  • Xu Liu
  • S D Buckingham
  • Agata Kolodziejczyk
  • Robert A Reenan
  • Ian McGonigle
  • Ryuichi Okada
  • Kei Ito
  • Sebastian Busch
  • Jose Agosto
  • Ronald L Davis
  • K Matsuda
  • Jacob Shun Jen Yang
  • Yingcong Zheng
  • Steven W Ludmerer
  • Dick R Nassel
  • K Narusuye
  • J J Rauh
  • Lina Enell
  • Mladen Iovchev
  • Charlotte D'Hulst
  • Daria S Hekmat-Scafe
  • Alastair M Hosie
  • Alain Hamon
  • Gaelle Le Goff
  • H G Zhang
  • K Aronstein
  • David B Sattelle
  • H A Baylis
  • Matthias Landgraf
  • Barry Hoopengardner
  • Kwang Min Choe
  • Ines Witte
  • Stuart J Lansdell
  • David C Hunt
  • Chaoxian Gengs
  • Doris F Cully
  • Paula R Towers
  • Y Ozoe
  • M B Jackson
  • Yiannis A Savva
  • Arthur U Sugden
  • Chio Yokose
  • Asli Sahin
  • C W Holyoke
  • Sarah C R Lummis
  • K M Höld
  • N S Kane
  • Kyung An Han
  • Takeshi Awasaki
  • Mareike Selcho
  • Hiromu Tanimoto
  • Monica E Buchanan
  • James C Choi
  • Jia min Bai
  • Leslie C Griffith
  • Ian A Meinertzhagen
  • E P Semenov
  • Tzumin Lee
  • Katherine M Parisky
  • C T Wang
  • Michael Rosbash
  • Xuejun Sun
  • T Nakao
  • K Hirase
  • Yasutaka Hamasaka
  • Y Nagatomi
  • R Abe
  • William C Krause
  • R T Roush
  • K A McGurk
  • Ivaylo Ivanov
  • Debby Van Dam
  • Bassem A Hassan
  • Steven D Buckingham
  • Adrian Wolstenholme
  • R Frank Kooy

Detail Information

Publications82

  1. ncbi Molecular biology of insect neuronal GABA receptors
    A M Hosie
    Babraham Institute, Dept of Zoology, Cambridge, UK
    Trends Neurosci 20:578-83. 1997
    Ionotropic gamma-aminobutyric acid (GABA) receptors are distributed throughout the nervous systems of many insect species...
  2. doi Gamma-aminobutyric acid (GABA)-mediated neural connections in the Drosophila antennal lobe
    Ryuichi Okada
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Comp Neurol 514:74-91. 2009
    Inhibitory synaptic connections mediated by gamma-aminobutyric acid (GABA) play important roles in the neural computation of the brain...
  3. ncbi gamma-Aminobutyric acid (GABA) signaling components in Drosophila: immunocytochemical localization of GABA(B) receptors in relation to the GABA(A) receptor subunit RDL and a vesicular GABA transporter
    Lina Enell
    Department of Zoology, Stockholm University, SE 106 91 Stockholm, Sweden
    J Comp Neurol 505:18-31. 2007
    gamma-Aminobutyric acid (GABA) is a major inhibitory neurotransmitter in insects and is widely distributed in the central nervous system (CNS)...
  4. ncbi Alternative splicing of a Drosophila GABA receptor subunit gene identifies determinants of agonist potency
    A M Hosie
    Babraham Institute, Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, Downing Street, CB2 3EJ, Cambridge, UK
    Neuroscience 102:709-14. 2001
    Alternative splicing of the Drosophila melanogaster Rdl gene yields four ionotropic GABA receptor subunits. The two Rdl splice variants cloned to date, RDL(ac) and RDL(bd) (DRC17-1-2), differ in their apparent agonist affinity...
  5. ncbi Nervous system targets of RNA editing identified by comparative genomics
    Barry Hoopengardner
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Science 301:832-6. 2003
    ..These results point to a pivotal role for RNA editing in nervous system function...
  6. ncbi Putative histamine-gated chloride channel subunits of the insect visual system and thoracic ganglion
    Ines Witte
    Zoologisches Institut, Abteilung Neurophysiologie, Universitat Hamburg, Hamburg, Germany
    J Neurochem 83:504-14. 2002
    ..These ion-channels are the first specific molecular markers for postsynaptic cells in the insect visual system, thus representing ideal tools to study its physiology and development...
  7. pmc The effect of a transmembrane amino acid on etomidate sensitivity of an invertebrate GABA receptor
    K A McGurk
    Department of Pharmacology and Neuroscience, Ninewells Hospital and Medical School, Dundee University, Scotland
    Br J Pharmacol 124:13-20. 1998
    ..the equivalent amino acid (M314) on the actions of this anaesthetic at an etomidate-insensitive invertebrate GABA receptor (Rdl) of Drosophila melanogaster. 2...
  8. pmc Glutamate, GABA and acetylcholine signaling components in the lamina of the Drosophila visual system
    Agata Kolodziejczyk
    Department of Zoology, Stockholm University, Stockholm, Sweden
    PLoS ONE 3:e2110. 2008
    ..combined Gal4 driven green fluorescent protein in specific lamina neurons with antisera to gamma-aminobutyric acid (GABA), glutamic acid decarboxylase, a GABA(B) type of receptor, L-glutamate, a vesicular glutamate transporter (vGluT), ..
  9. ncbi Identification of two novel Drosophila melanogaster histamine-gated chloride channel subunits expressed in the eye
    Yingcong Zheng
    Merck Research Laboratories, Merck and Co, Inc, Rahway, New Jersey 07065, USA
    J Biol Chem 277:2000-5. 2002
    ..either HisCl1 or HisCl2, produced substantial chloride currents in response to histamine but not in response to GABA, glycine, and glutamate. The histamine sensitivity was similar to that observed in insect laminar neurons...
  10. ncbi Characterization of a putative gamma-aminobutyric acid (GABA) receptor beta subunit gene from Drosophila melanogaster
    J E Henderson
    New York State Agricultural Experiment Station, Cornell University, Geneva 14456
    Biochem Biophys Res Commun 193:474-82. 1993
    ..Among characterized members of this gene family, this gene exhibits the greatest similarity to GABA receptor beta subunit genes...
  11. pmc Allosteric modulation of an expressed homo-oligomeric GABA-gated chloride channel of Drosophila melanogaster
    A M Hosie
    Department of Zoology, University of Cambridge
    Br J Pharmacol 117:1229-37. 1996
    1. Functional GABA-gated chloride channels are formed when cRNA encoding the Drosophila melanogaster GABA receptor subunit RDL is injected into the cytoplasm of Xenopus oocytes...
  12. pmc Agonist pharmacology of two Drosophila GABA receptor splice variants
    A M Hosie
    Department of Zoology, University of Cambridge
    Br J Pharmacol 119:1577-85. 1996
    ..The differences in the potency of agonists on RDLac and DRC 17-1-2 homo-oligomers observed in the present study may assist in identification of further molecular determinants of GABA receptor function.
  13. pmc The GABAA receptor RDL suppresses the conditioned stimulus pathway for olfactory learning
    Xu Liu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 29:1573-9. 2009
    ..Prior studies have shown that the GABA receptor RDL inhibits aversive olfactory learning via its role in the Drosophila mushroom bodies (MBs)...
  14. ncbi Are dendrites in Drosophila homologous to vertebrate dendrites?
    Natalia Sánchez-Soriano
    Faculty of Life Sciences, WTCCMR, The University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Dev Biol 288:126-38. 2005
    ..Implications of these findings for studies of dendrite development, neuronal polarity, transport and evolution are discussed...
  15. pmc A unique amino acid of the Drosophila GABA receptor with influence on drug sensitivity by two mechanisms
    H G Zhang
    Department of Physiology, Medical School, College of Agricultural and Life Sciences, University of Wisconsin, Madison 53706
    J Physiol 479:65-75. 1994
    1. The Drosophila gene Rdl (resistance to dieldrin) encodes a GABA receptor. An alanine-to-serine mutation in this gene at residue 302 confers resistance to cyclodiene insecticides and picrotoxin...
  16. ncbi Immunocytochemical mapping of a C-terminus anti-peptide antibody to the GABA receptor subunit, RDL in the nervous system in Drosophila melanogaster
    J B Harrison
    Babraham Institute Laboratory of Molecular Signalling, Cambridge, UK
    Cell Tissue Res 284:269-78. 1996
    ..on the C-terminal derived amino acid sequence from a cloned Drosophila melanogaster (fruit fly) gene, Rdl (resistant to dieldrin), was used to investigate localization of a GABA receptor subunit in adult male D. melanogaster...
  17. pmc Molecular cloning and transformation of cyclodiene resistance in Drosophila: an invertebrate gamma-aminobutyric acid subtype A receptor locus
    R H ffrench-Constant
    Department of Entomology, Russell Laboratories, University of Wisconsin, Madison 53706
    Proc Natl Acad Sci U S A 88:7209-13. 1991
    ..To our knowledge, this represents the first cloning of an invertebrate GABA receptor and also allows us to manipulate the resistance status of an insect via germ-line transformation...
  18. ncbi Stable expression of a functional homo-oligomeric Drosophila GABA receptor in a Drosophila cell line
    N S Millar
    Wellcome Laboratory of Molecular Pharmacology, Department of Pharmacology, University College London, U K
    Proc Biol Sci 258:307-14. 1994
    A cloned Drosophila gamma-aminobutyric acid GABA receptor subunit (Rdl) has been stably expressed as a functional homo-oligomeric ion channel in a Drosophila cell line...
  19. ncbi Replacement of asparagine with arginine at the extracellular end of the second transmembrane (M2) region of insect GABA receptors increases sensitivity to penicillin G
    Alastair M Hosie
    Department of Pharmacology, University College, Gower St, London WC1E 6BT, UK
    Invert Neurosci 6:75-9. 2006
    ..The A301S mutation that confers resistance to dieldrin did not significantly affect the antagonism by PCG.
  20. ncbi Development of a Drosophila seizure model for in vivo high-throughput drug screening
    Geoff E Stilwell
    Cambria Biosciences, 8A Henshaw St, Woburn, MA 01801, USA
    Eur J Neurosci 24:2211-22. 2006
    ..screening for antiepileptic drug candidates, we characterized a Drosophila chemical treatment model using the GABA(A) receptor antagonist picrotoxin...
  21. pmc Engineered alterations in RNA editing modulate complex behavior in Drosophila: regulatory diversity of adenosine deaminase acting on RNA (ADAR) targets
    James E C Jepson
    Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island 02912, USA
    J Biol Chem 286:8325-37. 2011
    ..Our data demonstrate that network-wide temporal and spatial regulation of ADAR activity can tune the complex system of RNA-editing sites and modulate multiple ethologically relevant behavioral modalities...
  22. pmc Adenosine-to-inosine genetic recoding is required in the adult stage nervous system for coordinated behavior in Drosophila
    James E C Jepson
    Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912, USA
    J Biol Chem 284:31391-400. 2009
    ....
  23. ncbi Decreased expression of the GABAA receptor in fragile X syndrome
    Charlotte D'Hulst
    Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
    Brain Res 1121:238-45. 2006
    ..melanogaster) model we also found almost 50% under expression of all 3 subunits which make up the invertebrate GABA receptor, namely Grd, Rdl and Lcch3...
  24. ncbi The pharmacological flexibility of the insect voltage gated sodium channel: toxicity of AaIT to knockdown resistant (kdr) flies
    E Zlotkin
    Merck Research Laboratories, Rahway, NJ, USA
    Insect Biochem Mol Biol 29:849-53. 1999
    ..The above data are interpreted in terms of the pharmacological diversity and flexibility ("allosteric coupling") of voltage gated sodium channels and their implications for the management of pesticide resistance are discussed...
  25. ncbi The target of Drosophila photoreceptor synaptic transmission is a histamine-gated chloride channel encoded by ort (hclA)
    Chaoxian Gengs
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 277:42113-20. 2002
    ..Moreover, the present work shows that this function of the HCLA (ORT) protein is its native function in vivo...
  26. ncbi Ivermectin and nodulisporic acid receptors in Drosophila melanogaster contain both gamma-aminobutyric acid-gated Rdl and glutamate-gated GluCl alpha chloride channel subunits
    Steven W Ludmerer
    Department of Parasite Biochemistry and Molecular Biology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Biochemistry 41:6548-60. 2002
    ..chloride channel subunit GluCl alpha (DmGluCl alpha) and the GABA-gated chloride channel subunit Rdl (DmRdl) proteins were generated and used to examine the possible coassembly of these two subunits within a single ..
  27. ncbi Dbeta3, an atypical nicotinic acetylcholine receptor subunit from Drosophila : molecular cloning, heterologous expression and coassembly
    Stuart J Lansdell
    Department of Pharmacology, University College London, London, UK
    J Neurochem 80:1009-18. 2002
    ....
  28. ncbi A Drosophila melanogaster cell line (S2) facilitates post-genome functional analysis of receptors and ion channels
    Paula R Towers
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, UK
    Bioessays 24:1066-73. 2002
    ..In addition, many useful orthologues of human disease genes are emerging from the Drosophila genome and the study of their functions and interactions is another area for postgenome applications of S2 cell lines...
  29. pmc Alpha-thujone (the active component of absinthe): gamma-aminobutyric acid type A receptor modulation and metabolic detoxification
    K M Höld
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, 114 Wellman Hall, University of California, Berkeley, CA 94720 3112, USA
    Proc Natl Acad Sci U S A 97:3826-31. 2000
    ..Four observations establish that alpha-thujone is a modulator of the gamma-aminobutyric acid (GABA) type A receptor...
  30. pmc Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasitics nodulisporic acid and ivermectin
    N S Kane
    Merck Research Laboratories, Merck and Co, Inc, PO Box 2000, R80Y 250, Rahway, NJ 07065, USA
    Proc Natl Acad Sci U S A 97:13949-54. 2000
    ....
  31. ncbi Drugs, flies, and videotape: the effects of ethanol and cocaine on Drosophila locomotion
    Adrian Rothenfluh
    Department of Anatomy, University of California at San Francisco, 513 Parnassus Avenue, 94143 0452, USA
    Curr Opin Neurobiol 12:639-45. 2002
    ..Surprising similarities between flies and mammals have begun to emerge at the behavioral, neurochemical and molecular levels...
  32. ncbi Charting the Drosophila neuropile: a strategy for the standardised characterisation of genetically amenable neurites
    Matthias Landgraf
    Department of Zoology, Downing Street, CB2 3EJ, Cambridge, UK
    Dev Biol 260:207-25. 2003
    ..Using the Fasciclin2-based mapping procedure as a standard (e.g., in a common database) would facilitate studies on the functional architecture of the neuropile and the identification of candiate circuit elements...
  33. pmc Dynein-dynactin complex is essential for dendritic restriction of TM1-containing Drosophila Dscam
    Jacob Shun Jen Yang
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA, USA
    PLoS ONE 3:e3504. 2008
    ..Many membrane proteins, including Drosophila Dscam, are enriched in dendrites or axons within neurons. However, little is known about how the differential distribution is established and maintained...
  34. ncbi Evolutionary convergence of alternative splicing in ion channels
    Richard R Copley
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Trends Genet 20:171-6. 2004
    ..The result has important implications for the analysis of regulation of alternative splicing using comparative genomics and our understanding of molecular evolution...
  35. pmc Modulation of GABAA receptor desensitization uncouples sleep onset and maintenance in Drosophila
    Jose Agosto
    Howard Hughes Medical Institute, Brandeis University, 415 South St, Waltham, Massachusetts 02454 9110, USA
    Nat Neurosci 11:354-9. 2008
    Many lines of evidence indicate that GABA and GABA(A) receptors make important contributions to human sleep regulation. Pharmacological manipulation of these receptors has differential effects on sleep onset and sleep maintenance insomnia...
  36. pmc GABAA receptor RDL inhibits Drosophila olfactory associative learning
    Xu Liu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 56:1090-102. 2007
    ..The GABAA receptor, resistance to dieldrin (Rdl), is highly expressed in the Drosophila mushroom bodies (MBs), a group of neurons playing essential ..
  37. ncbi Molecular cloning of a GABA receptor subunit from Laodelphax striatella (Fallén) and patch clamp analysis of the homo-oligomeric receptors expressed in a Drosophila cell line
    K Narusuye
    Department of Life Science and Biotechnology, Faculty of Life and Environmental Science, Shimane University, Matsue, Shimane, Japan
    Insect Mol Biol 16:723-33. 2007
    ..The L. striatella GABA receptor subunit was found to have high amino acid sequence similarity to the bd-type splice variant of the Drosophila ..
  38. ncbi Mutations in the K+/Cl- cotransporter gene kazachoc (kcc) increase seizure susceptibility in Drosophila
    Daria S Hekmat-Scafe
    Department of Environmental Science, Policy and Management, Division of Insect Biology, University of California, Berkeley, California 94720, USA
    J Neurosci 26:8943-54. 2006
    ..The developmental GABA switch is mediated primarily by KCC2, a neuronal K+/Cl- cotransporter that determines the intracellular ..
  39. ncbi Phylogenetic shadowing of a histamine-gated chloride channel involved in insect vision
    Mladen Iovchev
    Institute of Molecular Biology, Department of Molecular Neurobiology, Sofia 1113, Bulgaria
    Insect Biochem Mol Biol 36:10-7. 2006
    ..Real-time PCR analysis demonstrated that hclA-mRNA is abundant in heads of adult Drosophila. However, species- and sex-specific variations of the hclA expression levels were also observed...
  40. doi A map of octopaminergic neurons in the Drosophila brain
    Sebastian Busch
    Lehrstuhl für Genetik und Neurobiologie, Universitat Wurzburg, Germany
    J Comp Neurol 513:643-67. 2009
    ..The map may provide an anatomical framework for the functional constitution of the octopaminergic system. It also serves as a model for the single-cell organization of a particular neurotransmitter in the brain...
  41. ncbi Resistance to fipronil in Drosophila simulans: influence of two point mutations in the RDL GABA receptor subunit
    Gaelle Le Goff
    UMR 1112, INRA Université de Nice Sophia Antipolis, Sophia Antipolis, France
    J Neurochem 92:1295-305. 2005
    ..Molecular cloning of the cDNA encoding the RDL GABA receptor subunit of this strain revealed the presence of two mutations: the Rdl mutation (A301G) and an additional ..
  42. ncbi The influence of pioneer neurons on a growing motor nerve in Drosophila requires the neural cell adhesion molecule homolog FasciclinII
    Natalia Sánchez-Soriano
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester M13 9PT, United Kingdom
    J Neurosci 25:78-87. 2005
    ..Therefore, FasciclinII is to a degree required and sufficient for pioneer-follower interactions, but its mode of action cannot be explained merely through an equally bidirectional adhesive interaction...
  43. pmc Molecular characterization of agonists that bind to an insect GABA receptor
    Ian McGonigle
    Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK
    Biochemistry 49:2897-902. 2010
    ..One of the most widely studied insect GABA receptors is constructed from RDL (resistance to dieldrin) subunits from Drosophila melanogaster...
  44. pmc Cross-resistance with dieldrin of a novel tricyclic dinitrile GABA receptor antagonist
    K Matsuda
    The Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, USA
    Br J Pharmacol 127:1305-7. 1999
    ..tricyclic dinitrile, KN244, blocked the wild-type (dieldrin-sensitive) homo-oligomeric gamma-aminobutyric acid (GABA)-gated chloride channel of Drosophila melanogaster expressed in Xenopus oocytes...
  45. pmc Cation permeability and cation-anion interactions in a mutant GABA-gated chloride channel from Drosophila
    C T Wang
    Department of Physiology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Biophys J 77:691-700. 1999
    To investigate the structural basis of anion selectivity of Drosophila GABA-gated Cl(-) channels, the permeation properties of wild-type and mutant channels were studied in Xenopus oocytes...
  46. ncbi Blocking actions of BIDN, a bicyclic dinitrile convulsant compound, on wild-type and dieldrin-resistant GABA receptor homo-oligomers of Drosophila melanogaster expressed in Xenopus oocytes
    A M Hosie
    Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, UK
    Brain Res 693:257-60. 1995
    ..BIDN was found to be less effective against a mutant (A(302) --> S) form of the receptor resistant to dieldrin and picrotoxinin...
  47. ncbi Cloning and sequencing of the cyclodiene insecticide resistance gene from the yellow fever mosquito Aedes aegypti. Conservation of the gene and resistance associated mutation with Drosophila
    M Thompson
    Entomology Department, University of Wisconsin Madison 53706
    FEBS Lett 325:187-90. 1993
    ..between species we cloned a cDNA from the yellow fever mosquito Aedes aegypti homologous to the resistance gene Rdl in Drosophila. In D...
  48. ncbi A point mutation in a Drosophila GABA receptor confers insecticide resistance
    R H ffrench-Constant
    Department of Entomology, 237 Russell Laboratories, University of Wisconsin, Madison 53706
    Nature 363:449-51. 1993
    ..Previously, we used a field-isolated Drosophila mutant Rdl (Resistant to dieldrin) insensitive to PTX and cyclodienes to clone a putative GABA receptor...
  49. ncbi Expression of a Drosophila GABA receptor in a baculovirus insect cell system. Functional expression of insecticide susceptible and resistant GABA receptors from the cyclodiene resistance gene Rdl
    H J Lee
    Department of Entomology, University of Wisconsin Madison 53706
    FEBS Lett 335:315-8. 1993
    Recombinant baculoviruses containing two alternative splice forms of the Drosophila Rdl GABA receptor gene were constructed. Spodoptera frugiperda (Sf21) cells infected with either splice form expressed a transcript of expected size (2...
  50. pmc A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated with cyclodiene insecticide resistance in Drosophila populations
    R H ffrench-Constant
    Department of Entomology, University of Wisconsin, Madison 53706
    Proc Natl Acad Sci U S A 90:1957-61. 1993
    ....
  51. ncbi PCR-based homology probing reveals a family of GABA receptor-like genes in Drosophila melanogaster
    J E Henderson
    New York State Agricultural Experiment Station, Cornell University, Geneva 14456
    Insect Biochem Mol Biol 24:363-71. 1994
    ..genomic DNA for sequences encoding a conserved amino acid 'signature motif' known to be present in vertebrate GABA receptor and glycine receptor subunit genes...
  52. ncbi The molecular and population genetics of cyclodiene insecticide resistance
    R H ffrench-Constant
    Department of Entomology, University of Wisconsin Madison 53706
    Insect Biochem Mol Biol 24:335-45. 1994
    ..The cyclodiene resistance gene Rdl (resistance to dieldrin) was cloned from a mutant of the model insect Drosophila resistant to cyclodienes and picrotoxinin...
  53. ncbi Actions of agonists and convulsant antagonists on a Drosophila melanogaster GABA receptor (Rdl) homo-oligomer expressed in Xenopus oocytes
    S D Buckingham
    Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, UK
    Neurosci Lett 181:137-40. 1994
    ..injection of Xenopus oocytes with cDNA-derived RNA (cRNA) encoding a wild-type Drosophila melanogaster GABA receptor subunit (Rdl) resulted in functional expression of a GABA receptor homo-oligomer...
  54. ncbi Drosophila GABA-gated chloride channel: modified [3H]EBOB binding site associated with Ala-->Ser or Gly mutants of Rdl subunit
    L M Cole
    Department of Environmental Science, Policy and Management, University of California, Berkeley 94720 3112
    Life Sci 56:757-65. 1995
    ..melanogaster has been attributed to a mutation resulting in an Ala302-->Ser replacement in the Rdl GABA receptor subunit and in D. simulans to an homologous Ala-->Ser or Gly replacement...
  55. ncbi Actions of picrotoxinin analogues on an expressed, homo-oligomeric GABA receptor of Drosophila melanogaster
    Y Shirai
    Graduate School of Science and Technology, Kobe University, Hyogo Japan
    Neurosci Lett 189:1-4. 1995
    ..on a Drosophila melanogaster homo-oligomeric GABA (gamma-aminobutyric acid) receptor formed when RDL (resistance to dieldrin) subunits were expressed in Xenopus oocytes...
  56. ncbi GABA receptor minigene rescues insecticide resistance phenotypes in Drosophila
    G E Stilwell
    Department of Entomology, Russell Laboratories, Madison, WI 53706, USA
    J Mol Biol 253:223-7. 1995
    A single point mutation within the GABA receptor gene Resistance to dieldrin (Rdl) confers a high level of resistance to cyclodiene insecticides in a wide range of insects...
  57. ncbi Isolation of dieldrin resistance from field populations of Drosophila melanogaster (Diptera: Drosophilidae)
    R H ffrench-Constant
    Department of Entomology, Cornell University, Ithaca, New York 14853
    J Econ Entomol 83:1733-7. 1990
    High levels (about 4,000-fold) of resistance to dieldrin were isolated by screening field-collected populations of Drosophila melanogaster (Meigen). The resistance was made homozygous following 2-4 generations of selection...
  58. ncbi Gene mapping and cross-resistance in cyclodiene insecticide-resistant Drosophila melanogaster (Mg.)
    R H ffrench-Constant
    Department of Entomology, Cornell University, Ithaca, N Y 14853
    Genet Res 57:17-21. 1991
    Resistance to the cyclodiene insecticide dieldrin maps to a single gene (Rdl) on the left arm of chromosome III in Drosophila melanogaster (Meigen)...
  59. pmc Detection of DNA domains in Drosophila, human, and plant chromosomes possessing mainly 50- to 150-kilobase stretches of DNA
    N A Tchurikov
    Department of Genome Organization, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow
    Proc Natl Acad Sci U S A 89:6751-5. 1992
    ..We propose that f-DNA segments may correspond to some regular higher-order structures in the eukaryotic chromosomes...
  60. ncbi Functional analysis of a mosquito gamma-aminobutyric acid receptor gene promoter
    F Shotkoski
    Department of Neurobiology, University of Wisconsin Madison 53706, USA
    Gene 168:127-33. 1996
    A single point mutation in the insect gamma-aminobutyric acid receptor (GABAR)-encoding gene (Rdl) confers high levels of resistance to cyclodienes in Drosophila and other insects...
  61. ncbi pH-dependent actions of THIP and ZAPA on an ionotropic Drosophila melanogaster GABA receptor
    K Matsuda
    Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, UK
    Brain Res 739:335-8. 1996
    ..and ZAPA (Z-3-[(aminoiminomethyl)thio]prop-2-enoic acid) were tested on an ionotropic homo-oligomeric GABA receptor of Drosophila melanogaster...
  62. ncbi Drosophila cyclodiene resistance gene shows conserved genomic organization with vertebrate gamma-aminobutyric acidA receptors
    R H ffrench-Constant
    Entomology Department, University of Wisconsin, Madison 53706
    J Neurochem 59:1562-5. 1992
    Genomic clones from the Rdl locus of Drosophila, whose mutant phenotype is resistant to cyclodiene insecticides and picrotoxin, were characterized by restriction mapping and partial sequencing to determine intron/exon structure...
  63. pmc Why are there so few resistance-associated mutations in insecticide target genes?
    R H ffrench-Constant
    Department of Entomology, University of Wisconsin Madison 53706, USA
    Philos Trans R Soc Lond B Biol Sci 353:1685-93. 1998
    The genes encoding the three major targets of conventional insecticides are: Rdl, which encodes a gamma-aminobutyric acid receptor subunit (RDL); para, which encodes a voltage-gated sodium channel (PARA); and Ace, which encodes insect ..
  64. ncbi Wild-type and insecticide-resistant homo-oligomeric GABA receptors of Drosophila melanogaster stably expressed in a Drosophila cell line
    S D Buckingham
    Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, UK
    Neuropharmacology 35:1393-401. 1996
    RDL is an ionotropic GABA receptor subunit, a product of the Rdl gene, originally identified in the Maryland strain of Drosophila melanogaster...
  65. ncbi Conservation of cyclodiene insecticide resistance-associated mutations in insects
    M Thompson
    Department of Entomology, University of Wisconsin Madison 53706, USA
    Insect Mol Biol 2:149-54. 1993
    ..In Drosophila melanogaster resistance is associated with a single base pair substitution in the GABA receptor/chloride ion channel gene Rdl...
  66. ncbi Diversification of Drosophila chloride channel gene by multiple posttranscriptional mRNA modifications
    E P Semenov
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    J Neurochem 72:66-72. 1999
    ..These results give the first example of RNA editing in neurotransmitter-gated chloride channel genes or of alternative splicing in a glutamate-gated chloride channel gene of Drosophila...
  67. ncbi Identification of major phylogenetic branches of inhibitory ligand-gated channel receptors
    H Xue
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong
    J Mol Evol 47:323-33. 1998
    ..Branch IIIB, composed of invertebrate GluCl receptors, to form Branch III, which is designated NA for being non-GABA responsive. Branch IV is called UD for being undefined in specificity...
  68. ncbi Immunocytochemistry of a novel GABA receptor subunit Rdl in Drosophila melanogaster
    K Aronstein
    Department of Entomology, University of Wisconsin Madison 53706, USA
    Invert Neurosci 1:25-31. 1995
    Following our recent cloning of a novel gamma-aminobutyric acid (GABA) receptor subunit gene Resistance to dieldrin or Rdl form cyclodiene resistance locus in Drosophila melanogaster, we were interested in defining its pattern of ..
  69. ncbi Distribution of two GABA receptor-like subunits in the Drosophila CNS
    K Aronstein
    Department of Neuroscience, University of Wisconsin Madison, Russell Laboratories 53706, USA
    Invert Neurosci 2:115-20. 1996
    Previously we have described the distribution of the Rdl GABA receptor subunit in the Drosophila CNS...
  70. pmc Actions of the insecticide fipronil, on dieldrin-sensitive and- resistant GABA receptors of Drosophila melanogaster
    A M Hosie
    Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, Cambridge
    Br J Pharmacol 115:909-12. 1995
    ..forms of the Drosophila melanogaster GABA-gated chloride channel homo-oligomer, RDL (the product of the resistance to dieldrin locus: Rdl). 2...
  71. ncbi Transcriptional analysis of the Drosophila GABA receptor gene resistance to dieldrin
    G E Stilwell
    Center for Environmental Toxicology and Department of Entomology, University of Wisconsin Madison, 53706, USA
    J Neurobiol 36:468-84. 1998
    The Resistance to dieldrin (Rdl) gene encodes a novel subunit of a gamma-aminobutyric acid (GABA)-gated chloride ion channel in Drosophila...
  72. ncbi Subunit composition determines picrotoxin and bicuculline sensitivity of Drosophila gamma-aminobutyric acid receptors
    H G Zhang
    Department of Physiology, University of Wisconsin Madison 53706, USA
    Mol Pharmacol 48:835-40. 1995
    Few gamma-aminobutyric acid (GABA) receptor subunits have been cloned from insects. These include Resistance to dieldrin, or Rdl, and a homologue of the vertebrate GABAA receptor beta subunit...
  73. ncbi A current perspective on insect gene transformation
    A M Handler
    Center for Medical, Agricultural, and Veterinary Entomology, Agricultural Research Service, US Department of Agriculture, 1700 S W 23rd Drive, Gainesville, FL 32608, USA
    Insect Biochem Mol Biol 31:111-28. 2001
    ....
  74. ncbi Using Drosophila as a model insect
    D Schneider
    Whitehead Institute, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Rev Genet 1:218-26. 2000
    ..Specifically, I discuss recent work on the use of Drosophila to study the transmission of disease by insect vectors and to investigate insecticide function and development...
  75. ncbi Drosophila gamma-aminobutyric acid receptor gene Rdl shows extensive alternative splicing
    R H ffrench-Constant
    Department of Entomology, University of Wisconsin Madison 53706
    J Neurochem 60:2323-6. 1993
    ..All possible combinations of exons (a with c or d and b with c or d) were found in RNA isolated from early embryos. This is the first demonstration of alternative splicing in a GABA receptor gene from invertebrates.
  76. ncbi Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in Drosophila
    Kwang Min Choe
    Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Science 296:359-62. 2002
    ....
  77. pmc Cloning and functional expression of a Drosophila gamma-aminobutyric acid receptor
    R Chen
    CoCensys, Inc, Irvine, CA 92718
    Proc Natl Acad Sci U S A 91:6069-73. 1994
    A cDNA encoding a functional gamma-aminobutyric (GABA)-activated Cl- channel has been isolated from an adult Drosophila head cDNA library...
  78. pmc Effects of [3H]-BIDN, a novel bicyclic dinitrile radioligand for GABA-gated chloride channels of insects and vertebrates
    J J Rauh
    DuPont Agricultural Products, Stine Haskell Research Center, Newark, DE 19714, USA
    Br J Pharmacol 121:1496-505. 1997
    ..5. Expression in Xenopus oocytes of either rat brain mRNA, or cDNA-derived RNA encoding a GABA receptor subunit (Rdl) that is expressed widely in the nervous system of Drosophila melanogaster resulted in functional,..
  79. pmc Molecular architecture of the hsp70 promoter after deletion of the TATA box or the upstream regulation region
    J A Weber
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park 16802, USA
    Mol Cell Biol 17:3799-808. 1997
    ..GAGA factor alone might be capable of establishing an open chromatin structure that encompasses the upstream regulatory region as well as the core promoter region, thus facilitating the binding of TFIID...
  80. ncbi Cloning of a putative GABAA receptor from cyclodiene-resistant Drosophila: a case study in the use of insecticide-resistant mutants to isolate neuroreceptors
    R H ffrench-Constant
    University of Wisconsin Madison 53706
    EXS 63:210-23. 1993
    ..Thus examination of resistance-associated mutations in this receptor in a range of species will enhance our understanding of both the binding sites of toxic ligands and the genetic basis of pesticide resistance...
  81. ncbi Acute induction of conserved synaptic signaling pathways in Drosophila melanogaster
    C A Hoeffer
    Department of Molecular and Cellular Biology and Arizona Research Labs Division of Neurobiology, University of Arizona, Tucson, Arizona 85721, USA
    J Neurosci 23:6362-72. 2003
    ....
  82. pmc Actions of picrodendrin antagonists on dieldrin-sensitive and -resistant Drosophila GABA receptors
    A M Hosie
    Department of Zoology, University of Cambridge, UK
    Br J Pharmacol 119:1569-76. 1996
    ..related terpenoids have been assayed on homooligomeric GABA receptors formed by the expression of a Drosophila GABA receptor subunit (RDLac) in Xenopus oocytes. 2...

Research Grants1

  1. A TOXIN BASED DROSOPHILA PARKINSON'S DISEASE MODEL
    Geoffrey Stilwell; Fiscal Year: 2005
    ....