Gene Symbol: Prosap
Alias: BcDNA:GH23107, CG13354, CG30483, CG8122, D-ProSAP, Dmel\CG30483, ProSAP, Shank, anon-WO0118547.149, prosap, prosap, CG30483-PA, CG30483-PC, CG30483-PD, CG30483-PE, Prosap-PA, Prosap-PC, Prosap-PD, Prosap-PE, shank
Species: fruit fly
Diagana T, Thomas U, Prokopenko S, Xiao B, Worley P, Thomas J. Mutation of Drosophila homer disrupts control of locomotor activity and behavioral plasticity. J Neurosci. 2002;22:428-36 pubmed
..Our results argue that in the CNS, Homer-related proteins operate in the ER and in dendrites to regulate the development and function of neural networks underlying locomotor control and behavioral plasticity. ..
Perry T, McKenzie J, Batterham P. A Dalpha6 knockout strain of Drosophila melanogaster confers a high level of resistance to spinosad. Insect Biochem Mol Biol. 2007;37:184-8 pubmed
..This, combined with the high degree of evolutionary conservation of nAChR subunits, suggests that mutations in Dalpha6 orthologues may underpin the spinosad resistance identified in several economically important field pests. ..
Hilger M, Bonaldi T, Gnad F, Mann M. Systems-wide analysis of a phosphatase knock-down by quantitative proteomics and phosphoproteomics. Mol Cell Proteomics. 2009;8:1908-20 pubmed publisher
..Our analysis highlights a connection of Ptp61F to cytoskeletal regulation through GTPase regulating proteins and focal adhesion components. ..
Steinhauer J, Gijón M, Riekhof W, Voelker D, Murphy R, Treisman J. Drosophila lysophospholipid acyltransferases are specifically required for germ cell development. Mol Biol Cell. 2009;20:5224-35 pubmed publisher
..Our findings suggest that lysophospholipid acyltransferase activity is essential for germline development and could provide a mechanistic explanation for the etiology of the human MBOAT1 mutation. ..
Gerken A, Eller O, Hahn D, Morgan T. Constraints, independence, and evolution of thermal plasticity: probing genetic architecture of long- and short-term thermal acclimation. Proc Natl Acad Sci U S A. 2015;112:4399-404 pubmed publisher
..These results indicate substantial opportunity for short-term and long-term acclimation responses to evolve separately from each other and for short-term acclimation to evolve separately from basal thermotolerance. ..
Chow C, Kelsey K, Wolfner M, Clark A. Candidate genetic modifiers of retinitis pigmentosa identified by exploiting natural variation in Drosophila. Hum Mol Genet. 2016;25:651-9 pubmed publisher
..This study demonstrates the utility of studying a pathogenic mutation across a wide range of genetic backgrounds. These candidate modifiers provide new avenues of inquiry that may reveal new RP disease mechanisms and therapies. ..
Harris K, Akbergenova Y, Cho R, Baas Thomas M, Littleton J. Shank Modulates Postsynaptic Wnt Signaling to Regulate Synaptic Development. J Neurosci. 2016;36:5820-32 pubmed publisher
b>Prosap/Shank scaffolding proteins regulate the formation, organization, and plasticity of excitatory synapses. Mutations in SHANK family genes are implicated in autism spectrum disorder and other neuropsychiatric conditions...
Wu S, Gan G, Zhang Z, Sun J, Wang Q, Gao Z, et al
. A Presynaptic Function of Shank Protein in Drosophila. J Neurosci. 2017;37:11592-11604 pubmed publisher
..To better understand the in vivo functions of Shank and facilitate dissection of neuropathology associated with SHANK mutations in human, we generated multiple ..