Gene Symbol: qm
Description: quemao
Alias: CG8593, Dmel\CG8593, GGPPS, GGPPS/qm, bro2, quemao, CG8593-PA, CG8593-PB, CG8593-PC, geranylgeranyl pyrophosphate synthase, qm-PA, qm-PB, qm-PC, que mao
Species: fruit fly

Top Publications

  1. Lai C, McMahon R, Young C, Mackay T, Langley C. quemao, a Drosophila bristle locus, encodes geranylgeranyl pyrophosphate synthase. Genetics. 1998;149:1051-61 pubmed
    ..region of the qm transcript shares 42, 31, 13, 20, and 12% identical amino acid sequences with the geranylgeranyl pyrophosphate synthase (GGPPS) of fungi, yeast, plants, archaebacteria, and eubacteria, respectively...
  2. Santos A, Lehmann R. Isoprenoids control germ cell migration downstream of HMGCoA reductase. Dev Cell. 2004;6:283-93 pubmed
    ..The specificity and evolutionary conservation of the HMGCoAr pathway for germ cells suggest that an attractant common to invertebrates and vertebrates guides germ cells in early embryos. ..
  3. Yi P, Han Z, Li X, Olson E. The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1. Science. 2006;313:1301-3 pubmed
    ..Our findings reveal a cardial cell-autonomous requirement of Ggamma1 geranylgeranylation for heart formation and suggest the involvement of the mevalonate pathway in congenital heart disease. ..
  4. Deshpande G, Godishala A, Schedl P. Ggamma1, a downstream target for the hmgcr-isoprenoid biosynthetic pathway, is required for releasing the Hedgehog ligand and directing germ cell migration. PLoS Genet. 2009;5:e1000333 pubmed publisher
    ..We show that, like hmgcr, ggamma1 and quemao (which encodes the enzyme, geranylgeranyl diphosphate synthetase, that produces the substrate for geranylation of ..
  5. Mackay T, Fry J. Polygenic mutation in Drosophila melanogaster: genetic interactions between selection lines and candidate quantitative trait loci. Genetics. 1996;144:671-88 pubmed
    ..It is possible that much of the response to selection was from new mutations at candidate bristle number quantitative trait loci, and that for some of these loci, mutation rates were high. ..
  6. Lai C, Langley C. A homologue of the 19 kDa signal recognition particle protein locus in Drosophila melanogaster. Gene. 1997;203:59-63 pubmed
    ..It is located in the 65F region of the left arm on the third chromosome, approx. 500 bp 5' of the quemao locus...
  7. Mohan M, Bartkuhn M, Herold M, Philippen A, Heinl N, Bardenhagen I, et al. The Drosophila insulator proteins CTCF and CP190 link enhancer blocking to body patterning. EMBO J. 2007;26:4203-14 pubmed
    ..A short pulse of dCTCF expression during larval development rescues the dCTCF loss of function phenotype. Overall, we demonstrate the importance of dCTCF in fly development and in the regulation of abdominal segmentation. ..
  8. Hayashi R, Wainwright S, Liddell S, Pinchin S, Horswell S, Ish Horowicz D. A genetic screen based on in vivo RNA imaging reveals centrosome-independent mechanisms for localizing gurken transcripts in Drosophila. G3 (Bethesda). 2014;4:749-60 pubmed publisher
    ..groups affecting grk mRNA localization and other aspects of oogenesis, including alleles of elg1, scaf6, quemao, nudE, Tsc2/gigas, rasp, and Chd5/Wrb, and several null alleles of the armitage Piwi-pathway gene...
  9. Gurganus M, Nuzhdin S, Leips J, Mackay T. High-resolution mapping of quantitative trait loci for sternopleural bristle number in Drosophila melanogaster. Genetics. 1999;152:1585-604 pubmed

More Information


  1. Gerasimova T, Lei E, Bushey A, Corces V. Coordinated control of dCTCF and gypsy chromatin insulators in Drosophila. Mol Cell. 2007;28:761-72 pubmed
  2. Jones J, Macdonald P. Neurl4 contributes to germ cell formation and integrity in Drosophila. Biol Open. 2015;4:937-46 pubmed publisher
    ..Reducing CP110 activity suppresses the abnormal PGC morphology of Neurl4 mutants. These results extend prior analyses of Neurl4 in cultured cells, revealing a heightened requirement for Neurl4 in germ-line cells in Drosophila. ..
  3. Deshpande G, Zhou K, Wan J, Friedrich J, Jourjine N, Smith D, et al. The hedgehog pathway gene shifted functions together with the hmgcr-dependent isoprenoid biosynthetic pathway to orchestrate germ cell migration. PLoS Genet. 2013;9:e1003720 pubmed publisher
    ..Finally, potentiation of Hh by hmgcr appears to depend upon cholesterol modification. ..