Psn

Summary

Gene Symbol: Psn
Description: Presenilin
Alias: CG18803, CG5868, DPS, DPsn, DmPS, Dmel\CG18803, Dps, DrosPS, PS1, PSN, dPsn, l(3)77CDb, pres, psn, presenilin, CG18803-PA, CG18803-PB, CG18803-PC, CG18803-PD, CG18803-PE, Psn-PA, Psn-PB, Psn-PC, Psn-PD, Psn-PE, dPresenilin, pre-senelin
Species: fruit fly

Top Publications

  1. Kaspar M, Schneider M, Chia W, Klein T. Klumpfuss is involved in the determination of sensory organ precursors in Drosophila. Dev Biol. 2008;324:177-91 pubmed publisher
    ..We present a detailed structure function analysis that identifies functionally important domains within Klu. ..
  2. Klein T, Seugnet L, Haenlin M, Martinez Arias A. Two different activities of Suppressor of Hairless during wing development in Drosophila. Development. 2000;127:3553-66 pubmed
    ..After its release Su(H) can activate gene expression in absence of Nintra. ..
  3. Li A, Zhou C, Moore J, Zhang P, Tsai T, Lee H, et al. Changes in the expression of the Alzheimer’s disease-associated presenilin gene in drosophila heart leads to cardiac dysfunction. Curr Alzheimer Res. 2011;8:313-22 pubmed
    Mutations in the presenilin genes cause the majority of early-onset familial Alzheimer’s disease...
  4. Kopan R, Goate A. A common enzyme connects notch signaling and Alzheimer's disease. Genes Dev. 2000;14:2799-806 pubmed
  5. Chung H, Struhl G. Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila. Nat Cell Biol. 2001;3:1129-32 pubmed
    The transmembrane glycoprotein Nicastrin was identified in a complex with the multipass membrane protein Presenilin. Presenilin mediates transmembrane cleavage of single-pass transmembrane proteins with short extracellular domains, ..
  6. Francis R, McGrath G, Zhang J, Ruddy D, Sym M, Apfeld J, et al. aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev Cell. 2002;3:85-97 pubmed
    ..two genes, aph-1 and pen-2, encoding multipass transmembrane proteins, that interact strongly with sel-12/presenilin and aph-2/nicastrin. Human aph-1 and pen-2 partially rescue the C...
  7. Ye Y, Fortini M. Apoptotic activities of wild-type and Alzheimer's disease-related mutant presenilins in Drosophila melanogaster. J Cell Biol. 1999;146:1351-64 pubmed
    ..We show that loss of presenilin function in Drosophila melanogaster increases levels of apoptosis in developing tissues...
  8. Greeve I, Kretzschmar D, Tschäpe J, Beyn A, Brellinger C, Schweizer M, et al. Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila. J Neurosci. 2004;24:3899-906 pubmed
    ..This invertebrate model of amyloid plaque pathology demonstrates Abeta-induced neurodegeneration as a basic biological principle and may allow additional genetic analyses of the underlying molecular pathways. ..
  9. Li Y, Baker N. Proneural enhancement by Notch overcomes Suppressor-of-Hairless repressor function in the developing Drosophila eye. Curr Biol. 2001;11:330-8 pubmed
    ..lateral inhibition, the metalloprotease Kuzbanian, the EGF repeat 12 region of the Notch extracellular domain, Presenilin, and the Notch intracellular domain were required...

More Information

Publications76

  1. Lieber T, Kidd S, Young M. kuzbanian-mediated cleavage of Drosophila Notch. Genes Dev. 2002;16:209-21 pubmed
    ..Our data suggest that in Drosophila, kuzbanian can mediate S2 cleavage of Notch. ..
  2. Lukinova N, Roussakova V, Fortini M. Genetic characterization of cytological region 77A-D harboring the presenilin gene of Drosophila melanogaster. Genetics. 1999;153:1789-97 pubmed
    ..genomic region uncovered by Df(3L)rdgC-co2 (cytological interval 77A-D) to isolate mutations in the single known Presenilin (Psn) gene of Drosophila melanogaster...
  3. Ye Y, Fortini M. Characterization of Drosophila Presenilin and its colocalization with Notch during development. Mech Dev. 1998;79:199-211 pubmed
    Mutant Presenilin proteins cause early-onset familial Alzheimer's disease in humans and Caenorhabditis elegans Presenilins may facilitate Notch receptor signaling...
  4. van de Hoef D, Hughes J, Livne Bar I, Garza D, Konsolaki M, Boulianne G. Identifying genes that interact with Drosophila presenilin and amyloid precursor protein. Genesis. 2009;47:246-60 pubmed publisher
    ..Thus, presenilins appear to have diverse roles. To further understand presenilin function, we searched for Presenilin-interacting genes in Drosophila by performing a genetic modifier screen for ..
  5. Gross G, Feldman R, Ganguly A, Wang J, Yu H, Guo M. Role of X11 and ubiquilin as in vivo regulators of the amyloid precursor protein in Drosophila. PLoS ONE. 2008;3:e2495 pubmed publisher
    ..Since increased expression of X11 attenuates Abeta production and/or secretion in APP transgenic mice, but does not act on gamma-secretase directly, X11 may represent an attractive therapeutic target for AD. ..
  6. Ganguly A, Feldman R, Guo M. ubiquilin antagonizes presenilin and promotes neurodegeneration in Drosophila. Hum Mol Genet. 2008;17:293-302 pubmed
    ..Here, we show that Drosophila Ubiquilin (Ubqn) binds to Drosophila Presenilin (Psn), and that loss of ubqn function suppresses phenotypes that arise from loss of psn function in vivo...
  7. Stempfle D, Kanwar R, Loewer A, Fortini M, Merdes G. In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity. Mol Cell Biol. 2010;30:3165-75 pubmed publisher
    ..gamma-secretase, based on expression of epitope-tagged versions of the four core gamma-secretase components, Presenilin, Nicastrin, Aph-1, and Pen-2...
  8. Li A, Xie Z, Dong Y, McKay K, McKee M, Tanzi R. Isolation and characterization of the Drosophila ubiquilin ortholog dUbqln: in vivo interaction with early-onset Alzheimer disease genes. Hum Mol Genet. 2007;16:2626-39 pubmed
    ..Overexpression of dUbqln in the eye rescued a small, rough eye phenotype induced by overexpression of Drosophila presenilin (dPsn), and also rescuing dPsn-induced malformations in bristles...
  9. Loewer A, Soba P, Beyreuther K, Paro R, Merdes G. Cell-type-specific processing of the amyloid precursor protein by Presenilin during Drosophila development. EMBO Rep. 2004;5:405-11 pubmed
    The cleavage of proteins within their transmembrane domain by Presenilin (PS) has an important role in different signalling pathways and in Alzheimer's disease. Nevertheless, not much is known about the regulation of PS activity...
  10. Seidner G, Ye Y, Faraday M, Alvord W, Fortini M. Modeling clinically heterogeneous presenilin mutations with transgenic Drosophila. Curr Biol. 2006;16:1026-33 pubmed
    ..to analyze clinically graded aspects of human disease, we developed a transgenic fly model to characterize Presenilin (PS) gene mutations that cause early-onset familial Alzheimer's disease (FAD)...
  11. Struhl G, Greenwald I. Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature. 1999;398:522-5 pubmed
    ..Here we show that null mutations in the Drosophila Presenilin gene abolish Notch signal transduction and prevent its intracellular domain from entering the nucleus...
  12. Lu Y, Lv Y, Ye Y, Wang Y, Hong Y, Fortini M, et al. A role for presenilin in post-stress regulation: effects of presenilin mutations on Ca2+ currents in Drosophila. FASEB J. 2007;21:2368-78 pubmed
    It has been shown that presenilin is involved in maintaining Ca2+ homeostasis in neurons, including regulating endoplasmic reticulum (ER) Ca2+ storage...
  13. Guo Y, Livne Bar I, Zhou L, Boulianne G. Drosophila presenilin is required for neuronal differentiation and affects notch subcellular localization and signaling. J Neurosci. 1999;19:8435-42 pubmed
    ..Here, we have characterized the Drosophila presenilin gene and protein and studied their interaction with Notch in both mutants and transgenics...
  14. Rajendran L, Schneider A, Schlechtingen G, Weidlich S, Ries J, Braxmeier T, et al. Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting. Science. 2008;320:520-3 pubmed publisher
    ..In addition to effectively targeting beta-secretase, this strategy could also be used in designing potent drugs against other membrane protein targets. ..
  15. Hu Y, Fortini M. Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex. J Cell Biol. 2003;161:685-90 pubmed
    ..Four putative gamma-secretase components have been identified-presenilin (Psn), nicastrin (Nct), Aph-1, and Pen-2...
  16. Boulianne G, Livne Bar I, Humphreys J, Liang Y, Lin C, Rogaev E, et al. Cloning and characterization of the Drosophila presenilin homologue. Neuroreport. 1997;8:1025-9 pubmed
    Mutations in two genes, PS1 and PS2, coding for the presenilins, have been linked to the early onset form of familial Alzheimer's disease (AD)...
  17. Struhl G, Greenwald I. Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila. Proc Natl Acad Sci U S A. 2001;98:229-34 pubmed
    ..The familial Alzheimer's disease-associated protein Presenilin is required for LIN-12/Notch signaling, and several lines of evidence suggest that Presenilin mediates the ..
  18. Knight D, Iliadi K, Charlton M, Atwood H, Boulianne G. Presynaptic plasticity and associative learning are impaired in a Drosophila presenilin null mutant. Dev Neurobiol. 2007;67:1598-613 pubmed
    ..Recent evidence suggests that some of these defects may be due to a loss of normal presenilin activity...
  19. Lopez Schier H, St Johnston D. Drosophila nicastrin is essential for the intramembranous cleavage of notch. Dev Cell. 2002;2:79-89 pubmed
    The catalytic subunit of gamma-secretase is thought to be Presenilin, which is required for both the cleavage of APP and in the processing of Notch. Presenilin is found in a multisubunit complex that also contains Nicastrin...
  20. Koelzer S, Klein T. Regulation of expression of Vg and establishment of the dorsoventral compartment boundary in the wing imaginal disc by Suppressor of Hairless. Dev Biol. 2006;289:77-90 pubmed
    ..Thus, de-repression of its target genes obscures the involvement of Su(H) in this process. Furthermore, we provide evidence that Dx does not signal in a Su(H)-independent manner as has been suggested previously. ..
  21. Mukherjee T, Kim W, Mandal L, Banerjee U. Interaction between Notch and Hif-alpha in development and survival of Drosophila blood cells. Science. 2011;332:1210-3 pubmed publisher
    ..Studies in vertebrate myeloid cells have shown a similar up-regulation of Hif-? protein in well-oxygenated environments. This study provides a mechanistic paradigm for Hif-?/Notch interaction that may be conserved in mammals. ..
  22. Mahoney M, Parks A, Ruddy D, Tiong S, Esengil H, Phan A, et al. Presenilin-based genetic screens in Drosophila melanogaster identify novel notch pathway modifiers. Genetics. 2006;172:2309-24 pubmed
    b>Presenilin is the enzymatic component of gamma-secretase, a multisubunit intramembrane protease that processes several transmembrane receptors, such as the amyloid precursor protein (APP)...
  23. Sun J, Deng W. Hindsight mediates the role of notch in suppressing hedgehog signaling and cell proliferation. Dev Cell. 2007;12:431-42 pubmed
    ..Our studies suggest that Hindsight bridges the two antagonistic pathways, Notch and Hedgehog, in the temporal regulation of follicle-cell proliferation and differentiation. ..
  24. Koelzer S, Klein T. A Notch-independent function of Suppressor of Hairless during the development of the bristle sensory organ precursor cell of Drosophila. Development. 2003;130:1973-88 pubmed
    ..Our results further suggest that the position of the SOP in a proneural cluster is determined by very precise positional cues, which render the SOP insensitive to Dl. ..
  25. Guo M, Hong E, Fernandes J, Zipursky S, Hay B. A reporter for amyloid precursor protein gamma-secretase activity in Drosophila. Hum Mol Genet. 2003;12:2669-78 pubmed
    ..gamma-Secretase resides in a large multi-protein complex, of which Presenilin, Nicastrin, APH-1 and PEN-2 are four essential components...
  26. Coumailleau F, Fürthauer M, Knoblich J, Gonzalez Gaitan M. Directional Delta and Notch trafficking in Sara endosomes during asymmetric cell division. Nature. 2009;458:1051-5 pubmed publisher
  27. Ye Y, Lukinova N, Fortini M. Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants. Nature. 1999;398:525-9 pubmed
    b>Presenilin proteins have been implicated both in developmental signalling by the cell-surface protein Notch and in the pathogenesis of Alzheimer's disease...
  28. Hu Y, Ye Y, Fortini M. Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor. Dev Cell. 2002;2:69-78 pubmed
    ..elegans and is part of a large multiprotein complex along with Presenilin. Here we describe the isolation and characterization of Drosophila Nicastrin (Nic) mutants...
  29. Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, et al. The role of presenilin cofactors in the gamma-secretase complex. Nature. 2003;422:438-41 pubmed
    Mutations in presenilin genes account for the majority of the cases of the familial form of Alzheimer's disease (FAD)...
  30. Artavanis Tsakonas S, Rand M, Lake R. Notch signaling: cell fate control and signal integration in development. Science. 1999;284:770-6 pubmed
    ..Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis. ..
  31. Wilkin M, Tongngok P, Gensch N, Clemence S, Motoki M, Yamada K, et al. Drosophila HOPS and AP-3 complex genes are required for a Deltex-regulated activation of notch in the endosomal trafficking pathway. Dev Cell. 2008;15:762-72 pubmed publisher
    ..Notch to the limiting membrane of the lysosome, degradation of the Notch extracellular domain allows subsequent Presenilin-mediated release of N(ICD). This model accounts for positive and negative regulatory effects of Deltex in vivo...
  32. Struhl G, Adachi A. Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins. Mol Cell. 2000;6:625-36 pubmed
    ..The transmembrane cleavage depends on Presenilin, a protein also required for transmembrane cleavage of beta-APP...
  33. Carmine Simmen K, Proctor T, Tschäpe J, Poeck B, Triphan T, Strauss R, et al. Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function. Neurobiol Dis. 2009;33:274-81 pubmed publisher
    ..In addition, we found that the behavioral phenotypes precede extracellular amyloid deposit formation, supporting results that intracellular Abeta plays a key role in AD. ..
  34. Sun J, Spradling A. Ovulation in Drosophila is controlled by secretory cells of the female reproductive tract. elife. 2013;2:e00415 pubmed publisher
    ..Our results suggest that the reproductive tract signals to the ovary using glandular secretions, and that this pathway has been conserved during evolution. DOI:http://dx.doi.org/10.7554/eLife.00415.001. ..
  35. Anderson K, Beddington R. Pattern formation and developmental mechanisms. Curr Opin Genet Dev. 1997;7:455-8 pubmed
  36. M ller R, Jenny A, Stanley P. The EGF repeat-specific O-GlcNAc-transferase Eogt interacts with notch signaling and pyrimidine metabolism pathways in Drosophila. PLoS ONE. 2013;8:e62835 pubmed publisher
    ..We propose that eogt knock-down in the wing leads to metabolic and signaling perturbations that increase cytosolic uracil levels, thereby causing wing blister formation...
  37. Rincon Limas D, Jensen K, Fernandez Funez P. Drosophila models of proteinopathies: the little fly that could. Curr Pharm Des. 2012;18:1108-22 pubmed
    ..To remain relevant in this competitive environment, Drosophila models will need to expand their flexible, innovative, and multidisciplinary approaches to find new discoveries and translational applications. ..
  38. Delwig A, Bland C, Beem Miller M, Kimberly P, Rand M. Endocytosis-independent mechanisms of Delta ligand proteolysis. Exp Cell Res. 2006;312:1345-60 pubmed
    ..domain, proteolysis in the TM domain is facilitated by a thiol-sensitive aspartyl protease that is distinct from Presenilin. Furthermore, cleavage in the TM domain is upregulated in the presence of Notch...
  39. Michno K, Knight D, Campusano J, Campussano J, van de Hoef D, Boulianne G. Intracellular calcium deficits in Drosophila cholinergic neurons expressing wild type or FAD-mutant presenilin. PLoS ONE. 2009;4:e6904 pubmed publisher
    ..For example, mutations in the presenilin 1 and 2 genes have been linked to early onset familial forms of Alzheimer's disease (FAD)...
  40. Schlondorff J, Blobel C. Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding. J Cell Sci. 1999;112 ( Pt 21):3603-17 pubmed
  41. Yamakawa T, Yamada K, Sasamura T, Nakazawa N, Kanai M, Suzuki E, et al. Deficient Notch signaling associated with neurogenic pecanex is compensated for by the unfolded protein response in Drosophila. Development. 2012;139:558-67 pubmed publisher
    ..Our results indicate that the ER plays a previously unrecognized role in N signaling and that this ER function depends on pcx activity. ..
  42. Hassel C, Zhang B, Dixon M, Calvi B. Induction of endocycles represses apoptosis independently of differentiation and predisposes cells to genome instability. Development. 2014;141:112-23 pubmed publisher
    ..Our results reveal an unanticipated link between endocycles and the repression of apoptosis, with broader implications for how endocycles may contribute to genome instability and oncogenesis. ..
  43. Chan Y, Jan Y. Presenilins, processing of beta-amyloid precursor protein, and notch signaling. Neuron. 1999;23:201-4 pubmed
  44. Cervantes S, Gonzalez Duarte R, Marfany G. Homodimerization of presenilin N-terminal fragments is affected by mutations linked to Alzheimer's disease. FEBS Lett. 2001;505:81-6 pubmed
    ..The functional presenilin unit consists of a high molecular weight complex that contains both fragments...
  45. Zhang S, Guo Y, Boulianne G. Identification of a novel family of putative methyltransferases that interact with human and Drosophila presenilins. Gene. 2001;280:135-44 pubmed
    Mutations in the presenilin genes have been shown to cause the majority of cases of early-onset familial Alzheimer's disease (AD)...
  46. Cervantes S, Saura C, Pomares E, Gonzalez Duarte R, Marfany G. Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins. J Biol Chem. 2004;279:36519-29 pubmed
    ..These type I transmembrane proteins undergo two distinct presenilin-dependent cleavages within the transmembrane region, which result in the production of Abeta and APP ..
  47. Takasugi N, Takahashi Y, Morohashi Y, Tomita T, Iwatsubo T. The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals. J Biol Chem. 2002;277:50198-205 pubmed
    Mutations in presenilin 1 (PS1) and PS2 genes contribute to the pathogenesis of early onset familial Alzheimer's disease by increasing secretion of the pathologically relevant Abeta42 polypeptides...
  48. LeComte M, Wesley U, Mok L, Shepherd A, Wesley C. Evidence for the involvement of dominant-negative Notch molecules in the normal course of Drosophila development. Dev Dyn. 2006;235:411-26 pubmed
    ..Thus, it is possible that dominant-negative Notch molecules are produced in the normal course of tissue differentiation in Drosophila as part of an auto-down-regulation mechanism. ..
  49. Singh J, Mlodzik M. Hibris, a Drosophila nephrin homolog, is required for presenilin-mediated Notch and APP-like cleavages. Dev Cell. 2012;23:82-96 pubmed publisher
    ..Hbs also interacts molecularly and genetically with Presenilin (Psn) and other components of the ?-secretase complex...
  50. Isoo N, Sato C, Miyashita H, Shinohara M, Takasugi N, Morohashi Y, et al. Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate. J Biol Chem. 2007;282:12388-96 pubmed
    ..gamma-Secretase is a multimeric membrane protein complex composed of presenilin (PS), nicastrin, Aph-1, and Pen-2...
  51. Fortini M, Skupski M, Boguski M, Hariharan I. A survey of human disease gene counterparts in the Drosophila genome. J Cell Biol. 2000;150:F23-30 pubmed
  52. Cuc H, Seo J, Choi J, Kim W, Park S, Lee D, et al. Generation and characterization of monoclonal antibodies specific to Drosophila presenilin. Hybridoma (Larchmt). 2009;28:215-20 pubmed publisher
    The development of a monoclonal antibody (MAb) specific to Drosophila presenilin (Psn) proteins in vivo was the major aim of this study, since the absence of specific antibodies recognizing Psn proteins hampered our progress in ..
  53. Klein T. The tumour suppressor gene l(2)giant discs is required to restrict the activity of Notch to the dorsoventral boundary during Drosophila wing development. Dev Biol. 2003;255:313-33 pubmed
    ..The results further suggest that Lgd appears to act as a general repressor of Notch activity, because it also affects vein, eye, and bristle development. ..
  54. Nicholson S, Nicolay B, Frolov M, Moberg K. Notch-dependent expression of the archipelago ubiquitin ligase subunit in the Drosophila eye. Development. 2011;138:251-60 pubmed publisher
    ..These data suggest a model in which N acts through ago to restrict levels of the pro-mitotic factor Cyclin E. This N-Ago-Cyclin E link represents a significant new cell cycle regulatory mechanism in the developing eye. ..
  55. Ray W, Yao M, Nowotny P, Mumm J, Zhang W, Wu J, et al. Evidence for a physical interaction between presenilin and Notch. Proc Natl Acad Sci U S A. 1999;96:3263-8 pubmed
    ..in Caenorhabditis elegans demonstrate that sel-12 and hop-1, homologues of the Alzheimer's disease-associated presenilin genes, modify signaling through LIN-12 and GLP-1, homologues of the Notch cell surface receptor...
  56. Matsubayashi H, Sese S, Lee J, Shirakawa T, Iwatsubo T, Tomita T, et al. Biochemical characterization of the Drosophila wingless signaling pathway based on RNA interference. Mol Cell Biol. 2004;24:2012-24 pubmed
    ..aspects of the Wg pathway clarified that Wg-induced Dishevelled phosphorylation is due to CKIalpha and that presenilin and protein kinase A play little part in the regulation of Arm protein levels in Drosophila tissue culture cells. ..
  57. Hori K, Sen A, Kirchhausen T, Artavanis Tsakonas S. Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal. J Cell Biol. 2011;195:1005-15 pubmed publisher
    ..This activation mode of the receptor emphasizes the complexity of Notch signal modulation in a cell and has significant implications for both development and disease. ..
  58. Upadhyay A, Kandachar V, Zitserman D, Tong X, Roegiers F. Sanpodo controls sensory organ precursor fate by directing Notch trafficking and binding ?-secretase. J Cell Biol. 2013;201:439-48 pubmed publisher
    ..The interaction of Sanpodo with Presenilin, a component of the ?-secretase complex, was required for Notch activation and pIIa cell fate...
  59. Sun J, Deng W. Notch-dependent downregulation of the homeodomain gene cut is required for the mitotic cycle/endocycle switch and cell differentiation in Drosophila follicle cells. Development. 2005;132:4299-308 pubmed
    ..Our data suggest that Cut functions in regulating both cell differentiation and the cell cycle, and that downregulation of Cut by Notch contributes to the mitotic cycle/endocycle switch and cell differentiation in follicle cells. ..
  60. Herranz H, Milan M. Notch and affinity boundaries in Drosophila. Bioessays. 2006;28:113-6 pubmed
    ..The second report analyzes the differential requirements of Notch and the transcription factor Suppressor of Hairless in generating the affinity boundary. ..
  61. Smith O. Biomedicine. Nota bene. In the nic of time. Science. 2001;294:2118 pubmed
  62. Gilbert M, Robinson B, Moberg K. Functional interactions between the erupted/tsg101 growth suppressor gene and the DaPKC and rbf1 genes in Drosophila imaginal disc tumors. PLoS ONE. 2009;4:e7039 pubmed publisher
    ..The effect on Rbf1 can also be blocked by removal of the gamma-secretase component presenilin, suggesting that cleavage of a gamma-secretase target influences Rbf1 levels in ept mutant cells...
  63. Desbordes S, Chandraratna D, Sanson B. A screen for genes regulating the wingless gradient in Drosophila embryos. Genetics. 2005;170:749-66 pubmed
    ..Thus, our assay can be used effectively to screen for genes regulating Wingless distribution or transport. ..
  64. Troost T, Klein T. Sequential Notch signalling at the boundary of fringe expressing and non-expressing cells. PLoS ONE. 2012;7:e49007 pubmed publisher
    ..Because of these additional properties, differential expression of the ligands, which has been a prerequisite to restrict Notch activation to the FB in the current model, is not required to restrict Notch signalling to the FB. ..
  65. Jutras I, Laplante A, Boulais J, Brunet S, Thinakaran G, Desjardins M. Gamma-secretase is a functional component of phagosomes. J Biol Chem. 2005;280:36310-7 pubmed
    ..Our results indicate that the four components of gamma-secretase, viz. presenilin, nicastrin, APH-1, and PEN-2, are present and enriched on phagosome membranes from both murine macrophages and ..
  66. Noll E, Medina M, Hartley D, Zhou J, Perrimon N, Kosik K. Presenilin affects arm/beta-catenin localization and function in Drosophila. Dev Biol. 2000;227:450-64 pubmed
    b>Presenilin is an essential gene for development that when disrupted leads to a neurogenic phenotype that closely resembles Notch loss of function in Drosophila...
  67. van de Hoef D, Bonner J, Boulianne G. FKBP14 is an essential gene that regulates Presenilin protein levels and Notch signaling in Drosophila. Development. 2013;140:810-9 pubmed publisher
    ..We previously identified FKBP14, a member of the family of FK506-binding proteins (FKBPs), as a modifier of Presenilin in Drosophila...