Rbf

Summary

Gene Symbol: Rbf
Description: Retinoblastoma-family protein
Alias: CG7413, Dmel\CG7413, EG:34F3.3, FBF, RBF, RBF1, RBf1, Rb1, RbF, Rbf1, dRBF, pRb, rbf, rbf1, Retinoblastoma-family protein, CG7413-PA, Rbf-PA, retinoblastoma, retinoblastoma factor, retinoblastoma factor-1, retinoblastoma family protein 1, retinoblastoma-family homolog
Species: fruit fly
Products:     Rbf

Top Publications

  1. Wei N, Serino G, Deng X. The COP9 signalosome: more than a protease. Trends Biochem Sci. 2008;33:592-600 pubmed publisher
    ..The independent functions of CSN5 (also known as JAB1) add to the complexity of the CSN machinery. Here, we provide an updated view of the structure, functions and regulation of this protein complex. ..
  2. Nicolay B, Frolov M. Context-dependent requirement for dE2F during oncogenic proliferation. PLoS Genet. 2008;4:e1000205 pubmed publisher
    ..Thus, we uncovered a critical requirement for the dE2F family during inappropriate proliferation of Hippo pathway mutant cells. ..
  3. Gordon G, Zhang T, Zhao J, Du W. Deregulated G1-S control and energy stress contribute to the synthetic-lethal interactions between inactivation of RB and TSC1 or TSC2. J Cell Sci. 2013;126:2004-13 pubmed publisher
    ..treatment by specifically promoting the death of cancer cells with particular defects such as the loss of the RB (RB1) tumor suppressor...
  4. Nicolay B, Gameiro P, Tschop K, Korenjak M, Heilmann A, Asara J, et al. Loss of RBF1 changes glutamine catabolism. Genes Dev. 2013;27:182-96 pubmed publisher
    Inactivation of the retinoblastoma tumor suppressor (pRB) alters the expression of a myriad of genes...
  5. Baonza A, Freeman M. Control of cell proliferation in the Drosophila eye by Notch signaling. Dev Cell. 2005;8:529-39 pubmed
    ..Delta to Notch signaling derepresses the inhibition of dE2F1 by RBF, and Delta expression depends on the secreted proteins Hedgehog and Dpp...
  6. Swanhart L, Sanders A, Duronio R. Normal regulation of Rbf1/E2f1 target genes in Drosophila type 1 protein phosphatase mutants. Dev Dyn. 2007;236:2567-77 pubmed
    ..Here, we use genetic analyses to determine the role of PP1 in the regulation of Rbf1 activity during Drosophila development...
  7. Li B, Gordon G, Du C, Xu J, Du W. Specific killing of Rb mutant cancer cells by inactivating TSC2. Cancer Cell. 2010;17:469-80 pubmed publisher
    The retinoblastoma (Rb) tumor suppressor is often inactivated in cancers. To identify genes that can be used to specifically target such cancers, we carried out a genetic screen in Drosophila...
  8. Moon N, Di Stefano L, Dyson N. A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis. Mol Cell Biol. 2006;26:7601-15 pubmed
    The inactivation of retinoblastoma (Rb) family members sensitizes cells to apoptosis. This cell death affects the development of mutant animals and also provides a critical constraint to the malignant potential of Rb mutant tumor cells...
  9. Nicolay B, Bayarmagnai B, Islam A, Lopez Bigas N, Frolov M. Cooperation between dE2F1 and Yki/Sd defines a distinct transcriptional program necessary to bypass cell cycle exit. Genes Dev. 2011;25:323-35 pubmed publisher
    ..Consistently, RBF, a negative regulator of dE2F1, negates this synergy and limits the overall level of expression of the Yki/Sd-dE2F1 ..

More Information

Publications70

  1. Lee H, Ohno K, Voskoboynik Y, Ragusano L, Martinez A, Dimova D. Drosophila RB proteins repress differentiation-specific genes via two different mechanisms. Mol Cell Biol. 2010;30:2563-77 pubmed publisher
    ..The mechanisms of repression by the retinoblastoma protein (pRB) have been extensively studied at cell cycle-regulated promoters...
  2. Shibutani S, de la Cruz A, Tran V, Turbyfill W, Reis T, Edgar B, et al. Intrinsic negative cell cycle regulation provided by PIP box- and Cul4Cdt2-mediated destruction of E2f1 during S phase. Dev Cell. 2008;15:890-900 pubmed publisher
    ..the Cul4(Cdt2) E3 ubiquitin ligase and requires the Dp dimerization partner but not direct Cdk phosphorylation or Rbf1 binding...
  3. Stevaux O, Dimova D, Ji J, Moon N, Frolov M, Dyson N. Retinoblastoma family 2 is required in vivo for the tissue-specific repression of dE2F2 target genes. Cell Cycle. 2005;4:1272-80 pubmed
    In higher eukaryotes, the Retinoblastoma and E2F families of proteins control the transcription of a large number of target genes...
  4. Buttitta L, Katzaroff A, Perez C, de la Cruz A, Edgar B. A double-assurance mechanism controls cell cycle exit upon terminal differentiation in Drosophila. Dev Cell. 2007;12:631-43 pubmed
    ..In some differentiating cell types (e.g., neurons), known inhibitors including the retinoblastoma homolog Rbf and the p27 homolog Dacapo contribute to parallel repression of E2F and Cyclin E/Cdk2...
  5. Du W. Suppression of the rbf null mutants by a de2f1 allele that lacks transactivation domain. Development. 2000;127:367-79 pubmed
    ..of proteins including E2F transcription factors have been shown to interact with the tumor suppressor gene product pRB, but it is not clear to what extend the function of pRB is mediated by E2F...
  6. Morris E, Michaud W, Ji J, Moon N, Rocco J, Dyson N. Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo. PLoS Genet. 2006;2:e196 pubmed
    b>Retinoblastoma protein and E2-promoter binding factor (E2F) family members are important regulators of G1-S phase progression. Deregulated E2F also sensitizes cells to apoptosis, but this aspect of E2F function is poorly understood...
  7. Tanaka Matakatsu M, Xu J, Cheng L, Du W. Regulation of apoptosis of rbf mutant cells during Drosophila development. Dev Biol. 2009;326:347-56 pubmed publisher
    Inactivation of the retinoblastoma gene Rb leads to defects in cell proliferation, differentiation, or apoptosis, depending on specific cell or tissue types...
  8. Du W, Dyson N. The role of RBF in the introduction of G1 regulation during Drosophila embryogenesis. EMBO J. 1999;18:916-25 pubmed
    ..Mutant alleles of rbf were generated and analyzed to determine the role of RBF in this process...
  9. Moon N, Frolov M, Kwon E, Di Stefano L, Dimova D, Morris E, et al. Drosophila E2F1 has context-specific pro- and antiapoptotic properties during development. Dev Cell. 2005;9:463-75 pubmed
    ..These loss-of-function experiments demonstrate that E2F cannot be classified simply as a pro- or antiapoptotic factor. Instead, the overall role of E2F in the damage response varies greatly and depends on the cellular context. ..
  10. Du W, Vidal M, Xie J, Dyson N. RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev. 1996;10:1206-18 pubmed
    ..Such a regulator might be analogous to the family of RB-related proteins (pRB, p107, and p130) that associate with E2F in humans; however, extensive efforts have failed to find such homologs in ..
  11. Hsieh T, Nicolay B, Frolov M, Moon N. Tuberous sclerosis complex 1 regulates dE2F1 expression during development and cooperates with RBF1 to control proliferation and survival. PLoS Genet. 2010;6:e1001071 pubmed publisher
    ..In eye imaginal discs, the loss of tsc1 cooperates with rbf1 mutations to promote ectopic S-phase and cell death...
  12. Sukhanova M, Steele L, Zhang T, Gordon G, Du W. RBF and Rno promote photoreceptor differentiation onset through modulating EGFR signaling in the Drosophila developing eye. Dev Biol. 2011;359:190-8 pubmed publisher
    The retinoblastoma gene Rb is the prototype tumor suppressor and is conserved in Drosophila. We use the developing fly retina as a model system to investigate the role of Drosophila Rb (rbf) during differentiation...
  13. Neufeld T, de la Cruz A, Johnston L, Edgar B. Coordination of growth and cell division in the Drosophila wing. Cell. 1998;93:1183-93 pubmed
    ..Loss of dE2F or overproduction of its corepressor, RBF, retarded cell proliferation...
  14. Nicholson S, Gilbert M, Nicolay B, Frolov M, Moberg K. The archipelago tumor suppressor gene limits rb/e2f-regulated apoptosis in developing Drosophila tissues. Curr Biol. 2009;19:1503-10 pubmed publisher
    ..This reflects a requirement for ago to restrict apoptotic activity of the rbf1/de2f1 pathway adjacent to the eye-specific morphogenetic furrow (MF): ago mutant cells display elevated de2f1 ..
  15. de Nooij J, Letendre M, Hariharan I. A cyclin-dependent kinase inhibitor, Dacapo, is necessary for timely exit from the cell cycle during Drosophila embryogenesis. Cell. 1996;87:1237-47 pubmed
    ..dap during eye development interferes with cell cycle progression and interacts genetically with the retinoblastoma homolog (Rbf) and cyclin E. dap expression in embryos parallels the exit of cells from the cell cycle...
  16. Meyer C, Jacobs H, Datar S, Du W, Edgar B, Lehner C. Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression. EMBO J. 2000;19:4533-42 pubmed
    ..Here, we show that Drosophila Cdk4 interacts with Cyclin D and the Rb homolog RBF as expected, but is not absolutely essential...
  17. Li L, Vaessin H. Pan-neural Prospero terminates cell proliferation during Drosophila neurogenesis. Genes Dev. 2000;14:147-51 pubmed
    ..pros activity, hence, provides a critical regulatory link between neuronal lineage development and transcriptional regulation of cell cycle regulatory genes. ..
  18. Duman Scheel M, Johnston L, Du W. Repression of dMyc expression by Wingless promotes Rbf-induced G1 arrest in the presumptive Drosophila wing margin. Proc Natl Acad Sci U S A. 2004;101:3857-62 pubmed
    ..Wg signaling promotes activity of the Drosophila retinoblastoma family (Rbf) protein, which is required for G(1) arrest in the presumptive wing margin...
  19. Moon N, Di Stefano L, Morris E, Patel R, White K, Dyson N. E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage. PLoS Genet. 2008;4:e1000153 pubmed publisher
    ..Both dE2F1/dDP and dp53 are required for DNA damage-induced cell death, and the analysis of rbf1 mutant eye discs indicates that dE2F1/dDP and dp53 cooperatively promote cell death in irradiated discs...
  20. Longworth M, Herr A, Ji J, Dyson N. RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3. Genes Dev. 2008;22:1011-24 pubmed publisher
    The Drosophila retinoblastoma family of proteins (RBF1 and RBF2) and their mammalian homologs (pRB, p130, and p107) are best known for their regulation of the G1/S transition via the repression of E2F-dependent transcription...
  21. Bosco G, Du W, Orr Weaver T. DNA replication control through interaction of E2F-RB and the origin recognition complex. Nat Cell Biol. 2001;3:289-95 pubmed
    The E2F transcription factor and retinoblastoma protein control cell-cycle progression and DNA replication during S phase...
  22. Shibutani S, Swanhart L, Duronio R. Rbf1-independent termination of E2f1-target gene expression during early Drosophila embryogenesis. Development. 2007;134:467-78 pubmed
    ..The maintenance of G1(17) arrest requires Rbf1-dependent repression of E2f1-regulated replication factor genes, which are expressed continuously during cycles 1-..
  23. Hartl T, Boswell C, Orr Weaver T, Bosco G. Developmentally regulated histone modifications in Drosophila follicle cells: initiation of gene amplification is associated with histone H3 and H4 hyperacetylation and H1 phosphorylation. Chromosoma. 2007;116:197-214 pubmed
    ..in follicle cells is responsive to high Cyclin E activity, and it can be abolished by overexpressing the retinoblastoma homolog, Rbf, that represses Cyclin E...
  24. Keller S, Ullah Z, Buckley M, Henry R, Arnosti D. Distinct developmental expression of Drosophila retinoblastoma factors. Gene Expr Patterns. 2005;5:411-21 pubmed
    b>Retinoblastoma (RB) tumor suppressor proteins are important regulators of the cell cycle and are implicated in a wide variety of human tumors...
  25. Xin S, Weng L, Xu J, Du W. The role of RBF in developmentally regulated cell proliferation in the eye disc and in Cyclin D/Cdk4 induced cellular growth. Development. 2002;129:1345-56 pubmed
    ..We have examined the role of RBF, the Drosophila RB family homolog, in cell cycle progression in the second mitotic wave...
  26. Duman Scheel M, Weng L, Xin S, Du W. Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E. Nature. 2002;417:299-304 pubmed
    ..a mutation in patched (ptc), an inhibitor of Hh signalling, in a genetic screen for regulators of the Retinoblastoma (Rb) pathway in Drosophila...
  27. Acharya P, Raj N, Buckley M, Zhang L, Duperon S, Williams G, et al. Paradoxical instability-activity relationship defines a novel regulatory pathway for retinoblastoma proteins. Mol Biol Cell. 2010;21:3890-901 pubmed publisher
    The retinoblastoma (RB) transcriptional corepressor and related family of pocket proteins play central roles in cell cycle control and development, and the regulatory networks governed by these factors are frequently inactivated during ..
  28. Frolov M, Stevaux O, Moon N, Dimova D, Kwon E, Morris E, et al. G1 cyclin-dependent kinases are insufficient to reverse dE2F2-mediated repression. Genes Dev. 2003;17:723-8 pubmed
    ..and dE2F1/DAP lead to the surprising observation that dE2F2-mediated repression differs from retinoblastoma family protein 1 (RBF1) inhibition of dE2F1, and is resistant to both CycE/cdk2 and Cyclin D/cyclin-dependent kinase 4 ..
  29. Ferres Marco D, Gutierrez Garcia I, Vallejo D, Bolivar J, Gutiérrez Aviñó F, Dominguez M. Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing. Nature. 2006;439:430-6 pubmed
    ..Expression of the gene Retinoblastoma-family protein (Rbf) is downregulated in these tumours and, indeed, this downregulation is associated with DNA ..
  30. Stevaux O, Dimova D, Frolov M, Taylor Harding B, Morris E, Dyson N. Distinct mechanisms of E2F regulation by Drosophila RBF1 and RBF2. EMBO J. 2002;21:4927-37 pubmed
    b>RBF1, a Drosophila pRB family homolog, is required for cell cycle arrest and the regulation of E2F-dependent transcription. Here, we describe the properties of RBF2, a second family member...
  31. Korenjak M, Anderssen E, Ramaswamy S, Whetstine J, Dyson N. RBF binding to both canonical E2F targets and noncanonical targets depends on functional dE2F/dDP complexes. Mol Cell Biol. 2012;32:4375-87 pubmed publisher
    The retinoblastoma (RB) family of proteins regulate transcription. These proteins lack intrinsic DNA-binding activity but are recruited to specific genomic locations through interactions with sequence-specific DNA-binding factors...
  32. Acharya P, Negre N, Johnston J, Wei Y, White K, Henry R, et al. Evidence for autoregulation and cell signaling pathway regulation from genome-wide binding of the Drosophila retinoblastoma protein. G3 (Bethesda). 2012;2:1459-72 pubmed publisher
    The retinoblastoma (RB) tumor suppressor protein is a transcriptional cofactor with essential roles in cell cycle and development...
  33. Korenjak M, Taylor Harding B, Binné U, Satterlee J, Stevaux O, Aasland R, et al. Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes. Cell. 2004;119:181-93 pubmed
    The retinoblastoma tumor suppressor protein (pRb) regulates gene transcription by binding E2F transcription factors...
  34. DiAngelo J, Birnbaum M. Regulation of fat cell mass by insulin in Drosophila melanogaster. Mol Cell Biol. 2009;29:6341-52 pubmed publisher
  35. Steele L, Sukhanova M, Xu J, Gordon G, Huang Y, Yu L, et al. Retinoblastoma family protein promotes normal R8-photoreceptor differentiation in the absence of rhinoceros by inhibiting dE2F1 activity. Dev Biol. 2009;335:228-36 pubmed publisher
    The retinoblastoma gene Rb is a prototype tumor suppressor which is conserved in Drosophila. Although much is known about the roles of Rb in cell proliferation and apoptosis, much less is known about how Rb regulates cell differentiation...
  36. Weng L, Zhu C, Xu J, Du W. Critical role of active repression by E2F and Rb proteins in endoreplication during Drosophila development. EMBO J. 2003;22:3865-75 pubmed
    ..dE2F1(su89) is a novel allele of dE2F1 that disrupts dE2F1's association with RBF [the Drosophila retinoblastoma protein (Rb) homolog] but retains its transcription activation function...
  37. Ambrus A, Nicolay B, Rasheva V, Suckling R, Frolov M. dE2F2-independent rescue of proliferation in cells lacking an activator dE2F1. Mol Cell Biol. 2007;27:8561-70 pubmed
    ..Thus, mutation of bel relieves the dE2F2-mediated cell cycle arrest in de2f1 mutant cells through a novel Ci155-dependent mechanism without functional inactivation of the dE2F2 repressor. ..
  38. Frolov M, Huen D, Stevaux O, Dimova D, Balczarek Strang K, Elsdon M, et al. Functional antagonism between E2F family members. Genes Dev. 2001;15:2146-60 pubmed
    ..This study shows how repressor and activator E2Fs are used to pattern transcription and how the net effect of E2F on cell proliferation results from the interplay between two types of E2F complexes that have antagonistic functions. ..
  39. Shcherbata H, Althauser C, Findley S, Ruohola Baker H. The mitotic-to-endocycle switch in Drosophila follicle cells is executed by Notch-dependent regulation of G1/S, G2/M and M/G1 cell-cycle transitions. Development. 2004;131:3169-81 pubmed
    ..This study provides a comprehensive picture of the logic that external signaling pathways may use to control cell cycle transitions by the coordinated regulation of the cell cycle. ..
  40. Nicolay B, Bayarmagnai B, Moon N, Benevolenskaya E, Frolov M. Combined inactivation of pRB and hippo pathways induces dedifferentiation in the Drosophila retina. PLoS Genet. 2010;6:e1000918 pubmed publisher
    Functional inactivation of the Retinoblastoma (pRB) pathway is an early and obligatory event in tumorigenesis. The importance of pRB is usually explained by its ability to promote cell cycle exit...
  41. Milet C, Rincheval Arnold A, Mignotte B, Guenal I. The Drosophila retinoblastoma protein induces apoptosis in proliferating but not in post-mitotic cells. Cell Cycle. 2010;9:97-103 pubmed
    The retinoblastoma protein, pRb, plays important roles in many processes implicated in cell fate decisions, including cell cycle, differentiation and apoptosis...
  42. Firth L, Baker N. Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye. Dev Cell. 2005;8:541-51 pubmed
    ..Unusually, Cyclin E levels are not limiting for retinal cell cycles. Rbf/E2F and the Cyclin E antagonist Dacapo are important, however...
  43. Manning A, Longworth M, Dyson N. Loss of pRB causes centromere dysfunction and chromosomal instability. Genes Dev. 2010;24:1364-76 pubmed publisher
    ..By monitoring chromosome segregation, we show that depletion of the retinoblastoma protein (pRB) causes rates of missegregation comparable with those seen in CIN tumor cells...
  44. Prober D, Edgar B. Ras1 promotes cellular growth in the Drosophila wing. Cell. 2000;100:435-46 pubmed
    ..We propose that Ras primarily promotes growth and that growth is coupled to G1/S progression via cyclin E. Interestingly, upregulation of growth by Ras did not deregulate G2/M progression or a developmentally regulated cell cycle exit. ..
  45. Popova M, He W, Korenjak M, Dyson N, Moon N. Rb deficiency during Drosophila eye development deregulates EMC, causing defects in the development of photoreceptors and cone cells. J Cell Sci. 2011;124:4203-12 pubmed publisher
    b>Retinoblastoma tumor suppressor protein (pRb) regulates various biological processes during development and tumorigenesis...
  46. Elenbaas J, Mouawad R, Henry R, Arnosti D, Payankaulam S. Role of Drosophila retinoblastoma protein instability element in cell growth and proliferation. Cell Cycle. 2015;14:589-97 pubmed publisher
    ..We recently described an evolutionarily conserved C-terminal "instability element" (IE) of the Drosophila Rbf1 retinoblastoma protein that regulates its turnover...
  47. Miles W, Korenjak M, Griffiths L, Dyer M, Provero P, Dyson N. Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells. EMBO J. 2014;33:2201-15 pubmed publisher
    Inactivation of the retinoblastoma tumor suppressor (pRb) is a common oncogenic event that alters the expression of genes important for cell cycle progression, senescence, and apoptosis...
  48. Ahlander J, Bosco G. Sqd interacts with the Drosophila retinoblastoma tumor suppressor Rbf. Biochem Biophys Res Commun. 2009;383:363-7 pubmed publisher
    The retinoblastoma tumor suppressor (RB) serves as a scaffold to coordinate binding of numerous proteins, including E2F and histone deacetylases, through its C-terminal domain...
  49. Datar S, Galloni M, de la Cruz A, Marti M, Edgar B, Frei C. Mammalian cyclin D1/Cdk4 complexes induce cell growth in Drosophila. Cell Cycle. 2006;5:647-52 pubmed
    ..Furthermore, Hif-1 prolyl hydroxylase (Hph) is required for both complexes to drive growth. Our data suggest that the growth-specific function of CycD/Cdk4 is conserved from arthropods to mammals. ..
  50. Kuzin B, Regulski M, Stasiv Y, Scheinker V, Tully T, Enikolopov G. Nitric oxide interacts with the retinoblastoma pathway to control eye development in Drosophila. Curr Biol. 2000;10:459-62 pubmed
    ..larvae, cell cycle progression is controlled by a modified version of the well-characterized mammalian retinoblastoma (Rb) pathway [3] [4], which integrates signals from multiple effectors ranging from growth factors and ..
  51. Datar S, Jacobs H, de la Cruz A, Lehner C, Edgar B. The Drosophila cyclin D-Cdk4 complex promotes cellular growth. EMBO J. 2000;19:4543-54 pubmed
    ..Their levels rise upon growth factor stimulation, and they can phosphorylate and thus neutralize Retinoblastoma (Rb) family proteins to promote an E2F-dependent transcriptional program and S-phase entry...
  52. Potter C, Xu T. Mechanisms of size control. Curr Opin Genet Dev. 2001;11:279-86 pubmed
    ..The mechanisms of organ size control could also be critical targets for evolutionary events or disease processes such as tumorigenesis. ..
  53. Zhang T, Liao Y, Hsu F, Zhang R, Searle J, Pei X, et al. Hyperactivated Wnt signaling induces synthetic lethal interaction with Rb inactivation by elevating TORC1 activities. PLoS Genet. 2014;10:e1004357 pubmed publisher
    ..to metabolic stress induced by fasting, and induces synergistic apoptosis with mutation of fly Rb ortholog, rbf. Furthermore, hyperactivation of Wg signaling by other components of the Wg pathway also induces synergistic ..
  54. Nedelsky N, Pennuto M, Smith R, Palazzolo I, Moore J, Nie Z, et al. Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy. Neuron. 2010;67:936-52 pubmed publisher
    ..These findings indicate that SBMA pathogenesis is mediated by misappropriation of native protein function, a mechanism that may apply broadly to polyglutamine diseases...
  55. Silver D, Montell D. A new trick for Cyclin-Cdk: activation of STAT. Dev Cell. 2003;4:148-9 pubmed
    ..Cdk4 overexpression can bypass requirements for JAK but not STAT. These results demonstrate a new function for Cdk4 and a new mode of STAT activation. ..
  56. Martín Castellanos C, Edgar B. A characterization of the effects of Dpp signaling on cell growth and proliferation in the Drosophila wing. Development. 2002;129:1003-13 pubmed
    ..Stimulation of cell cycle progression by Tkv(Q253D) was blocked by the cell cycle inhibitor RBF, and required normal activity of the growth effector, PI3K...
  57. Zhang L, Wei Y, Pushel I, Heinze K, Elenbaas J, Henry R, et al. Integrated stability and activity control of the Drosophila Rbf1 retinoblastoma protein. J Biol Chem. 2014;289:24863-73 pubmed publisher
    The retinoblastoma (RB) family transcriptional corepressors regulate diverse cellular events including cell cycle, senescence, and differentiation...
  58. Milet C, Rincheval Arnold A, Moriéras A, Clavier A, Garrigue A, Mignotte B, et al. Mutating RBF can enhance its pro-apoptotic activity and uncovers a new role in tissue homeostasis. PLoS ONE. 2014;9:e102902 pubmed publisher
    The tumor suppressor retinoblastoma protein (pRb) is inactivated in a wide variety of cancers...
  59. Gilbert M, Robinson B, Moberg K. Functional interactions between the erupted/tsg101 growth suppressor gene and the DaPKC and rbf1 genes in Drosophila imaginal disc tumors. PLoS ONE. 2009;4:e7039 pubmed publisher
    ..through the G1-to-S phase transition and express reduced levels of the tumor suppressor ortholog and G1/S inhibitor Rbf1. Genetic reductions of the Drosophila aPKC kinase (DaPKC), which has been shown to promote tumor growth in other ..
  60. Campuzano S. Emc, a negative HLH regulator with multiple functions in Drosophila development. Oncogene. 2001;20:8299-307 pubmed
    ..However, while maintaining this repressive molecular mechanism, emc also appears to act as a positive regulator of differentiation...
  61. Miles W, Tschop K, Herr A, Ji J, Dyson N. Pumilio facilitates miRNA regulation of the E2F3 oncogene. Genes Dev. 2012;26:356-68 pubmed publisher
    ..These studies suggest that Pumilio-miRNA repression of E2F3 translation provides an important level of E2F regulation that is frequently abrogated in cancer cells. ..