Gene Symbol: rasp
Description: rasp
Alias: 7F21, CG11495, Dmel\CG11495, RASP, Rasp, cmn, cnm, l(3)63Bg, l(3)M47, l(3)SG3, l(3)m47, rsp, sig/ski, sit, ski, ski/sit, rasp, CG11495-PA, central missing, lethal(3)63Bg, lethal(3)SG3, rasp-PA, sightless, skinny hedgehog
Species: fruit fly

Top Publications

  1. Miura G, Buglino J, Alvarado D, Lemmon M, Resh M, Treisman J. Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion. Dev Cell. 2006;10:167-76 pubmed
    ..Wnt families are also palmitoylated; this modification, which requires the related transmembrane acyltransferases Rasp and Porcupine, can enhance their secretion, transport, or activity...
  2. Chamoun Z, Mann R, Nellen D, von Kessler D, Bellotto M, Beachy P, et al. Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal. Science. 2001;293:2080-4 pubmed
    ..Here, we identify a segment polarity gene in Drosophila melanogaster, skinny hedgehog (ski), and show that its product is required in Hh-expressing cells for production of appropriate signaling ..
  3. Lee J, Treisman J. Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein. Curr Biol. 2001;11:1147-52 pubmed
    ..We have identified a novel gene, sightless (sit), which is required for the activity of Drosophila Hh in the eye and wing imaginal discs and in embryonic ..
  4. Micchelli C, The I, Selva E, Mogila V, Perrimon N. Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling. Development. 2002;129:843-51 pubmed
    ..In a screen for zygotic lethal mutations associated with maternal effects, we have identified rasp, a novel Drosophila segment polarity gene...
  5. Gatti M, Baker B. Genes controlling essential cell-cycle functions in Drosophila melanogaster. Genes Dev. 1989;3:438-53 pubmed
  6. Hayashi R, Wainwright S, Liddell S, Pinchin S, Horswell S, Ish Horowicz D. A genetic screen based on in vivo RNA imaging reveals centrosome-independent mechanisms for localizing gurken transcripts in Drosophila. G3 (Bethesda). 2014;4:749-60 pubmed publisher
    ..grk mRNA localization and other aspects of oogenesis, including alleles of elg1, scaf6, quemao, nudE, Tsc2/gigas, rasp, and Chd5/Wrb, and several null alleles of the armitage Piwi-pathway gene...
  7. Vincent J, Magee T. Argosomes: membrane fragments on the run. Trends Cell Biol. 2002;12:57-60 pubmed
    ..Recent work demonstrates the transfer of membrane fragments in a live epithelium and, importantly, suggests that these fragments might be used as a vehicle to transport morphogens in a developing tissue. ..
  8. Steinhauer J, Gijón M, Riekhof W, Voelker D, Murphy R, Treisman J. Drosophila lysophospholipid acyltransferases are specifically required for germ cell development. Mol Biol Cell. 2009;20:5224-35 pubmed publisher
    ..Our findings suggest that lysophospholipid acyltransferase activity is essential for germline development and could provide a mechanistic explanation for the etiology of the human MBOAT1 mutation. ..
  9. Linder M, Deschenes R. Model organisms lead the way to protein palmitoyltransferases. J Cell Sci. 2004;117:521-6 pubmed
    ..b>Rasp is required in vivo for the production of functional Hedgehog and shares sequence identity with membrane-bound O-..

More Information


  1. Wendler F, Franch Marro X, Vincent J. How does cholesterol affect the way Hedgehog works?. Development. 2006;133:3055-61 pubmed
    ..However, the absence of the cholesterol adduct affects the spread of Hh within tissues. As we discuss here, the exact nature of this effect is controversial. ..
  2. Hardy R, Resh M. Identification of N-terminal residues of Sonic Hedgehog important for palmitoylation by Hedgehog acyltransferase. J Biol Chem. 2012;287:42881-9 pubmed publisher
    ..However, an N-terminal Ser served as a substrate for Hhat, but not the Drosophila melanogaster ortholog Rasp, highlighting a critical difference between the mammalian and fly enzymes...
  3. Steinhauer J, Liu H, Miller E, Treisman J. Trafficking of the EGFR ligand Spitz regulates its signaling activity in polarized tissues. J Cell Sci. 2013;126:4469-78 pubmed publisher
    ..Taken together, our data support the model that localized trafficking of the pro-protein restricts its ability to activate the receptor in polarized tissues. ..
  4. Wohlwill A, Bonner J. Genetic analysis of chromosome region 63 of Drosophila melanogaster. Genetics. 1991;128:763-75 pubmed
    ..Four loci, including the Minute gene, are candidates for hsp82 mutations by cytogenetic mapping. These loci were tested for complementation with a P element carrying the hsp82 gene. However, none of the mutations was rescued...
  5. Amanai K, Jiang J. Distinct roles of Central missing and Dispatched in sending the Hedgehog signal. Development. 2001;128:5119-27 pubmed
    ..In addition, we identified a novel component in the hh pathway, which we name central missing (cmn)...
  6. Ingham P. Hedgehog signaling: a tale of two lipids. Science. 2001;294:1879-81 pubmed
    ..Recent studies suggest that the lipid adducts regulate the range and potency of the signals, whereas the sterol-sensing domain is essential for receptor activity. ..
  7. Linder M, Deschenes R. New insights into the mechanisms of protein palmitoylation. Biochemistry. 2003;42:4311-20 pubmed
    ..This review discusses recent advances in the understanding of mechanisms of addition of palmitate to proteins and removal of palmitate from proteins. ..
  8. Nusse R. Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface. Development. 2003;130:5297-305 pubmed
    ..Several other aspects of Wnt and Hedgehog transport and signaling are discussed, as well as the possible origin of these pathways. ..
  9. Dawber R, Hebbes S, Herpers B, Docquier F, van den Heuvel M. Differential range and activity of various forms of the Hedgehog protein. BMC Dev Biol. 2005;5:21 pubmed
  10. Shearn A, Rice T, Garen A, Gehring W. Imaginal disc abnormalities in lethal mutants of Drosophila. Proc Natl Acad Sci U S A. 1971;68:2594-8 pubmed
    ..The late lethals are therefore a major source of mutants for studying the genetic control of disc formation. ..
  11. Lum L, Beachy P. The Hedgehog response network: sensors, switches, and routers. Science. 2004;304:1755-9 pubmed