Gene Symbol: Prx2540-2
Description: Peroxiredoxin 2540-2
Alias: CG11765, DPx-2540-2, DPx2540, Dmel\CG11765, Prx2540, peroxiredoxin 2540-2, CG11765-PA, Prx2540-2-PA, peroxiredoxin, peroxiredoxin 2540
Species: fruit fly

Top Publications

  1. Radyuk S, Klichko V, Spinola B, Sohal R, Orr W. The peroxiredoxin gene family in Drosophila melanogaster. Free Radic Biol Med. 2001;31:1090-100 pubmed
    Five peroxiredoxin genes have been identified in Drosophila melanogaster on the basis of a genome-wide search...
  2. Peterson T, Luckhart S. A mosquito 2-Cys peroxiredoxin protects against nitrosative and oxidative stresses associated with malaria parasite infection. Free Radic Biol Med. 2006;40:1067-82 pubmed
    ..Hence, whereas the NO-mediated defense response is toxic to both host and parasite, AsPrx-4783 may shift the balance in favor of the mosquito. ..
  3. Li D, Blasevich F, Theopold U, Schmidt O. Possible function of two insect phospholipid-hydroperoxide glutathione peroxidases. J Insect Physiol. 2003;49:1-9 pubmed
    ..A possible function of a non-enzymatic extracellular PHGPx-like protein is discussed. ..
  4. Rand M, Bland C, Bond J. Methylmercury activates enhancer-of-split and bearded complex genes independent of the notch receptor. Toxicol Sci. 2008;104:163-76 pubmed publisher
    ..MeHg transcriptional activation is partially mimicked by iodoacetamide but not by N-ethylmaleimide, two thiol-specific electrophiles, revealing a degree of specificity of cellular thiol targets in MeHg-induced transcriptional events. ..
  5. Herz H, Mohan M, Garrett A, Miller C, Casto D, Zhang Y, et al. Polycomb repressive complex 2-dependent and -independent functions of Jarid2 in transcriptional regulation in Drosophila. Mol Cell Biol. 2012;32:1683-93 pubmed publisher
    ..Identification of Jarid2 as a conserved PRC2 interactor in flies provides an opportunity to begin to probe some of its novel functions in Drosophila development. ..
  6. Sun X, Komatsu T, Lim J, Laslo M, Yolitz J, Wang C, et al. Nutrient-dependent requirement for SOD1 in lifespan extension by protein restriction in Drosophila melanogaster. Aging Cell. 2012;11:783-93 pubmed publisher
  7. Favrin G, Bean D, Bilsland E, Boyer H, Fischer B, Russell S, et al. Identification of novel modifiers of Aβ toxicity by transcriptomic analysis in the fruitfly. Sci Rep. 2013;3:3512 pubmed publisher
    ..In particular, we uncovered two new modifiers of the Aβ phenotype, namely Sod3 and PGRP-SC1b. ..
  8. Ruiz M, Ganfornina M, Correnti C, Strong R, Sanchez D. Ligand binding-dependent functions of the lipocalin NLaz: an in vivo study in Drosophila. FASEB J. 2014;28:1555-67 pubmed publisher
    ..Control of energy metabolites on starvation appears to be, however, insensitive to the modification of the NLaz binding pocket. ..
  9. Bozoky Z, Alexa A, Dancsok J, Gogl G, Klement E, Medzihradszky K, et al. Identifying calpain substrates in intact S2 cells of Drosophila. Arch Biochem Biophys. 2009;481:219-25 pubmed publisher
    ..In a typical run, 11 candidate substrates were recognized; out of these, four were randomly selected: all four were verified to be calpain substrates, by digestion of the recombinant protein with recombinant calpain. ..

More Information


  1. Li Y, Padmanabha D, Gentile L, Dumur C, Beckstead R, Baker K. HIF- and non-HIF-regulated hypoxic responses require the estrogen-related receptor in Drosophila melanogaster. PLoS Genet. 2013;9:e1003230 pubmed publisher
    ..These results indicate that competent hypoxic responses arise from complex interactions between HIF-dependent and -independent mechanisms, and that dERR plays a central role in both of these programs. ..
  2. Mishra M, Sharma A, Shukla A, Pragya P, Murthy R, de Pomerai D, et al. Transcriptomic analysis provides insights on hexavalent chromium induced DNA double strand breaks and their possible repair in midgut cells of Drosophila melanogaster larvae. Mutat Res. 2013;747-748:28-39 pubmed publisher