pum

Summary

Gene Symbol: pum
Description: pumilio
Alias: CG9755, CG9763, Dmel\CG9755, EP(3)0883, PKL, PUM, Pum, anon-WO0172774.19, bem, fs(3)02003, l(3)01688, ova, ovt, pkl, pumilio, CG9755-PA, CG9755-PB, CG9755-PC, CG9755-PD, CG9755-PE, CG9755-PF, CG9755-PG, CG9755-PH, bemused, milord, ovarette, pum-PA, pum-PB, pum-PC, pum-PD, pum-PE, pum-PF, pum-PG, pum-PH, pumillio, pumuckel
Species: fruit fly

Top Publications

  1. Li Y, Minor N, Park J, McKearin D, Maines J. Bam and Bgcn antagonize Nanos-dependent germ-line stem cell maintenance. Proc Natl Acad Sci U S A. 2009;106:9304-9 pubmed publisher
    ..and differentiation in Drosophila ovaries is mediated by the antagonistic relationship between the Nanos (Nos)-Pumilio translational repressor complex, which promotes GSC self-renewal, and expression of Bam, a key differentiation ..
  2. Szakmary A, Cox D, Wang Z, Lin H. Regulatory relationship among piwi, pumilio, and bag-of-marbles in Drosophila germline stem cell self-renewal and differentiation. Curr Biol. 2005;15:171-8 pubmed
    ..piwi and pumilio (pum) are essential for GSC self-renewal, whereas bag-of-marbles (bam) is required for cystoblast differentiation...
  3. Ye B, Petritsch C, Clark I, Gavis E, Jan L, Jan Y. Nanos and Pumilio are essential for dendrite morphogenesis in Drosophila peripheral neurons. Curr Biol. 2004;14:314-21 pubmed
    ..For example, long-term memory in adult Drosophila requires Pumilio (Pum), an RNA binding protein that interacts with the RNA binding protein Nanos (Nos) to form a localized ..
  4. Zamore P, Williamson J, Lehmann R. The Pumilio protein binds RNA through a conserved domain that defines a new class of RNA-binding proteins. RNA. 1997;3:1421-33 pubmed
    ..Translational repression also requires the action of two proteins: Pumilio (PUM), a sequence-specific RNA-binding protein; and Nanos, a protein that determines the location of repression...
  5. Verrotti A, Wharton R. Nanos interacts with cup in the female germline of Drosophila. Development. 2000;127:5225-32 pubmed
    ..is a translational regulator that governs abdominal segmentation of the Drosophila embryo in collaboration with Pumilio (Pum)...
  6. Cho P, Gamberi C, Cho Park Y, Cho Park I, Lasko P, Sonenberg N. Cap-dependent translational inhibition establishes two opposing morphogen gradients in Drosophila embryos. Curr Biol. 2006;16:2035-41 pubmed
    ..Inhibition of hb mRNA translation requires an mRNP complex (the NRE complex), which consists of Nanos (Nos), Pumilio (Pum), and Brain tumor (Brat) proteins, and the Nos responsive element (NRE) present in the 3' UTR of hb mRNA ...
  7. Muraro N, Weston A, Gerber A, Luschnig S, Moffat K, Baines R. Pumilio binds para mRNA and requires Nanos and Brat to regulate sodium current in Drosophila motoneurons. J Neurosci. 2008;28:2099-109 pubmed publisher
    ..Our previous work has identified the translational repressor Pumilio (Pum) as a regulator of sodium current (I(Na)) and excitability in Drosophila motoneurons...
  8. Dean K, Aggarwal A, Wharton R. Translational repressors in Drosophila. Trends Genet. 2002;18:572-7 pubmed
    ..These repressors do not work in isolation - each binds multiple sites in the appropriate mRNA, and the resulting RNA-protein complexes appear to recruit co-repressors by a variety of mechanisms. ..
  9. Schweers B, Walters K, Stern M. The Drosophila melanogaster translational repressor pumilio regulates neuronal excitability. Genetics. 2002;161:1177-85 pubmed
    ..One such mutant is the P-element insertion mutant bemused (bem). The bem mutant exhibits female sterility, sluggishness, and increased motor neuron excitability...

More Information

Publications86

  1. Loedige I, Stotz M, Qamar S, Kramer K, Hennig J, Schubert T, et al. The NHL domain of BRAT is an RNA-binding domain that directly contacts the hunchback mRNA for regulation. Genes Dev. 2014;28:749-64 pubmed publisher
    The Drosophila protein brain tumor (Brat) forms a complex with Pumilio (Pum) and Nanos (Nos) to repress hunchback (hb) mRNA translation at the posterior pole during early embryonic development...
  2. Wang Z, Lin H. Nanos maintains germline stem cell self-renewal by preventing differentiation. Science. 2004;303:2016-9 pubmed
    ..Thus, Nanos is essential for both establishing and maintaining GSCs by preventing their precocious entry into oogenesis. These functions are likely achieved by repressing the translation of differentiation factors in PGCs and GSCs. ..
  3. Macdonald P. The Drosophila pumilio gene: an unusually long transcription unit and an unusual protein. Development. 1992;114:221-32 pubmed
    ..During embryogenesis this determinant appears to move anteriorly in a process dependent on the pumilio (pum) gene...
  4. Gilboa L, Lehmann R. Repression of primordial germ cell differentiation parallels germ line stem cell maintenance. Curr Biol. 2004;14:981-6 pubmed
    ..Furthermore, PGCs that are mutant for nanos (nos), pumilio (pum) or for signaling components of the decapentaplegic (dpp) pathway also differentiate...
  5. Mee C, Pym E, Moffat K, Baines R. Regulation of neuronal excitability through pumilio-dependent control of a sodium channel gene. J Neurosci. 2004;24:8695-703 pubmed
    ..Thus, para mRNA is significantly elevated in a loss-of-function allele of pum (pum(bemused)), whereas expression of a full-length pum transgene is sufficient to reduce para mRNA...
  6. Gamberi C, Peterson D, He L, Gottlieb E. An anterior function for the Drosophila posterior determinant Pumilio. Development. 2002;129:2699-710 pubmed
    Bicoid is a key determinant of anterior Drosophila development. We demonstrate that the prototypical Puf protein Pumilio temporally regulates bicoid (bcd) mRNA translation via evolutionarily conserved Nanos response elements (NRE) in its ..
  7. Wharton R, Sonoda J, Lee T, Patterson M, Murata Y. The Pumilio RNA-binding domain is also a translational regulator. Mol Cell. 1998;1:863-72 pubmed
    Posterior patterning in the Drosophila embryo requires the action of Nanos (Nos) and Pumilio (Pum), which collaborate to regulate the translation of maternal hunchback (hb) mRNA...
  8. Chen G, Li W, Zhang Q, Regulski M, Sinha N, Barditch J, et al. Identification of synaptic targets of Drosophila pumilio. PLoS Comput Biol. 2008;4:e1000026 pubmed publisher
    Drosophila Pumilio (Pum) protein is a translational regulator involved in embryonic patterning and germline development...
  9. Barker D, Wang C, Moore J, Dickinson L, Lehmann R. Pumilio is essential for function but not for distribution of the Drosophila abdominal determinant Nanos. Genes Dev. 1992;6:2312-26 pubmed
    The Drosophila gene pumilio is expressed maternally, and its function is essential during early embryogenesis for the formation of abdominal segments...
  10. Kadyrova L, Habara Y, Lee T, Wharton R. Translational control of maternal Cyclin B mRNA by Nanos in the Drosophila germline. Development. 2007;134:1519-27 pubmed
    In the Drosophila embryo, Nanos and Pumilio collaborate to repress the translation of hunchback mRNA in the somatic cytoplasm...
  11. Kim J, Lee Y, Kim C. Direct inhibition of Pumilo activity by Bam and Bgcn in Drosophila germ line stem cell differentiation. J Biol Chem. 2010;285:4741-6 pubmed publisher
    ..The RNA-binding translational repressor Pumilio (Pum) in conjunction with Nanos (Nos) is required for self-renewal, whereas Bam (bag-of-marbles) and Bgcn (benign ..
  12. Chau J, Kulnane L, Salz H. Sex-lethal facilitates the transition from germline stem cell to committed daughter cell in the Drosophila ovary. Genetics. 2009;182:121-32 pubmed publisher
    ..Together these data demonstrate a novel role for Sxl in the lineage progression from stem cell to committed daughter cell and suggest a model in which Sxl partners with bam to facilitate this transition. ..
  13. Murata Y, Wharton R. Binding of pumilio to maternal hunchback mRNA is required for posterior patterning in Drosophila embryos. Cell. 1995;80:747-56 pubmed
    ..One of the NRE-binding factors is encoded by pumilio (pum), a gene that, like nos, is essential for abdominal segmentation...
  14. Sonoda J, Wharton R. Drosophila Brain Tumor is a translational repressor. Genes Dev. 2001;15:762-73 pubmed
    ..assay, we show that Brain Tumor is recruited to hunchback (hb) mRNA through interactions with Nanos and Pumilio, which bind to the RNA to repress its translation...
  15. Parisi M, Lin H. The Drosophila pumilio gene encodes two functional protein isoforms that play multiple roles in germline development, gonadogenesis, oogenesis and embryogenesis. Genetics. 1999;153:235-50 pubmed
    ..Here we report on a phenotypic analysis using pum(ovarette) mutations, which reveals multiple functions of pum in primordial germ cell proliferation, larval ovary formation,..
  16. Menon K, Sanyal S, Habara Y, Sanchez R, Wharton R, Ramaswami M, et al. The translational repressor Pumilio regulates presynaptic morphology and controls postsynaptic accumulation of translation factor eIF-4E. Neuron. 2004;44:663-76 pubmed
    Translational repression by Drosophila Pumilio (Pum) protein controls posterior patterning during embryonic development...
  17. Dubnau J, Chiang A, Grady L, Barditch J, Gossweiler S, McNeil J, et al. The staufen/pumilio pathway is involved in Drosophila long-term memory. Curr Biol. 2003;13:286-96 pubmed
    ..The pumilio translational repressor was found from both approaches, along with six additional genes with established roles in ..
  18. Asaoka Taguchi M, Yamada M, Nakamura A, Hanyu K, Kobayashi S. Maternal Pumilio acts together with Nanos in germline development in Drosophila embryos. Nat Cell Biol. 1999;1:431-7 pubmed
    The maternal RNA-binding proteins Pumilio (Pum) and Nanos (Nos) act together to specify the abdomen in Drosophila embryos. Both proteins later accumulate in pole cells, the germline progenitors...
  19. Sonoda J, Wharton R. Recruitment of Nanos to hunchback mRNA by Pumilio. Genes Dev. 1999;13:2704-12 pubmed
    ..region of hb mRNA (the Nanos response elements or NREs), as well as two trans-acting factors-Nanos and Pumilio. Pumilio recognizes the NREs via a conserved binding motif. The mechanism of Nanos action has not been clear...
  20. Chen D, McKearin D. Gene circuitry controlling a stem cell niche. Curr Biol. 2005;15:179-84 pubmed
    ..In Drosophila, germline stem cell (GSC) maintenance requires regulation of several genes, including dpp, piwi, pumilio, and bam...
  21. Shi W, Chen Y, Gan G, Wang D, Ren J, Wang Q, et al. Brain tumor regulates neuromuscular synapse growth and endocytosis in Drosophila by suppressing mad expression. J Neurosci. 2013;33:12352-63 pubmed publisher
    ..These results together reveal an important and previously unidentified role for Brat in synaptic development and endocytosis mediated by suppression of BMP signaling. ..
  22. Harris R, Pargett M, Sutcliffe C, Umulis D, Ashe H. Brat promotes stem cell differentiation via control of a bistable switch that restricts BMP signaling. Dev Cell. 2011;20:72-83 pubmed publisher
    Drosophila ovarian germline stem cells (GSCs) are maintained by Dpp signaling and the Pumilio (Pum) and Nanos (Nos) translational repressors...
  23. Forbes A, Lehmann R. Nanos and Pumilio have critical roles in the development and function of Drosophila germline stem cells. Development. 1998;125:679-90 pubmed
    The zinc-finger protein Nanos and the RNA-binding protein Pumilio act together to repress the translation of maternal hunchback RNA in the posterior of the Drosophila embryo, thereby allowing abdomen formation...
  24. Zamore P, Bartel D, Lehmann R, Williamson J. The PUMILIO-RNA interaction: a single RNA-binding domain monomer recognizes a bipartite target sequence. Biochemistry. 1999;38:596-604 pubmed
    ..The PUMILIO (PUM) protein is thought to bind the NREs and thereby repress hb translation...
  25. Newton F, Harris R, Sutcliffe C, Ashe H. Coordinate post-transcriptional repression of Dpp-dependent transcription factors attenuates signal range during development. Development. 2015;142:3362-73 pubmed publisher
    ..one GSC daughter differentiates into a cystoblast (CB) and this fate is stabilised by Brain tumour (Brat) and Pumilio (Pum)-mediated post-transcriptional repression of mRNAs, including that encoding the Dpp transducer, Mad...
  26. Miles W, Tschop K, Herr A, Ji J, Dyson N. Pumilio facilitates miRNA regulation of the E2F3 oncogene. Genes Dev. 2012;26:356-68 pubmed publisher
    ..This screen identified components of the Pumilio translational repressor complex (Pumilio, Nanos, and Brain tumor) as suppressors of dE2F1-RNAi phenotypes...
  27. Jack T, McGinnis W. Establishment of the Deformed expression stripe requires the combinatorial action of coordinate, gap and pair-rule proteins. EMBO J. 1990;9:1187-98 pubmed
    ..In addition, the activation code for Deformed is redundant; other pair-rule genes in addition to even-skipped can apparently act in combination with bicoid and hunchback to activate Deformed. ..
  28. Kim Ha J, Smith J, Macdonald P. oskar mRNA is localized to the posterior pole of the Drosophila oocyte. Cell. 1991;66:23-35 pubmed
    ..In addition, we find that nonsense oskar mutations disrupt osk mRNA localization, while missense oskar mutations do not. ..
  29. Spradling A, de Cuevas M, Drummond Barbosa D, Keyes L, Lilly M, Pepling M, et al. The Drosophila germarium: stem cells, germ line cysts, and oocytes. Cold Spring Harb Symp Quant Biol. 1997;62:25-34 pubmed
  30. Kuwabara P. Gametogenesis: keeping the male element under control. Curr Biol. 1998;8:R278-81 pubmed
    ..This switch involves repression of fem-3 mRNA, mediated by a protein that binds RNA through a conserved motif; a similar motif mediates RNA binding by the Drosophila pattern-regulatory protein Pumilio.
  31. Tirronen M, Lahti V, Heino T, Roos C. Two otu transcripts are selectively localised in Drosophila oogenesis by a mechanism that requires a function of the otu protein. Mech Dev. 1995;52:65-75 pubmed
    ..The otu protein is also required for the correct distribution of the pumilio and oskar mRNAs, while the Bic-D, K10 and staufen mRNAs are localised in wild type fashion in otu mutants...
  32. Edwards T, Wilkinson B, Wharton R, Aggarwal A. Model of the brain tumor-Pumilio translation repressor complex. Genes Dev. 2003;17:2508-13 pubmed
    ..Recruitment is mediated by interactions between the Pumilio RNA-binding Puf repeats and the NHL domain of Brat, a conserved structural motif present in a large family of ..
  33. Ding D, Whittaker K, Lipshitz H. Mitochondrially encoded 16S large ribosomal RNA is concentrated in the posterior polar plasm of early Drosophila embryos but is not required for pole cell formation. Dev Biol. 1994;163:503-15 pubmed
    ..These data argue against previous hypotheses that the 16S RNA serves an obligatory function in pole cell formation. ..
  34. Flores H, DuMont V, Fatoo A, Hubbard D, Hijji M, Barbash D, et al. Adaptive evolution of genes involved in the regulation of germline stem cells in Drosophila melanogaster and D. simulans. G3 (Bethesda). 2015;5:583-92 pubmed publisher
    ..05. These genes play diverse roles in the regulation of germline stem cells, suggesting that positive selection in response to several evolutionary pressures may be acting to drive the adaptive evolution of these genes. ..
  35. Lin H. The tao of stem cells in the germline. Annu Rev Genet. 1997;31:455-91 pubmed
    ..In addition, the GSC mechanism is related to that for germline and sex determination. Current knowledge has provided a solid framework for further study of GSCs and stem cells in general. ..
  36. Nüsslein Volhard C. The bicoid morphogen papers (I): account from CNV. Cell. 2004;116:S1-5, 2 p following S9 pubmed
  37. Vardy L, Pesin J, Orr Weaver T. Regulation of Cyclin A protein in meiosis and early embryogenesis. Proc Natl Acad Sci U S A. 2009;106:1838-43 pubmed publisher
    ..PNG promotes further polyadenylation of cyclin A mRNA and appears to antagonize repression of translation by the PUMILIO inhibitor...
  38. Collart M, Panasenko O. The Ccr4--not complex. Gene. 2012;492:42-53 pubmed publisher
    ..This model suggests that the Ccr4-Not complex might function as a "chaperone platform". ..
  39. Hilgers V, Lemke S, Levine M. ELAV mediates 3' UTR extension in the Drosophila nervous system. Genes Dev. 2012;26:2259-64 pubmed publisher
    ..We propose that this mechanism for coordinating 3' UTR extension may be generally used in a variety of cellular processes. ..
  40. de Renzis S, Elemento O, Tavazoie S, Wieschaus E. Unmasking activation of the zygotic genome using chromosomal deletions in the Drosophila embryo. PLoS Biol. 2007;5:e117 pubmed
    ..We propose that this regulatory mode links morphogen gradients with temporal regulation during the maternal-to-zygotic transition. ..
  41. Ford D, Hoe N, Landis G, Tozer K, Luu A, Bhole D, et al. Alteration of Drosophila life span using conditional, tissue-specific expression of transgenes triggered by doxycyline or RU486/Mifepristone. Exp Gerontol. 2007;42:483-97 pubmed
    ..In contrast, motor-neuron-specific over-expression of MnSOD had no detectable effect on life span. The results suggest that motor-neuron tissue is not the essential tissue for either MnSOD induced longevity or toxicity in adult males. ..
  42. Knoblich J. Mechanisms of asymmetric cell division during animal development. Curr Opin Cell Biol. 1997;9:833-41 pubmed
    ..The identification of Numb homologs in other species has suggested that this machinery might be conserved from Drosophila to vertebrates. ..
  43. Weidmann C, Raynard N, Blewett N, Van Etten J, Goldstrohm A. The RNA binding domain of Pumilio antagonizes poly-adenosine binding protein and accelerates deadenylation. RNA. 2014;20:1298-319 pubmed publisher
    ..In this study, we investigated mechanisms of repression by the founding PUF, Drosophila Pumilio, and its human orthologs...
  44. Wolfgang W, Forte M. Posterior localization of the Drosophila Gi alpha protein during early embryogenesis requires a subset of the posterior group genes. Int J Dev Biol. 1995;39:581-6 pubmed
    ..It is important to note that mutations in posterior genes lower in the putative hierarchy vasa, tudor nanos, and pumilio did not affect Gi alpha redistribution...
  45. Olesnicky E, Bhogal B, Gavis E. Combinatorial use of translational co-factors for cell type-specific regulation during neuronal morphogenesis in Drosophila. Dev Biol. 2012;365:208-18 pubmed publisher
    The translational regulators Nanos (Nos) and Pumilio (Pum) work together to regulate the morphogenesis of dendritic arborization (da) neurons of the Drosophila larval peripheral nervous system...
  46. Niessing D, Rivera Pomar R, La Rosée A, Hader T, Schock F, Purnell B, et al. A cascade of transcriptional control leading to axis determination in Drosophila. J Cell Physiol. 1997;173:162-7 pubmed
  47. Miles W, Lepesant J, Bourdeaux J, Texier M, Kerenyi M, Nakakido M, et al. The LSD1 Family of Histone Demethylases and the Pumilio Posttranscriptional Repressor Function in a Complex Regulatory Feedback Loop. Mol Cell Biol. 2015;35:4199-211 pubmed publisher
    ..Here, we report that reductions in the expression of the Pumilio (PUM) translational repressor complex enhanced phenotypes due to dLsd1 depletion in Drosophila...
  48. Maisonhaute C, Ogereau D, Hua Van A, Capy P. Amplification of the 1731 LTR retrotransposon in Drosophila melanogaster cultured cells: origin of neocopies and impact on the genome. Gene. 2007;393:116-26 pubmed
    ..Evol. 21, 2281-2289). Moreover, neocopies are shown to be inserted in different sets of genes in the two cell lines suggesting they might be involved in the biological and physiological differences observed between Kc and S2 cell lines. ..
  49. Carreira Rosario A, Bhargava V, Hillebrand J, Kollipara R, Ramaswami M, Buszczak M. Repression of Pumilio Protein Expression by Rbfox1 Promotes Germ Cell Differentiation. Dev Cell. 2016;36:562-71 pubmed publisher
    ..During germline cyst differentiation, Rbfox1 targets pumilio mRNA for destabilization and translational silencing, thereby promoting germ cell development...
  50. Smith J, Wilson J, Macdonald P. Overexpression of oskar directs ectopic activation of nanos and presumptive pole cell formation in Drosophila embryos. Cell. 1992;70:849-59 pubmed
    ..Strikingly, formation of these ectopic pole cells is enhanced in nanos mutants. This observation may reflect competition between nanos and the germ cell determinant for a shared and limiting precursor. ..
  51. Raff J, Whitfield W, Glover D. Two distinct mechanisms localise cyclin B transcripts in syncytial Drosophila embryos. Development. 1990;110:1249-61 pubmed
    ..The distribution pattern of the transcript at the posterior pole throughout embryogenesis and in a variety of mutant embryos suggests that this component is associated with polar granules. ..
  52. Burnette J, Miyamoto Sato E, Schaub M, Conklin J, Lopez A. Subdivision of large introns in Drosophila by recursive splicing at nonexonic elements. Genetics. 2005;170:661-74 pubmed
    ..We discuss currently known and potential roles for recursive splicing. ..
  53. Stern M, Blake N, Zondlo N, Walters K. Increased neuronal excitability conferred by a mutation in the Drosophila bemused gene. J Neurogenet. 1995;10:103-18 pubmed
    ..This mutation, called bemused (bem) is the result of a P element insertion at cytological position 85D...
  54. Burow D, Umeh Garcia M, True M, Bakhaj C, Ardell D, Cleary M. Dynamic regulation of mRNA decay during neural development. Neural Dev. 2015;10:11 pubmed publisher
    ..A search for candidate cis-regulatory elements identified enrichment of the Pumilio recognition element (PRE) in mRNAs encoding regulators of neurogenesis...
  55. Fernandez Funez P, Nino Rosales M, de Gouyon B, She W, Luchak J, Martinez P, et al. Identification of genes that modify ataxin-1-induced neurodegeneration. Nature. 2000;408:101-6 pubmed
    ..These findings may be relevant to the treatment of polyglutamine diseases and, perhaps, to other neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. ..
  56. Ding D, Lipshitz H. Localized RNAs and their functions. Bioessays. 1993;15:651-8 pubmed
    ..Emphasis here will be on localized RNAs in the most intensively studied systems-Drosophila and Xenopus eggs and early embryos. ..
  57. Goto J, Mikawa Y, Koganezawa M, Ito H, Yamamoto D. Sexually dimorphic shaping of interneuron dendrites involves the hunchback transcription factor. J Neurosci. 2011;31:5454-9 pubmed publisher
    ..The present results suggest that Hb is essential for male-typical shaping of the contralateral neurites by Fru. ..
  58. Kwak J, Drier E, Barbee S, Ramaswami M, Yin J, Wickens M. GLD2 poly(A) polymerase is required for long-term memory. Proc Natl Acad Sci U S A. 2008;105:14644-9 pubmed publisher
    ..These findings provide strong evidence that cytoplasmic polyadenylation is critical for memory formation, and that GLD2 is the enzyme responsible. ..
  59. Cinnamon E, Gur Wahnon D, Helman A, St Johnston D, Jiménez G, Paroush Z. Capicua integrates input from two maternal systems in Drosophila terminal patterning. EMBO J. 2004;23:4571-82 pubmed
  60. Rongo C, Broihier H, Moore L, Van Doren M, Forbes A, Lehmann R. Germ plasm assembly and germ cell migration in Drosophila. Cold Spring Harb Symp Quant Biol. 1997;62:1-11 pubmed
    ..Further genetic studies will reveal the extent to which molecular aspects of germ cell migration and gonad formation are conserved. ..
  61. Hake L, Richter J. Translational regulation of maternal mRNA. Biochim Biophys Acta. 1997;1332:M31-8 pubmed
  62. Heller A, Steinmann Zwicky M. In Drosophila, female gonadal cells repress male-specific gene expression in XX germ cells. Mech Dev. 1998;73:203-9 pubmed
    ..Our results suggest that XX germ cells express male-specific genes, unless these genes are repressed by feminizing short range signals produced by the somatic cells of the prospective ovary. ..
  63. Tuxworth R, Chen H, Vivancos V, Carvajal N, Huang X, Tear G. The Batten disease gene CLN3 is required for the response to oxidative stress. Hum Mol Genet. 2011;20:2037-47 pubmed publisher
    ..Together, our data suggest that the lack of CLN3 function leads to a failure to manage the response to oxidative stress and this may be the key deficit in JNCL that leads to neuronal degeneration. ..
  64. Li X, Quon G, Lipshitz H, Morris Q. Predicting in vivo binding sites of RNA-binding proteins using mRNA secondary structure. RNA. 2010;16:1096-107 pubmed publisher
    ..Based on this work, we introduce a new motif-finding algorithm that identifies accessible sequence-specific RBP motifs from in vivo binding data. ..
  65. Joly W, Chartier A, Rojas Ríos P, Busseau I, Simonelig M. The CCR4 deadenylase acts with Nanos and Pumilio in the fine-tuning of Mei-P26 expression to promote germline stem cell self-renewal. Stem Cell Reports. 2013;1:411-24 pubmed publisher
    ..GSC self-renewal requires two translational repressors, Nanos (Nos) and Pumilio (Pum), which repress the expression of differentiation factors in the stem cells...
  66. Salazar A, Silverman E, Menon K, Zinn K. Regulation of synaptic Pumilio function by an aggregation-prone domain. J Neurosci. 2010;30:515-22 pubmed publisher
    We identified Pumilio (Pum), a Drosophila translational repressor, in a computational search for metazoan proteins whose activities might be regulated by assembly into ordered aggregates...
  67. Berger K, Kong E, Dubnau J, Tully T, Moore M, Heberlein U. Ethanol sensitivity and tolerance in long-term memory mutants of Drosophila melanogaster. Alcohol Clin Exp Res. 2008;32:895-908 pubmed publisher
    ..The corresponding genes in these mutants represent areas of potential overlap between learning and memory and behavioral responses to alcohol. These genes also define components shared between different ethanol behavioral responses. ..
  68. Lehmann R, Nusslein Volhard C. The maternal gene nanos has a central role in posterior pattern formation of the Drosophila embryo. Development. 1991;112:679-91 pubmed
    ..have used genetic as well as cytoplasmic transfer experiments to order seven of the posterior group genes (nanos, pumilio, oskar, valois, vasa, staufen and tudor) into a functional pathway...
  69. Clark I, Giniger E, Ruohola Baker H, Jan L, Jan Y. Transient posterior localization of a kinesin fusion protein reflects anteroposterior polarity of the Drosophila oocyte. Curr Biol. 1994;4:289-300 pubmed
    ..The genetic requirements for this localization and its sensitivity to colchicine, both of which are shared with the posterior transport of oskar mRNA and Staufen protein, suggest that similar mechanism may function in both processes. ..
  70. Schmucker D, Jackle H, Gaul U. Genetic analysis of the larval optic nerve projection in Drosophila. Development. 1997;124:937-48 pubmed
  71. Wilson J, Macdonald P. Formation of germ cells in Drosophila. Curr Opin Genet Dev. 1993;3:562-5 pubmed
    ..Although recent results largely support the notion of a simple pathway for assembly of pole plasm, complexities are becoming apparent. ..
  72. Grossniklaus U, Bellen H, Wilson C, Gehring W. P-element-mediated enhancer detection applied to the study of oogenesis in Drosophila. Development. 1989;107:189-200 pubmed
    ..On the basis of our results, we suggest new strategies, which are not primarily based on the generation of mutants, to screen for and isolated female sterile genes. ..
  73. MacDonald P. Diversity in translational regulation. Curr Opin Cell Biol. 2001;13:326-31 pubmed
    ..Diversity seems to be a central feature of translational control, both in the mechanisms themselves and in the situations where this form of regulation is used. ..
  74. Tautz D. Regulation of the Drosophila segmentation gene hunchback by two maternal morphogenetic centres. Nature. 1988;332:281-4 pubmed
  75. Bhogal B, Plaza Jennings A, Gavis E. Nanos-mediated repression of hid protects larval sensory neurons after a global switch in sensitivity to apoptotic signals. Development. 2016;143:2147-59 pubmed publisher
    ..The translational repressors Nanos (Nos) and Pumilio (Pum) are required to maintain dendrite growth and branching of Drosophila larval class IV dendritic arborization ..
  76. Getahun M, Olsson S, Lavista Llanos S, Hansson B, Wicher D. Insect odorant response sensitivity is tuned by metabotropically autoregulated olfactory receptors. PLoS ONE. 2013;8:e58889 pubmed publisher
    ..Our results indicate that Orco-mediated regulation of OR sensitivity provides tunable ionotropic receptors capable of detecting odors over a wider range of concentrations, providing broadened sensitivity over IRs themselves. ..
  77. Schulz D, Baines R, Hempel C, Li L, Liss B, Misonou H. Cellular excitability and the regulation of functional neuronal identity: from gene expression to neuromodulation. J Neurosci. 2006;26:10362-7 pubmed