pros

Summary

Gene Symbol: pros
Description: prospero
Alias: 0244/09, 0320/10, 0441/16, 0451/09, 0563/18, 0585/13, 0664/07, 0671/02, 0763/13, 0989/01, 1135/07, 1135/09, 1167/13, 1316/02, 671/2, BcDNA:HL08040, CG17228, DMPROSPER, DROPROSA, Dmel\CG17228, PROS, PROS-1, PROS-2, Pro, Pros, Prosp, Voila, anon-WO0140519.15, l(3)10419, l(3)j12C8, l(3)j6E2, l(3)rH013, l(3)rI160, l(3)rJ806, l(3)rK137, l(3)rK204, l(3)rL433, l(3)rO534, pro, CG17228-PH, CG17228-PI, CG17228-PJ, CG17228-PK, CG17228-PL, CG17228-PM, a la voile et a la vapeur, pros-PH, pros-PI, pros-PJ, pros-PK, pros-PL, pros-PM
Species: fruit fly

Top Publications

  1. ncbi Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells
    Joerg Betschinger
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Cell 124:1241-53. 2006
  2. doi dFezf/Earmuff maintains the restricted developmental potential of intermediate neural progenitors in Drosophila
    Mo Weng
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA
    Dev Cell 18:126-35. 2010
  3. pmc Amplification of neural stem cell proliferation by intermediate progenitor cells in Drosophila brain development
    Bruno C Bello
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Neural Dev 3:5. 2008
  4. pmc Identification of Drosophila type II neuroblast lineages containing transit amplifying ganglion mother cells
    Jason Q Boone
    Institute of Neuroscience and Institute of Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, Oregon 97403, USA
    Dev Neurobiol 68:1185-95. 2008
  5. ncbi Role of inscuteable in orienting asymmetric cell divisions in Drosophila
    R Kraut
    Institute of Molecular and Cell Biology, National University of Singapore
    Nature 383:50-5. 1996
  6. pmc Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts
    Hongyan Wang
    Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore 117604
    Genes Dev 20:3453-63. 2006
  7. pmc Drosophila type II neuroblast lineages keep Prospero levels low to generate large clones that contribute to the adult brain central complex
    Omer Ali Bayraktar
    Howard Hughes Medical Institute, University of Oregon, Eugene, 97403, USA
    Neural Dev 5:26. 2010
  8. ncbi Staufen-dependent localization of prospero mRNA contributes to neuroblast daughter-cell fate
    J Broadus
    Department of Cell and Structural Biology, Howard Hughes Medical Institute, University of Illinois, Urbana 61801, USA
    Nature 391:792-5. 1998
  9. ncbi Postsynaptic filopodia in muscle cells interact with innervating motoneuron axons
    S Ritzenthaler
    Department of Cell and Structural Biology, University of Illinois, B605 CLS Laboratory, 601 South Goodwin Ave, Urbana, Illinois 61801, USA
    Nat Neurosci 3:1012-7. 2000
  10. ncbi Evidence that stem cells reside in the adult Drosophila midgut epithelium
    Craig A Micchelli
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 439:475-9. 2006

Research Grants

  1. GENETIC AND MOLECULAR STUDIES OF NEUROGENESIS
    Chris Q Doe; Fiscal Year: 2010
  2. REGULATORY CASCADES IN GASTROINTESTINAL PROLIFERATION
    KLAUS KAESTNER; Fiscal Year: 2006
  3. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2006
  4. Molecular and genetic analysis of sanpodo
    JAMES SKEATH; Fiscal Year: 2006
  5. GENETIC CONTROL OF TISSUE POLARITY
    Paul Adler; Fiscal Year: 2005
  6. Patterning of the Primitive Heart Tube in Zebrafish
    Jau Nian Chen; Fiscal Year: 2007
  7. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
  8. Physiological regulation and function of asymmetric stem cell division
    Yukiko Yamashita; Fiscal Year: 2011
  9. Molecular and genetic analysis of sanpodo
    JAMES SKEATH; Fiscal Year: 2009
  10. DEVELOPMENT OF IDENTIFIED MOTONEURONS
    Judith Eisen; Fiscal Year: 2009

Detail Information

Publications131 found, 100 shown here

  1. ncbi Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells
    Joerg Betschinger
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Cell 124:1241-53. 2006
    ..Similar defects are seen in lethal giant larvae (lgl) mutants where Brat and Prospero are not asymmetric. We have identified a molecular mechanism that may control self-renewal and prevent tumor formation in other stem cells as well...
  2. doi dFezf/Earmuff maintains the restricted developmental potential of intermediate neural progenitors in Drosophila
    Mo Weng
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA
    Dev Cell 18:126-35. 2010
    ..We conclude that Erm dependence functionally distinguishes intermediate neural progenitors from neuroblasts in the Drosophila larval brain, balancing neurogenesis with stem cell maintenance...
  3. pmc Amplification of neural stem cell proliferation by intermediate progenitor cells in Drosophila brain development
    Bruno C Bello
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Neural Dev 3:5. 2008
    ..Here we investigate whether specific neural stem cell-like neuroblasts in the brain of Drosophila might also amplify neuronal proliferation by generating symmetrically dividing intermediate progenitors...
  4. pmc Identification of Drosophila type II neuroblast lineages containing transit amplifying ganglion mother cells
    Jason Q Boone
    Institute of Neuroscience and Institute of Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, Oregon 97403, USA
    Dev Neurobiol 68:1185-95. 2008
    ..Type II lineages allow more neurons to be produced faster than Type I lineages, which may be advantageous in a rapidly developing organism like Drosophila...
  5. ncbi Role of inscuteable in orienting asymmetric cell divisions in Drosophila
    R Kraut
    Institute of Molecular and Cell Biology, National University of Singapore
    Nature 383:50-5. 1996
    ..The Inscuteable protein localizes to the apical cell cortex before mitosis, suggesting that Inscuteable functions in establishing polarity for asymmetric cell division...
  6. pmc Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts
    Hongyan Wang
    Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore 117604
    Genes Dev 20:3453-63. 2006
    ..We have identified a novel mechanism for controlling the balance between self-renewal and neuronal differentiation during the asymmetric division of Drosophila larval NBs...
  7. pmc Drosophila type II neuroblast lineages keep Prospero levels low to generate large clones that contribute to the adult brain central complex
    Omer Ali Bayraktar
    Howard Hughes Medical Institute, University of Oregon, Eugene, 97403, USA
    Neural Dev 5:26. 2010
    ..In addition, we use 9D11 lineage tracing to show that type II lineages generate both small-field and large-field neurons within the adult central complex, a brain region required for locomotion, flight, and visual pattern memory...
  8. ncbi Staufen-dependent localization of prospero mRNA contributes to neuroblast daughter-cell fate
    J Broadus
    Department of Cell and Structural Biology, Howard Hughes Medical Institute, University of Illinois, Urbana 61801, USA
    Nature 391:792-5. 1998
    ..The prospero (pros) mRNA and the RNA-binding protein Staufen (Stau) are asymmetrically localized in mitotic neuroblasts and are ..
  9. ncbi Postsynaptic filopodia in muscle cells interact with innervating motoneuron axons
    S Ritzenthaler
    Department of Cell and Structural Biology, University of Illinois, B605 CLS Laboratory, 601 South Goodwin Ave, Urbana, Illinois 61801, USA
    Nat Neurosci 3:1012-7. 2000
    ..Thus, postsynaptic filopodia are capable of intimate interaction with innervating presynaptic axons. We propose that, by contributing to direct long-distance cellular communication, they are dynamically involved in synaptic matchmaking...
  10. ncbi Evidence that stem cells reside in the adult Drosophila midgut epithelium
    Craig A Micchelli
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 439:475-9. 2006
    ..The ability to identify, manipulate and genetically trace cell lineages in the midgut should lead to the discovery of additional genes that regulate stem and progenitor cell biology in the gastrointestinal tract...
  11. pmc The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila
    Sarah K Bowman
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3, 1030 Vienna, Austria
    Dev Cell 14:535-46. 2008
    ..Our data describe a transit-amplifying lineage in the Drosophila nervous system and suggest that different vulnerabilities in intermediate cell types can affect the outcome of tumor suppressor loss in stem cell lineages...
  12. ncbi inscuteable, a neural precursor gene of Drosophila, encodes a candidate for a cytoskeleton adaptor protein
    R Kraut
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Cologne, Germany
    Dev Biol 174:65-81. 1996
    ..The inscuteable mutant phenotype, together with these other observations, suggests a possible role for the protein in cytoskeleton organization...
  13. ncbi Regulation of post-embryonic neuroblasts by Drosophila Grainyhead
    Mara S Almeida
    Department of Anatomy, University of Cambridge, Downing Street, CA CB2 3DY, UK
    Mech Dev 122:1282-93. 2005
    ..Thus one way Grh could regulate pNBs is through expression of E-cadherin, a protein that is thought to mediate interactions with the glial niche...
  14. pmc The cell fate determinant numb interacts with EHD/Rme-1 family proteins and has a role in endocytic recycling
    Christian A Smith
    Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8
    Mol Biol Cell 15:3698-708. 2004
    ..In addition, we present evidence that Numb has a novel function in endosomal recycling and intracellular trafficking of receptors...
  15. ncbi The adult Drosophila posterior midgut is maintained by pluripotent stem cells
    Benjamin Ohlstein
    Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution of Washington, 3520 San Martin Drive, Baltimore, Maryland 21218, USA
    Nature 439:470-4. 2006
    ..The identification of Drosophila intestinal stem cells with striking similarities to their vertebrate counterparts will facilitate the genetic analysis of normal and abnormal intestinal function...
  16. ncbi Inscuteable and Staufen mediate asymmetric localization and segregation of prospero RNA during Drosophila neuroblast cell divisions
    P Li
    Developmental Neurobiology Laboratory, Institute of Molecular and Cell Biology, National University of Singapore
    Cell 90:437-47. 1997
    ..Stau, as one component of this complex, is required only for RNA localization. Hence staufen also acts zygotically, downstream of inscuteable, to effect aspects of neuroblast asymmetry...
  17. ncbi The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts
    Claudia Petritsch
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Dev Cell 4:273-81. 2003
    ..Our studies demonstrate that a class VI myosin is necessary for basal protein targeting and spindle orientation in neuroblasts...
  18. pmc Coordinate control of synaptic-layer specificity and rhodopsins in photoreceptor neurons
    Marta Morey
    Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    Nature 456:795-9. 2008
    ..We show that R7 targeting requires the R7-specific transcription factor Prospero (Pros) in parallel to repression of the R8 targeting pathway by NF-YC...
  19. pmc Postembryonic development of transit amplifying neuroblast lineages in the Drosophila brain
    Natalya Izergina
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Neural Dev 4:44. 2009
    ..In this report we use MARCM-based clonal analysis together with immunocytochemical labeling techniques to investigate the type and fate of neural cells generated in the DM lineages...
  20. ncbi Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal
    Cheng Yu Lee
    Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, 97403, USA
    Dev Cell 10:441-9. 2006
    ..Single neuroblast clones lacking Prospero have a similar phenotype. We conclude that Brat suppresses neuroblast stem cell self-renewal and promotes neuronal differentiation...
  21. ncbi The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila
    Bruno Bello
    Biozentrum, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Development 133:2639-48. 2006
    ..number of cells, which have molecular features of undifferentiated progenitor cells that lack nuclear Prospero (Pros)...
  22. ncbi Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster
    Emmanuel Caussinus
    Cell Biology and Biophysics Program, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nat Genet 37:1125-9. 2005
    ..We found that larval brain tissue carrying neuroblasts with mutations in raps (also called pins), mira, numb or pros grew to more than 100 times their initial size, invading other tissues and killing the hosts in 2 weeks...
  23. pmc Identification of an evolutionarily divergent U11 small nuclear ribonucleoprotein particle in Drosophila
    Claudia Schneider
    Department of Cellular Biochemistry, Max Planck Institute of Biophysical Chemistry, 37077 Goettingen, Germany
    Proc Natl Acad Sci U S A 101:9584-9. 2004
    ..A comparison of U11 snRNAs that we have identified from vertebrates, plants, and insects, suggests that an evolutionarily divergent U11 snRNA may be unique to Drosophila and not characteristic of insects in general...
  24. ncbi Biochemical analysis of ++Prospero protein during asymmetric cell division: cortical Prospero is highly phosphorylated relative to nuclear Prospero
    S Srinivasan
    Department of Cell and Structural Biology, HHMI, Urbana, Illinois, 61801, USA
    Dev Biol 204:478-87. 1998
    ....
  25. ncbi Suppression of polyglutamine toxicity by a Drosophila homolog of myeloid leukemia factor 1
    Parsa Kazemi-Esfarjani
    Department of Physiology and Biophysics, Center for Neuroscience, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14214, USA
    Hum Mol Genet 11:2657-72. 2002
    ....
  26. ncbi A primary cell culture of Drosophila postembryonic larval neuroblasts to study cell cycle and asymmetric division
    Julian Ceron
    Instituto de Neurociencias, CSIC and Universidad Miguel Hernandez, San Juan, E 03550 Alicante, Spain
    Eur J Cell Biol 85:567-75. 2006
    ..The combination of this cell culture system and genetic tools of Drosophila will provide a powerful experimental model for the analysis of cell cycle and asymmetric cell division of neural progenitor cells...
  27. ncbi Spindle orientation and asymmetric cell fate
    M S Rhyu
    National Cancer Institute, Bethesda, Maryland 20892, USA
    Cell 82:523-6. 1995
  28. doi AP-1 clathrin adaptor and CG8538/Aftiphilin are involved in Notch signaling during eye development in Drosophila melanogaster
    Satoshi Kametaka
    Department of Anatomy and Histology, Fukushima Medical University, 1 Hikarigaoka, Fukushima, Fukushima 960 1295, Japan
    J Cell Sci 125:634-48. 2012
    ..These results suggest that AP-1 and Aftiphilin are cooperatively involved in the intracellular trafficking of Notch during eye development in Drosophila...
  29. pmc Binary sibling neuronal cell fate decisions in the Drosophila embryonic central nervous system are nonstochastic and require inscuteable-mediated asymmetry of ganglion mother cells
    M Buescher
    Institute of Molecular and Cell Biology, National University of Singapore, Singapore
    Genes Dev 12:1858-70. 1998
    ..Moreover, our data suggest that the fate of some sibling neurons may be regulated by signals that do not require lateral interaction between the sibling cells...
  30. pmc Regulation of spindle orientation and neural stem cell fate in the Drosophila optic lobe
    Boris Egger
    The Wellcome Trust Cancer Research UK Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Neural Dev 2:1. 2007
    ..In some tissues cell fate appears to dictate the type of cell division, whereas in other tissues it is thought that stochastic variation in spindle position dictates subsequent sibling cell fate...
  31. ncbi Rotation and asymmetry of the mitotic spindle direct asymmetric cell division in the developing central nervous system
    J A Kaltschmidt
    Wellcome CRC Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Nat Cell Biol 2:7-12. 2000
    ..This observation contradicts the widely held hypothesis that the cleavage furrow is always placed midway between the two centrosomes...
  32. pmc Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization
    Frederik Wirtz-Peitz
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3, 1030 Vienna, Austria
    Cell 135:161-73. 2008
    ..Our data reveal a molecular mechanism for the asymmetric localization of Numb and show how cell polarity can be coupled to cell-cycle progression...
  33. ncbi Regulation of R7 and R8 differentiation by the spalt genes
    Pedro M Domingos
    Howard Hughes Medical Institute, Strang Laboratory of Cancer Research, The Rockefeller University, New York, NY 10021, USA
    Dev Biol 273:121-33. 2004
    ..Taken together, our results suggest that while spalt is required for R7 differentiation during larval stages, spalt and senseless promote terminal R8 differentiation during pupal stages, including the regulation of rhodopsin expression...
  34. doi Cell cycle independent role of Cyclin E during neural cell fate specification in Drosophila is mediated by its regulation of Prospero function
    Christian Berger
    Institute for Genetics, University of Mainz, D 55099 Mainz, Germany
    Dev Biol 337:415-24. 2010
    ..e. asymmetric cell division of NB6-4t. Furthermore our data imply that CycE is required for the maintenance of stem cell identity of most other neuroblasts...
  35. ncbi prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila
    H Vaessin
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0724
    Cell 67:941-53. 1991
    ..prospero encodes a large nuclear protein with multiple homopolymeric amino acid stretches and is expressed in neuronal precursors early during their formation. It is probably generally required for proper neuronal differentiation...
  36. ncbi Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localization
    F Yu
    Institute of Molecular and Cell Biology, National University of Singapore, Singapore
    Cell 100:399-409. 2000
    ....
  37. ncbi Localization-dependent and -independent roles of numb contribute to cell-fate specification in Drosophila
    Sheetal Bhalerao
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Curr Biol 15:1583-90. 2005
    ..Our results suggest that two classes of asymmetric cell division exist, each with different requirements for asymmetric inheritance of cell-fate determinants...
  38. ncbi The prospero gene encodes a divergent homeodomain protein that controls neuronal identity in Drosophila
    Q Chu-LaGraff
    Department of Cell and Structural Biology, University of Illinois, Urbana 61801
    Development . 1991
    ..Recently we identified the prospero (pros) gene, which is expressed in embryonic neuroblasts...
  39. ncbi Cell diversity in the retina: more than meets the eye
    Tiffany Cook
    New York University, New York NY 10003, USA
    Bioessays 25:921-5. 2003
    ..As Prospero, the Drosophila homolog of Prox1, also participates in retinal cell specification, these data provide a forum for asking new questions concerning pathways that may regulate retinogenesis across evolution...
  40. pmc Dual roles of Drosophila p53 in cell death and cell differentiation
    Y Fan
    Department of Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Cell Death Differ 17:912-21. 2010
    ..this study, using the developing eye as a model, we show that Dp53-induced apoptosis is primarily dependent on the pro-apoptotic gene, head involution defective (hid), but not reaper (rpr), and occurs through the canonical apoptosis ..
  41. pmc Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon
    Hongyan Wang
    Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore 117604
    Nature 449:96-100. 2007
    ..Our results reveal a biochemical link between the cell cycle and the asymmetric protein localization machinery, and indicate that Polo can inhibit progenitor self-renewal by regulating the localization and function of Numb...
  42. ncbi Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts
    A Wodarz
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Germany
    Nature 402:544-7. 1999
    ..As Bazooka is also responsible for the maintenance of apical-basal polarity in epithelial tissues, it may be the missing link between epithelial polarity and neuroblast polarity...
  43. ncbi Regulation of temporal identity transitions in Drosophila neuroblasts
    Ruth Grosskortenhaus
    Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, University of Oregon 1254, Eugene, Oregon 97403, USA
    Dev Cell 8:193-202. 2005
    ..We conclude that two distinct "timers" regulate neuroblast gene expression: a hunchback --> Kruppel timer requiring cytokinesis, and a Kruppel --> pdm1 --> castor timer which is cell cycle independent...
  44. ncbi Partner of Numb colocalizes with Numb during mitosis and directs Numb asymmetric localization in Drosophila neural and muscle progenitors
    B Lu
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco 94143 0725, USA
    Cell 95:225-35. 1998
    ..We propose that PON is one component of a multimolecular machinery that localizes Numb by responding to polarity cues conserved in neural precursors and epithelial cells...
  45. ncbi Sibling cell fate in the Drosophila adult external sense organ lineage is specified by prospero function, which is regulated by Numb and Notch
    G V Reddy
    Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Rd, Mumbai 400005, India
    Development 126:2083-92. 1999
    ..We show that the homeodomain transcription factor Prospero (Pros) acts as an intrinsic signal for the specification of cell fates within the mechanosensory lineage...
  46. ncbi Prospero distinguishes sibling cell fate without asymmetric localization in the Drosophila adult external sense organ lineage
    L Manning
    Howard Hughes Medical Institute, Department of Cell and Structural Biology, University of Illinois, Urbana, IL 61801, USA
    Development 126:2063-71. 1999
    ..Finally, in contrast to previous studies, we find that the IIb cell divides prior to the IIa cell in the SOP lineage...
  47. ncbi Control of spindle orientation in Drosophila by the Par-3-related PDZ-domain protein Bazooka
    U Kuchinke
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstrasse 1, 40225 Dusseldorf, Germany
    Curr Biol 8:1357-65. 1998
    ..None of the genes identified so far that are involved in these processes seems to have been conserved between flies and nematodes...
  48. ncbi Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors
    Hamed Jafar-Nejad
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Dev Cell 9:351-63. 2005
    ..Our data indicate that Sec15 mediates a specific vesicle trafficking event to ensure proper neuronal fate specification in Drosophila...
  49. ncbi Apical complex genes control mitotic spindle geometry and relative size of daughter cells in Drosophila neuroblast and pI asymmetric divisions
    Yu Cai
    Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Singapore
    Cell 112:51-62. 2003
    ..In sensory organ precursors, Bazooka/DaPKC and Pins/G alpha i localize to opposite sides of the cortex and function in opposition to generate a symmetric spindle...
  50. ncbi The glial cell undergoes apoptosis in the microchaete lineage of Drosophila
    Pierre Fichelson
    UMR 7622, CNRS Universite Paris VI, 9, quai St Bernard, 75252 Paris Cedex 05, France
    Development 130:123-33. 2003
    ..Fragmentation was blocked after overexpression of the caspase inhibitor p35 or removal of the pro-apoptotic genes reaper, hid and grim, showing that the glial cell undergoes apoptosis...
  51. ncbi Mother-daughter precursor cell fate transformation after Cdc2 down-regulation in the Drosophila bristle lineage
    Pierre Fichelson
    UMR 7622, CNRS Universite Paris VI, 9, quai St Bernard, 75252 Paris Cedex 05, France
    Dev Biol 276:367-77. 2004
    ..These transformations in cell identity suggest that, although synchronized, cell cycle and fate determination are independent phenomena in the bristle lineage...
  52. ncbi Yan regulates Lozenge during Drosophila eye development
    Kristina Jackson Behan
    Department of Biological Sciences, Carnegie Mellon University, Pittsburg, PA 15213, USA
    Dev Genes Evol 212:267-76. 2002
    ..We propose that upregulated Lozenge acts as a cofactor to alter Pointed affinity, by a mechanism that is recapitulated in mammalian development...
  53. ncbi Redundant function of Runt Domain binding partners, Big brother and Brother, during Drosophila development
    J S Kaminker
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Development 128:2639-48. 2001
    ..These studies highlight a mechanism for transcriptional control by a Runt Domain protein and a redundant pair of partners in the specification of cell fate during development...
  54. ncbi Translational repression determines a neuronal potential in Drosophila asymmetric cell division
    M Okabe
    Division of Developmental Genetics, National Institute of Genetics, and Department of Genetics, Graduate University for Advanced Studies, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Nature 411:94-8. 2001
    ..Thus, Notch signalling is likely to regulate MSI activity rather than its expression. Our results define cell-type-specific translational control of ttk69 by MSI as a downstream event of Notch signalling in asymmetric cell division...
  55. pmc Prospero maintains the mitotic potential of glial precursors enabling them to respond to neurons
    Rachel L Griffiths
    NeuroDevelopment Group, Department of Genetics, University of Cambridge, Cambridge, UK
    EMBO J 23:2440-50. 2004
    ..This enables prospero-expressing cells alone to divide further upon elimination of neurons and to adjust glial number to axons during development...
  56. ncbi Taste, movement, and death: varying effects of new prospero mutants during Drosophila development
    Yael Grosjean
    Unité de Recherche 5548 Associée au Centre National de la Recherche Scientifique, Faculte des Sciences, Universite de Bourgogne, 6, Bd Gabriel, 21 000 Dijon, France
    J Neurobiol 55:1-13. 2003
    ..inserted upstream of the pan-neural gene prospero (pros) causes several neural and behavioral defects in the Voila(1) strain...
  57. ncbi Combinatorial expression of Prospero, Seven-up, and Elav identifies progenitor cell types during sense-organ differentiation in the Drosophila antenna
    Anindya Sen
    Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Rd, Mumbai 400005, India
    Dev Biol 254:79-92. 2003
    ..An understanding of the lineage and development of olfactory sense-organs provides a handle for the analysis of how olfactory neurons acquire distinct terminal fates...
  58. pmc In vivo analysis of a developmental circuit for direct transcriptional activation and repression in the same cell by a Runx protein
    Jude Canon
    Department of Biological Chemistry and Department of Molecular, Cell, and Developmental Biology, Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA
    Genes Dev 17:838-43. 2003
    ..This study provides a mechanistic basis for the dual function of Runx proteins that is likely to be conserved in mammalian systems...
  59. ncbi Drosophila pod-1 crosslinks both actin and microtubules and controls the targeting of axons
    Michael E Rothenberg
    Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, 533 Parnassus Avenue, San Francisco, CA 94143, USA
    Neuron 39:779-91. 2003
    ..Taken together, these results reveal novel activities for pod-1 and show that proper levels of Dpod1, an actin/MT crosslinker, must be maintained in the growth cone for correct axon guidance...
  60. doi Temporal transcription factors and their targets schedule the end of neural proliferation in Drosophila
    Cédric Maurange
    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Cell 133:891-902. 2008
    ..These studies identify the timing mechanism ending CNS proliferation and reveal how aging progenitors transduce bursts of transcription factors into long-lasting changes in cell proliferation and cell identity...
  61. ncbi Alternative splicing removes an Ets interaction domain from Lozenge during Drosophila eye development
    Kristina Jackson Behan
    University of West Florida, Pensacola 32514, USA
    Dev Genes Evol 215:423-35. 2005
    ..We suggest that during eye development, Lozenge isoforms function in divergent roles, either interacting with Pointed on downstream targets or by functioning independently to establish distinct cell fates...
  62. doi A conserved nuclear receptor, Tailless, is required for efficient proliferation and prolonged maintenance of mushroom body progenitors in the Drosophila brain
    Mitsuhiko Kurusu
    Structural Biology Center, National Institute of Genetics, and Department of Genetics, The Graduate University for Advanced Studies, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Dev Biol 326:224-36. 2009
    ..These results as a whole uncover a distinct regulatory mechanism of self-renewal and differentiation of the MB progenitors that is different from the mechanisms found in other progenitors...
  63. ncbi Multipotent Drosophila intestinal stem cells specify daughter cell fates by differential notch signaling
    Benjamin Ohlstein
    Howard Hughes Medical Institute, Department of Embryology, Carnegie Institution of Washington, 3520 San Martin Drive, Baltimore, MD 21218, USA
    Science 315:988-92. 2007
    ..Thus, ISCs control daughter cell fate by modulating Notch signaling over time. Our studies suggest that ISCs actively coordinate cell production with local tissue requirements by this mechanism...
  64. doi Loss of seven-up from Drosophila R1/R6 photoreceptors reveals a stochastic fate choice that is normally biased by Notch
    Adam C Miller
    Institute of Molecular Biology, University of Oregon, 1370 Franklin Blvd, Eugene, OR 97403, USA
    Development 135:707-15. 2008
    ..We show that N specifies the R7 fate by a novel branched pathway: N represses Svp expression, thereby exposing an underlying stochastic choice between the R7 and R8 fates, and then tips this choice towards the R7 fate...
  65. ncbi Cloning of the Drosophila prospero gene and its expression in ganglion mother cells
    F Matsuzaki
    Division of Molecular Genetics, National Institute of Neuroscience, NCNP, Tokyo, Japan
    Biochem Biophys Res Commun 182:1326-32. 1992
    ..Among genes known to control neurogenesis, prospero (pros) was recently identified as a gene required for gene expression specifying properties of some identified neurons...
  66. ncbi Asymmetric cell division: fly neuroblast meets worm zygote
    C Q Doe
    Institute of Molecular Biology, Institute of Neuroscience, Howard Hughes Medical Institute, 1254 University of Oregon, Eugene, Oregon 97403, USA
    Curr Opin Cell Biol 13:68-75. 2001
    ..Mammalian epithelia also use this complex to regulate apical/basal polarity. Recent results have allowed us to compare the mechanisms regulating asymmetric cell division in Drosophila neuroblasts and the C. elegans zygote...
  67. ncbi Transcription factors in eye development: a gorgeous mosaic?
    J Kumar
    Department of Biological Sciences, University of Southern California, Los Angeles 90089 1340, USA
    Genes Dev 11:2023-8. 1997
  68. pmc The N terminus of the Drosophila Numb protein directs membrane association and actin-dependent asymmetric localization
    J A Knoblich
    Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco 94143 0724, USA
    Proc Natl Acad Sci U S A 94:13005-10. 1997
    ....
  69. ncbi Control of daughter cell fates during asymmetric division: interaction of Numb and Notch
    M Guo
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0724, USA
    Neuron 17:27-41. 1996
    ..This leads to Ttk expression in the daughter cell that does not inherit Numb. Thus, the inherited determinant Numb bestows a bias in the machinery for cell-cell communication to allow the specification of distinct daughter cell fates...
  70. pmc Pan-neural Prospero terminates cell proliferation during Drosophila neurogenesis
    L Li
    Department of Molecular Genetics, Ohio State University, Columbus, Ohio 43210 USA
    Genes Dev 14:147-51. 2000
    ..Loss of pros results in aberrant expression of multiple cell-cycle regulatory genes and ectopic mitotic activity...
  71. ncbi Control of the cell death pathway by Dapaf-1, a Drosophila Apaf-1/CED-4-related caspase activator
    H Kanuka
    Department of Neuroscience, Osaka University Graduate School of Medicine, Japan
    Mol Cell 4:757-69. 1999
    ..These data suggest that Dapaf-1/cytochrome c-dependent cell death-inducing machinery is present in Drosophila, and the requirement of Dapaf-1/Apaf-1 in neural cell death is conserved through evolution...
  72. ncbi Extrinsic cues, intrinsic cues and microfilaments regulate asymmetric protein localization in Drosophila neuroblasts
    J Broadus
    Department of Cell and Structural Biology, Howard Hughes Medical Institute, University of Illinois, Urbana 61801, USA
    Curr Biol 7:827-35. 1997
    ..Here we use in vitro culture of neuroblasts to investigate the role of intrinsic and extrinsic cues and the cytoskeleton in asymmetric localization of Inscuteable, Prospero and Staufen proteins...
  73. ncbi A glial cell arises from an additional division within the mechanosensory lineage during development of the microchaete on the Drosophila notum
    G V Reddy
    Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Rd, Mumbai 400 005 and the National Centre for Biological Sciences, TIFR, Bangalore 560 065, India
    Development 126:4617-22. 1999
    ..The proposed modification in lineage has important implications for previous studies on sibling cell fate choice and cell fate specification in sensory systems...
  74. ncbi Miranda directs Prospero to a daughter cell during Drosophila asymmetric divisions
    H Ikeshima-Kataoka
    Department of Molecular Genetics, National Institute of Neuroscience, Tokyo, Japan
    Nature 390:625-9. 1997
    ..miranda thus creates intrinsic differences between sibling cells by mediating the asymmetric segregation of a transcription factor into only one daughter cell during neural stem-cell division...
  75. ncbi Revisiting the Drosophila microchaete lineage: a novel intrinsically asymmetric cell division generates a glial cell
    M Gho
    Ecole Normale Superieure, ATIPE URA1857, 75005 Paris, France
    Development 126:3573-84. 1999
    ..This revised description of the sense organ lineage provides the basis for future studies on how polarity and fate are regulated in asymmetrically dividing cells...
  76. ncbi Only a subset of the binary cell fate decisions mediated by Numb/Notch signaling in Drosophila sensory organ lineage requires Suppressor of Hairless
    S Wang
    Howard Hughes Medical Institute, and Department of Physiology, University of California, San Francisco 94143 0724, USA
    Development 124:4435-46. 1997
    ..These studies reveal that Suppressor of Hairless is required for only a subset of the asymmetric divisions that depend on the function of numb and Notch...
  77. ncbi The Drosophila sanpodo gene controls sibling cell fate and encodes a tropomodulin homolog, an actin/tropomyosin-associated protein
    C A Dye
    Department of Cell Biology, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA
    Development 125:1845-56. 1998
    ..Loss of sanpodo leads to an aberrant F-actin distribution and causes differentiation defects of actin-containing sensory structures. Our data suggest that an actin-based process is involved in Notch signaling...
  78. ncbi Frizzled signalling controls orientation of asymmetric sense organ precursor cell divisions in Drosophila
    M Gho
    Laboratoire de Génétique du Développement de la Drosophile, URA 1857, Ecole Normale Superieure, Paris, France
    Nature 393:178-81. 1998
    ..This difference in cell-division orientation is largely independent of the identity of the secondary precursor cells, and is regulated by Frizzled-independent mechanisms...
  79. ncbi Miranda is required for the asymmetric localization of Prospero during mitosis in Drosophila
    C P Shen
    Howard Hughes Medical Institute and Department of Physiology, University of California at San Francisco, 94143 0724, USA
    Cell 90:449-58. 1997
    ..Our results suggest that miranda functions downstream of inscuteable and works as an adapter that connects Prospero to the basal cell membrane during asymmetric cell division...
  80. pmc Miranda mediates asymmetric protein and RNA localization in the developing nervous system
    A J Schuldt
    Wellcome CRC Institute and Department of Genetics, Cambridge CB2 1QR, UK
    Genes Dev 12:1847-57. 1998
    ..Thus Miranda, which localizes Prospero protein, also localizes prospero RNA through its interaction with Staufen protein...
  81. pmc A family of snail-related zinc finger proteins regulates two distinct and parallel mechanisms that mediate Drosophila neuroblast asymmetric divisions
    Y Cai
    Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore
    EMBO J 20:1704-14. 2001
    ....
  82. ncbi The prospero gene specifies cell fates in the Drosophila central nervous system
    C Q Doe
    Department of Cell and Structural Biology, University of Illinois, Urbana 61801
    Cell 65:451-64. 1991
    ..prospero is therefore a novel type of gene expressed in neuroblasts and known to specify neuronal fate...
  83. ncbi Adherens junctions inhibit asymmetric division in the Drosophila epithelium
    B Lu
    Howard Hughes Medical Institute and Department of Physiology, University of California at San Francisco, 94143 0725, USA
    Nature 409:522-5. 2001
    ..Our results indicate that neuroepithelial cells have all the necessary components to execute asymmetric division, but that this pathway is normally overridden by the planar polarity cue provided by adherens junctions...
  84. ncbi Lineage, cell polarity and inscuteable function in the peripheral nervous system of the Drosophila embryo
    V Orgogozo
    Ecole Normale Superieure, UMR 8544 46, rue d Ulm, 75230 Paris Cedex 05, France
    Development 128:631-43. 2001
    ..This study establishes for the first time the function of Inscuteable in the PNS, and provides the basis for studying the mechanisms controlling planar and apical-basal cell polarities in the embryonic sensory organ lineages...
  85. ncbi Asymmetric cell division
    Y N Jan
    Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, 94143 0725, USA
    Nature 392:775-8. 1998
    ....
  86. ncbi Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast
    T Ohshiro
    CREST, Japan Science and Technology Corporation, Sendai
    Nature 408:593-6. 2000
    ..Thus, Lgl and Dlg act in a common process that differentially mediates cortical protein targeting in mitotic neuroblasts, and that creates intrinsic differences between daughter cells...
  87. ncbi The prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila
    E P Spana
    Howard Hughes Medical Institute, Department of Cell and Structural Biology, University of Illinois, Urbana 61801, USA
    Development 121:3187-95. 1995
    ..The asymmetric cortical localization of prospero at mitosis is a mechanism for rapidly establishing distinct sibling cell fates in the CNS and possibly other tissues...
  88. ncbi Overlapping activators and repressors delimit transcriptional response to receptor tyrosine kinase signals in the Drosophila eye
    C Xu
    Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260, USA
    Cell 103:87-97. 2000
    ..We show that Sevenless activates prospero independent of the enhancer and involves targeted degradation of Tramtrack, a transcription repressor...
  89. ncbi Innervation directs receptor synthesis and localization in Drosophila embryo synaptogenesis
    K Broadie
    Department of Zoology, University of Cambridge, UK
    Nature 361:350-3. 1993
    ..prospero (pros) is not expressed in the muscles or their precursors...
  90. ncbi CNS midline cells in Drosophila induce the differentiation of lateral neural cells
    T V Menne
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Germany
    Development 124:4949-58. 1997
    ..Furthermore, ectopic midline cells are able to induce enhanced expression of some lateral CNS cell markers. We thus conclude that the CNS midline plays an important role in the differentiation or maintenance of the lateral CNS cortex...
  91. pmc Nonclinality of molecular variation implicates selection in maintaining a morphological cline of Drosophila melanogaster
    J Gockel
    Galton Laboratory, Department of Biology, University College, 4 Stephenson Way, London NW1 2HE, United Kingdom
    Genetics 158:319-23. 2001
    ..Explicit incorporation of the relevant environmental gradient can result in a simple and powerful test of selection. For the Australian cline, our analysis provides strong internal evidence that the cline is due to selection...
  92. ncbi A microRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila eye
    Xin Li
    Department of Biochemistry, Molecular Biology and Cell Biology, 2205 Tech Drive, Northwestern University, Evanston, Illinois 60208, USA
    Cell 123:1267-77. 2005
    ..Expression is switched when EGFR signaling transiently triggers Yan degradation. This two-tiered mechanism explains how signal transduction activity can robustly generate a stable change in gene-expression patterns...
  93. ncbi Selection and analysis of rare second-site suppressors of Drosophila RNA polymerase II mutations
    I Krasnoselskaya
    Laboratory of Biochemistry, NIH NCI, Bethesda, MD 20892 4255, USA
    Mol Gen Genet 258:457-65. 1998
    ..The mutations recovered are not random and might provide insights into possible mechanisms for mutagenesis in eukaryotes...
  94. ncbi Role of proneural genes in the formation of the larval olfactory organ of Drosophila
    Nicola Grillenzoni
    Department of Biology, University of Fribourg, Chemin du Musee 10, 1700, Fribourg, Switzerland
    Dev Genes Evol 217:209-19. 2007
    ....
  95. pmc P-element insertion alleles of essential genes on the third chromosome of Drosophila melanogaster: mutations affecting embryonic PNS development
    A Salzberg
    Howard Hughes Medical Institute, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genetics 147:1723-41. 1997
    ..A comparison between this screen and a chemical mutagenesis screen undertaken earlier highlights the complementarity of the two types of genetic screens...
  96. ncbi Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila
    Yaopan Mao
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 133:2539-51. 2006
    ..Our results implicate Dachs as a crucial downstream component of a Fat signaling pathway that influences growth, affinity and gene expression during development...
  97. ncbi Biparous: a novel bHLH gene expressed in neuronal and glial precursors in Drosophila
    A Bush
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Dev Biol 180:759-72. 1996
    ..The bHLH domain is sufficiently different from previously described bHLH domains to imply a novel function...
  98. ncbi Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphology
    Wesley B Grueber
    Departments of Physiology and Biochemistry, University of California, San Francisco, Rock Hall, Room GD481, 1550 4th Street, San Francisco, CA 94143, USA
    Development 134:55-64. 2007
    ....
  99. ncbi Drosophila abl and genetic redundancy in signal transduction
    F M Hoffmann
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Trends Genet 7:351-5. 1991
    ..Molecular isolation and analysis of the genes identified by these second-site mutations should define the molecular basis for the genetic redundancy...
  100. ncbi huckebein specifies aspects of CNS precursor identity required for motoneuron axon pathfinding
    Q Chu-LaGraff
    Howard Hughes Medical Institute, Department of Cell and Structural Biology, University of Illinois, Urbana 61801, USA
    Neuron 15:1041-51. 1995
    ..Thus, huckebein regulates aspects of GMC and neuronal identity required for proper motoneuron axon pathfinding in the NB 4-2 lineage...
  101. ncbi Chromatid segregation at anaphase requires the barren product, a novel chromosome-associated protein that interacts with Topoisomerase II
    M A Bhat
    Howard Hughes Medical Institute, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 87:1103-14. 1996
    ..We propose that this association is required for proper chromosomal segregation by facilitating the decatenation of chromatids at anaphase...

Research Grants68

  1. GENETIC AND MOLECULAR STUDIES OF NEUROGENESIS
    Chris Q Doe; Fiscal Year: 2010
    ..Thus, we propose to continue our investigation of temporal patterning in the Drosophila CMS,with the goal of providing insight into the mechanisms regulating temporal patterning during mammalian neurogenesis. ..
  2. REGULATORY CASCADES IN GASTROINTESTINAL PROLIFERATION
    KLAUS KAESTNER; Fiscal Year: 2006
    ..Together, these studies will further our understanding of the regulatory circuits that control gastrointestinal proliferation in normal development and carcinogenesis. ..
  3. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2006
    ..The new resources generated through this project will be made available to the NIDDK-funded biotechnology centers and the diabetes research community at large. ..
  4. Molecular and genetic analysis of sanpodo
    JAMES SKEATH; Fiscal Year: 2006
    ....
  5. GENETIC CONTROL OF TISSUE POLARITY
    Paul Adler; Fiscal Year: 2005
    ..For one of these genes we will determine the relative importance of adhesion versus signal transduction for the mutant phenotype. ..
  6. Patterning of the Primitive Heart Tube in Zebrafish
    Jau Nian Chen; Fiscal Year: 2007
    ..The combination of cellular, molecular and genetic studies proposed in this project will provide new and in-depth insight into mechanisms of primitive heart tube morphogenesis. ..
  7. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
    ....
  8. Physiological regulation and function of asymmetric stem cell division
    Yukiko Yamashita; Fiscal Year: 2011
    ..Understanding of such mechanisms may allow us to manipulate stem cell behavior;for example, normal stem cells can be expanded in culture for transplantation, or we can inhibit the expansion of cancerous stem cells. ..
  9. Molecular and genetic analysis of sanpodo
    JAMES SKEATH; Fiscal Year: 2009
    ..Such insight should help us understand the etiology of diseases in which this process is de-regulated and design new methods to treat these diseases. ..
  10. DEVELOPMENT OF IDENTIFIED MOTONEURONS
    Judith Eisen; Fiscal Year: 2009
    ..Our proposed studies will help reveal mechanisms that regulate motoneuron differentiation and survival, thus providing insights that should facilitate new therapies for treatment of motoneuron diseases and injury. ..
  11. Molecular and genetic analysis of sanpodo
    James B Skeath; Fiscal Year: 2010
    ..Such insight should help us understand the etiology of diseases in which this process is de-regulated and design new methods to treat these diseases. ..
  12. GENETIC AND MOLECULAR STUDIES OF NEUROGENESIS
    Chris Doe; Fiscal Year: 2009
    ..Thus, we propose to continue our investigation of temporal patterning in the Drosophila CNS, with the goal of providing insight into the mechanisms regulating temporal patterning during mammalian neurogenesis. ..
  13. DEVELOPMENT OF IDENTIFIED MOTONEURONS
    Judith Eisen; Fiscal Year: 2007
    ..Our proposed studies will provide insights that should facilitate new therapies for treatment of motoneuron diseases and injury. ..
  14. DEVELOPMENT OF IDENTIFIED MOTONEURONS
    Judith Eisen; Fiscal Year: 1993
    ..We will learn whether death of a specific motoneuron can be prevented, and we will learn its fate when it survives. We will learn whether motoneurons that do not typically behave as an equivalence pair can be induced to do so...
  15. STOCHASTIC MODELS IN MEDICINE AND BIOLOGY
    Samuel Karlin; Fiscal Year: 1980
    ..Parallel simulation studies are also in progress which complement the combined empirical and model buttressed exploratory methodology that we are developing...
  16. COMPARATIVE GENOMIC AND EVOLUTIONARY STUDIES
    Samuel Karlin; Fiscal Year: 2002
    ..We will further investigate rare and frequent words, motifs, or compositional biases. Finally, we will continue the development of versatile code that implements all our computational and statistical methods for sequence analysis. ..
  17. MOLECULAR GENETIC ANALYSIS OF ASYMMETRIC CELL DIVISIONS
    Chris Doe; Fiscal Year: 2002
    ..We will do RNA and protein localization studies; our collaborator, Dr. G. Oliver will generate and assay the gene knock-out mice. ..
  18. SIGNALING SPECIFICITY IN DROSOPHILA SERPENTINE RECEPTORS
    Andrew Tomlinson; Fiscal Year: 2002
    ..Aim 2 will test the specific hypothesis that the serpentine receptors activate heterotrimeric G proteins. Aim 3 will use an elegant genetic screen to identify new genes in the Wg signaling pathway. ..
  19. GENETIC CONTROL OF TISSUE POLARITY
    Paul Adler; Fiscal Year: 2001
    ..We will also carry out experiments designed to distinguish between models proposed to explain the function of the fz signaling/signal transduction pathway in the development of tissue polarity. ..
  20. REGULATORY CASCADES IN GASTROINTESTINAL PROLIFERATION
    KLAUS KAESTNER; Fiscal Year: 2001
    ..Together, these studies will further our understanding of the regulatory circuits that control gastrointestinal proliferation in normal development and carcinogenesis. ..
  21. DEVELOPMENT OF IDENTIFIED MOTONEURONS
    Judith Eisen; Fiscal Year: 2000
    ....
  22. MECHANISMS OF NEURAL PATTERNING IN MAMMALIAN FOREBRAIN
    Gordon Fishell; Fiscal Year: 2007
    ..abstract_text> ..