Gene Symbol: rdgB
Description: retinal degeneration B
Alias: CG11111, Dmel\CG11111, DrdgB, DrdgBalpha, RdgB, RdgBalpha, hypoF, ota1, rdbB(ota1), x36, retinal degeneration B, CG11111-PA, CG11111-PB, CG11111-PC, CG11111-PD, CG11111-PE, CG11111-PF, CG11111-PG, CG11111-PH, CG11111-PI, CG11111-PJ, CG11111-PK, rdgB-PA, rdgB-PB, rdgB-PC, rdgB-PD, rdgB-PE, rdgB-PF, rdgB-PG, rdgB-PH, rdgB-PI, rdgB-PJ, rdgB-PK, receptor degeneration B, receptor-degeneration-II
Species: fruit fly

Top Publications

  1. Sawin McCormack E, Sokolowski M, Campos A. Characterization and genetic analysis of Drosophila melanogaster photobehavior during larval development. J Neurogenet. 1995;10:119-35 pubmed
    ..These results suggest that the transition from negative phototaxis toward photoneutral behavior characteristic of the wandering third instar larva requires vision. ..
  2. Wang T, Montell C. A phosphoinositide synthase required for a sustained light response. J Neurosci. 2006;26:12816-25 pubmed
    ..dPIS suppressed the retinal degeneration resulting from two other mutations affecting PIP2 cycling, rdgB (retinal degeneration B) and cds (CDP-diacylglycerol synthase)...
  3. Sarfare S, Ahmad S, Joyce M, Boggess B, O Tousa J. The Drosophila ninaG oxidoreductase acts in visual pigment chromophore production. J Biol Chem. 2005;280:11895-901 pubmed
    ..These results indicate that the ninaG oxidoreductase acts in the biochemical pathway responsible for conversion of retinal to the rhodopsin chromophore, 3-hydroxyretinal. ..
  4. Hsu C, Whaley M, Frazer K, Miller D, Mitchell K, Adams S, et al. Limited role of developmental programmed cell death pathways in Drosophila norpA retinal degeneration. J Neurosci. 2004;24:500-7 pubmed
    ..These results establish that the pathways responsible for PCD in development do not play a major role in adult retinal degeneration caused by norpA. ..
  5. Litvak V, Tian D, Carmon S, Lev S. Nir2, a human homolog of Drosophila melanogaster retinal degeneration B protein, is essential for cytokinesis. Mol Cell Biol. 2002;22:5064-75 pubmed
    ..These results provide new insight into the cellular functions of Nir2 and introduce it as a novel regulator of cytokinesis. ..
  6. Colley N, Cassill J, Baker E, Zuker C. Defective intracellular transport is the molecular basis of rhodopsin-dependent dominant retinal degeneration. Proc Natl Acad Sci U S A. 1995;92:3070-4 pubmed
    ..We demonstrate that retinal degeneration results from interference in the maturation of wild-type rhodopsin by the mutant proteins. ..
  7. Lev S. The role of the Nir/rdgB protein family in membrane trafficking and cytoskeleton remodeling. Exp Cell Res. 2004;297:1-10 pubmed
    ..The Drosophila retinal degeneration B (rdgB), a protein that is required for photoreceptor cell viability and light response, was the first to ..
  8. Chang J, Milligan S, Li Y, Chew C, Wiggs J, Copeland N, et al. Mammalian homolog of Drosophila retinal degeneration B rescues the mutant fly phenotype. J Neurosci. 1997;17:5881-90 pubmed
    Mutations in the Drosophila rdgB gene, which encodes a transmembrane phosphatidylinositol transfer protein (PITP), cause a light-enhanced retinal degeneration...
  9. Minke B, Rubinstein C, Sahly I, Bar Nachum S, Timberg R, Selinger Z. Phorbol ester induces photoreceptor-specific degeneration in a Drosophila mutant. Proc Natl Acad Sci U S A. 1990;87:113-7 pubmed
    In the retinal degeneration B (rdgB) mutant of Drosophila, the major class of photoreceptors degenerate when the fly is raised in the light for several days; raising the fly in the dark largely prevents the degeneration...

More Information


  1. Lee Y, Shah S, Suzuki E, Zars T, O Day P, Hyde D. The Drosophila dgq gene encodes a G alpha protein that mediates phototransduction. Neuron. 1994;13:1143-57 pubmed
    ..Retinas of double mutants of DGq1, but not DGq2, with the light-dependent retinal degeneration mutant rdgB degenerated even in the dark. DGq1 stimulation of rdgB retinal degeneration in the dark was norpA-dependent...
  2. Vihtelic T, Goebl M, Milligan S, O Tousa J, Hyde D. Localization of Drosophila retinal degeneration B, a membrane-associated phosphatidylinositol transfer protein. J Cell Biol. 1993;122:1013-22 pubmed
    The Drosophila retinal degeneration B (rdgB) mutation causes abnormal photoreceptor response and light-enhanced retinal degeneration. Immunoblots using polyclonal anti-rdgB serum showed that rdgB is a 160-kD membrane protein...
  3. Steele F, O Tousa J. Rhodopsin activation causes retinal degeneration in Drosophila rdgC mutant. Neuron. 1990;4:883-90 pubmed
    ..Thus the rdgC+ gene product is required to prevent retinal degeneration that results from a previously unrecognized consequence of rhodopsin stimulation. ..
  4. Xu X, Chien F, Butler A, Salkoff L, Montell C. TRPgamma, a drosophila TRP-related subunit, forms a regulated cation channel with TRPL. Neuron. 2000;26:647-57 pubmed
    ..While TRPL and TRPgamma homomultimers are constitutively active, we demonstrate that TRPL-TRPgamma heteromultimers form a regulated phospholipase C- (PLC-) stimulated channel. ..
  5. Harris W, Stark W. Hereditary retinal degeneration in Drosophila melanogaster. A mutant defect associated with the phototransduction process. J Gen Physiol. 1977;69:261-91 pubmed
    Two genes in Drosophila, rdgA and rdgB, which when defective cause retinal degeneration, were discovered by Hotta and Benzer (Hotta, Y., and S. Benzer. 1970. Proc. Natl, Acad. Sci. U. S, A. 67:1156-1163)...
  6. Milligan S, Alb J, Elagina R, Bankaitis V, Hyde D. The phosphatidylinositol transfer protein domain of Drosophila retinal degeneration B protein is essential for photoreceptor cell survival and recovery from light stimulation. J Cell Biol. 1997;139:351-63 pubmed
    The Drosophila retinal degeneration B (rdgB) gene encodes an integral membrane protein involved in phototransduction and prevention of retinal degeneration...
  7. Paetkau D, Elagin V, Sendi L, Hyde D. Isolation and characterization of Drosophila retinal degeneration B suppressors. Genetics. 1999;151:713-24 pubmed
    The Drosophila retinal degeneration B protein (RdgB) is a novel integral membrane phosphatidylinositol transfer protein required for photoreceptor cell viability and light response...
  8. Smith D, Ranganathan R, Hardy R, Marx J, Tsuchida T, Zuker C. Photoreceptor deactivation and retinal degeneration mediated by a photoreceptor-specific protein kinase C. Science. 1991;254:1478-84 pubmed
    ..Light adaptation was also defective in inaC mutant flies. In flies carrying the retinal degeneration mutation rdgB, absence of eye-PKC suppressed photoreceptor cell degeneration...
  9. Vihtelic T, Hyde D, O Tousa J. Isolation and characterization of the Drosophila retinal degeneration B (rdgB) gene. Genetics. 1991;127:761-8 pubmed
    Retinal degeneration-B (rdgB) mutants of Drosophila melanogaster undergo rapid light-induced retinal degeneration. We conducted a molecular characterization of the rdgB gene to examine the nature of the gene product...
  10. Hardie R. Phototransduction in Drosophila melanogaster. J Exp Biol. 2001;204:3403-9 pubmed
  11. Raghu P, Usher K, Jonas S, Chyb S, Polyanovsky A, Hardie R. Constitutive activity of the light-sensitive channels TRP and TRPL in the Drosophila diacylglycerol kinase mutant, rdgA. Neuron. 2000;26:169-79 pubmed
    ..The findings suggest that early degeneration in rdgA is caused by uncontrolled Ca2+ influx and support the proposal that diacylglycerol or its metabolites are messengers of excitation in Drosophila photoreceptors. ..
  12. Alloway P, Howard L, Dolph P. The formation of stable rhodopsin-arrestin complexes induces apoptosis and photoreceptor cell degeneration. Neuron. 2000;28:129-38 pubmed
    ..We propose that an identical mechanism may be responsible for the pathology found in a subset of human retinal degenerative disorders. ..
  13. Hotta Y, Benzer S. Genetic dissection of the Drosophila nervous system by means of mosaics. Proc Natl Acad Sci U S A. 1970;67:1156-63 pubmed
    ..e., a mutant eye always functions abnormally, regardless of the amount of normal tissue present elsewhere, indicating that the primary causes of the behavioral deficits in these mutants are within the eye. ..
  14. Zuker C. The biology of vision of Drosophila. Proc Natl Acad Sci U S A. 1996;93:571-6 pubmed
    ..In this manuscript I review some of our recent findings and the strategies used to dissect this process. ..
  15. Inoue H, Yoshioka T, Hotta Y. Membrane-associated phospholipase C of Drosophila retina. J Biochem. 1988;103:91-4 pubmed
    ..The effects of pH on these two enzyme activities differed to some extent. ..
  16. Hardie R, Raghu P, Moore S, Juusola M, Baines R, Sweeney S. Calcium influx via TRP channels is required to maintain PIP2 levels in Drosophila photoreceptors. Neuron. 2001;30:149-59 pubmed
    ..Two independent mutations in the PIP2 recycling pathway (rdgB and cds) prevented recovery from inactivation...
  17. Carlson J. Olfaction in Drosophila: from odor to behavior. Trends Genet. 1996;12:175-80 pubmed
    ..Genetic and molecular analyses of the Drosophila olfactory system have identified some of its molecular components, and have revealed some principles of its function and organization. ..
  18. Ferrus A, Canal I. The behaving brain of a fly. Trends Neurosci. 1994;17:479-86 pubmed
  19. Jiang K, Liu Y, Fan J, Zhang J, Li X, Evers B, et al. PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail. PLoS Biol. 2016;14:e1002375 pubmed publisher
  20. Sahly I, Bar Nachum S, Suss Toby E, Rom A, Peretz A, Kleiman J, et al. Calcium channel blockers inhibit retinal degeneration in the retinal-degeneration-B mutant of Drosophila. Proc Natl Acad Sci U S A. 1992;89:435-9 pubmed
    Light accelerates degeneration of photoreceptor cells of the retinal degeneration B (rdgB) mutant of Drosophila...
  21. Shetty K, Kurada P, O Tousa J. Rab6 regulation of rhodopsin transport in Drosophila. J Biol Chem. 1998;273:20425-30 pubmed
    ..These results establish that rhodopsin is transported via a Rab6 regulated pathway and that defects in trafficking pathways lead to retinal degeneration. ..
  22. Lee J, Song M, Hong S. Negative regulation of the novel norpA(P24) suppressor, diehard4, in the endo-lysosomal trafficking underlies photoreceptor cell degeneration. PLoS Genet. 2013;9:e1003559 pubmed publisher
    ..Loss of its function suppresses retinal degeneration in norpA(P24), rdgC(306), and trp(1), but not in rdgB(2), suggesting a common cause of photoreceptor death...
  23. Ranganathan R, Harris W, Zuker C. The molecular genetics of invertebrate phototransduction. Trends Neurosci. 1991;14:486-93 pubmed
    ..The results of a combination of molecular, genetic, physiological and biochemical studies are beginning to produce a clearer model for the complex mechanisms involved in invertebrate visual transduction. ..
  24. Lu C, Vihtelic T, Hyde D, Li T. A neuronal-specific mammalian homolog of the Drosophila retinal degeneration B gene with expression restricted to the retina and dentate gyrus. J Neurosci. 1999;19:7317-25 pubmed
    Mutations in the Drosophila retinal degeneration B (rdgB) gene cause a rapid loss of the electrophysiological light response and subsequent light-enhanced photoreceptor degeneration...
  25. Shirsat N, Siddiqi O. Olfaction in invertebrates. Curr Opin Neurobiol. 1993;3:553-7 pubmed
    ..This is essential for understanding the sensory code and higher olfactory functions. Neurogenetic analysis has provided useful insights into olfaction and olfactory learning. ..
  26. Garner K, Hunt A, Koster G, Somerharju P, Groves E, Li M, et al. Phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) binds and transfers phosphatidic acid. J Biol Chem. 2012;287:32263-76 pubmed publisher
    ..an uncharacterized soluble PITP, phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) (alternative name, RdgB?), of the Class II family...
  27. Rubboli F, Bulfone A, Bogni S, Marchitiello A, Zollo M, Borsani G, et al. A mammalian homologue of the Drosophila retinal degeneration B gene: implications for the evolution of phototransduction mechanisms. Genes Funct. 1997;1:205-13 pubmed
    ..The Drosophila retinal degeneration B (rdgB) gene encodes a protein involved in phototransduction in the fly...
  28. Sahly I, Schroder W, Zierold K, Minke B. Accumulation of calcium in degenerating photoreceptors of several Drosophila mutants. Vis Neurosci. 1994;11:763-72 pubmed
    ..Light- and dark-raised mutants of the following strains were studied: retinal degeneration B (rdgB); retinal degeneration C (rdgC); neither inactivation nor afterpotential C (ninaC), and no receptor ..
  29. O Dell K. The effect of the inactive mutation on longevity, sex, rhythm and resistance to p-cresol in Drosophila melanogaster. Heredity (Edinb). 1993;70 ( Pt 4):393-9 pubmed
    ..Some inferences on the possible mode of action of the iav gene product are discussed. ..
  30. Chen Z, Chen H, Montell C. TRP and Rhodopsin Transport Depends on Dual XPORT ER Chaperones Encoded by an Operon. Cell Rep. 2015;13:573-584 pubmed publisher
    ..Our work highlights a coordinated network of chaperones required for the biosynthesis of the TRP channel and rhodopsin in Drosophila photoreceptor cells. ..
  31. Yoon C, Hirosawa K, Suzuki E. Studies on the structure of ocellar photoreceptor cells of Drosophila melanogaster with special reference to subrhabdomeric cisternae. Cell Tissue Res. 1996;284:77-85 pubmed
    ..These membranous structures were immunopositive for the rdgB protein, a phosphatidylinositol transfer protein that is localized to the subrhabdomeric cisternae in compound eyes...
  32. Landry C, Castillo Davis C, Ogura A, Liu J, Hartl D. Systems-level analysis and evolution of the phototransduction network in Drosophila. Proc Natl Acad Sci U S A. 2007;104:3283-8 pubmed
    ..These results provide a preliminary quantification of variation and divergence of gene expression between species in a known gene network and provide a foundation for a system-level understanding of functional and evolutionary change. ..
  33. Ward E, Thaipisuttikul I, Terayama M, French R, Jackson S, Cosand K, et al. GAL4 enhancer trap patterns during Drosophila development. Genesis. 2002;34:46-50 pubmed
  34. Woodard C, Huang T, Sun H, Helfand S, Carlson J. Genetic analysis of olfactory behavior in Drosophila: a new screen yields the ota mutants. Genetics. 1989;123:315-26 pubmed
    ..Mutations representing each complementation group, as well as one of the dominant mutations, were mapped. For the mutants with defective visual system physiology, the visual defects were shown to cosegregate with olfactory phenotypes. ..
  35. Hibbard K, O Tousa J. A role for the cytoplasmic DEAD box helicase Dbp21E2 in rhodopsin maturation and photoreceptor viability. J Neurogenet. 2012;26:177-88 pubmed publisher
    ..The molecular genetic analysis described here reveals an unexpected role for the Dbp21E2 helicase and provides an experimental system to further characterize its function. ..
  36. Gerresheim F. Isolation of Drosophila melanogaster mutants with a wavelength-specific alteration in their phototactic response. Behav Genet. 1988;18:227-46 pubmed
  37. Riesgo Escovar J, Woodard C, Carlson J. Olfactory physiology in the Drosophila maxillary palp requires the visual system gene rdgB. J Comp Physiol A. 1994;175:687-93 pubmed
    ..and show that the rate of recovery from odorant stimulation is affected by mutation of the rdgB (retinal degeneration B) gene. We use immunocytochemistry to confirm that the rdgB gene product is expressed in the maxillary palp...
  38. Acharya J, Labarca P, Delgado R, Jalink K, Zuker C. Synaptic defects and compensatory regulation of inositol metabolism in inositol polyphosphate 1-phosphatase mutants. Neuron. 1998;20:1219-29 pubmed
    ..We also show that Li+ phenocopies this effect in wild-type synapses. Together, these results support a role for phosphoinositides in synaptic vesicle function in vivo and mechanistically question the "lithium hypothesis." ..
  39. Hekmat Scafe D, Carlson J. Genetic and molecular studies of olfaction in Drosophila. Ciba Found Symp. 1996;200:285-96; discussion 296-301 pubmed
    ..It may also be possible to study olfactory genes, such as those encoding PBPs, from other insects by mutating them, introducing them into Drosophila and analysing their function in vivo. ..
  40. Yadav S, Garner K, Georgiev P, Li M, Gomez Espinosa E, Panda A, et al. RDGBα, a PtdIns-PtdOH transfer protein, regulates G-protein-coupled PtdIns(4,5)P2 signalling during Drosophila phototransduction. J Cell Sci. 2015;128:3330-44 pubmed publisher
    ..b>RDGBα (hereafter RDGB) is a multi-domain protein with a PtdIns transfer protein (PITP) domain (RDGB-PITPd)...
  41. Chakrabarti P, Kolay S, Yadav S, Kumari K, Nair A, Trivedi D, et al. A dPIP5K dependent pool of phosphatidylinositol 4,5 bisphosphate (PIP2) is required for G-protein coupled signal transduction in Drosophila photoreceptors. PLoS Genet. 2015;11:e1004948 pubmed publisher
    ..Our results define the existence of multiple pools of PIP2 in photoreceptors generated by distinct lipid kinases and supporting specific molecular processes at neuronal membranes. ..
  42. Blest A, Stowe S, Clausen J, Carter M. The distribution of actin immunoreactivity in rhabdomeres of tipulid flies in relation to extracellular membrane shedding. Cell Tissue Res. 1991;265:465-72 pubmed
    ..The implications of these conclusions are discussed in relation to some functional models of arthropod photoreceptor microvilli. ..
  43. Shieh B, Zhu M. Regulation of the TRP Ca2+ channel by INAD in Drosophila photoreceptors. Neuron. 1996;16:991-8 pubmed
    ..Given the impaired electrophysiology of the InaD mutant, this novel interaction suggests that INAD functions as a regulatory subunit of the TRP Ca2+ channel. ..
  44. LaLonde M, Janssens H, Rosenbaum E, Choi S, Gergen J, Colley N, et al. Regulation of phototransduction responsiveness and retinal degeneration by a phospholipase D-generated signaling lipid. J Cell Biol. 2005;169:471-9 pubmed
    ..Altogether, these findings suggest that Pld facilitates phototransduction by maintaining adequate levels of PIP2 and by protecting the visual system from metarhodopsin-induced, low light degeneration. ..
  45. Lee S, Xu H, Kang L, Amzel L, Montell C. Light adaptation through phosphoinositide-regulated translocation of Drosophila visual arrestin. Neuron. 2003;39:121-32 pubmed
    ..Since phospholipase C activity is required for activation of Drosophila phototransduction, these data point to a dual role of PIs in phototransduction. ..
  46. Spatz H. Karl-Friedrich Fischbach's first publications and their impact in the biological sciences. J Neurogenet. 2014;28:167-70 pubmed publisher
    ..Also a model, proposed already in 1977 by Karl-Friedrich and colleagues, to explain the nonmonotonous dependence on light intensity of phototaxis in Drosophila, finds support in recent studies of functional neuroanatomy. ..
  47. Homyk T, Szidonya J, Suzuki D. Behavioral mutants of Drosophila melanogaster. III. Isolation and mapping of mutations by direct visual observations of behavioral phenotypes. Mol Gen Genet. 1980;177:553-65 pubmed
  48. Lev S, Hernandez J, Martinez R, Chen A, Plowman G, Schlessinger J. Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein. Mol Cell Biol. 1999;19:2278-88 pubmed
    ..The Nir proteins are the human homologues of the Drosophila retinal degeneration B protein (rdgB), a protein implicated in the visual transduction pathway in flies...
  49. Inoue H, Yoshioka T, Hotta Y. Diacylglycerol kinase defect in a Drosophila retinal degeneration mutant rdgA. J Biol Chem. 1989;264:5996-6000 pubmed
    ..Therefore, it is strongly suggested that rdgA gene correlates closely with DG kinase activity, and the defect of DG kinase activity is a primary cause of retinal degeneration in rdgA mutant. ..
  50. Cockcroft S. Phosphatidylinositol transfer proteins: a requirement in signal transduction and vesicle traffic. Bioessays. 1998;20:423-32 pubmed
    ..We are just beginning to unravel the intriguing mechanisms by which PITP/SEC14 may accomplish its function in eukaryotic cells in signal transduction and membrane trafficking. ..
  51. Zerr D, Hall J, Rosbash M, Siwicki K. Circadian fluctuations of period protein immunoreactivity in the CNS and the visual system of Drosophila. J Neurosci. 1990;10:2749-62 pubmed
    ..These genetic and environmental manipulations affected the expression of the per protein in ways that usually parallelled their effects on circadian behaviors. ..
  52. Gardiner K, Brookes A, Mural R. Of messages and meaning. Trends Genet. 1997;13:92-3 pubmed
  53. Deak I, Bellamy P, Bienz M, Dubuis Y, Fenner E, Gollin M, et al. Mutations affecting the indirect flight muscles of Drosophila melanogaster. J Embryol Exp Morphol. 1982;69:61-81 pubmed
    ..The absence of reduction of the 54 K protein was strongly correlated with aberrant Z-bands. ..
  54. Smith D. Olfactory mechanisms in Drosophila melanogaster. Curr Opin Neurobiol. 1996;6:500-5 pubmed
    ..In addition, members of the family of invertebrate odorant-binding proteins have been identified in Drosophila and may play an important role in the olfactory process. ..
  55. Stark W, Carlson S. Ultrastructural pathology of the compound eye and optic neuropiles of the retinal degeneration mutant (w rdg BKS222) Drosophila melanogaster. Cell Tissue Res. 1982;225:11-22 pubmed
    ..The debris from cell bodies and axon terminals or R1-6 seems diminished, so that some phagocytosis probably takes place along with gliosis in the lamina. ..
  56. Woodard C, Alcorta E, Carlson J. The rdgB gene of Drosophila: a link between vision and olfaction. J Neurogenet. 2007;21:291-305 pubmed
    ..of Drosophila isolated by virtue of abnormal olfactory behavior, is shown to be an allele of rdgB (retinal degeneration B), a gene required for normal visual system physiology...
  57. Pak W. Drosophila in vision research. The Friedenwald Lecture. Invest Ophthalmol Vis Sci. 1995;36:2340-57 pubmed
  58. Zuker C. Phototransduction in Drosophila: a paradigm for the genetic dissection of sensory transduction cascades. Curr Opin Neurobiol. 1992;2:622-7 pubmed
    ..The availability of Drosophila mutants with defects in visual physiology allows for an in vivo dissection of this complex sensory signal transduction process. ..
  59. Stark W, Sapp R, Carlson S. Ultrastructure of the ocellar visual system in normal and mutant Drosophila melanogaster. J Neurogenet. 1989;5:127-53 pubmed
    ..The trp. rdgBKS222 and rgdAPC47 mutants are essentially normal with respect to structure and survival of ocellar receptors and synapses. ..
  60. Fullwood Y, dos Santos M, Hsuan J. Cloning and characterization of a novel human phosphatidylinositol transfer protein, rdgBbeta. J Biol Chem. 1999;274:31553-8 pubmed
    The various PITP, retinal degeneration B (rdgB), and amino-terminal domain interacting receptor (Nir) phosphatidylinositol transfer proteins can be divided into two structural families...
  61. Higgs H, Han M, Johnson G, Glomset J. Cloning of a phosphatidic acid-preferring phospholipase A1 from bovine testis. J Biol Chem. 1998;273:5468-77 pubmed
    ..proteins: a potential counterpart of the phospholipase A1 in Caenorhabditis elegans, two putative lipases in yeast, and three proteins separately encoded by the Drosophila retinal degeneration B gene and its mouse and human homologues.
  62. Garcia Murillas I, Pettitt T, Macdonald E, Okkenhaug H, Georgiev P, Trivedi D, et al. lazaro encodes a lipid phosphate phosphohydrolase that regulates phosphatidylinositol turnover during Drosophila phototransduction. Neuron. 2006;49:533-46 pubmed
    ..Together our results demonstrate the contribution of PI depletion to the rdgA phenotype and provide evidence that depletion of PI and its metabolites might be a key signal for TRP channel activation in vivo. ..
  63. Woodard C, Alcorta E, Carlson J. The rdgB gene of Drosophila: a link between vision and olfaction. J Neurogenet. 1992;8:17-31 pubmed
    ..of Drosophila isolated by virtue of abnormal olfactory behavior, is shown to be an allele of rdgB (retinal degeneration B), a gene required for normal visual system physiology...
  64. Carlson J. Olfaction in Drosophila: genetic and molecular analysis. Trends Neurosci. 1991;14:520-4 pubmed
    ..Recent analysis of some of these genes is beginning to provide insight into their functions. ..
  65. Gaines P, Carlson J. The olfactory and visual systems are closely related in Drosophila. Braz J Med Biol Res. 1995;28:161-7 pubmed
    ..The rdgB (retinal degeneration B) gene is required not only for the maintenance and physiology of the visual system, but also for olfactory ..