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Genomes and GenesSpecies | RdlSummaryGene Symbol: Rdl Description: Resistant to dieldrin Alias: CG10537, CT29555, DmRDL, DmRdl, Dmel\CG10537, GABA, GABA[[A]], GABA[[A]] receptor, GABA[[A]]R, GABAr, LCCH1, RDL, Rd1, gaba, rdl, CG10537-PA, CG10537-PC, CG10537-PD, CG10537-PE, CG10537-PF, CG10537-PG, GABA A beta-subunit, GABA receptor, GABA[[A]] receptor, Rdl-PA, Rdl-PC, Rdl-PD, Rdl-PE, Rdl-PF, Rdl-PG, resistance to dieldrin, resistant to dieldrin Species: fruit fly Top Publications
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Publications
Molecular biology of insect neuronal GABA receptorsA M Hosie
Babraham Institute, Dept of Zoology, Cambridge, UK
Trends Neurosci 20:578-83. 1997Ionotropic gamma-aminobutyric acid (GABA) receptors are distributed throughout the nervous systems of many insect species...- Immunocytochemical mapping of a C-terminus anti-peptide antibody to the GABA receptor subunit, RDL in the nervous system in Drosophila melanogasterJ B Harrison
Babraham Institute Laboratory of Molecular Signalling, Cambridge, UK
Cell Tissue Res 284:269-78. 1996..on the C-terminal derived amino acid sequence from a cloned Drosophila melanogaster (fruit fly) gene, Rdl (resistant to dieldrin), was used to investigate localization of a GABA receptor subunit in adult male D. melanogaster... 
Allosteric modulation of an expressed homo-oligomeric GABA-gated chloride channel of Drosophila melanogasterA M Hosie
Department of Zoology, University of Cambridge
Br J Pharmacol 117:1229-37. 19961. Functional GABA-gated chloride channels are formed when cRNA encoding the Drosophila melanogaster GABA receptor subunit RDL is injected into the cytoplasm of Xenopus oocytes...- The effect of a transmembrane amino acid on etomidate sensitivity of an invertebrate GABA receptorK A McGurk
Department of Pharmacology and Neuroscience, Ninewells Hospital and Medical School, Dundee University, Scotland
Br J Pharmacol 124:13-20. 1998..the equivalent amino acid (M314) on the actions of this anaesthetic at an etomidate-insensitive invertebrate GABA receptor (Rdl) of Drosophila melanogaster. 2... - Agonist pharmacology of two Drosophila GABA receptor splice variantsA M Hosie
Department of Zoology, University of Cambridge
Br J Pharmacol 119:1577-85. 1996..The differences in the potency of agonists on RDLac and DRC 17-1-2 homo-oligomers observed in the present study may assist in identification of further molecular determinants of GABA receptor function. - Identification of two novel Drosophila melanogaster histamine-gated chloride channel subunits expressed in the eyeYingcong Zheng
Merck Research Laboratories, Merck and Co, Inc, Rahway, New Jersey 07065, USA
J Biol Chem 277:2000-5. 2002..either HisCl1 or HisCl2, produced substantial chloride currents in response to histamine but not in response to GABA, glycine, and glutamate. The histamine sensitivity was similar to that observed in insect laminar neurons... - Are dendrites in Drosophila homologous to vertebrate dendrites?Natalia Sánchez-Soriano
Faculty of Life Sciences, WTCCMR, The University of Manchester, Oxford Road, Manchester M13 9PT, UK
Dev Biol 288:126-38. 2005..Implications of these findings for studies of dendrite development, neuronal polarity, transport and evolution are discussed... - Characterization of a putative gamma-aminobutyric acid (GABA) receptor beta subunit gene from Drosophila melanogasterJ E Henderson
New York State Agricultural Experiment Station, Cornell University, Geneva 14456
Biochem Biophys Res Commun 193:474-82. 1993..Among characterized members of this gene family, this gene exhibits the greatest similarity to GABA receptor beta subunit genes... - Glutamate, GABA and acetylcholine signaling components in the lamina of the Drosophila visual systemAgata Kolodziejczyk
Department of Zoology, Stockholm University, Stockholm, Sweden
PLoS ONE 3:e2110. 2008..combined Gal4 driven green fluorescent protein in specific lamina neurons with antisera to gamma-aminobutyric acid (GABA), glutamic acid decarboxylase, a GABA(B) type of receptor, L-glutamate, a vesicular glutamate transporter (vGluT), .. - Stable expression of a functional homo-oligomeric Drosophila GABA receptor in a Drosophila cell lineN S Millar
Wellcome Laboratory of Molecular Pharmacology, Department of Pharmacology, University College London, U K
Proc Biol Sci 258:307-14. 1994A cloned Drosophila gamma-aminobutyric acid GABA receptor subunit (Rdl) has been stably expressed as a functional homo-oligomeric ion channel in a Drosophila cell line... 
Gamma-aminobutyric acid (GABA)-mediated neural connections in the Drosophila antennal lobeRyuichi Okada
Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
J Comp Neurol 514:74-91. 2009Inhibitory synaptic connections mediated by gamma-aminobutyric acid (GABA) play important roles in the neural computation of the brain...- Molecular cloning and transformation of cyclodiene resistance in Drosophila: an invertebrate gamma-aminobutyric acid subtype A receptor locusR H ffrench-Constant
Department of Entomology, Russell Laboratories, University of Wisconsin, Madison 53706
Proc Natl Acad Sci U S A 88:7209-13. 1991..To our knowledge, this represents the first cloning of an invertebrate GABA receptor and also allows us to manipulate the resistance status of an insect via germ-line transformation... - The GABAA receptor RDL suppresses the conditioned stimulus pathway for olfactory learningXu Liu
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 29:1573-9. 2009..Prior studies have shown that the GABA receptor RDL inhibits aversive olfactory learning via its role in the Drosophila mushroom bodies (MBs)... - A unique amino acid of the Drosophila GABA receptor with influence on drug sensitivity by two mechanismsH G Zhang
Department of Physiology, Medical School, College of Agricultural and Life Sciences, University of Wisconsin, Madison 53706
J Physiol 479:65-75. 19941. The Drosophila gene Rdl (resistance to dieldrin) encodes a GABA receptor. An alanine-to-serine mutation in this gene at residue 302 confers resistance to cyclodiene insecticides and picrotoxin... - Alternative splicing of a Drosophila GABA receptor subunit gene identifies determinants of agonist potencyA M Hosie
Babraham Institute, Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, Downing Street, CB2 3EJ, Cambridge, UK
Neuroscience 102:709-14. 2001Alternative splicing of the Drosophila melanogaster Rdl gene yields four ionotropic GABA receptor subunits. The two Rdl splice variants cloned to date, RDL(ac) and RDL(bd) (DRC17-1-2), differ in their apparent agonist affinity... - Alpha-thujone (the active component of absinthe): gamma-aminobutyric acid type A receptor modulation and metabolic detoxificationK M Höld
Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, 114 Wellman Hall, University of California, Berkeley, CA 94720 3112, USA
Proc Natl Acad Sci U S A 97:3826-31. 2000..Four observations establish that alpha-thujone is a modulator of the gamma-aminobutyric acid (GABA) type A receptor... - The target of Drosophila photoreceptor synaptic transmission is a histamine-gated chloride channel encoded by ort (hclA)Chaoxian Gengs
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
J Biol Chem 277:42113-20. 2002..Moreover, the present work shows that this function of the HCLA (ORT) protein is its native function in vivo... - Ivermectin and nodulisporic acid receptors in Drosophila melanogaster contain both gamma-aminobutyric acid-gated Rdl and glutamate-gated GluCl alpha chloride channel subunitsSteven W Ludmerer
Department of Parasite Biochemistry and Molecular Biology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
Biochemistry 41:6548-60. 2002..chloride channel subunit GluCl alpha (DmGluCl alpha) and the GABA-gated chloride channel subunit Rdl (DmRdl) proteins were generated and used to examine the possible coassembly of these two subunits within a single .. - Cation permeability and cation-anion interactions in a mutant GABA-gated chloride channel from DrosophilaC T Wang
Department of Physiology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
Biophys J 77:691-700. 1999To investigate the structural basis of anion selectivity of Drosophila GABA-gated Cl(-) channels, the permeation properties of wild-type and mutant channels were studied in Xenopus oocytes... - Dbeta3, an atypical nicotinic acetylcholine receptor subunit from Drosophila : molecular cloning, heterologous expression and coassemblyStuart J Lansdell
Department of Pharmacology, University College London, London, UK
J Neurochem 80:1009-18. 2002.... - Cross-resistance with dieldrin of a novel tricyclic dinitrile GABA receptor antagonistK Matsuda
The Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, USA
Br J Pharmacol 127:1305-7. 1999..tricyclic dinitrile, KN244, blocked the wild-type (dieldrin-sensitive) homo-oligomeric gamma-aminobutyric acid (GABA)-gated chloride channel of Drosophila melanogaster expressed in Xenopus oocytes... - Why are there so few resistance-associated mutations in insecticide target genes?R H ffrench-Constant
Department of Entomology, University of Wisconsin Madison 53706, USA
Philos Trans R Soc Lond B Biol Sci 353:1685-93. 1998The genes encoding the three major targets of conventional insecticides are: Rdl, which encodes a gamma-aminobutyric acid receptor subunit (RDL); para, which encodes a voltage-gated sodium channel (PARA); and Ace, which encodes insect .. - The pharmacological flexibility of the insect voltage gated sodium channel: toxicity of AaIT to knockdown resistant (kdr) fliesE Zlotkin
Merck Research Laboratories, Rahway, NJ, USA
Insect Biochem Mol Biol 29:849-53. 1999..The above data are interpreted in terms of the pharmacological diversity and flexibility ("allosteric coupling") of voltage gated sodium channels and their implications for the management of pesticide resistance are discussed... - Molecular characterization of agonists that bind to an insect GABA receptorIan McGonigle
Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK
Biochemistry 49:2897-902. 2010..One of the most widely studied insect GABA receptors is constructed from RDL (resistance to dieldrin) subunits from Drosophila melanogaster... - A Drosophila melanogaster cell line (S2) facilitates post-genome functional analysis of receptors and ion channelsPaula R Towers
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, UK
Bioessays 24:1066-73. 2002..In addition, many useful orthologues of human disease genes are emerging from the Drosophila genome and the study of their functions and interactions is another area for postgenome applications of S2 cell lines... - A map of octopaminergic neurons in the Drosophila brainSebastian Busch
Lehrstuhl für Genetik und Neurobiologie, Universitat Wurzburg, Germany
J Comp Neurol 513:643-67. 2009..The map may provide an anatomical framework for the functional constitution of the octopaminergic system. It also serves as a model for the single-cell organization of a particular neurotransmitter in the brain... - Dynein-dynactin complex is essential for dendritic restriction of TM1-containing Drosophila DscamJacob Shun Jen Yang
Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA, USA
PLoS ONE 3:e3504. 2008..Many membrane proteins, including Drosophila Dscam, are enriched in dendrites or axons within neurons. However, little is known about how the differential distribution is established and maintained... - Modulation of GABAA receptor desensitization uncouples sleep onset and maintenance in DrosophilaJose Agosto
Howard Hughes Medical Institute, Brandeis University, 415 South St, Waltham, Massachusetts 02454 9110, USA
Nat Neurosci 11:354-9. 2008Many lines of evidence indicate that GABA and GABA(A) receptors make important contributions to human sleep regulation. Pharmacological manipulation of these receptors has differential effects on sleep onset and sleep maintenance insomnia... - GABAA receptor RDL inhibits Drosophila olfactory associative learningXu Liu
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Neuron 56:1090-102. 2007..The GABAA receptor, resistance to dieldrin (Rdl), is highly expressed in the Drosophila mushroom bodies (MBs), a group of neurons playing essential .. - Molecular cloning of a GABA receptor subunit from Laodelphax striatella (Fallén) and patch clamp analysis of the homo-oligomeric receptors expressed in a Drosophila cell lineK Narusuye
Department of Life Science and Biotechnology, Faculty of Life and Environmental Science, Shimane University, Matsue, Shimane, Japan
Insect Mol Biol 16:723-33. 2007..The L. striatella GABA receptor subunit was found to have high amino acid sequence similarity to the bd-type splice variant of the Drosophila .. - Mutations in the K+/Cl- cotransporter gene kazachoc (kcc) increase seizure susceptibility in DrosophilaDaria S Hekmat-Scafe
Department of Environmental Science, Policy and Management, Division of Insect Biology, University of California, Berkeley, California 94720, USA
J Neurosci 26:8943-54. 2006..The developmental GABA switch is mediated primarily by KCC2, a neuronal K+/Cl- cotransporter that determines the intracellular .. - Phylogenetic shadowing of a histamine-gated chloride channel involved in insect visionMladen Iovchev
Institute of Molecular Biology, Department of Molecular Neurobiology, Sofia 1113, Bulgaria
Insect Biochem Mol Biol 36:10-7. 2006..Real-time PCR analysis demonstrated that hclA-mRNA is abundant in heads of adult Drosophila. However, species- and sex-specific variations of the hclA expression levels were also observed... - Resistance to fipronil in Drosophila simulans: influence of two point mutations in the RDL GABA receptor subunitGaelle Le Goff
UMR 1112, INRA Université de Nice Sophia Antipolis, Sophia Antipolis, France
J Neurochem 92:1295-305. 2005..Molecular cloning of the cDNA encoding the RDL GABA receptor subunit of this strain revealed the presence of two mutations: the Rdl mutation (A301G) and an additional .. - The influence of pioneer neurons on a growing motor nerve in Drosophila requires the neural cell adhesion molecule homolog FasciclinIINatalia Sánchez-Soriano
Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester M13 9PT, United Kingdom
J Neurosci 25:78-87. 2005..Therefore, FasciclinII is to a degree required and sufficient for pioneer-follower interactions, but its mode of action cannot be explained merely through an equally bidirectional adhesive interaction... - Evolutionary convergence of alternative splicing in ion channelsRichard R Copley
Wellcome Trust Centre for Human Genetics, Oxford, UK
Trends Genet 20:171-6. 2004..The result has important implications for the analysis of regulation of alternative splicing using comparative genomics and our understanding of molecular evolution... - Nervous system targets of RNA editing identified by comparative genomicsBarry Hoopengardner
Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
Science 301:832-6. 2003..These results point to a pivotal role for RNA editing in nervous system function... - Charting the Drosophila neuropile: a strategy for the standardised characterisation of genetically amenable neuritesMatthias Landgraf
Department of Zoology, Downing Street, CB2 3EJ, Cambridge, UK
Dev Biol 260:207-25. 2003..Using the Fasciclin2-based mapping procedure as a standard (e.g., in a common database) would facilitate studies on the functional architecture of the neuropile and the identification of candiate circuit elements... - Drugs, flies, and videotape: the effects of ethanol and cocaine on Drosophila locomotionAdrian Rothenfluh
Department of Anatomy, University of California at San Francisco, 513 Parnassus Avenue, 94143 0452, USA
Curr Opin Neurobiol 12:639-45. 2002..Surprising similarities between flies and mammals have begun to emerge at the behavioral, neurochemical and molecular levels... - Diversification of Drosophila chloride channel gene by multiple posttranscriptional mRNA modificationsE P Semenov
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
J Neurochem 72:66-72. 1999..These results give the first example of RNA editing in neurotransmitter-gated chloride channel genes or of alternative splicing in a glutamate-gated chloride channel gene of Drosophila... - Drosophila cyclodiene resistance gene shows conserved genomic organization with vertebrate gamma-aminobutyric acidA receptorsR H ffrench-Constant
Entomology Department, University of Wisconsin, Madison 53706
J Neurochem 59:1562-5. 1992Genomic clones from the Rdl locus of Drosophila, whose mutant phenotype is resistant to cyclodiene insecticides and picrotoxin, were characterized by restriction mapping and partial sequencing to determine intron/exon structure... - pH-dependent actions of THIP and ZAPA on an ionotropic Drosophila melanogaster GABA receptorK Matsuda
Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, UK
Brain Res 739:335-8. 1996..and ZAPA (Z-3-[(aminoiminomethyl)thio]prop-2-enoic acid) were tested on an ionotropic homo-oligomeric GABA receptor of Drosophila melanogaster... - Functional analysis of a mosquito gamma-aminobutyric acid receptor gene promoterF Shotkoski
Department of Neurobiology, University of Wisconsin Madison 53706, USA
Gene 168:127-33. 1996A single point mutation in the insect gamma-aminobutyric acid receptor (GABAR)-encoding gene (Rdl) confers high levels of resistance to cyclodienes in Drosophila and other insects... - Blocking actions of BIDN, a bicyclic dinitrile convulsant compound, on wild-type and dieldrin-resistant GABA receptor homo-oligomers of Drosophila melanogaster expressed in Xenopus oocytesA M Hosie
Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, UK
Brain Res 693:257-60. 1995..BIDN was found to be less effective against a mutant (A(302) --> S) form of the receptor resistant to dieldrin and picrotoxinin... - Cloning and sequencing of the cyclodiene insecticide resistance gene from the yellow fever mosquito Aedes aegypti. Conservation of the gene and resistance associated mutation with DrosophilaM Thompson
Entomology Department, University of Wisconsin Madison 53706
FEBS Lett 325:187-90. 1993..between species we cloned a cDNA from the yellow fever mosquito Aedes aegypti homologous to the resistance gene Rdl in Drosophila. In D... - A point mutation in a Drosophila GABA receptor confers insecticide resistanceR H ffrench-Constant
Department of Entomology, 237 Russell Laboratories, University of Wisconsin, Madison 53706
Nature 363:449-51. 1993..Previously, we used a field-isolated Drosophila mutant Rdl (Resistant to dieldrin) insensitive to PTX and cyclodienes to clone a putative GABA receptor... - Actions of picrotoxinin analogues on an expressed, homo-oligomeric GABA receptor of Drosophila melanogasterY Shirai
Graduate School of Science and Technology, Kobe University, Hyogo Japan
Neurosci Lett 189:1-4. 1995..on a Drosophila melanogaster homo-oligomeric GABA (gamma-aminobutyric acid) receptor formed when RDL (resistance to dieldrin) subunits were expressed in Xenopus oocytes... - Expression of a Drosophila GABA receptor in a baculovirus insect cell system. Functional expression of insecticide susceptible and resistant GABA receptors from the cyclodiene resistance gene RdlH J Lee
Department of Entomology, University of Wisconsin Madison 53706
FEBS Lett 335:315-8. 1993Recombinant baculoviruses containing two alternative splice forms of the Drosophila Rdl GABA receptor gene were constructed. Spodoptera frugiperda (Sf21) cells infected with either splice form expressed a transcript of expected size (2... - Drosophila GABA-gated chloride channel: modified [3H]EBOB binding site associated with Ala-->Ser or Gly mutants of Rdl subunitL M Cole
Department of Environmental Science, Policy and Management, University of California, Berkeley 94720 3112
Life Sci 56:757-65. 1995..melanogaster has been attributed to a mutation resulting in an Ala302-->Ser replacement in the Rdl GABA receptor subunit and in D. simulans to an homologous Ala-->Ser or Gly replacement... - PCR-based homology probing reveals a family of GABA receptor-like genes in Drosophila melanogasterJ E Henderson
New York State Agricultural Experiment Station, Cornell University, Geneva 14456
Insect Biochem Mol Biol 24:363-71. 1994..genomic DNA for sequences encoding a conserved amino acid 'signature motif' known to be present in vertebrate GABA receptor and glycine receptor subunit genes... - The molecular and population genetics of cyclodiene insecticide resistanceR H ffrench-Constant
Department of Entomology, University of Wisconsin Madison 53706
Insect Biochem Mol Biol 24:335-45. 1994..The cyclodiene resistance gene Rdl (resistance to dieldrin) was cloned from a mutant of the model insect Drosophila resistant to cyclodienes and picrotoxinin... - A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated with cyclodiene insecticide resistance in Drosophila populationsR H ffrench-Constant
Department of Entomology, University of Wisconsin, Madison 53706
Proc Natl Acad Sci U S A 90:1957-61. 1993.... - Wild-type and insecticide-resistant homo-oligomeric GABA receptors of Drosophila melanogaster stably expressed in a Drosophila cell lineS D Buckingham
Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, UK
Neuropharmacology 35:1393-401. 1996RDL is an ionotropic GABA receptor subunit, a product of the Rdl gene, originally identified in the Maryland strain of Drosophila melanogaster... - Identification of major phylogenetic branches of inhibitory ligand-gated channel receptorsH Xue
Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong
J Mol Evol 47:323-33. 1998..Branch IIIB, composed of invertebrate GluCl receptors, to form Branch III, which is designated NA for being non-GABA responsive. Branch IV is called UD for being undefined in specificity... - Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasitics nodulisporic acid and ivermectinN S Kane
Merck Research Laboratories, Merck and Co, Inc, PO Box 2000, R80Y 250, Rahway, NJ 07065, USA
Proc Natl Acad Sci U S A 97:13949-54. 2000.... - Distribution of two GABA receptor-like subunits in the Drosophila CNSK Aronstein
Department of Neuroscience, University of Wisconsin Madison, Russell Laboratories 53706, USA
Invert Neurosci 2:115-20. 1996Previously we have described the distribution of the Rdl GABA receptor subunit in the Drosophila CNS... - Immunocytochemistry of a novel GABA receptor subunit Rdl in Drosophila melanogasterK Aronstein
Department of Entomology, University of Wisconsin Madison 53706, USA
Invert Neurosci 1:25-31. 1995Following our recent cloning of a novel gamma-aminobutyric acid (GABA) receptor subunit gene Resistance to dieldrin or Rdl form cyclodiene resistance locus in Drosophila melanogaster, we were interested in defining its pattern of .. - Detection of DNA domains in Drosophila, human, and plant chromosomes possessing mainly 50- to 150-kilobase stretches of DNAN A Tchurikov
Department of Genome Organization, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow
Proc Natl Acad Sci U S A 89:6751-5. 1992..We propose that f-DNA segments may correspond to some regular higher-order structures in the eukaryotic chromosomes... - Gene mapping and cross-resistance in cyclodiene insecticide-resistant Drosophila melanogaster (Mg.)R H ffrench-Constant
Department of Entomology, Cornell University, Ithaca, N Y 14853
Genet Res 57:17-21. 1991Resistance to the cyclodiene insecticide dieldrin maps to a single gene (Rdl) on the left arm of chromosome III in Drosophila melanogaster (Meigen)... - Isolation of dieldrin resistance from field populations of Drosophila melanogaster (Diptera: Drosophilidae)R H ffrench-Constant
Department of Entomology, Cornell University, Ithaca, New York 14853
J Econ Entomol 83:1733-7. 1990High levels (about 4,000-fold) of resistance to dieldrin were isolated by screening field-collected populations of Drosophila melanogaster (Meigen). The resistance was made homozygous following 2-4 generations of selection... - Conservation of cyclodiene insecticide resistance-associated mutations in insectsM Thompson
Department of Entomology, University of Wisconsin Madison 53706, USA
Insect Mol Biol 2:149-54. 1993..In Drosophila melanogaster resistance is associated with a single base pair substitution in the GABA receptor/chloride ion channel gene Rdl... - GABA receptor minigene rescues insecticide resistance phenotypes in DrosophilaG E Stilwell
Department of Entomology, Russell Laboratories, Madison, WI 53706, USA
J Mol Biol 253:223-7. 1995A single point mutation within the GABA receptor gene Resistance to dieldrin (Rdl) confers a high level of resistance to cyclodiene insecticides in a wide range of insects... - Actions of agonists and convulsant antagonists on a Drosophila melanogaster GABA receptor (Rdl) homo-oligomer expressed in Xenopus oocytesS D Buckingham
Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, UK
Neurosci Lett 181:137-40. 1994..injection of Xenopus oocytes with cDNA-derived RNA (cRNA) encoding a wild-type Drosophila melanogaster GABA receptor subunit (Rdl) resulted in functional expression of a GABA receptor homo-oligomer... - Drosophila gamma-aminobutyric acid receptor gene Rdl shows extensive alternative splicingR H ffrench-Constant
Department of Entomology, University of Wisconsin Madison 53706
J Neurochem 60:2323-6. 1993..All possible combinations of exons (a with c or d and b with c or d) were found in RNA isolated from early embryos. This is the first demonstration of alternative splicing in a GABA receptor gene from invertebrates. - Subunit composition determines picrotoxin and bicuculline sensitivity of Drosophila gamma-aminobutyric acid receptorsH G Zhang
Department of Physiology, University of Wisconsin Madison 53706, USA
Mol Pharmacol 48:835-40. 1995Few gamma-aminobutyric acid (GABA) receptor subunits have been cloned from insects. These include Resistance to dieldrin, or Rdl, and a homologue of the vertebrate GABAA receptor beta subunit... - Cloning and functional expression of a Drosophila gamma-aminobutyric acid receptorR Chen
CoCensys, Inc, Irvine, CA 92718
Proc Natl Acad Sci U S A 91:6069-73. 1994A cDNA encoding a functional gamma-aminobutyric (GABA)-activated Cl- channel has been isolated from an adult Drosophila head cDNA library... - Effects of [3H]-BIDN, a novel bicyclic dinitrile radioligand for GABA-gated chloride channels of insects and vertebratesJ J Rauh
DuPont Agricultural Products, Stine Haskell Research Center, Newark, DE 19714, USA
Br J Pharmacol 121:1496-505. 1997..5. Expression in Xenopus oocytes of either rat brain mRNA, or cDNA-derived RNA encoding a GABA receptor subunit (Rdl) that is expressed widely in the nervous system of Drosophila melanogaster resulted in functional,.. - Molecular architecture of the hsp70 promoter after deletion of the TATA box or the upstream regulation regionJ A Weber
Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park 16802, USA
Mol Cell Biol 17:3799-808. 1997..GAGA factor alone might be capable of establishing an open chromatin structure that encompasses the upstream regulatory region as well as the core promoter region, thus facilitating the binding of TFIID... - Actions of picrodendrin antagonists on dieldrin-sensitive and -resistant Drosophila GABA receptorsA M Hosie
Department of Zoology, University of Cambridge, UK
Br J Pharmacol 119:1569-76. 1996..related terpenoids have been assayed on homooligomeric GABA receptors formed by the expression of a Drosophila GABA receptor subunit (RDLac) in Xenopus oocytes. 2... - A current perspective on insect gene transformationA M Handler
Center for Medical, Agricultural, and Veterinary Entomology, Agricultural Research Service, US Department of Agriculture, 1700 S W 23rd Drive, Gainesville, FL 32608, USA
Insect Biochem Mol Biol 31:111-28. 2001.... - Using Drosophila as a model insectD Schneider
Whitehead Institute, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nat Rev Genet 1:218-26. 2000..Specifically, I discuss recent work on the use of Drosophila to study the transmission of disease by insect vectors and to investigate insecticide function and development... - Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in DrosophilaKwang Min Choe
Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Science 296:359-62. 2002.... - Acute induction of conserved synaptic signaling pathways in Drosophila melanogasterC A Hoeffer
Department of Molecular and Cellular Biology and Arizona Research Labs Division of Neurobiology, University of Arizona, Tucson, Arizona 85721, USA
J Neurosci 23:6362-72. 2003.... - Cloning of a putative GABAA receptor from cyclodiene-resistant Drosophila: a case study in the use of insecticide-resistant mutants to isolate neuroreceptorsR H ffrench-Constant
University of Wisconsin Madison 53706
EXS 63:210-23. 1993..Thus examination of resistance-associated mutations in this receptor in a range of species will enhance our understanding of both the binding sites of toxic ligands and the genetic basis of pesticide resistance... - Actions of the insecticide fipronil, on dieldrin-sensitive and- resistant GABA receptors of Drosophila melanogasterA M Hosie
Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, Cambridge
Br J Pharmacol 115:909-12. 1995..forms of the Drosophila melanogaster GABA-gated chloride channel homo-oligomer, RDL (the product of the resistance to dieldrin locus: Rdl). 2... - Transcriptional analysis of the Drosophila GABA receptor gene resistance to dieldrinG E Stilwell
Center for Environmental Toxicology and Department of Entomology, University of Wisconsin Madison, 53706, USA
J Neurobiol 36:468-84. 1998The Resistance to dieldrin (Rdl) gene encodes a novel subunit of a gamma-aminobutyric acid (GABA)-gated chloride ion channel in Drosophila...