Gene Symbol: PyK
Description: Pyruvate kinase
Alias: CG7070, Dmel\CG7070, PYK, Pyk, l(3)rQ178, l(3)r[Q178], pyruvate kinase, CG7070-PA, CG7070-PB, PyK-PA, PyK-PB, lethal (3) rQ178
Species: fruit fly

Top Publications

  1. Tixier V, Bataillé L, Etard C, Jagla T, Weger M, Daponte J, et al. Glycolysis supports embryonic muscle growth by promoting myoblast fusion. Proc Natl Acad Sci U S A. 2013;110:18982-7 pubmed publisher
    ..our screen identifies six other genes involved in glycolysis or in pyruvate metabolism (Pfk, Tpi, Gapdh, Pgk, Pyk, and Impl3)...
  2. Saha N, Liu M, Gajan A, Pile L. Genome-wide studies reveal novel and distinct biological pathways regulated by SIN3 isoforms. BMC Genomics. 2016;17:111 pubmed publisher
    ..These data establish the role of SIN3 isoforms in regulating distinct biological processes. This study substantially contributes to our understanding of the complexity of gene regulation by SIN3. ..
  3. Zeng Q, Avilov V, Shippy S. Prefractionation methods for individual adult fruit fly hemolymph proteomic analysis. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;1015-1016:74-81 pubmed publisher
    ..The demonstration of this method establishes a means to deepen proteomic analysis to this commonly used, important biological model system. ..
  4. Thomson T, Liu N, Arkov A, Lehmann R, Lasko P. Isolation of new polar granule components in Drosophila reveals P body and ER associated proteins. Mech Dev. 2008;125:865-73 pubmed publisher
    ..Our recovery of ER associated proteins TER94 and ME31B confirms that polar granules are closely linked to the translational machinery and to mRNP assembly. ..
  5. Schriner S, Lee K, Truong S, Salvadora K, Maler S, Nam A, et al. Extension of Drosophila lifespan by Rhodiola rosea through a mechanism independent from dietary restriction. PLoS ONE. 2013;8:e63886 pubmed publisher
    ..The latter conclusion is especially relevant given the limited potential for DR to improve human health and lifespan, and presents R. rosea as a potential viable candidate to treat aging and age-related diseases in humans. ..
  6. Wang T, Montell C. Rhodopsin formation in Drosophila is dependent on the PINTA retinoid-binding protein. J Neurosci. 2005;25:5187-94 pubmed
    ..Moreover, our data implicate Drosophila retinal pigment cells as functioning in the conversion of dietary all-trans-retinol to 11-cis-retinal and suggest that these cells are the closest invertebrate equivalent to the RPE. ..
  7. Parisi F, Riccardo S, Zola S, Lora C, Grifoni D, Brown L, et al. dMyc expression in the fat body affects DILP2 release and increases the expression of the fat desaturase Desat1 resulting in organismal growth. Dev Biol. 2013;379:64-75 pubmed publisher
    ..In addition, the regulation of Desat1 controls the synthesis of triglycerides in FB and this may affect the humoral signal that controls DILP2 release in the brain. ..
  8. Buescher J, Musselman L, Wilson C, Lang T, Keleher M, Baranski T, et al. Evidence for transgenerational metabolic programming in Drosophila. Dis Model Mech. 2013;6:1123-32 pubmed publisher
    ..Our data indicate that nutritional programming mechanisms could be highly conserved and support the use of Drosophila as a model for evaluating the underlying genetic and epigenetic contributions to this phenomenon. ..
  9. Gao M, Thomson T, Creed T, Tu S, Loganathan S, Jackson C, et al. Glycolytic enzymes localize to ribonucleoprotein granules in Drosophila germ cells, bind Tudor and protect from transposable elements. EMBO Rep. 2015;16:379-86 pubmed publisher
    ..Our data indicate that germ cells, similarly to stem cells and tumor cells, might prefer to produce energy through the glycolytic pathway, thus linking a particular metabolism to pluripotency. ..

More Information


  1. Rust K, Collier G. Localization of a dosage sensitive region for pyruvate kinase in Drosophila melanogaster. J Hered. 1985;76:39-44 pubmed
    ..segment of chromosome 1, 12AB-12C, in Drosophila melanogaster is dosage-sensitive for the glycolytic enzyme pyruvate kinase (EC We suggest that the enzyme is coded by a gene, Pyk+, located within this region...
  2. Clyne P, Brotman J, Sweeney S, Davis G. Green fluorescent protein tagging Drosophila proteins at their native genomic loci with small P elements. Genetics. 2003;165:1433-41 pubmed
    ..This technology allows the generation of GFP-tagged reagents on a genome-wide scale with diverse potential applications. ..
  3. Eanes W, Merritt T, Flowers J, Kumagai S, Sezgin E, Zhu C. Flux control and excess capacity in the enzymes of glycolysis and their relationship to flight metabolism in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2006;103:19413-8 pubmed
    ..Furthermore, enzymes catalyzing near-equilibrium reactions show strong genetic dominance down to low levels of activity. This implies considerable excess enzyme capacity for these enzymes. ..
  4. Garrido D, Rubin T, Poidevin M, Maroni B, Le Rouzic A, Parvy J, et al. Fatty acid synthase cooperates with glyoxalase 1 to protect against sugar toxicity. PLoS Genet. 2015;11:e1004995 pubmed publisher
    ..In contrast, FA-synthesis appears to be required to limit a cell-autonomous accumulation of MG-derived-AGEs, supporting the notion that MG is the most deleterious α-oxoaldehyde at the intracellular level. ..