Rca1

Summary

Gene Symbol: Rca1
Description: Regulator of cyclin A1
Alias: 152549_at, CG10800, CLD4, Dmel\CG10800, Emi1, FBXO5, P3300, RCA1, S(rux)2A, l(2)03300, rca1, regulator of cyclin A1, CG10800-PA, Rca1-PA, regulator of cyclin A, regulator of cyclin A 1, suppressor of rux 2A
Species: fruit fly

Top Publications

  1. Zielke N, Querings S, Rottig C, Lehner C, Sprenger F. The anaphase-promoting complex/cyclosome (APC/C) is required for rereplication control in endoreplication cycles. Genes Dev. 2008;22:1690-703 pubmed publisher
    ..Geminin is only abundant in cells with high CycE-Cdk2 activity, suggesting that APC/C-Fzr activity is periodically inhibited by CycE-Cdk2, to prevent relicensing in S-phase cells. ..
  2. Narbonne Reveau K, Senger S, Pal M, Herr A, Richardson H, Asano M, et al. APC/CFzr/Cdh1 promotes cell cycle progression during the Drosophila endocycle. Development. 2008;135:1451-61 pubmed publisher
  3. Grosskortenhaus R, Sprenger F. Rca1 inhibits APC-Cdh1(Fzr) and is required to prevent cyclin degradation in G2. Dev Cell. 2002;2:29-40 pubmed
    We demonstrate that Rca1 is an essential inhibitor of the anaphase-promoting complex/cyclosome (APC) in Drosophila...
  4. Dong X, Zavitz K, Thomas B, Lin M, Campbell S, Zipursky S. Control of G1 in the developing Drosophila eye: rca1 regulates Cyclin A. Genes Dev. 1997;11:94-105 pubmed
    ..One of these genes, regulator of cyclin A (rca1), encodes a novel protein required for both mitotic and meiotic cell cycle progression...
  5. Hériché J, Ang D, Bier E, O Farrell P. Involvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in Drosophila. BMC Genet. 2003;4:9 pubmed
    ..We have used genetic and physical interactions to identify the G1/S transcription factor E2F as an SCFSlmb target in Drosophila. These results argue that the SCFSlmb ubiquitin ligase directs E2F destruction in S phase. ..
  6. Dienemann A, Sprenger F. Requirements of cyclin a for mitosis are independent of its subcellular localization. Curr Biol. 2004;14:1117-23 pubmed
    ..We noted that Cyclin B (CycB) protein disappears prematurely in CycA mutants, reminiscent of rca1 mutants...
  7. Buttitta L, Katzaroff A, Edgar B. A robust cell cycle control mechanism limits E2F-induced proliferation of terminally differentiated cells in vivo. J Cell Biol. 2010;189:981-96 pubmed publisher
    ..These mechanisms are essential for proper development, as evading them leads to tissue outgrowths composed of dividing but terminally differentiated cells. ..
  8. Lear B, Skeath J, Patel N. Neural cell fate in rca1 and cycA mutants: the roles of intrinsic and extrinsic factors in asymmetric division in the Drosophila central nervous system. Mech Dev. 1999;88:207-19 pubmed
    In the central nervous system (CNS) of Drosophila embryos lacking regulator of cyclin A (rca1) or cyclin A, we observe that several ganglion mother cells (GMCs) fail to divide...
  9. Wai P, Truong B, Bhat K. Cell division genes promote asymmetric interaction between Numb and Notch in the Drosophila CNS. Development. 1999;126:2759-70 pubmed
    ..We have used loss-of-function mutations in N and nb, cell division mutants cyclinA (cycA), regulator of cyclin A1 (rca1) and string/cdc25 phosphatase (stg), and the microtubule destabilizing agent, nocodazole, to ..

More Information

Publications26

  1. Han Z, Bodmer R. Myogenic cells fates are antagonized by Notch only in asymmetric lineages of the Drosophila heart, with or without cell division. Development. 2003;130:3039-51 pubmed
    ..In addition, we provide evidence that whether or not Suppressor-of-Hairless can become a transcriptional activator is the key switch for the Numb/Notch activity in determining a myocardial versus pericardial cell fate. ..
  2. Araki M, Wharton R, Tang Z, Yu H, Asano M. Degradation of origin recognition complex large subunit by the anaphase-promoting complex in Drosophila. EMBO J. 2003;22:6115-26 pubmed
    ..These observations suggest that in Drosophila, ORC1 regulates origin utilization much as does Cdc6 in budding yeast. ..
  3. Rogers G, Rusan N, Roberts D, Peifer M, Rogers S. The SCF Slimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication. J Cell Biol. 2009;184:225-39 pubmed publisher
    ..Using a Plk4 Slimb-binding mutant and Slimb RNAi, we show that Slimb regulates Plk4 localization to centrioles during interphase, thus regulating centriole number and ensuring the block to centriole reduplication. ..
  4. Erhardt S, Mellone B, Betts C, Zhang W, Karpen G, Straight A. Genome-wide analysis reveals a cell cycle-dependent mechanism controlling centromere propagation. J Cell Biol. 2008;183:805-18 pubmed publisher
    ..We also identified the mitotic cyclin A (CYCA) and the anaphase-promoting complex (APC) inhibitor RCA1/Emi1 as regulators of centromere propagation...
  5. Harper J, Burton J, Solomon M. The anaphase-promoting complex: it's not just for mitosis any more. Genes Dev. 2002;16:2179-206 pubmed
  6. Zielke N, Querings S, Grosskortenhaus R, Reis T, Sprenger F. Molecular dissection of the APC/C inhibitor Rca1 shows a novel F-box-dependent function. EMBO Rep. 2006;7:1266-72 pubmed
    Rca1 (regulator of Cyclin A)/Emi (early mitotic inhibitor) proteins are essential inhibitors of the anaphase-promoting complex/cyclosome (APC/C)...
  7. de Nooij J, Graber K, Hariharan I. Expression of the cyclin-dependent kinase inhibitor Dacapo is regulated by cyclin E. Mech Dev. 2000;97:73-83 pubmed
    ..Our results argue for a mechanism where Cyclin E/Cdk activity induces Dacapo expression but only within certain windows that are permissive for dacapo expression. ..
  8. Rogulja D, Young M. Control of sleep by cyclin A and its regulator. Science. 2012;335:1617-21 pubmed publisher
    ..We show that cyclin A (CycA) and regulator of cyclin A1, essential cell cycle factors, function in postmitotic neurons to promote sleep in Drosophila melanogaster...
  9. Bandura J, Jiang H, Nickerson D, Edgar B. The molecular chaperone Hsp90 is required for cell cycle exit in Drosophila melanogaster. PLoS Genet. 2013;9:e1003835 pubmed publisher
    ..Our results reveal that Hsp83 plays a heretofore unappreciated role in promoting APC/C function during cell cycle exit and suggest a mechanism by which Hsp90 inhibition could promote genomic instability and carcinogenesis. ..
  10. Acquaviva C, Pines J. The anaphase-promoting complex/cyclosome: APC/C. J Cell Sci. 2006;119:2401-4 pubmed
  11. Skaar J, Pagan J, Pagano M. SnapShot: F box proteins I. Cell. 2009;137:1160-1160.e1 pubmed publisher
  12. Tian X, Hansen D, Schedl T, Skeath J. Epsin potentiates Notch pathway activity in Drosophila and C. elegans. Development. 2004;131:5807-15 pubmed
    ..Our results suggest that epsins play a specific, evolutionarily conserved role to promote Notch signaling during animal development and support the idea that they do so by targeting ligands of the Notch pathway for endocytosis. ..
  13. Treisman J, Heberlein U. Eye development in Drosophila: formation of the eye field and control of differentiation. Curr Top Dev Biol. 1998;39:119-58 pubmed
  14. Chen D, Ahlford A, Schnorrer F, Kalchhauser I, Fellner M, Viragh E, et al. High-resolution, high-throughput SNP mapping in Drosophila melanogaster. Nat Methods. 2008;5:323-9 pubmed publisher
    ..3 kb, and demonstrated the utility of these tools by rapidly mapping 14 mutations that disrupt embryonic muscle patterning. These resources enable high-resolution high-throughput genetic mapping in Drosophila. ..
  15. Baker N. Cell proliferation, survival, and death in the Drosophila eye. Semin Cell Dev Biol. 2001;12:499-507 pubmed
    ..Reiterated episodes of cell death also contribute to precise regulation of retinal cell number. The EGF receptor homolog has multiple roles in retinal proliferation and survival. ..
  16. Zielke N, Kim K, Tran V, Shibutani S, Bravo M, Nagarajan S, et al. Control of Drosophila endocycles by E2F and CRL4(CDT2). Nature. 2011;480:123-7 pubmed publisher
    ..Many of the regulatory interactions essential to this novel cell cycle oscillator are conserved in animals and plants, indicating that elements of this mechanism act in most growth-dependent cell cycles. ..
  17. Secombe J, Pispa J, Saint R, Richardson H. Analysis of a Drosophila cyclin E hypomorphic mutation suggests a novel role for cyclin E in cell proliferation control during eye imaginal disc development. Genetics. 1998;149:1867-82 pubmed
    ..In addition, this analysis has identified cyclin A and string as DmcycEJP interactors, suggesting a novel role for cyclin E in the regulation of Cyclin A and String function during eye development. ..